Abstract:
BACKGROUND:Avascular osteonecrosis (AVN) is a serious complication of allogeneic stem cell transplantation (SCT). Graft-versus-host disease and its treatment with steroids are the main risk factors; underlying diagnosis, age and gender are further risk factors. It has been speculated that low baseline bone mineral density (BMD) is associated with AVN posttransplant. Furthermore, rapid bone loss with consecutive microarchitectural changes might prone patients to AVN. METHODS:In a single-center prospective cohort study, 255 patients undergoing allogeneic SCT for CML, AML, MDS, and ALL were followed for at least 5 years. We measured BMD (spine, femoral neck, total body) and body indices (body weight, body mass index, body composition determined by dual-energy x-ray absorptiometry) at baseline. Annual changes of BMD and body indices were prospectively observed for 5 years. Incidence of hip AVN necessitating total arthroplasty (severe adverse event) was determined. Univariate and multifactorial nominal logistic as well as Cox proportional hazard analysis were performed. RESULTS:Severe adverse events occurred in nine patients (5-year cumulative incidence rate 6.9%). Baseline BMD and body indices were within normal limits. Rapid and intense bone loss occurred, especially during the first year, accompanied by loss of body and especially muscle mass. AVN occurrence was not associated with BMD or body indices at baseline neither with prospectively observed changes of BMD or body indices. CONCLUSIONS:AVN is a devastating frequent complication of allogeneous SCT. Allogeneous SCT is followed by dramatic changes in BMD and body composition. However, low BMD and rapid bone loss per se do not dispose patients to AVN occurrence.
journal_name
Transplantationjournal_title
Transplantationauthors
Schulte CM,Beelen DWdoi
10.1097/01.tp.0000164353.86447.dbsubject
Has Abstractpub_date
2005-06-27 00:00:00pages
1748-55issue
12eissn
0041-1337issn
1534-6080pii
00007890-200506270-00018journal_volume
79pub_type
临床试验,杂志文章相关文献
TRANSPLANTATION文献大全abstract:UNLABELLED:Most isolated intestinal graft losses are immunological. We conducted a pilot study to evaluate the feasibility of national sharing of HLA no-mismatch allografts for cadaveric isolated intestinal transplantation. METHODS:UNOS data were analyzed in a theoretical model. Part I: All solid organ donors between ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003150-00032
更新日期:2000-03-15 00:00:00
abstract::The intestinal phase of the graft-versus-host reaction (GVHR) has been investigated in adult F1 mice bearing grafts of fetal gut using an H-2-incompatible and an H-2-compatible, Mls-incompatible combination. The results indicate that the mitotic activity of the intestinal crypts and the number of intraepithelial lymph...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198109000-00011
更新日期:1981-09-01 00:00:00
abstract::Programmed cell death (PCD) is currently one of the most intensively studied areas in cell biology. Substantial evidence now exists demonstrating the integral role of PCD in many fundamental immunologic processes; therefore, understanding the mechanisms of PCD may provide advances with broad implications in immunobiol...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/00007890-199809270-00001
更新日期:1998-09-27 00:00:00
abstract:BACKGROUND:Bone marrow stromal cells (BMSC) transplantation offers promise in the treatment of chronic paraplegia in rodents. Here, we report the effect of this cell therapy in adult pigs suffering chronic paraplegia. METHODS:Three months after spinal cord injury, autologous BMSC in autologous plasma was injected into...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318186198f
更新日期:2008-09-27 00:00:00
abstract:BACKGROUND:Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high interpatient and intrapatient variability (IPV) leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC IPV (I...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002052
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Antibody-mediated rejection (AMR) remains associated with reduced kidney graft survival and no clear prognostic marker is available. METHODS:We investigated whether donor-specific antibodies (DSA) ability to bind C1q in comparison with AMR C4d status, both indirect signs of complement activation, improve ri...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002265
更新日期:2018-11-01 00:00:00
abstract::Hamster hearts transplanted into stable rat recipients of hamster livers (OLT rats) were hyperacutely rejected after transfer with unaltered rat antihamster hyperimmune serum (HS). This was followed by immediate liver xenograft rejection in 4 of 5 rats. In contrast, simple heat inactivation of the rat HS resulted in p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199403270-00025
更新日期:1994-03-27 00:00:00
abstract::IL-10 is a regulatory cytokine of both T cells and monocytes. We have investigated the ability of IL-10 to regulate responses to alloantigens in vitro and in vivo. Addition of IL-10 to mixed lymphocyte cultures profoundly decreased the proliferation and IL-2 production by donor B10.BR cells stimulated with CBA cells e...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-12-15 00:00:00
abstract:BACKGROUND:Organs for transplantation are a scarce community resource but community preferences and how they are incorporated into allocation policies are unclear. This systematic review aimed to ascertain community preferences for organ allocation and the principles underpinning these preferences. METHODS:Medline, Em...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e3181cf1ee1
更新日期:2010-04-15 00:00:00
abstract:BACKGROUND:If pancreas transplantation is a validated alternative for type 1 diabetic patients with end-stage renal disease, the management of patients who have lost their primary graft is poorly defined. This study aims at evaluating pancreas retransplantation outcome. METHODS:Between 1976 and 2008, 569 pancreas tran...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0b013e318271d795
更新日期:2013-01-27 00:00:00
abstract::Ontogenic development of suppressor cells was studied in mouse embryos. It was found that liver cells of embryos at various stages of gestation were capable of interfering with the mixed leukocyte culture (MLC) reaction. The MLC reaction was also inhibited by embryonic spleen and thymus cells. However, the latter were...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197812000-00016
更新日期:1978-12-01 00:00:00
abstract::Patients who require cystectomy are usually treated with an ileal conduit or intestinal neobladder for urinary control. In some of them, however, the bowel segment cannot be used because of previous abdominal surgery or radiation treatment. Bladder transplantation from cadavers may be beneficial to these patients, if ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199704150-00002
更新日期:1997-04-15 00:00:00
abstract::Hepatic artery thrombosis is a dreadful complication of orthotopic liver transplantation. It should be suspected in cases of fulminant liver failure, delayed bile leak, or intermittent sepsis of unknown cause after liver transplantation. Accurate diagnosis is assisted by ultrasound and computerized tomography scans, b...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198512000-00019
更新日期:1985-12-01 00:00:00
abstract::The science of composite tissue allotransplantation (CTA) is rooted in progressive thinking by surgeons, fueled by innovative solutions, and aided by understanding the immunology of tolerance and rejection. These three factors have allowed CTA to progress from science fiction to science fact. Research using preclinica...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e318184ca6a
更新日期:2008-09-15 00:00:00
abstract::Experimental studies of vein homografts in rats have shown prolonged patency resulting from an attenuated immune response. This study examined the response to Golden Syrian hamster vein xenografts. While one group of Sprague-Dawley rats served as a control, a second group was sensitized with 5 X 10(6) viable hamster s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198511000-00011
更新日期:1985-11-01 00:00:00
abstract::Intestinal transplantation has become the treatment of choice for patients who are experiencing life-threatening complications of intestinal failure. Early attempts with intestinal transplantation were unsuccessful as a consequence of both technical and immunologic failures. The introduction of tacrolimus provided the...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000126931.23349.15
更新日期:2004-05-15 00:00:00
abstract::FK506, an immunosuppresant, was isolated from Streptomyces tsukubaensis. Intramuscular administration of FK506 (0.32 mg/kg or more) 5 days a week for two weeks after grafting prolonged the acceptance time of F344 skin allograft to WKA rats. Similar results were obtained with cyclosporine at 32 mg/kg or more, but other...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198801000-00042
更新日期:1988-01-01 00:00:00
abstract::Ranolazine is a new drug with a novel mode of action as a metabolic modulator and membrane stabilizer. In this prospective randomized double-blind trial, a porcine model of renal autotransplantation was used to assess the effects of this drug during preservation and reperfusion of kidneys cold-stored for 24 hr in phos...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199011000-00004
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Brain death (BD) affects the viability of lungs for transplantation. A correlation exists between high lung inflammation after BD and the decrease in female sex hormones, especially estradiol. Therefore, we investigated the effects of 17β-estradiol (E2) treatment on the lungs of female brain dead rats. METH...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003467
更新日期:2020-10-07 00:00:00
abstract:BACKGROUND:To investigate immune reactions after reduced-intensity cord-blood transplantation (RI-CBT). MATERIALS AND METHODS:We reviewed medical records of 57 adult RI-CBT recipients. Preparative regimen comprised fludarabine, total-body irradiation, and either melphalan (n=51) or busulfan (n=6). Graft-versus-host di...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000163289.20406.86
更新日期:2005-07-15 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the efficacy of cariporide (a sodium-hydrogen exchanger inhibitor), BMS180448 (a pharmacologic ischemic preconditioning agent), and the combination thereof, as adjuvant therapies for extended cardiac allograft preservation. METHODS:A porcine model of donor brain death ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000079254.81264.6D
更新日期:2003-09-15 00:00:00
abstract:BACKGROUND:Although used for more than 20 years, optimal dosing strategies of most immunosuppressants have never been determined. Tacrolimus, one of the newer agents used in solid-organ transplantation, is gaining increasing popularity because of its ability to reverse refractory rejection in cyclosporine-treated patie...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-200210270-00014
更新日期:2002-10-27 00:00:00
abstract:BACKGROUND:The objective of this study was to investigate purine nucleotide metabolism in peripheral blood mononuclear cells (PBMC) of cardiac transplant recipients switched from azathioprine to mycophenolate mofetil (MMF). METHODS:Concentrations of guanosine 5'triphosphate (GTP) and adenosine 5'triphosphate (ATP), th...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000225759.54343.23
更新日期:2006-07-15 00:00:00
abstract:BACKGROUND:Transplantation enhances the risk of malignancies, due to the chronic use of antirejection medication. In the case of Kaposi's sarcoma (KS) the permissive effect of immunosuppression has been extensively studied, and cyclosporine (CsA) appears to play a key role. Here we have compared the incidence of KS in ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173803.97398.31
更新日期:2005-09-27 00:00:00
abstract::For the development of liver injury during preservation for transplantation, phospholipid degradation may be of importance. We therefore measured the degradation of [3H]-arachidonic acid (20:4)- and [14C]-linoleic acid (18:2)-labeled phospholipids during cold and warm preservation of rat livers in Eurocollins, Univers...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199404270-00003
更新日期:1994-04-27 00:00:00
abstract::A prospective randomized trial was performed comparing survival of cadaveric grafts allocated by HLA-A+B matching and HLA-DR matching. The two allocation methods resulted in very similar graft survivals. HLA-A matching had no significant effect on graft survival. HLA-B and HLA-DR matching were shown to have approximat...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-198407000-00010
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated that long-term tolerance of class I mismatched renal allografts in miniature swine is induced by a short course of cyclosporine (CyA), and that a total thymectomy 21 days before transplantation abrogates the induction of stable tolerance. We have now examined the effects of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199904270-00005
更新日期:1999-04-27 00:00:00
abstract:BACKGROUND:The spleen is considered to be an important secondary lymphoid organ where acute graft-versus-host disease (GVHD) is initiated by donor T cells that recognize host alloantigens after allogeneic bone-marrow transplantation (BMT). The influence of splenectomy on the development of GVHD prior to BMT has yet to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200205270-00027
更新日期:2002-05-27 00:00:00
abstract:BACKGROUND:The cascade of immunological effects brought about by donor bone marrow cell (DBMC) infusions in human organ transplantation, especially in the context of continuous pharmacologic immunosuppression, is not fully understood. Yet, in inbred rodents and even primates, administration of specific bone marrow cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199804150-00015
更新日期:1998-04-15 00:00:00
abstract:BACKGROUND:Human leukocyte antigen (HLA) antibodies, especially those that fix complement, are associated with antibody-mediated rejection and graft failure. The C1q assay on single antigen beads detects a subset of HLA antibodies that can fix complement and precede C4d deposition. The aim of this study was to determin...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318203fd26
更新日期:2011-02-15 00:00:00