Reversibility of allograft arteriosclerosis after retransplantation to donor strain.

abstract：:Complement plays important roles in both ischemia-reperfusion injury (IRI) and antibody-mediated rejection (AMR) of solid organ allografts. One approach to possibly improve outcomes after transplantation is the use of C1 inhibitor (C1-INH), which blocks the first step in both the classical and lectin pathways of compl...

journal_title：Transplantation

authors： Berger M,Lefaucheur C,Jordan SC

更新日期：2019-09-01 00:00:00

abstract：:Numerous studies have reported successful allotransplantation of hepatocytes. However, none have shown long-term correction of a liver-related metabolic defect. In this study, we used a method of regional hepatocyte transplantation and subsequent induction of transplanted cell proliferation by regeneration response in...

journal_title：Transplantation

authors： Eguchi S,Rozga J,Lebow LT,Chen SC,Wang CC,Rosenthal R,Fogli L,Hewitt WR,Middleton Y,Demetriou AA

更新日期：1996-09-15 00:00:00

abstract：:For the development of liver injury during preservation for transplantation, phospholipid degradation may be of importance. We therefore measured the degradation of [3H]-arachidonic acid (20:4)- and [14C]-linoleic acid (18:2)-labeled phospholipids during cold and warm preservation of rat livers in Eurocollins, Univers...

journal_title：Transplantation

authors： Ar'Rajab A,Ahrén B,Nilsson A

更新日期：1994-04-27 00:00:00

abstract：:Second clinical kidney grafts often survive longer than first grafts. Using a rat cardiac allograft model, we examined the conditions under which survival of a second graft can be longer than first graft survival. In the BUF-to-LEW combination, following rejection of the first transplant, second cardiac allografts fro...

journal_title：Transplantation

authors： Yanagiya A,Terasaki PI,Iwaki Y,Ho BB,Drinkwater DC,Laks H

更新日期：1992-10-01 00:00:00

abstract：:Previous studies have demonstrated that donor antigen-specific primed-lymphocyte-test (PLT) reactivity of bronchoalveolar lavage lymphocytes is strongly associated with acute pulmonary rejection and with obliterative bronchiolitis (OB); however, a systematic analysis of PLT reactivity as being class I-or II-directed h...

journal_title：Transplantation

authors： Reinsmoen NL,Bolman RM,Savik K,Butters K,Hertz M

更新日期：1992-01-01 00:00:00

abstract：:Recipients of solid organ allografts require lifelong immunosuppression in order to prevent graft rejection and to maintain graft function. In general, such immunosuppression greatly impairs the cellular immune system, as this level of the immune system is principally responsible for self and non-self recognition. The...

journal_title：Transplantation

authors： Van Thiel DH,Finkel R,Friedlander L,Gavaler JS,Wright HI,Gordon R

更新日期：1992-08-01 00:00:00

abstract：:Increasing numbers of sensitized patients are either precluded from receiving an allograft or experience accelerated rejection which may be refractory to conventional therapy. Using a rat model, we have shown that accelerated (24 hr) rejection of LBN cardiac Tx in LEW rats sensitized with BN skin grafts 7 days earlier...

journal_title：Transplantation

authors： Hancock WW,DiStefano R,Braun P,Schweizer RT,Tilney NL,Kupiec-Weglinski JW

更新日期：1990-02-01 00:00:00

abstract：:We have studied organ allograft survival in rhesus monkeys conditioned with myeloablative total-body irradiation and T cell-depleted autologous bone marrow transplantation then given a heterotopic MHC-mismatched cardiac allograft in the immediate postmyeloablative period. This model has enabled us to investigate the r...

journal_title：Transplantation

authors： Moses RD,Sundeen JT,Orr KS,Roberts RR,Gress RE

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Despite the success rate of solitary pancreas transplantation in type 1 diabetes with preserved kidney function has greatly improved in recent years, a residual proportion of failures persists. METHODS:With the aim of investigating autoimmunity as an unrecognized cause of graft failure, we measured autoanti...

journal_title：Transplantation

authors： Occhipinti M,Lampasona V,Vistoli F,Bazzigaluppi E,Scavini M,Boggi U,Marchetti P,Bosi E

更新日期：2011-09-27 00:00:00

abstract：BACKGROUND:In this study, we investigated the effects of selective endothelin (ET) receptor antagonism during different periods of cold ischemia on glomerular and tubular function and long-term survival in renal transplantation. METHODS:Left renal transplantation was performed in Lewis rats after 2 hr of cold ischemia...

journal_title：Transplantation

authors： Hammad FT,Davis G,Zhang XY,Wheatley AM

更新日期：2001-03-15 00:00:00

abstract：:The influence of ultraviolet (UVB) irradiation on the survival of H-2 class II-disparate skin grafts was studied in congenic mouse strains. Isolated skin was UVB irradiated in vitro at a dose of 40 mJ/cm2 from both sides to remove Ia immunogenicity. Immediately after irradiation the skin was transplanted onto the flan...

journal_title：Transplantation

authors： Vermeer BJ,Santerse B,Van De Kerckhove BA,Schothorst AA,Claas FH

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Bone marrow cells (BMCs) are believed to have the ability to generate functional hepatocytes and have some merits as a therapeutic modality for metabolic liver diseases. However, the appearance of BMC-derived hepatocytes (BMDHs) is low. We hypothesized that early BMC injection would be feasible for creating ...

journal_title：Transplantation

authors： Misawa R,Soeda J,Ise H,Takahashi M,Kubota K,Mita A,Nakata T,Miyagawa S

更新日期：2009-04-27 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent endothelial cell growth and permeability factor, expressed in the lung. Overexpression of VEGF is associated with increased vascular permeability in the early stage of acute lung injury in mice. The role of various forms of VEGF in transplantation-induced...

journal_title：Transplantation

authors： Abraham D,Taghavi S,Riml P,Paulus P,Hofmann M,Baumann C,Kocher A,Klepetko W,Aharinejad S

更新日期：2002-06-15 00:00:00

abstract：:The mortality rates for CVDs in transplant recipients are greater than those in the general population (13). CVDs are a major cause of both patient and graft loss in renal transplant recipients, and improving cardiovascular health may help to extend both patient and graft survival. A complication of chronic renal fail...

journal_title：Transplantation

authors： Wheeler DC,Steiger J

更新日期：2000-12-15 00:00:00

abstract：BACKGROUND:Acute liver failure (ALF) carries a high mortality unless urgent orthotopic liver transplantation (OLT) is performed on time. Live donors are utilized to treat this irreversible condition first in pediatric cases and then in adults. Herein, we aimed to report our experience with live donors for ALF in a coun...

journal_title：Transplantation

authors： Kilic M,Aydin U,Noyan A,Arikan C,Aydogdu S,Akyildiz M,Karasu Z,Zeytunlu M,Alper M,Batur Y

更新日期：2007-08-27 00:00:00

abstract：:Untreated anephric LEW rats die ca. 9 days following transplantation of LBNF1 kidney allografts. Although treatment with ART-18, a mouse antirat IL-2R mAb (300 micrograms/kg/day x 10 days), prolonged graft survival to ca. 3 weeks, the severely impaired renal function was comparable to untreated controls (creatinine le...

journal_title：Transplantation

authors： Ueda H,Hancock WW,Cheung YC,Diamantstein T,Tilney NL,Kupiec-Weglinski JW

更新日期：1990-10-01 00:00:00

abstract：:To determine whether a disparity at a single miH genetic loci are sufficient to generate GVHD in mice, we focused on well-known genetic alleleic differences at the miH gene loci, H3 and H4. For H3 congenic GVHD studies, C57BL/10 (H2b) mice were used as recipients of miH-disparate B10.LP-H3b donor cells. For H4 congeni...

journal_title：Transplantation

authors： Blazar BR,Roopenian DC,Taylor PA,Christianson GJ,Panoskaltsis-Mortari A,Vallera DA

更新日期：1996-02-27 00:00:00

abstract：:The success of kidney transplants is limited by the lack of robust improvements in long-term survival. It is now recognized that alloimmune responses are responsible for the majority of allograft failures. Development of novel therapies to decrease allosensitization is critical. The lack of new drug development in kid...

journal_title：Transplantation

authors： Jordan SC,Choi J,Kim I,Wu G,Toyoda M,Shin B,Vo A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:In hamster-to-rat cardiac xenografts, long-term survival (LTS) is obtained in 60% of recipients if vascular rejection is overcome by cobra venom factor and cyclosporine (CsA). It has been suggested that this accommodation state could be due to the Th2 response. METHODS:We examined the infiltrate by using im...

journal_title：Transplantation

authors： Brouard S,Blancho G,Moreau A,Heslan JM,Cuturi MC,Soulillou JP

更新日期：1998-06-27 00:00:00

abstract：:We present the youngest successful patient with combined heart-lung-liver transplantation. The patient was a 2.5-year-old child with Alagille syndrome suffering from tetralogy of Fallot with pulmonary atresia and multiple aortopulmonary collaterals and familial cholestasis. ...

journal_title：Transplantation

authors： Gandhi SK,Reyes J,Webber SA,Siewers RD,Pigula FA

更新日期：2002-06-27 00:00:00

abstract：BACKGROUND:Success of human pancreatic islet isolation depends largely on the techniques used during pancreas procurement and the quality of the gland. Warm ischemia of the pancreas of any duration during organ procurement may be detrimental to subsequent islet yield and functional viability of the islets. The aim of t...

journal_title：Transplantation

authors： Lakey JR,Kneteman NM,Rajotte RV,Wu DC,Bigam D,Shapiro AM

更新日期：2002-04-15 00:00:00

abstract：:A considerable amount of data indicates that transplanted patients are at increased risk for de novo and recurrent cancer. Treatment of this population is difficult. It remains unclear if the immunosuppressive therapy should be continued, tapered or even stopped or if immunosuppressive drugs with antiproliferative pro...

journal_title：Transplantation

authors： Andrassy J,Graeb C,Rentsch M,Jauch KW,Guba M

更新日期：2005-09-27 00:00:00

abstract：:Reports of early success with cryopreserved saphenous veins (CSV) as arterial conduits led us to develop cryopreserved iliac veins (CIV) as interposition grafts for portal vein reconstruction in living-related liver transplantation (LRLT). Despite encouraging short-term results, retrospective analysis of long-term cry...

journal_title：Transplantation

authors： Kuang AA,Renz JF,Ferrell LD,Ring EJ,Rosenthal P,Lim RC,Roberts JP,Ascher NL,Emond JC

更新日期：1996-09-27 00:00:00

abstract：:Publicly available program-specific data from the scientific registry of transplant recipients were used to determine the association between adult lung transplant center volume and 1-year recipient mortality from 2000 to 2007. We found a significant inverse association between the center volume of adult lung transpla...

journal_title：Transplantation

authors： Scarborough JE,Bennett KM,Davis RD,Lin SS,Tracy ET,Kuo PC,Pappas TN

更新日期：2010-03-27 00:00:00

abstract：BACKGROUND:We sought to compare the immunoreactive potential of human cord blood (CB) versus normal adult bone marrow (BM) versus mobilized blood (peripheral blood stem cells; PBSC) from cancer patients. METHODS:Forty mice were randomized to receive a range of doses of T cell-replete cell preparations from one of the ...

journal_title：Transplantation

authors： Leung W,Ramírez M,Mukherjee G,Perlman EJ,Civin CI

更新日期：1999-09-15 00:00:00

abstract：:Incompatibility for DBA/2 (D2) minor histocompatibility antigens (MiHA) alone leads to a severe lethal graft-versus-host reaction (GVHR) in irradiated (D2 X B10.D2)F1 mice receiving a bone-marrow-plus-spleen-cell graft from B10.D2 donors. This mortality is abrogated when the donors are preimmunized simultaneously agai...

journal_title：Transplantation

authors： Pritchard LL,Halle-Pannenko O

更新日期：1983-09-01 00:00:00

abstract：:Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was ini...

journal_title：Transplantation

authors： Nisbet NW,Menage J,Loutit JF

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:Generation of non-human primate regulatory T cells (Treg) with alloantigen (alloAg) specificity would allow their testing in preclinical transplant models. Low recovery of Treg from peripheral blood limits their potential utility. In small animals and humans, conventional myeloid dendritic cells (DC) have be...

journal_title：Transplantation

authors： Zahorchak AF,Raimondi G,Thomson AW

更新日期：2009-11-15 00:00:00

abstract：BACKGROUND:At the time of transplantation, a recipient's serum is tested against the prospective donor's lymphocytes to identify specific reactivity and to look for a donor-specific crossmatch (CXM). Here, we investigated the relationship between the pretransplantation lymphocytotoxic CXM results and the long-term outc...

journal_title：Transplantation

authors： Shin M,Moon HH,Kim JM,Park JB,Kwon CH,Kim SJ,Lee SK,Joh JW

更新日期：2013-06-15 00:00:00

abstract：:The incidence of interstitial pneumonitis (IP) was reviewed in 70 consecutive patients who received autologous marrow transplants for hematologic malignancies. All patients were treated with total-body irradiation (TBI), with or without other chemotherapeutic agents. Seven patients (10%) developed IP, 3 were due to cy...

journal_title：Transplantation

authors： Pecego R,Hill R,Appelbaum FR,Amos D,Buckner CD,Fefer A,Thomas ED

更新日期：1986-11-01 00:00:00