Optical determination of fatty change of the graft liver with near-infrared time-resolved spectroscopy.

abstract：:In a prospective randomized double-blind placebo-controlled trial, the effect of rh-SOD, given in a dose of 200 mg intravenously during surgery to cyclosporine-treated recipients of cadaveric renal allografts, on both acute and chronic rejection events as well as patient and graft survival was investigated by analyzin...

journal_title：Transplantation

authors： Land W,Schneeberger H,Schleibner S,Illner WD,Abendroth D,Rutili G,Arfors KE,Messmer K

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Controversy exists about the conditions effecting the development of forkhead/winghead helix transcription factor P3 (FOXP3) expressing T cells and their relevance in transplant recipients. METHODS:We generated carboxy-fluorescein diacetate succinimidyl ester-labeled CD4+CD25 high FOXP3+ cells in mixed lymp...

journal_title：Transplantation

authors： Levitsky J,Miller J,Leventhal J,Huang X,Flaa C,Wang E,Tambur A,Burt RK,Gallon L,Mathew JM

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Conversion from tacrolimus to cyclosporin has not previously been reported as routine clinical practice, but only as indicated by rejection or adverse effects. METHODS:The safety and metabolic outcome of elective conversion from tacrolimus to cyclosporin was examined in 19 recipients of cadaver renal transp...

journal_title：Transplantation

authors： Higgins RM,Hart P,Lam FT,Kashi H

更新日期：2000-07-15 00:00:00

abstract：:Cyclosporine, but not its nonimmunosuppressive analog cyclosporine H (CsH), caused in a variety of hematopoietic cell types a growth arrest in the G0/G1 phase of the cell cycle. This arrest was associated with a significant reduction in the c-myc mRNA levels, which could be observed already 1 hr following CsA treatmen...

journal_title：Transplantation

authors： Yonish-Rouach E,Kimchi A,Rubinstein M

更新日期：1991-06-01 00:00:00

abstract：:: Hepatitis C virus (HCV) infection is common in solid organ allograft recipients and is a significant cause of morbidity and mortality after transplantation, so effective management will improve outcomes. In this review, we discuss the extent of the problem associated with HCV infection in donors and kidney, heart, a...

journal_title：Transplantation

authors： Carbone M,Mutimer D,Neuberger J

更新日期：2013-03-27 00:00:00

abstract：BACKGROUND:Calcineurin is a ubiquitously expressed calcium-dependent phosphatase that is inhibited by the immunosuppressant drugs cyclosporine and tacrolimus. Measuring calcineurin activity in transplant patients has been complicated by a lack of consistent correlation between drug level and enzyme activity, particular...

journal_title：Transplantation

authors： Pena JA,Titus L,Jackson J,Kirk AD,Gooch JL

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Interspecies differences create important shortcomings in existing animal models used to describe in vivo events responsible for allograft rejection. Alloimmune destruction of human dermal microvessels, histologically consistent with rejection, has been demonstrated in human skin-grafted severe combined immu...

journal_title：Transplantation

authors： Lorber MI,Wilson JH,Robert ME,Schechner JS,Kirkiles N,Qian HY,Askenase PW,Tellides G,Pober JS

更新日期：1999-03-27 00:00:00

abstract：BACKGROUND:Donor-derived cell-free DNA (dd-cfDNA) is a potential noninvasive molecular marker of graft rejection after kidney transplant, whose diagnostic accuracy remains controversial. METHODS:We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of dd-cfDNA. Relevant literature was ...

journal_title：Transplantation

authors： Xiao H,Gao F,Pang Q,Xia Q,Zeng X,Peng J,Fan L,Liu J,Wang Z,Li H

更新日期：2020-09-02 00:00:00

abstract：:The nature of cell-mediated immunity in the American cockroach (Periplaneta americana) was studied by observing the events involved in graft reactivity. Adult roaches received integumentary xenografts from Blaberus giganteus, as well as control autografts. Grafts were scored histologically by counting the number of nu...

journal_title：Transplantation

authors： George JF,Karp RD,Rheins LA

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:The first generic tacrolimus product gained Food and Drug Administration approval in August 2009. This prospective, observational trial sought to determine the need for dose titrations and measure drug cost savings on conversion to generic tacrolimus. METHODS:Transplant recipients on stable tacrolimus doses...

journal_title：Transplantation

authors： McDevitt-Potter LM,Sadaka B,Tichy EM,Rogers CC,Gabardi S

更新日期：2011-09-27 00:00:00

abstract：BACKGROUND:Renal dysfunction early after kidney transplantation has multiple causes including ischemia-reperfusion (I/R) injury and drug-induced nephrotoxicity. This study assesses the acute nephrotoxicity of tacrolimus (Tac) and sirolimus (Sir) in a rat renal isograft model. METHODS:Lewis renal isografts and uninephr...

journal_title：Transplantation

authors： Ninova D,Covarrubias M,Rea DJ,Park WD,Grande JP,Stegall MD

更新日期：2004-08-15 00:00:00

abstract：BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...

journal_title：Transplantation

authors： Sola E,Gonzalez-Molina M,Cabello M,Burgos D,Ramos J,Gutierrez C,Lopez V,Soler J,de la Vega E,Hernandez D

更新日期：2010-03-27 00:00:00

abstract：BACKGROUND:Guillain-Barre Syndrome (GBS) is believed to be caused by autoimmune mechanisms that are predominantly T-cell mediated. We report GBS in organ transplant patients and bone marrow transplant patients, both of whom have iatrogenically suppressed T-cell function. METHODS:We reviewed the Duke University Medical...

journal_title：Transplantation

authors： Bulsara KR,Baron PW,Tuttle-Newhall JE,Clavien PA,Morgenlander J

更新日期：2001-04-27 00:00:00

abstract：:Although bisphosponates are proposed as first-line treatment for posttransplant bone disease they are not optimal in all situations. A kidney transplant recipient developed hypercalcemia from mobilization of extraskeletal calcium. He had low serum parathyroid hormone and vitamin D; high calcium excretion; and normal c...

journal_title：Transplantation

authors： Dhingra RK,Sprague SM,Ojo AO,Leavey SF

更新日期：2001-06-27 00:00:00

abstract：BACKGROUND:We have previously shown that recognition of human erythrocytes by porcine Kupffer cells is mediated by a carbohydrate-dependent mechanism. The present study explores the possible ligands existing on human glycophorin A and tests their ability to inhibit erythrocyte rosette formation. METHODS:Human erythroc...

journal_title：Transplantation

authors： Burlak C,Twining LM,Rees MA

更新日期：2005-08-15 00:00:00

abstract：:Acute rejection is a frequent cause of early graft dysfunction in renal transplantation, and serum creatinine is the most important measure of clinical response. However, there is little information on serum creatinine during rejection episodes. In this study, the determinants that might influence the clinical respons...

journal_title：Transplantation

authors： Nankivell BJ,Allen RD,O'Connell PJ,Chapman JR

更新日期：1995-07-15 00:00:00

abstract：BACKGROUND:AGI-1096 is a novel phenolic intracellular antioxidant with anti-inflammatory and antiproliferative properties. In vitro, AGI-1096 inhibited the inducible expression of vascular cell adhesion molecule (VCAM)-1, E-selectin, and monocyte chemoattractant protein (MCP)-1 in endothelial cells and tumor necrosis f...

journal_title：Transplantation

authors： Murata S,Sundell CL,Lijkwan MA,Balsam LB,Hammainen P,Coleman C,York C,Luchoomun J,Suen KL,Howard R,Somers PK,Morris RE,Robbins RC

更新日期：2004-05-27 00:00:00

abstract：BACKGROUND:Progressively better therapies have largely prevented or at least effectively treated acute allograft rejection. Consequently, the long-term survival of solid organ transplants has increasingly become limited primarily by the development of chronic allograft rejection. The mechanisms of chronic rejection rem...

journal_title：Transplantation

authors： Heslan JM,Renaudin K,Thebault P,Josien R,Cuturi MC,Chiffoleau E

更新日期：2006-11-15 00:00:00

abstract：:Although ELISA on purified HLA molecules for detecting anti-HLA antibody (P-S ELISA) does detect some antibodies previously missed by the conventional complement dependent cytotoxicity method (C Cytotox), HLA ELISA should not fail to detect antibodies already detected by the conventional reference method to be able to...

journal_title：Transplantation

authors： Pierquin A,Masson D,Toupance O,Tabary T,Bougy F,Bensa JC,Chanard J,Cohen JH

更新日期：1996-11-27 00:00:00

abstract：BACKGROUND:Success of human pancreatic islet isolation depends largely on the techniques used during pancreas procurement and the quality of the gland. Warm ischemia of the pancreas of any duration during organ procurement may be detrimental to subsequent islet yield and functional viability of the islets. The aim of t...

journal_title：Transplantation

authors： Lakey JR,Kneteman NM,Rajotte RV,Wu DC,Bigam D,Shapiro AM

更新日期：2002-04-15 00:00:00

abstract：BACKGROUND:Operational tolerance is defined as long-term acceptance of a transplanted organ after complete cessation of immunosuppression (IS), but may not always protect against antigen-dependent changes in graft morphology. METHOD:IS free patients after living-donor liver transplantation (LDLT) underwent protocol bi...

journal_title：Transplantation

authors： Yoshitomi M,Koshiba T,Haga H,Li Y,Zhao X,Cheng D,Miyagawa A,Sakashita H,Tsuruyama T,Ohe H,Ueda M,Okamoto S,Egawa H,Wood K,Sakaguchi S,Manabe T,Tanaka K,Uemoto S

更新日期：2009-02-27 00:00:00

abstract：:A murine monoclonal antihuman T cell antibody is described that is pan-T in that it reacts with all T cells, including those from thymus, but not with B cells or other cells, except for a small subpopulation of null cells. Biochemical analysis demonstrated that the antigen detected is a glycoprotein, Mr 50,000 daltons...

journal_title：Transplantation

authors： Thurlow PJ,Lovering E,d'Apice AJ,McKenzie IF

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:Prolonged persistence of donor-derived T cells after organ transplantation has been proposed to improve long-term allograft survival. However, surviving transplant-derived T cells are also able to mediate devastating graft-versus-host disease (GvHD). Currently, GvHD after organ transplantation is usually ref...

journal_title：Transplantation

authors： Kuball J,Theobald M,Ferreira EA,Hess G,Burg J,Maccagno G,Barreiros AP,Lüth S,Schimanski CC,Schuchmann M,Schwarting A,Neurath M,Otto G,Galle PR,Lohse AW

更新日期：2004-12-27 00:00:00

abstract：BACKGROUND:Bone marrow stromal cells (BMSC) transplantation offers promise in the treatment of chronic paraplegia in rodents. Here, we report the effect of this cell therapy in adult pigs suffering chronic paraplegia. METHODS:Three months after spinal cord injury, autologous BMSC in autologous plasma was injected into...

journal_title：Transplantation

authors： Zurita M,Vaquero J,Bonilla C,Santos M,De Haro J,Oya S,Aguayo C

更新日期：2008-09-27 00:00:00

abstract：:It has been demonstrated both in vivo and in vitro that cytomegalovirus regulates not only MHC class I but also class II antigen expression on vascular endothelial cells. The CMV-linked MHC induction is believed to be involved in acute rejection mechanisms and chronic vasculopathy after transplantation. In this study,...

journal_title：Transplantation

authors： Ustinov JA,Lahtinen TT,Bruggeman CA,Häyry PJ,Lautenschlager IT

更新日期：1994-11-15 00:00:00

abstract：BACKGROUND:Histologic evaluation of small bowel allograft biopsies is important for the diagnosis of acute rejection. However, a standard histologic schema to grade the severity of intestinal acute rejection is not currently available. The primary goal of this study was to develop a histologic grading system for the di...

journal_title：Transplantation

authors： Wu T,Abu-Elmagd K,Bond G,Nalesnik MA,Randhawa P,Demetris AJ

更新日期：2003-04-27 00:00:00

abstract：:Sequential titers of five different humoral antibodies (antirat erythrocyte, antisheep erythrocyte, isoantibodies, rheumatoid factors, and serum agglutinators) were simultaneously performed on 20 patients with renal transplants, 12 patients with skin transplants, and 2 patient populations (one hospitalized and one amb...

journal_title：Transplantation

authors： Waller M,Pierce JC,Lee HM,Levinson HJ

更新日期：1975-03-01 00:00:00

abstract：:Humoral or antibody-mediated rejection in cardiac transplant recipients is mediated by donor-specific cytotoxic antibodies and is histologically defined by linear deposits of immunoglobulin and complement in the myocardial capillaries. Antibody-mediated rejection often is accompanied by hemodynamic compromise and is a...

journal_title：Transplantation

authors： Aranda JM Jr,Scornik JC,Normann SJ,Lottenberg R,Schofield RS,Pauly DF,Miles M,Hill JA,Sleasman JW,Skoda-Smith S

更新日期：2002-03-27 00:00:00

abstract：:Distribution of cadaveric donor kidneys, based upon the donor-recipient HLA match grade, remains one of the major controversies in transplantation. To determine whether matching results in fewer rejection episodes and better graft survival, we retrospectively studied our single-center patient population of 683 cyclosp...

journal_title：Transplantation

authors： Kerman RH,Kimball PM,Lindholm A,Van Buren CT,Katz SM,Lewis RM,McClain J,Podbielski J,Williams J,Kahan BD

更新日期：1993-11-01 00:00:00

abstract：:Ninety-eight renal transplant recipients who had been followed for 1-6.5 years (median 3.2 years) were reviewed to determine the effect of donor and recipient hepatitis B surface antigen status on the incidence of hepatitis and on patient survival. The cumulative risk of developing hepatitis posttransplant was signifi...

journal_title：Transplantation

authors： Chan PC,Lok AS,Cheng IK,Chan MK

更新日期：1992-01-01 00:00:00