The vascular endothelial cell antigen system.

Abstract:

:Vascular endothelial cells (VEC) are clearly immunogenic and express antigens unique to vascular endothelial cells. The observation that peripheral blood monocytes also express this VEC antigen system made prospective testing feasible. Preformed antibody to the VEC/monocyte antigen system of the donor usually leads to graft rejection in HLA-identical combinations, but antibody directed against donor monocytes exclusively (monocyte-specific antigens) appears to be benign. Clearly the VEC antigen system is an important immunogen in HLA-identical living-related donor combinations--and, in addition, this antigen system may be equally important in the non-HLA-identical combinations. The identification of antibody directed against the VEC/monocyte antigens of the donor is frequently masked by the concurrent development of anti-HLA antibody. Preliminary family segregation studies support the concept of genetic linkage between the VEC/monocyte antigen system and the major histocompatibility complex. A group of 153 consecutive, prospective monocyte crossmatches performed have yielded approximately a 7% incidence of positive monocyte crossmatches, with traditional crossmatches being negative. This frequency of patients sensitized to the VEC/monocyte antigens of the donor could conceivably account for up to 70% of the observed early graft loss in living-related donors. We think a positive monocyte crossmatch to the donor in the presence of positive reactivity to concordant VEC and monocytes remains a contraindication to transplantation.

journal_name

Transplantation

journal_title

Transplantation

authors

Cerilli J,Brasile L,Galouzis T,Lempert N,Clarke J

doi

10.1097/00007890-198503000-00016

subject

Has Abstract

pub_date

1985-03-01 00:00:00

pages

286-9

issue

3

eissn

0041-1337

issn

1534-6080

journal_volume

39

pub_type

杂志文章
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    abstract::The incidence of malignant disease (renal cancer and skin cancer excluded) was analyzed in 934 renal transplant patients from one center, transplanted between 1965 and 1981, and followed through 1983. National Cancer Registry data were used for statistical comparison. Cancers of the lip, vulva, and anus and malignant ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Blohmé I,Brynger H

    更新日期:1985-01-01 00:00:00

  • Fulminant hepatitis is significantly increased in hepatitis B carriers after allogeneic bone marrow transplantation.

    abstract:BACKGROUND:Bone marrow transplantation (BMT) is effective treatment for many hematologic disease, but performed in a population with a high endemic hepatitis B virus carrier rate, the incidence of liver function impairment and fulminant hepatitis (FH) is expected to be raised. METHODS:Forty-three hepatitis B virus car...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199906150-00006

    authors: Chen PM,Chiou TJ,Fan FS,Liu JM,Hsieh RK,Yen CC,Wang WS,Liu JH

    更新日期:1999-06-15 00:00:00

  • Parvovirus B19 infection-related complications in renal transplant recipients: treatment with intravenous immunoglobulin.

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199712270-00037

    authors: Moudgil A,Shidban H,Nast CC,Bagga A,Aswad S,Graham SL,Mendez R,Jordan SC

    更新日期:1997-12-27 00:00:00

  • Inverse correlation of cyclosporine binding with sensitivity and resistance.

    abstract::The primary effects of CsA on human lymphocyte responses in vitro appear to be the inhibition of IL-2 production and the inhibition of cytotoxic T cell activation. Induction of suppressor T cell activity is resistant to the effects of CsA. These data imply two distinct subsets of lymphocytes: CsA-resistant and CsA-sen...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198808001-00012

    authors: Hess AD,Colombani PM

    更新日期:1988-08-01 00:00:00

  • Rhesus monkey immature monocyte-derived dendritic cells generate alloantigen-specific regulatory T cells from circulating CD4+CD127-/lo T cells.

    abstract:BACKGROUND:Generation of non-human primate regulatory T cells (Treg) with alloantigen (alloAg) specificity would allow their testing in preclinical transplant models. Low recovery of Treg from peripheral blood limits their potential utility. In small animals and humans, conventional myeloid dendritic cells (DC) have be...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181ba6b1f

    authors: Zahorchak AF,Raimondi G,Thomson AW

    更新日期:2009-11-15 00:00:00

  • Altered threshold for the induction of graft-versus-host immunodeficiency following murine cytomegalovirus infection. Host and donor contributions.

    abstract::Acute murine cytomegalovirus (MCMV) infection enhances the ability of parental spleen cells to induce graft-vs.-host immunodeficiency (GVHID) in F1 hybrid mice when the two processes occur simultaneously in the recipient. The present study assessed GVHID as the ability of spleen cells to generate in vitro cytotoxic T ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198808000-00021

    authors: Via CS,Shanley JD,Weatherly BR,Lang P,Shearer GM

    更新日期:1988-08-01 00:00:00

  • Competitive equality of donor cells expressing a disparate MHC antigen following stem cell-enriched bone marrow transplantation.

    abstract:INTRODUCTION:Bone marrow cells expressing foreign MHC antigens survive poorly after transplantation. Stable mixed hematopoietic chimerism requires reconstitution with a relatively large number of foreign bone marrow cells and intensive depletion of host cells. In addition, when foreign MHC-transduced autologous bone ma...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000159871.01132.5d

    authors: Zhang JL,Cai J,Jackson JD,Walls S,Kuszynski CA,Fox IJ

    更新日期:2005-05-27 00:00:00

  • Effect of preprocurement ventilation on lungs donated after cardiac death in a canine lung transplantation model.

    abstract:BACKGROUND:One method of countering chronic lung donor shortages is the practice of donation after cardiac death (DCD). However, this technique inevitably leads to pulmonary dysfunction related to warm ischemia. One promising method of alleviating this problem is ventilation. However, it can rarely be initiated from th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31822d87c6

    authors: Sakamoto J,Chen F,Yamada T,Nakajima D,Ohsumi A,Kikuchi R,Zhao X,Fujinaga T,Shoji T,Sakai H,Bando T,Date H

    更新日期:2011-10-27 00:00:00

  • The impact of donor age on living donor liver transplantation.

    abstract:BACKGROUND:The impact of the age of the donor on the outcome of living related liver transplantation is yet to be clarified. METHODS:During October 14, 1996 and December 20, 1999, 34 living related liver transplantations were performed. Of these, 26 cases were performed using the extended left lobe graft, which were c...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200012270-00007

    authors: Ikegami T,Nishizaki T,Yanaga K,Shimada M,Kishikawa K,Nomoto K,Uchiyama H,Sugimachi K

    更新日期:2000-12-27 00:00:00

  • Clinicopathologic features of graft rejection of the first human hand allograft.

    abstract:BACKGROUND:The first human hand allograft, performed in Lyon, France, on September 23, 1998, was removed during month 29 posttransplantation as the result of rejection because the patient did not comply with the immunosuppressive treatment. METHODS:The patient was regularly examined from the day of transplantation to ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000079458.81970.9A

    authors: Kanitakis J,Jullien D,Petruzzo P,Hakim N,Claudy A,Revillard JP,Owen E,Dubernard JM

    更新日期:2003-08-27 00:00:00

  • Primary kidney tumors before and after renal transplantation.

    abstract::Three groups of patients were reviewed. Primary carcinomas were found in donors kidneys of 47 recipients. In 30 instances a tumor was present at harvesting. When a neoplasm was removed immediately pretransplantation or early posttransplantation there were no recurrences in 14 recipients. In another two instances, a tu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Penn I

    更新日期:1995-02-27 00:00:00

  • Human allogeneic vascular rejection after arterial transplantation and peripheral lymphoid reconstitution in severe combined immunodeficient mice.

    abstract:BACKGROUND:Interspecies differences create important shortcomings in existing animal models used to describe in vivo events responsible for allograft rejection. Alloimmune destruction of human dermal microvessels, histologically consistent with rejection, has been demonstrated in human skin-grafted severe combined immu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199903270-00018

    authors: Lorber MI,Wilson JH,Robert ME,Schechner JS,Kirkiles N,Qian HY,Askenase PW,Tellides G,Pober JS

    更新日期:1999-03-27 00:00:00

  • Effect of cyclosporine, cyclosporine metabolite 17, and other cyclosporine-related compounds on T lymphocyte clones derived from rejected human kidney grafts. I. Inhibition of proliferation.

    abstract::The effect of cyclosporine and metabolite 17 (M17) as well as other CsA-related compounds (CsG, dihydro-CsC, dihydro-CsD, CsH, B5.49, and H7.94) was tested on T lymphocyte clone proliferation. In these experiments, antigen and interleukin 2 (IL-2) dependent long-term T lymphocyte clones derived from a rejected human k...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198712000-00019

    authors: Chabannes D,Moreau JF,Soulillou JP

    更新日期:1987-12-01 00:00:00

  • The case to abandon human leukocyte antigen matching for kidney allocation: would it be wise to throw out the baby with the bathwater?

    abstract::Since major histocompatibility (MHC) antigen matching was introduced in the early 1970s as the key factor determining kidney transplant allocation, several studies, mainly arising from organ-sharing organizations in the United States and Europe, have debated this complex issue. The first fundamental concern is the int...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.tp.0000103730.16444.e7

    authors: Hiesse C,Pessione F,Houssin D

    更新日期:2004-02-27 00:00:00

  • Pharmacokinetics of the conventional and microemulsion formulations of cyclosporine in pancreas-kidney transplant recipients with gastroparesis.

    abstract::Cyclosporine (CsA) is an immunosuppressive drug requiring dose individualization and regular control due to its highly variable pharmacokinetics. Since gastroparesis may influence the absorption of CsA, a randomized cross-over study was performed to assess the pharmacokinetics and tolerability of a novel microemulsion...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007890-199608270-00006

    authors: van der Pijl JW,Srivastava N,Denouël J,Burggraaf J,Schoemaker RC,van der Woude FJ,Cohen AF

    更新日期:1996-08-27 00:00:00

  • New mouse model to study islet transplantation in insulin-dependent diabetes mellitus.

    abstract:BACKGROUND:Islet transplantation studies with diabetic rodents frequently use treatment with diabetogens such as alloxan or streptozotocin to render hosts hyperglycemic. These chemicals produce unwanted toxic side effects, which complicate interpretations of damage produced by hyperglycemia versus direct toxin-induced ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200204270-00024

    authors: Mathews CE,Langley SH,Leiter EH

    更新日期:2002-04-27 00:00:00

  • Prevention of late renal changes after initial ischemia/reperfusion injury by blocking early selectin binding.

    abstract:BACKGROUND:Increasing clinical evidence suggests that delayed initial function secondary to ischemia/reperfusion injury alone, and particularly in combination with early episodes of acute rejection, reduces kidney allograft survival over time. METHODS:We investigated changes developing over the long term following a s...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199712150-00003

    authors: Takada M,Nadeau KC,Shaw GD,Tilney NL

    更新日期:1997-12-15 00:00:00

  • A prospective controlled trial of cold-storage versus machine-perfusion preservation in cadaveric renal transplantation.

    abstract::A prospective controlled study was carried out in 60 consecutive cadaver renal donors comparing cold storage to pulsatile machine-perfusion preservation. Each donor served as its own control, by allocating one of the kidneys to each of the two preservation methods. There were 51 evaluable pairs of kidneys. Recipient a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199008000-00011

    authors: Merion RM,Oh HK,Port FK,Toledo-Pereyra LH,Turcotte JG

    更新日期:1990-08-01 00:00:00

  • Hypertonic citrate solution as an alternative to modified Euro-Collins' solution for lung preservation.

    abstract::In a canine model of acute ischemic lung injury, a hypertonic citrate solution (HTC) widely used for renal preservation in the United Kingdom, was compared with modified Euro-Collins' solution (ECS) currently the most widely clinically used pulmonary perfusate. Ten beagle dogs underwent left thoracotomy and exclusion ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199105000-00022

    authors: Hooper TL,Jones MT,Thomson DS,Cook L,Owen S,Wilkes S,Woodcock A,Webster AH,Hasleton P,McGregor CG

    更新日期:1991-05-01 00:00:00

  • Mucosal plasma cell barrier disruption during intestine transplant rejection.

    abstract:BACKGROUND:Intestinal allograft mucosa undergoes repopulation with host immunocytes. However, critical changes within key immunocyte subsets are not known. METHODS:To explain acute cellular rejection after intestine transplantation (ITx) on the basis of altered mucosal immunocytes, rejecting and rejection-free ITx all...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182708d9d

    authors: Ningappa M,Ashokkumar C,Ranganathan S,Schmitt L,Higgs BW,Sun Q,Branca M,Mazariegos G,Zeevi A,Abu-Elmagd K,Squires R,Rudolph J,Alissa F,Hakonarson H,Sindhi R

    更新日期:2012-12-27 00:00:00

  • Local cellular immunity in the draining lymph nodes of mice after immunization with histocompatibility alloantigens.

    abstract::Mice immunized with allogeneic cells exhibit a local component of cellular immunity that is confined to lymph nodes draining the site of immunization. After immunization of C3H mice by skin grafting or by i.p. or footpad injection of F1 hybrid spleen cells, draining lymph nodes show increased responsiveness toward the...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198107000-00006

    authors: Snow C,Hilgard HR

    更新日期:1981-07-01 00:00:00

  • Studies on the induction and expression of T cell-mediated immunity. V. Lectin-induced nonspecific cell-mediated cytotoxicity by alloimmune lymphocytes.

    abstract::Murine lymphoid cells sensitized against allografts express two types of cytotoxicity measured in vitro in short-term assays of 2 to 3 hr by 51Cr release. One type of cytotoxicity is specific against target cells carrying the sensitizing alloantigens, and the other type is nonspecific against both syngeneic and unrela...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197602000-00002

    authors: Bonavida B,Bradley TP

    更新日期:1976-02-01 00:00:00

  • An analysis of the lack of donor pancreas utilization from younger adult organ donors.

    abstract::Donor pancreas utilization rates for whole organ transplant have remained low and have decreased over time. To identify the reasons for nonuse of pancreas from donors who meet common baseline acceptance criteria, we examined Organ Procurement and Transplantation Network data from 2005 to 2007 and identified a subgroup...

    journal_title:Transplantation

    pub_type: 社论,评审

    doi:10.1097/TP.0b013e3181e9fea4

    authors: Wiseman AC,Wainright JL,Sleeman E,McBride MA,Baker T,Samana C,Stock P

    更新日期:2010-09-15 00:00:00

  • Full reconstitution of hematopoietic system by murine umbilical cord blood.

    abstract:BACKGROUND:Murine umbilical cord blood cells (UCBCs) were studied for their ability to reconstitute the hematopoietic system. METHODS:On average, 150 microL of cord blood per fetus containing 1.2 to 2 x 10(4) nucleated cells were collected from day 18.5 fetal umbilical cord, and 3 to 6 x 10(3) cells per fetus were obt...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000065295.99190.03

    authors: Migishima F,Oikawa A,Kondo S,Ema H,Morita Y,Nakauchi H,Yokoyama M,Song SY,Nishijima M,Okabe M,Shinohara N

    更新日期:2003-06-15 00:00:00

  • Renal function after kidney transplantation in children. A comparison of conventional immunosuppression with cyclosporine.

    abstract::Clearance studies were performed in 32 transplanted children treated with CsA in combination with low-dose prednisolone (CsA group), and the results were compared with those of 29 children transplanted earlier and treated with azathioprine and prednisolone (CIS group). Serum creatinine and urea levels 6 weeks and 1 ye...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198704000-00006

    authors: Hoyer PF,Krohn HP,Offner G,Byrd DJ,Brodehl J,Wonigeit K,Pichlmayr R

    更新日期:1987-04-01 00:00:00

  • Major histocompatibility complex control of NK-related allogeneic lymphocyte cytotoxicity in rats. The contributions of strong and medial transplantation antigens.

    abstract::Allogeneic lymphocyte cytotoxicity (ALC) describes the elimination of allogeneic lymphocytes in vivo by an NK-related activity. There is evidence that ALC is demonstrable between donor and recipient when these are incompatible at MHC gene loci alone. Since ALC is a property of T cell-deficient nude rats, the role of t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198811000-00025

    authors: Ager A,Fajumi J,Sparshott SM,Ford WL,Butcher GW

    更新日期:1988-11-01 00:00:00

  • Regulatory T cells: potential in organ transplantation.

    abstract::Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune ...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.TP.0000106477.70852.29

    authors: Wood KJ,Luo S,Akl A

    更新日期:2004-01-15 00:00:00

  • Nutritional immunomodulation enhances cardiac allograft survival in rats treated with donor-specific transfusion and cyclosporine.

    abstract::The aim of this study was to assess the efficacy of an enteral diet fortified with arginine, RNA, and fish oil (Impact), alone and in combination with cyclosporine (CsA) and donor-specific transfusion (DST) on allograft survival in the ACI:Lewis rat cardiac transplant model. Animals were fed ad libitum with either sta...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Levy AE,Alexander JW

    更新日期:1995-10-27 00:00:00

  • Simultaneous Liver Kidney Transplant in Elderly Patients With Chronic Kidney Disease: Is There an Appropriate Upper Age Cutoff?

    abstract:BACKGROUND:The aging of liver transplant (LT) recipients, the weighting of the model for end-stage liver disease score, and the increased prevalence of nonalcoholic steatohepatitis has led to an increased number of older LT recipients with pre-LT chronic kidney disease (CKD). There are limited data on the impact of inc...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003147

    authors: Goldberg DS,Vianna RM,Martin EF,Martin P,Arosemena Benitez LR,O'Brien CB,Bhamidimarri KR

    更新日期:2020-12-01 00:00:00

  • Prevalence and correlates of self-reported pretransplant nonadherence with medication in heart, liver, and lung transplant candidates.

    abstract:BACKGROUND:Evidence on prevalence and correlates of pretransplant medication nonadherence (MNA) is limited. The present study explored self-reported prevalence and correlates of MNA before heart, liver, and lung transplantation. METHODS:This cross-sectional descriptive study included 174 patients: 69 lung, 33 heart, a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000158430.06507.87

    authors: Dobbels F,Vanhaecke J,Desmyttere A,Dupont L,Nevens F,De Geest S

    更新日期:2005-06-15 00:00:00