Comparison of human islet isolation outcomes using a new mammalian tissue-free enzyme versus collagenase NB-1.

abstract：BACKGROUND:Immunological unresponsiveness of T cells to alloantigen can be induced by intrathymic injection of donor-specific antigen in small-animal models. Intrathymic tolerance to vascularized grafts in large animals has not previously been reported. METHODS:Thirty-two dogs were allocated into dog leukocyte antigen...

journal_title：Transplantation

authors： Horton PJ,Hawthorne WJ,Walters S,Patel T,Stewart GJ,Allen RD,Chapman JR

更新日期：2008-12-27 00:00:00

abstract：:The number of patients awaiting hepatic transplantation continues to exceed organ donation. As a result, many liver transplant candidates will develop life-threatening complications of their liver disease and not survive the pretransplant waiting period. Recent studies have demonstrated that hepatic lidocaine metaboli...

journal_title：Transplantation

authors： Shiffman ML,Fisher RA,Sanyal AJ,Edinboro LE,Luketic VA,Purdum PP 3rd,Raymond P,Posner MP

更新日期：1993-04-01 00:00:00

abstract：:The expression of Ia antigens on leukoagglutinin-induced blast cells was studied using a sensitive protein A-rosetting technique and quantitative absorption with conventional and monoclonal Ia antibodies. By direct testing, 40 to 60% of CBA (Iak) blast cells were shown to be Ia+ (Iak+, Ia.17+, and Ias-), expressing bo...

journal_title：Transplantation

authors： Michaelides M,McKenzie IF

更新日期：1981-05-01 00:00:00

abstract：:To improve long-term outcome after renal transplantation, attention should be placed on the tailored use of immunosuppressive regimens that have a more favorable impact on the immunological and nonimmunological risk profiles of an individual recipient. Tacrolimus is widely used for maintenance and rejection immunosupp...

journal_title：Transplantation

authors： First MR

更新日期：2001-09-27 00:00:00

abstract：BACKGROUND:Preemptive kidney transplantation (prior to the institution of dialysis) avoids the morbidity and mortality of dialysis; however, detailed studies of high-risk patients are lacking. The aim of the current study was to compare recent outcomes of preemptive (P) versus nonpreemptive (NP) living donor kidney tra...

journal_title：Transplantation

authors： Innocenti GR,Wadei HM,Prieto M,Dean PG,Ramos EJ,Textor S,Khamash H,Larson TS,Cosio F,Kosberg K,Fix L,Bauer C,Stegall MD

更新日期：2007-01-27 00:00:00

abstract：INTRODUCTION:We investigated the putative candidate biomarkers of graft rejection in peripheral blood of intestinal transplant patients. MATERIALS AND METHODS:Peripheral blood gene expression analysis was performed in intestinal transplant patients. The results were matched with concurrent graft biopsies using bioinfo...

journal_title：Transplantation

authors： Andreev VP,Tryphonopoulos P,Blomberg BB,Tsinoremas N,Weppler D,Neuman DR,Volsky A,Nishida S,Tekin A,Selvaggi G,Levi DM,Tzakis AG,Ruiz P

更新日期：2011-12-27 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether screening for anti-human leukocyte antigen (HLA) antibodies (Abs) could predict development of acute rejection (AR) before clinical evidence of kidney allograft dysfunction in nonsensitized recipients. METHODS:Eighty-four non-HLA identical kidney transplant...

journal_title：Transplantation

authors： Gill JS,Landsberg D,Johnston O,Shapiro RJ,Magil AB,Wu V,Tinckam K,Keown P

更新日期：2010-01-27 00:00:00

abstract：:The use of immunosuppressive agents (primarily azathioprine and prednisone) to promote human allograft survival is known to be associated with an enhanced rate of skin cancer development by ultraviolet radiation (UVR). These observations raise the question of whether the immunosuppressive agents are functioning as coc...

journal_title：Transplantation

authors： Servilla KS,Burnham DK,Daynes RA

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate purine nucleotide metabolism in peripheral blood mononuclear cells (PBMC) of cardiac transplant recipients switched from azathioprine to mycophenolate mofetil (MMF). METHODS:Concentrations of guanosine 5'triphosphate (GTP) and adenosine 5'triphosphate (ATP), th...

journal_title：Transplantation

authors： Devyatko E,Zuckermann A,Bohdjalian A,Roedler S,Dunkler D,Grimm M,Weigel G

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:Ischemia/reperfusion (I/R) injury is a limiting factor in liver transplantation. We have recently shown that pyruvate (PY) inhibits intestinal and renal I/R injury. This study aims to evaluate the protective effect of PY on hepatic I/R injury. METHODS:ACI rats were treated with PY, whereas control animals r...

journal_title：Transplantation

authors： Sileri P,Schena S,Morini S,Rastellini C,Pham S,Benedetti E,Cicalese L

更新日期：2001-07-15 00:00:00

abstract：BACKGROUND:The authors studied the relationship between the dynamics of Epstein-Barr virus (EBV) load, CD8 T-cell activation and differentiation, and EBV-associated symptoms in 25 children after kidney transplantation (Tx). METHODS:Twenty-two patients were enrolled at the time of Tx and three at diagnosis of EBV-induc...

journal_title：Transplantation

authors： Baudouin V,Dehée A,Pédron-Grossetete B,Ansart-Pirenne H,Haddad E,Maisin A,Loirat C,Sterkers G

更新日期：2004-06-15 00:00:00

abstract：BACKGROUND:Monocarboxylate transporter (MCT)-1, a member of a family of molecules, transports monocarboxylates such as lactate. Inhibiting MCT-1 leads to long-term graft survival in rodent heart transplantation and induces tolerance. We evaluated an MCT-1 inhibitor, AS2495674, in a rat heart transplant model and analyz...

journal_title：Transplantation

authors： Cho KS,Yamada T,Wynn C,Behanna HA,Hong IC,Manaves V,Nakanishi T,Hirose J,Abe Y,Jiang H,Tamura K,Saita Y

更新日期：2010-12-27 00:00:00

abstract：BACKGROUND:Hyperacute rejection (HAR) of pig-to-primate discordant xenografts is caused by the deposition of preexisting natural antibodies that recognize Galalpha1-3Gal (alphaGal)-terminating oligosaccharides on glycoproteins and glycolipids, followed by complement-mediated lysis of the graft's endothelium. In vitro, ...

journal_title：Transplantation

authors： Simon PM,Neethling FA,Taniguchi S,Goode PL,Zopf D,Hancock WW,Cooper DK

更新日期：1998-02-15 00:00:00

abstract：:By using the lysostrip and the blocking of cytotoxicity by Fab2 fragments, HLA-A and B antibodies were detected in sera from rabbits and goats immunized with human high-density lipoprotein (HDL)-associated HLA antigens isolated from sera and from cultured lymphoid cells. After appropriate absorptions, the xenoantisera...

journal_title：Transplantation

authors： Richiardi P,Pellegrino MA,Ferrone S

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:Obesity is a common problem following renal transplantation. Rimonabant, a cannabinoid-1 receptor blocker, offers a new approach for reducing obesity. METHODS:The potential pharmacokinetic interaction between rimonabant and cyclosporine A (CsA, n=10) and tacrolimus (Tac, n=8) was assessed in stable renal tr...

journal_title：Transplantation

authors： Amundsen R,Asberg A,Robertsen I,Vethe NT,Bergan S,Hartmann A,Midtvedt K

更新日期：2009-04-27 00:00:00

abstract：BACKGROUND:Steroid-resistant acute rejection is a risk factor for inferior renal allograft outcome. METHODS:From 873 kidney transplant recipients (1995-2005), 108 patients with a first rejection episode were selected for study using strict inclusion criteria and clinical endpoint definition. We aimed to predict respon...

journal_title：Transplantation

authors： Rekers NV,Bajema IM,Mallat MJ,Zuidwijk K,Anholts JD,Goemaere N,Haasnoot GW,van Groningen MC,van Kooten C,de Fijter JW,Claas FH,Eikmans M

更新日期：2012-09-27 00:00:00

abstract：BACKGROUND:Clinical and epidemiological data of pandemic influenza A H1N1 infection in solid-organ transplant recipients have been described, but scarce data compare these outcomes with nonimmunocompromised patients. METHODS:We retrospectively reviewed and compared the clinical presentation, morbidity, and mortality o...

journal_title：Transplantation

authors： Camargo LF,de Sandes-Freitas TV,Silva CD,Bittante CD,Ono G,Corrêa L,Silva M Jr,Bellei NC,Goto JM,Medeiros EA,Gomes PS,Medina-Pestana JO

更新日期：2012-01-15 00:00:00

abstract：:Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated ...

journal_title：Transplantation

authors： Courivaud C,Ferrand C,Deschamps M,Tiberghien P,Chalopin JM,Duperrier A,Saas P,Ducloux D

更新日期：2006-04-27 00:00:00

abstract：:Exposure to the equine-derived polyclonal antithymocyte preparation, ATGAM, frequently elicits human anti-ATGAM antibody formation. The influence of concomitant immunosuppressants on this antiantibody response has not been established. We therefore evaluated IgG antibody formation to ATGAM in 47 patients receiving ATG...

journal_title：Transplantation

authors： Kimball JA,Pescovitz MD,Book BK,Norman DJ

更新日期：1995-12-27 00:00:00

abstract：BACKGROUND:The use of kidneys from non-heartbeating donors (NHB) remains controversial. An increased incidence of delayed primary function and primary nonfunction is common. We report a characteristic syndrome of transaminitis and thrombocytopenia after NHB renal transplantation, which may be predictive of graft outcom...

journal_title：Transplantation

authors： Andrews PA,Denton MD,Compton FC,Koffman CG

更新日期：1997-05-27 00:00:00

abstract：BACKGROUND:Scarring can greatly impact quality of life for individuals (ie, causing depression posttraumatic stress disorder, body image issues). Those who wish to be anonymous live liver donors are warned of the potential negative psychological impacts associated with the large scar left from liver donation surgery. G...

journal_title：Transplantation

authors： Krause S,Pritlove C,Abbey S,Jung J

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:In 2013, the public health service (PHS) changed the criteria intended to identify organ donors that put the associated organ recipients at increased risk for acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). The changing donor demographics, organ utilization...

journal_title：Transplantation

authors： Pruett TL,Clark MA,Taranto SE

更新日期：2017-07-01 00:00:00

abstract：UNLABELLED:Most isolated intestinal graft losses are immunological. We conducted a pilot study to evaluate the feasibility of national sharing of HLA no-mismatch allografts for cadaveric isolated intestinal transplantation. METHODS:UNOS data were analyzed in a theoretical model. Part I: All solid organ donors between ...

journal_title：Transplantation

authors： Fishbein TM,Bodian CA,Miller CM

更新日期：2000-03-15 00:00:00

abstract：BACKGROUND:This study evaluates whether surgical strategies such as the portosystemic shunt and ischemic preconditioning can protect against hepatic and pulmonary injury associated with liver transplantation. METHODS:The effect of the portosystemic shunt, ischemic preconditioning, and both surgical procedures together...

journal_title：Transplantation

authors： Fernández L,Heredia N,Peralta C,Xaus C,Roselló-Catafau J,Rimola A,Marco A,Serafín A,Deulofeu R,Gelpí E,Grande L

更新日期：2003-07-27 00:00:00

abstract：:Mouse thyroid tissue was dissociated with collagenase, fixed in periodate-lysine-paraformaldehyde (PLP), and further dissociated with EDTA and trypsin to yield cell suspensions containing mainly follicle epithelial cells and vascular endothelial cells. H-2 complex antigens were detected on the vascular endothelial cel...

journal_title：Transplantation

authors： Parr EL,Lafferty KJ,Bowen KM,McKenzie IF

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:In the development of chronic kidney allograft rejection acute rejection (AR) is the single most important risk factor. Although Cyclosporin A (CsA) medication has decreased the incidence of AR, chronic rejection (CR) is still the major reason for late allograft loss. Platelet-derived growth factor (PDGF) is...

journal_title：Transplantation

authors： Savikko J,Kallio EA,Taskinen E,von Willebrand E

更新日期：2002-02-27 00:00:00

abstract：:Clinical transplantation of fetal porcine islet-like cell clusters (ICC) to kidney transplanted diabetic patients has shown both morphological and biochemical evidence of prolonged xenograft survival, but no effect was seen on the insulin requirement of the transplanted patients. One possible explanation for this rela...

journal_title：Transplantation

authors： Sandberg JO,Andersson A

更新日期：1996-04-27 00:00:00

abstract：:Hamster hearts transplanted into stable rat recipients of hamster livers (OLT rats) were hyperacutely rejected after transfer with unaltered rat antihamster hyperimmune serum (HS). This was followed by immediate liver xenograft rejection in 4 of 5 rats. In contrast, simple heat inactivation of the rat HS resulted in p...

journal_title：Transplantation

authors： Valdivia LA,Fung JJ,Demetris AJ,Celli S,Pan F,Tsugita M,Starzl TE

更新日期：1994-03-27 00:00:00

abstract：BACKGROUND:Immunomodulatory protocols including intravenous immunoglobulin/rituximab (IVIG/R) are employed to decrease anti-human leukocyte antigen (HLA) antibody levels for patients broadly sensitized to HLA and increase chances for transplantation with a compatible deceased donor (DD). The aim of our study was to ide...

journal_title：Transplantation

authors： Lai CH,Cao K,Ong G,Naim M,Wang Q,Mirocha J,Vo A,Jordan SC,Reinsmoen NL

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:Survival after lung transplantation is mainly limited by the development of chronic lung allograft dysfunction (CLAD). The aim of this study was to investigate if platelet inhibition by clopidogrel has a functionally relevant influence on the microvascular integrity of orthotopic tracheal allografts as an an...

journal_title：Transplantation

authors： Heim C,Khan MA,von Silva-Tarouca B,Kuckhahn A,Stamminger T,Ramsperger-Gleixner M,Nicolls MR,Weyand M,Ensminger SM

更新日期：2019-05-01 00:00:00