Abstract:
:Acute rejection episodes still occur after kidney transplantation in spite of modern immunosuppressive protocols including combined tacrolimus, mycophenolate mofetil, and prednisolone. The authors present seven cases of biopsy-proven acute rejection after kidney transplantation refractory to conventional rejection therapy with repeated pulses of high-dose steroids followed by polyclonal or monoclonal antibodies that responded well to photopheresis treatment. Photopheresis is an atoxic immunomodulatory apheresis-based treatment with no generalized immunosuppressive action; rather, it is directed at suppressing donor-specific T-cell clones. At the last follow-up, 9 to 43 months after transplantation, all patients had functioning grafts, with serum creatinine levels ranging from 105 to 312 microM. The authors conclude that photopheresis treatment contributed to the favorable outcome. Therefore, the authors are presently designing a prospective, randomized trial to evaluate the effect of photopheresis as an adjuvant prophylactic treatment after renal transplantation.
journal_name
Transplantationjournal_title
Transplantationauthors
Kumlien G,Genberg H,Shanwell A,Tydén Gdoi
10.1097/01.tp.0000147197.24050.61subject
Has Abstractpub_date
2005-01-15 00:00:00pages
123-5issue
1eissn
0041-1337issn
1534-6080pii
00007890-200501150-00020journal_volume
79pub_type
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