Abstract:
:Immunosuppressive therapy increases the risk of recurrence of initial cancers in organ transplant patients, and compelling therapeutic protocols are needed to suppress the malignancy and protect the allograft. We examined the potential use of 15-deoxyspergualin (DSG) in relation to organ transplantation and cancer. The effect of DSG on established liver metastatic tumors in recipient rats bearing a heart allograft was evaluated using an in vivo luminescent technique with luciferase-expressing RCN-H4 rat colon cancer cells. The inhibition of cell growth by DSG was correlated with NF-kappa B activity and caspase-3/7 activity in vitro. In the cyclosporine A (CsA)-induced cancer progression model of rats, DSG treatment (3 mg/kg) blocked the increase in tumor-derived luciferase activity, while CsA (15 mg/kg) facilitated luciferase activity up to around day 20 after cardiac transplantation. Our data suggest that DSG may be a therapeutic candidate for the control of tumor growth in transplant patients.
journal_name
Transplantationjournal_title
Transplantationauthors
Ohsawa I,Uemoto S,Kobayashi E,Murakami Tdoi
10.1097/01.tp.0000271496.75233.f6subject
Has Abstractpub_date
2007-08-15 00:00:00pages
424-8issue
3eissn
0041-1337issn
1534-6080pii
00007890-200708150-00021journal_volume
84pub_type
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