Strategies to minimize immunological and nonimmunological risk factors in the renal transplant population.

abstract：:The recent introduction of a variety of techniques for removing T cells from bone marrow grafts has reduced the incidence of graft-versus-host disease (GVHD)-associated morbidity and mortality. Whether this advance will be translated into improved patient survival is unclear at present, mainly because these procedures...

journal_title：Transplantation

authors： Bunjes D,Heit W,Arnold R,Schmeiser T,Wiesneth M,Carbonell F,Porzsolt F,Raghavachar A,Heimpel H

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Immunosuppressive drugs that target T cells are useful for prolonging allograft survival. The anti-CD3 immunotoxin FN18-CRM9 has been shown to effectively prolong renal allograft survival in a rhesus monkey model of transplantation. However, immunotoxin-treated monkeys showed increased levels of inflammatory...

journal_title：Transplantation

authors： Hamawy MM,Tsuchida M,Manthei ER,Dong Y,Fechner JE,Knechtle JS

更新日期：1999-09-15 00:00:00

abstract：BACKGROUND:Suppressive dendritic cells (DCs) are a promising tool for tolerance induction in transplantation. A human DCs subpopulation, which constitutively expresses indoleamine-2,3-dioxygenase (IDO), a molecule shown to prevent the rejection of fetus during pregnancy, has recently been described. This subset, charac...

journal_title：Transplantation

authors： Löb S,Ebner S,Wagner S,Weinreich J,Schäfer R,Königsrainer A

更新日期：2007-02-27 00:00:00

abstract：:Several approaches have been attempted to manage renal allograft dysfunction in cyclosporine-prednisone (CsA-Pred)-treated patients. Conversion to conventional therapy and perioperative triple drug have been associated with high rates of acute rejection episodes, infections, or neoplasms. We report our experience in d...

journal_title：Transplantation

authors： Pascual J,Marcén R,Orofino L,Quereda C,Mampaso F,Liaño F,Ortuño J

更新日期：1991-08-01 00:00:00

abstract：:Hemorrhagic cystitis (HC) is a major cause of morbidity after BMT; we have analyzed its incidence, risk factors, and complications in 977 patients undergoing BMT between 1974 and 1988. Despite vigorous hydration and frequent voiding in all patients receiving cyclophosphamide, 135/977 (15% by Kaplan-Meier projection) d...

journal_title：Transplantation

authors： Sencer SF,Haake RJ,Weisdorf DJ

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Short-term outcomes using steroid-free immunosuppression after renal transplantation have been promising. No studies have examined the incidence of and reasons for steroid-avoidance protocol failures. METHODS:We present a single-center analysis of steroid-free immunosuppression failures among 129 pediatric ...

journal_title：Transplantation

authors： Sutherland S,Li L,Concepcion W,Salvatierra O,Sarwal MM

更新日期：2009-06-15 00:00:00

abstract：:Previous studies have demonstrated that donor antigen-specific primed-lymphocyte-test (PLT) reactivity of bronchoalveolar lavage lymphocytes is strongly associated with acute pulmonary rejection and with obliterative bronchiolitis (OB); however, a systematic analysis of PLT reactivity as being class I-or II-directed h...

journal_title：Transplantation

authors： Reinsmoen NL,Bolman RM,Savik K,Butters K,Hertz M

更新日期：1992-01-01 00:00:00

abstract：:Tacrolimus (FK) and cyclosporine (Cs) are potent immunosuppressants that effectively prevent the rejection of transplanted organs including liver and small intestine. Our study examined the effects of these immunosuppressants on Peyer's patches, which play an important role in mucosal immune response through uptake an...

journal_title：Transplantation

authors： Fujimura Y,Owen RL

更新日期：2002-04-15 00:00:00

abstract：:In a DBA/2 (H-2d) pancreatic islet-to-B6AF1 (H-2b/k.d) recipient combination, the graft survival of hand-picked islets was compared with that of "crude digested" islets that were prepared simply by collagenase digestion and Ficoll gradient separation and were contaminated with lymph nodes and vascular and ductal tissu...

journal_title：Transplantation

authors： Gotoh M,Maki T,Satomi S,Porter J,Monaco AP

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:In patients with cytomegalovirus (CMV) disease, regular monitoring of viral loads and treatment until negative are recommended. However, with more sensitive polymerase chain reaction (PCR) assays and cellular peripheral sample types, detection of low-level viremia is achievable. We compared a whole blood rea...

journal_title：Transplantation

authors： Lisboa LF,Asberg A,Kumar D,Pang X,Hartmann A,Preiksaitis JK,Pescovitz MD,Rollag H,Jardine AG,Humar A

更新日期：2011-01-27 00:00:00

abstract：BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...

journal_title：Transplantation

authors： Molnar MZ,Ravel V,Streja E,Kovesdy CP,Mehrotra R,Kalantar-Zadeh K

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:It is imperative for healthcare providers to examine Western Muslim attitudes on organ donation, because they are reluctant donors. We explored such opinion with the aid of a quantitative survey. METHODS:Voluntary completion of an anonymous survey was promoted (online and paper sampling). For a population t...

journal_title：Transplantation

authors： Sharif A,Jawad H,Nightingale P,Hodson J,Lipkin G,Cockwell P,Ball S,Borrows R

更新日期：2011-11-27 00:00:00

abstract：BACKGROUND:New-onset diabetes is common after kidney transplantation, but the benefit of lifestyle intervention to improve glucose metabolism posttransplantation is unproven. METHODS:We conducted a single-center, randomized controlled trial involving 130 nondiabetic kidney transplant recipients with stable function be...

journal_title：Transplantation

authors： Kuningas K,Driscoll J,Mair R,Smith H,Dutton M,Day E,Sharif AA

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Immunotherapy given post-autologous stem cell transplantation may eliminate residual tumor cells escaping the conditioning protocol. METHODS:Five children suffering from stage IV neuroblastoma were treated by recombinant interleukin-2 (IL-2) post-autologous peripheral blood stem cell transplantation. The pa...

journal_title：Transplantation

authors： Toren A,Nagler A,Rozenfeld-Granot G,Levanon M,Davidson J,Bielorai B,Kaplinsky C,Meitar D,Mandel M,Ackerstein A,Ballin A,Attias D,Biniaminov M,Rosenthal E,Brok-Simoni F,Rechavi G,Kaufmann Y

更新日期：2000-10-15 00:00:00

abstract：BACKGROUND:The leflunomide analog, FK778, is a selective pyrimidine synthesis inhibitor. In rodent models, FK778 is efficacious in the prevention of allograft and xenograft rejection, and a combination of FK778 and cyclosporine has synergistic immunosuppressive efficacy. METHODS:Heterotopic renal transplantation was p...

journal_title：Transplantation

authors： Kyles AE,Gregory CR,Griffey SM,Bernsteen L,Pierce J,Lilja HS,Morris RE

更新日期：2003-04-27 00:00:00

abstract：INTRODUCTION:The importance of HLA matching for renal transplantation outcomes has been appreciated for several decades. It has been hypothesized that as pharmacologic immunosuppression becomes stronger and more specific, the impact of HLA matching may be vanishing. Mycophenolate Mofetil (MMF) has been demonstrated to ...

journal_title：Transplantation

authors： Meier-Kriesche HU,Ojo AO,Leichtman AB,Magee JC,Rudich SM,Hanson JA,Cibrik DM,Kaplan B

更新日期：2001-02-15 00:00:00

abstract：:An isolated vascularized bone marrow transplant (iVBMT) model was previously developed in the rat to specifically study the role of bone marrow and its environment in a composite tissue allotransplant. An extraperitoneal model was successfully created to avoid laparotomy and cross-clamping of the great vessels. The ex...

journal_title：Transplantation

authors： Tai CY,France MA,Strande LF,Eydelman R,Sheng X,Matthews MS,Dalsey R,Hewitt CW

更新日期：2003-05-15 00:00:00

abstract：:Late deaths (after more than 1 year) after liver transplantation were analyzed in a series of 464 consecutive patients who received liver grafts between 1982 and 1993. Recipients who survived the first posttransplant year (n = 365) had actuarial 5- and 10-year survival rates of 92% and 84%, respectively. Thirty-five p...

journal_title：Transplantation

authors： Asfar S,Metrakos P,Fryer J,Verran D,Ghent C,Grant D,Bloch M,Burns P,Wall W

更新日期：1996-05-15 00:00:00

abstract：BACKGROUND:Diarrhea is common in solid organ transplant recipients. Colonoscopy with random biopsies is performed frequently in the diagnostic evaluation of the posttransplant population with diarrhea. The purpose of this study was to determine the sensitivity of colonoscopy with random biopsy in determining a specific...

journal_title：Transplantation

authors： Rice JP,Spier BJ,Cornett DD,Walker AJ,Richie K,Pfau PR

更新日期：2009-08-15 00:00:00

abstract：:Effects of liver denervation on bile formation were studied in eight dogs prepared with chronic biliary fistulas. The animals were studied in the basal state, after feeding, and during infusion of glucagon 50 ng/kg/min, secretin 2 U/kg/hr, or somatostatin 200 ng/kg/min. After this first set of experiments the animals ...

journal_title：Transplantation

authors： Cucchiaro G,Branum GD,Farouk M,Mansour G,Kuhn CM,Anthony DC,Meyers WC

更新日期：1992-07-01 00:00:00

abstract：:Transplantation provides life-saving therapy to critically ill patients with end-stage organ failure. We found that the specialized knowledge of mental health clinicians and physicians, committed to the evaluation and management of transplant recipients, is essential for the optimal care of these patients who require ...

journal_title：Transplantation

authors： Surman OS,Cosimi AB,DiMartini A

更新日期：2009-06-27 00:00:00

abstract：:Immunosuppressive therapy increases the risk of recurrence of initial cancers in organ transplant patients, and compelling therapeutic protocols are needed to suppress the malignancy and protect the allograft. We examined the potential use of 15-deoxyspergualin (DSG) in relation to organ transplantation and cancer. Th...

journal_title：Transplantation

authors： Ohsawa I,Uemoto S,Kobayashi E,Murakami T

更新日期：2007-08-15 00:00:00

abstract：BACKGROUND:Solitary pancreas transplants, both pancreas transplant alone (PTA) and pancreas after kidney (PAK), have higher rejection rates and lower graft survivals than simultaneous pancreas-kidney transplants (SPK). The aim of this study is to compare three different antibody induction regimens in solitary pancreas ...

journal_title：Transplantation

authors： Stegall MD,Kim DY,Prieto M,Cohen AJ,Griffin MD,Schwab TR,Nyberg SL,Velosa JA,Gloor JM,Innocenti F,Bohorquez H,Dean PG,Carpenter HA,Leontovich ON,Sterioff S,Larson TS

更新日期：2001-11-27 00:00:00

abstract：:Created by the US National Organ Transplant Act in 1984, the Scientific Registry of Transplant Recipients (SRTR) is obligated to publicly report data on transplant program and organ procurement organization performance in the United States. These reports include risk-adjusted assessments of graft and patient survival,...

journal_title：Transplantation

authors： Snyder JJ,Salkowski N,Kim SJ,Zaun D,Xiong H,Israni AK,Kasiske BL

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:The first generic tacrolimus product gained Food and Drug Administration approval in August 2009. This prospective, observational trial sought to determine the need for dose titrations and measure drug cost savings on conversion to generic tacrolimus. METHODS:Transplant recipients on stable tacrolimus doses...

journal_title：Transplantation

authors： McDevitt-Potter LM,Sadaka B,Tichy EM,Rogers CC,Gabardi S

更新日期：2011-09-27 00:00:00

abstract：BACKGROUND:Rising numbers of patients reaching end-stage kidney disease intensify the demand for expansion of the living-kidney-donor pool. On the basis of low risk in white donors with essential hypertension, our transplant center undertook a structured program of accepting hypertensive donors if kidney function and u...

journal_title：Transplantation

authors： Textor SC,Taler SJ,Driscoll N,Larson TS,Gloor J,Griffin M,Cosio F,Schwab T,Prieto M,Nyberg S,Ishitani M,Stegall M

更新日期：2004-07-27 00:00:00

abstract：BACKGROUND:The organ shortage has led many transplant centers to accept kidneys from old, suboptimal deceased donors, and make increasing use of old-for-old allocation systems. We report the experience of an Italian transplant center in the utilization of "ultra-old" (>75 years old) donors. METHODS:Sixty grafts from d...

journal_title：Transplantation

authors： Collini A,Kalmar P,Dhamo A,Ruggieri G,Carmellini M

更新日期：2009-06-27 00:00:00

abstract：:Patients who require cystectomy are usually treated with an ileal conduit or intestinal neobladder for urinary control. In some of them, however, the bowel segment cannot be used because of previous abdominal surgery or radiation treatment. Bladder transplantation from cadavers may be beneficial to these patients, if ...

journal_title：Transplantation

authors： Takeuchi K,Takechi S,Ohoka H,Yokoyama M,Iwata H,Takeuchi M,Matsuda S

更新日期：1997-04-15 00:00:00

abstract：:The effect of the graft-versus-host reaction in response to minor histocompatibility antigens on the antibody response to a T-dependent antigen was studied in four strains of mice. Lethally irradiated mice were transplanted with bone marrow plus graded numbers of spleen cells from H-2-compatible donors. Recipients of ...

journal_title：Transplantation

authors： Hamilton BL,Ochs HD

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Nephrotoxicity is a major side effect of calcineurin inhibitors (CNI). Earlier we reported 8% of our heart transplant recipients reaching end-stage renal failure (ESRF). Now, with an extended follow up of 20 years, we re-evaluated the development of ESRF and studied its influence on survival and the impact o...

journal_title：Transplantation

authors： van de Wetering J,Weimar CH,Balk AH,Roodnat JI,Holweg CT,Baan CC,van Domburg RT,Weimar W

更新日期：2006-12-27 00:00:00