Zinc transporter 8 autoantibodies increase the predictive value of islet autoantibodies for function loss of technically successful solitary pancreas transplant.

abstract：BACKGROUND:Vitamin D deficiency has been reported in different chronic pulmonary diseases like asthma and chronic obstructive pulmonary disease, but little is known in lung transplant recipients. METHODS:Serum 25-hydroxyvitamin D (25-OHD) levels and pulmonary function (forced expiratory volume in 1 sec [FEV(1)] %predi...

journal_title：Transplantation

authors： Verleden SE,Vos R,Geenens R,Ruttens D,Vaneylen A,Dupont LJ,Verleden GM,van Raemdonck DE,Vanaudenaerde BM

更新日期：2012-01-27 00:00:00

abstract：:We report the largest single-center experience with extracorporeal photopheresis (ECP) for bronchiolitis obliterans syndrome (BOS) and recurrent acute rejection (AR) after lung transplantation. Lung transplant recipients undergoing ECP for BOS and recurrent AR were included (1997-2007). The rate of forced expiratory v...

journal_title：Transplantation

authors： Benden C,Speich R,Hofbauer GF,Irani S,Eich-Wanger C,Russi EW,Weder W,Boehler A

更新日期：2008-12-15 00:00:00

abstract：:Several studies have reported the development of antiidiotypic antibodies to anti-HLA alloantibodies in renal allograft transplant recipients, postulating their potential beneficial role in allograft survival. In order to evaluate the role of anti-HLA antiidiotypic antibodies in human liver transplant recipients and t...

journal_title：Transplantation

authors： Chauhan B,Phelan DL,Marsh JW,Mohanakumar T

更新日期：1993-08-01 00:00:00

abstract：:The effect of cyclosporine on lymphocyte intracellular free calcium [( Ca2+]i) is controversial, and potential age-related differences in lymphocyte CsA sensitivity have not been studied. We measured the mitogen-induced change in [Ca2+]i in peripheral blood lymphocytes (PBLs) following intravenous CsA infusion (5 mg/k...

journal_title：Transplantation

authors： Tsao PW,Diaz RJ,Radde IC,Wong PY,Martell MF,Augustine JM,Wilson GJ,Coles JG

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:The hepatic arteries (HAs) in a hepatic graft are usually reconstructed using the recipient's left or right HAs in living donor liver transplantation (LDLT). There have been no apparent selection criteria concerning which of the recipient's HAs should be used. This study retrospectively investigated whether ...

journal_title：Transplantation

authors： Uchiyama H,Ikegami T,Soejima Y,Ninomiya M,Kayashima H,Taketomi A,Shirabe K,Maehara Y

更新日期：2010-04-27 00:00:00

abstract：:Human herpesvirus type 6 (HHV-6) causes roseola infantum (exanthema subitum) upon primary infection in young children. Thereafter it persists lifelong in the organism. Like other herpesviruses, HHV-6 can be reactivated in periods of immunosuppression - e.g., after organ transplantation. In order to study the incidence...

journal_title：Transplantation

authors： Schmidt CA,Wilbron F,Weiss K,Brinkmann V,Oettle H,Lohmann R,Langrehr JM,Neuhaus P,Siegert W

更新日期：1996-02-27 00:00:00

abstract：:Imaging methods such as nuclear medicine (including positron emission tomography), magnetic resonance imaging, ultrasound, and optical imaging can be used to provide information about the expression of genes, and the location of molecules and cells in intact animals or patients. In the setting of transplantation, this...

journal_title：Transplantation

authors： George AJ,Bhakoo KK,Haskard DO,Larkman DJ,Reynolds PR

更新日期：2006-11-15 00:00:00

abstract：BACKGROUND:Immunosuppressive regimens for kidney transplantation which reduce the long-term burden of immunosuppression are attractive, but little data are available to judge the safety and efficacy of the different strategies used. We tested the hypothesis that the simple, cheap, regimen of alemtuzumab induction combi...

journal_title：Transplantation

authors： Chan K,Taube D,Roufosse C,Cook T,Brookes P,Goodall D,Galliford J,Cairns T,Dorling A,Duncan N,Hakim N,Palmer A,Papalois V,Warrens AN,Willicombe M,McLean AG

更新日期：2011-10-15 00:00:00

abstract：BACKGROUND:Vaccine-preventable viral infections are associated with increased risk of morbidity and mortality in immunocompromised patients. Current guidelines recommend routine screening and vaccination of all patients before solid organ transplantation. We studied rates of immunity against vaccine-preventable viruses...

journal_title：Transplantation

authors： Gardiner A,Liu K,Bonnichsen M,Joshi V,Davis RJ,Strasser SI

更新日期：2019-11-01 00:00:00

abstract：:Endothelial chimerism in transplanted organs is a fascinating phenomenon, indicative of a mechanism by which progenitor recipient cells replace the donor endothelium. It has been hypothesized that this replacement could lead to a decrease in alloreactivity and thus would positively influence graft outcome. However, re...

journal_title：Transplantation

authors： Koopmans M,Kremer Hovinga IC,Baelde HJ,de Heer E,Bruijn JA,Bajema IM

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:Extensive third degree burn wounds can be permanently covered by the transplantation of autologous cultured keratinocytes. Many modifications to Green and colleagues' original technique have been suggested, including the use of a fibrin matrix. However, the properties of the cultured cells must be assessed u...

journal_title：Transplantation

authors： Ronfard V,Rives JM,Neveux Y,Carsin H,Barrandon Y

更新日期：2000-12-15 00:00:00

abstract：:We examined the effect of methotrexate (MTX) combined with cyclosporine (CSP) on the prevention of graft-versus-host disease (GVHD) in dogs. Ten recipients were prepared for grafting with 9 Gy of total-body irradiation and given marrow and buffy coat cells from littermate donors differing for one DLA haplotype (AA lea...

journal_title：Transplantation

authors： Deeg HJ,Storb R,Appelbaum FR,Kennedy MS,Graham TC,Thomas ED

更新日期：1984-01-01 00:00:00

abstract：:Arterial ketone body ratio (AKBR [acetoacetate/beta-hydroxybutyrate]) was measured in nineteen patients under medical supportive therapy for fulminant hepatic failure (FHF), in order to evaluate its predictive value relative to liver transplantation. Of the 19 patients 8 (42%) were salvaged and 11 (58%) died. Seven of...

journal_title：Transplantation

authors： Saibara T,Onishi S,Sone J,Yamamoto N,Shimahara Y,Mori K,Ozawa K,Yamamoto Y

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Microvascular endothelial cells (ECs) are central to an allograft's immunogenicity. Cold ischemia and reperfusion injury associated with static cold storage and warm reperfusion activates ECs and increases the immunogenicity of the allograft. After reperfusion, mitochondrial permeability transition pore (mPT...

journal_title：Transplantation

authors： Tran DT,Esckilsen S,Mulligan J,Mehrotra S,Atkinson C,Nadig SN

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:T lymphocyte activation mediated by CD28 costimulation plays a critical role in graft rejection. Plant alkaloid tetrandrine, purified from a Chinese antirheumatic herb, is a potent immunosuppressant. Here, we examined its effects on several CD28-costimulated T-cell activities. In addition, such effects were ...

journal_title：Transplantation

authors： Lai JH,Ho LJ,Kwan CY,Chang DM,Lee TC

更新日期：1999-11-15 00:00:00

abstract：BACKGROUND:Transplant vasculopathy in kidney and heart allografts is associated with marked elevation of endothelin-1 (ET-1), but a role for ET-1 in the pathogenesis of transplant vasculopathy and chronic rejection has not been established. We, therefore, tested whether inhibition of ET-1-converting enzyme by phosphora...

journal_title：Transplantation

authors： Simonson MS,Herman WH,Robinson A,Schulak J,Hricik DE

更新日期：1999-06-27 00:00:00

abstract：:Renal vasoconstriction has been implicated as a major contributing factor for the nephrotoxic effects of cyclosporine. In an attempt to assess the relative contribution of thromboxane (Tx), the effects of coadministering CsA with the selective Tx synthetase inhibitor, Dazmegrel (DAZ) (Pfizer, Inc.), were determined. R...

journal_title：Transplantation

authors： Gladue RP,Newborg MF

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Because CD4CD25Foxp3 regulatory T cells (Tregs) are essential for the maintenance of self-tolerance, significant interest surrounds the developmental cues for thymic-derived natural Tregs (nTregs) and periphery-generated adaptive Tregs (aTregs). In the transplant setting, the allograft may play a role in the...

journal_title：Transplantation

authors： Kim JI,O'connor MR,Duff PE,Zhao G,Lee KM,Eliades P,Deng S,Yeh H,Caton AJ,Markmann JF

更新日期：2011-04-15 00:00:00

abstract：:Skin grafts can be significantly prolonged in ALS-treated mice by the injection of 25 x 10(6) donor bone marrow cells or 50 x 10(6) spleen cells. Lymph node cells and thymocytes are only minimally effective in prolonging grafts. The effect of a hematopoietic growth factor, granulocyte-macrophage colony stimulating fac...

journal_title：Transplantation

authors： Monaco AP,Wood ML,Gottschalk R,Seiler FR

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Immunomodulatory protocols including intravenous immunoglobulin/rituximab (IVIG/R) are employed to decrease anti-human leukocyte antigen (HLA) antibody levels for patients broadly sensitized to HLA and increase chances for transplantation with a compatible deceased donor (DD). The aim of our study was to ide...

journal_title：Transplantation

authors： Lai CH,Cao K,Ong G,Naim M,Wang Q,Mirocha J,Vo A,Jordan SC,Reinsmoen NL

更新日期：2011-07-15 00:00:00

abstract：:We investigated the preventive effect of the immunosuppressive agent FK506 on autoimmune insulitis in nonobese diabetic mice. The mice were given FK506 in a dose of 1.0 mg/kg, every other day, from age 2 to 12, 2 to 6, and 4 to 12 weeks, respectively; after which, the incidence of insulitis and overt diabetes was moni...

journal_title：Transplantation

authors： Kai N,Motojima K,Tsunoda T,Kanematsu T

更新日期：1993-04-01 00:00:00

abstract：:We report the management of a patient with the late onset of chronic graft-versus-host disease (GVHD) after orthotopic liver transplantation. GVHD is a rare complication of solid organ transplants that usually presents early after transplantation and is fatal in the majority of cases. Our patient differs from the typi...

journal_title：Transplantation

authors： Dunn SP,Krueger LJ,Butani L,Punnett H

更新日期：2001-05-27 00:00:00

abstract：BACKGROUND AND AIMS:Liver endothelial cells (LECs) perform an essential role in important pathophysiologic functions in the liver. Establishment of a human LEC line facilitates advances in LEC research. Here, we present immortalization of human LECs using retroviral gene transfer of simian virus 40 large T antigen (SV4...

journal_title：Transplantation

authors： Matsumura T,Takesue M,Westerman KA,Okitsu T,Sakaguchi M,Fukazawa T,Totsugawa T,Noguchi H,Yamamoto S,Stolz DB,Tanaka N,Leboulch P,Kobayashi N

更新日期：2004-05-15 00:00:00

abstract：BACKGROUND:Persistent massive ascites (PMAS) longer than 14 days after living donor liver transplantation is not uncommon and associated with worse outcome. A predictive risk scoring system was constructed after analysis of recipient, graft, and surgery-related factors. METHODS:We retrospectively reviewed adult living...

journal_title：Transplantation

authors： Wu YJ,Wang SH,Elsarawy AM,Chan YC,Chen CL,Cheng BC,Li LC,Chiu CH,Lee YW,Lin YC,Wee SY,Pan CC,Kao YY,Chen YH,Lin HW,Lin LM,Lin CC

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Avascular osteonecrosis (AVN) is a serious complication of allogeneic stem cell transplantation (SCT). Graft-versus-host disease and its treatment with steroids are the main risk factors; underlying diagnosis, age and gender are further risk factors. It has been speculated that low baseline bone mineral dens...

journal_title：Transplantation

authors： Schulte CM,Beelen DW

更新日期：2005-06-27 00:00:00

abstract：BACKGROUND:Randomized controlled trials and U.S. Registry data have demonstrated that mycophenolate mofetil (MMF) reduces acute rejection rates and improves graft survival. We undertook the first paired kidney analysis comparing the effects of MMF and azathioprine on graft outcome in the United Kingdom. METHODS:In all...

journal_title：Transplantation

authors： Shah S,Collett D,Johnson R,Thuraisingham RC,Raftery MJ,Rudge CJ,Yaqoob MM

更新日期：2006-12-27 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion injury (IRI) significantly contributes to delayed graft function and inflammation, leading to graft loss. Ischemia-reperfusion injury is exacerbated by the thrombospondin-1-CD47 system through inhibition of nitric oxide signaling. We postulate that CD47 blockade and prevention of nitric ...

journal_title：Transplantation

authors： Lin Y,Manning PT,Jia J,Gaut JP,Xiao Z,Capoccia BJ,Chen CC,Hiebsch RR,Upadhya G,Mohanakumar T,Frazier WA,Chapman WC

更新日期：2014-08-27 00:00:00

abstract：BACKGROUND:Infants (<12 months) who require liver transplantation (LTx) represent a particularly challenging and understudied group of patients. METHODS:This retrospective study aimed to describe a large single-center experience of infants who received isolated LTx, illustrate important differences in infants versus o...

journal_title：Transplantation

authors： Venick RS,Farmer DG,McDiarmid SV,Duffy JP,Gordon SA,Yersiz H,Hong JC,Vargas JH,Ament ME,Busuttil RW

更新日期：2010-03-15 00:00:00

abstract：BACKGROUND:Hemophagocytic syndrome (HPS) is a serious hematological disorder caused by activated T lymphocytes in immunologically compromised patients. There is no report of HPS in liver transplant recipients. METHODS:Among 135 patients who underwent living-related liver transplantation between June 1990 and October 2...

journal_title：Transplantation

authors： Chisuwa H,Hashikura Y,Nakazawa Y,Kamijo T,Nakazawa K,Nakayama J,Oh-Ishi T,Ikegami T,Terada M,Kawasaki S

更新日期：2001-12-15 00:00:00

abstract：:The purpose of this study was to investigate two promising immunosuppressive agents, didemnin B (DB) and FK506 (FK), during pregnancy to assess potential adverse maternal or fetal effects. Pregnant C3H mice were randomized into control and high- and low-dose treatment groups for each drug. Animals received daily injec...

journal_title：Transplantation

authors： Farley DE,Shelby J,Alexander D,Scott JR

更新日期：1991-07-01 00:00:00