Photochemotherapy induces a faster apoptosis of alloreactive activated T cells than of nonalloreactive resting T cells in graft versus host disease.

abstract：:We have previously observed that transplant recipient sera with endothelial antibodies are bound to epidermal cells, as shown by immunofluorescence on sections of skin. It was also reported that early kidney failures that occurred despite negative T cell crossmatches were associated with, and could have been predicted...

journal_title：Transplantation

authors： Moraes JR,Moraes ME,Luo YM,Stastny P

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...

journal_title：Transplantation

authors： Molnar MZ,Ravel V,Streja E,Kovesdy CP,Mehrotra R,Kalantar-Zadeh K

更新日期：2016-10-01 00:00:00

abstract：:To determine the nature and sequence of the histologic changes in the early rejection of pancreaticoduodenal allografts and to assess the correlation between pancreaticoduodenal biopsy findings and the pathologic changes in the graft, we performed serial cystoscopically directed needle biopsies of pancreaticoduodenal ...

journal_title：Transplantation

authors： Carpenter HA,Barr D,Marsh CL,Miller AR,Perkins JD

更新日期：1989-11-01 00:00:00

abstract：:Based on a log-linear model for analyzing multiple effects, center variation in the UCLA Transplant Registry is the most influential factor in early renal graft survival. Among 68 active centers accounting for 70% of all transplants between 1985 and 1989, the 1-year graft survival (adjusted for 15 covariates) varied f...

journal_title：Transplantation

authors： Gjertson DW,Terasaki PI

更新日期：1992-02-01 00:00:00

abstract：:A major impediment to the wider application of clinical liver transplantation is the paucity of acceptable organs. Most centers refuse organs that come from donors who are hepatitis B core antibody positive because of a fear of transmission of hepatitis B virus (HBV) infection to the recipient. The risk related to the...

journal_title：Transplantation

authors： Van Thiel DH,De Maria N,Colantoni A,Friedlander L

更新日期：1999-08-27 00:00:00

abstract：BACKGROUND:More than 60% children with small bowel transplantation (SBTx) experience acute cellular rejection. PURPOSE/METHODS:To identify children at risk of rejection, donor- and third-party-induced proliferation of T-helper and T cytotoxic (Tc) cells, and their naïve and memory (M) subsets was evaluated simultaneou...

journal_title：Transplantation

authors： Ashokkumar C,Gupta A,Sun Q,Higgs BW,Ningappa M,Snyder S,Johnson M,Mazariegos G,Soltys K,Bond G,Abu-Elmagd K,Sindhi R

更新日期：2010-06-15 00:00:00

abstract：:Endothelial chimerism in transplanted organs is a fascinating phenomenon, indicative of a mechanism by which progenitor recipient cells replace the donor endothelium. It has been hypothesized that this replacement could lead to a decrease in alloreactivity and thus would positively influence graft outcome. However, re...

journal_title：Transplantation

authors： Koopmans M,Kremer Hovinga IC,Baelde HJ,de Heer E,Bruijn JA,Bajema IM

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:The vast majority of polyomavirus nephropathy (PVN) are due to BK virus, but rare cases result from JC virus reactivation. To date, only a handful of biopsy-proven JC-PVN cases have been reported. Here, we describe the clinical and pathologic findings in 7 patients with biopsy-proven JC-PVN. METHODS:Search ...

journal_title：Transplantation

authors： Wiegley N,Walavalkar V,Aujla H,Chen LX,Huang Y,Lee BK,Jen KY

更新日期：2020-06-17 00:00:00

abstract：BACKGROUND:Immunogenicity of a graft depends on its expression of major histocompatability complex (MHC) antigens and adhesion molecules and on the amount of intragraft leukocytes, the so-called passenger leukocytes. Although long-term culture reduces passenger leukocytes, permanent acceptance is not necessarily observ...

journal_title：Transplantation

authors： Kuttler B,Hartmann A,Wanka H

更新日期：2002-08-27 00:00:00

abstract：BACKGROUND:The organ shortage has led many transplant centers to accept kidneys from old, suboptimal deceased donors, and make increasing use of old-for-old allocation systems. We report the experience of an Italian transplant center in the utilization of "ultra-old" (>75 years old) donors. METHODS:Sixty grafts from d...

journal_title：Transplantation

authors： Collini A,Kalmar P,Dhamo A,Ruggieri G,Carmellini M

更新日期：2009-06-27 00:00:00

abstract：BACKGROUND:Perioperative renal dysfunction in liver transplant recipients complicates maintenance immunosuppressive therapy, particularly in patients with hepatitis C. Calcineurin inhibitors exacerbate renal dysfunction and mammalian target-of-rapamycin inhibitors are generally avoided because of perceived perioperativ...

journal_title：Transplantation

authors： LaMattina JC,Jason MP,Hanish SI,Ottmann SE,Klassen DK,Potosky D,Hutson WR,Barth RN

更新日期：2014-01-27 00:00:00

abstract：:Portal vein (PV) complications after living donor liver transplant (LDLT) have been a major concern in pediatric liver transplantation. The incidence of PV complications is more in pediatric (0%-33%) than in adult recipients. Early diagnosis and treatment of PV complications may ensure optimal graft function and good ...

journal_title：Transplantation

authors： Cheng YF,Ou HY,Yu CY,Tsang LL,Huang TL,Chen TY,Concejero A,Wang CC,Wang SH,Lin TS,Liu YW,Yang CH,Yong CC,Chiu KW,Jawan B,Eng HL,Chen CL

更新日期：2014-04-27 00:00:00

abstract：:There is substantial evidence that increased cellular calcium may activate processes that lead to cellular injury and death, and calcium entry blockers (CEB) have been shown to protect against renal ischemic injury. This approach has been used experimentally to enhance kidney preservation during both warm and cold isc...

journal_title：Transplantation

authors： Nakamoto M,Shapiro JI,Mills SD,Schrier RW,Chan L

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:The delayed allograft rejection in C6-deficient PVG C6- rats compared with normal PVG rats has been attributed to the lack of alloantibody activation of the membrane attack complex of complement. As T cells alone have been shown to effect graft rejection, we examined T-cell responses in PVG C6- rats. METHOD...

journal_title：Transplantation

authors： Merten S,Chen JC,Ha H,Plain K,Boyd RA,Penny MJ,Leenaerts P,Hall BM

更新日期：1998-05-15 00:00:00

abstract：:Islet transplantation may be optimized by islet immunoisolation to prevent direct contact between the islet graft and the host tissue. In this study, we examined the glycemia and insulin secretion in streptozotocin-diabetic rats transplanted with islets subjected to immunoisolation with Algire diffusion chamber or wit...

journal_title：Transplantation

authors： Ar'Rajab A,Bengmark S,Ahrén B

更新日期：1991-03-01 00:00:00

abstract：:Recipient dogs were conditioned with 9.2 Gy of total-body irradiation followed by the infusion of bone marrow and peripheral blood leukocytes from a DLA-haploidentical littermate (N = 10) or a completely allogeneic unrelated donor (n = 9). Graft-vs.-host disease (GVHD) prophylaxis consisted of methotrexate (MTX) and c...

journal_title：Transplantation

authors： Deeg HJ,Severns E,Raff RF,Sale GE,Storb R

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species and the subsequent production of antibodies to environmental mi...

journal_title：Transplantation

authors： Nozawa S,Xing PX,Wu GD,Gochi E,Kearns-Jonker M,Swensson J,Starnes VA,Sandrin MS,McKenzie IF,Cramer DV

更新日期：2001-07-15 00:00:00

abstract：:One of the most powerful influences on cadaveric renal graft survival is the enhancing effect of blood transfusions from unrelated individuals (1, 2). However, the optimum number of transfusions required to achieve this effect remains controversial. Enhanced graft survival following only one or two transfusions has be...

journal_title：Transplantation

authors： Martin S,Dyer PA,Harris R,Manos J,Mallick NP,Gokal R,Johnson RW

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:The influence of recipient body mass index (BMI) on pediatric-donor kidney transplant outcomes is unclear. We aimed to determine graft survival and functional outcomes of pediatric-donor kidneys compared with adult kidneys stratified by recipient BMI group. METHODS:Scientific Registry of Transplant Recipien...

journal_title：Transplantation

authors： Kayler LK,Zendejas I,Gregg A,Wen X

更新日期：2012-02-27 00:00:00

abstract：:Zero-time kidney biopsies, obtained at time of transplantation, are performed in many transplant centers worldwide. Decisions on kidney discard, kidney allocation, and choice of peritransplant and posttransplant treatment are sometimes based on the histological information obtained from these biopsies. This comprehens...

journal_title：Transplantation

authors： Naesens M

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Low-molecular-weight heparin (LMWH) has been shown to prolong survival of rat cardiac allografts independently from immunosuppressive treatment. Furthermore, long-term treatment reduces the development of chronic graft vascular disease after experimental heart transplantation. The aim of the present study wa...

journal_title：Transplantation

authors： Braun C,Schultz M,Fang L,Schaub M,Back WE,Herr D,Laux V,Rohmeiss P,Schnuelle P,van der Woude FJ

更新日期：2001-07-27 00:00:00

abstract：:A non-complement-binding monoclonal antibody, TA-1, recognizing determinants on human T lymphocytes, was linked to the plant seed toxin ricin, either the intact molecule or purified ricin A chain. Peripheral blood lymphocytes were pretreated with conjugate for 2 hr, washed, and then measured in vitro for T cell prolif...

journal_title：Transplantation

authors： Vallera DA,Quinones RR,Azemove SM,Soderling CC

更新日期：1984-04-01 00:00:00

abstract：:Several groups have reported technical complications and poor graft survival rates in kidney transplants from pediatric donors to adult recipients. Increased incidences of acute rejections, vascular thrombosis, and early glomerulosclerotic lesions have led many groups to abandon this graft combination. Over the last 4...

journal_title：Transplantation

authors： Portolés J,Marañes A,Prats D,Torrente J,Marrón B,Perez-Contín MJ,Herrero JA,Coronel F,Grimalt J,Barrientos A

更新日期：1996-01-15 00:00:00

abstract：:A group of 170 patients having functional renal allografts were evaluated at least six months after renal transplantation. They were assessed for symptoms and signs of tendinitis in the Achilles and Supraspinatus tendons. Of the 170 patients, 34 had tendinitis. Four patients (11.8%) had spontaneous rupture of the Achi...

journal_title：Transplantation

authors： Murison MS,Eardley I,Slapak M

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Successful kidney transplantation normalizes elevated proatrial natriuretic peptide (proANP) plasma concentrations of renal failure patients in the early posttransplant period. We evaluated plasma and urinary proANP fragments in the late posttransplant period. METHODS:Immunoreactive proANP(1-30) and proANP(...

journal_title：Transplantation

authors： Franz M,Woloszczuk W,Hörl WH

更新日期：2001-07-15 00:00:00

abstract：:Hepatitis C virus (HCV) remains the leading indication for liver transplant in much of the world and has traditionally been associated with diminished posttransplant survival due to recurrent HCV-related liver disease. This field has been dramatically changed by the advent of safe and effective direct-acting antiviral...

journal_title：Transplantation

authors： Verna EC,Brown RS Jr

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Better preservation strategies for the storage of donation after circulatory death grafts are essential to improve graft function and to increase the kidney donor pool. We compared continuous normothermic ex vivo kidney perfusion (NEVKP) with hypothermic anoxic machine perfusion (HAMP) and static cold storag...

journal_title：Transplantation

authors： Urbanellis P,Hamar M,Kaths JM,Kollmann D,Linares I,Mazilescu L,Ganesh S,Wiebe A,Yip PM,John R,Konvalinka A,Mucsi I,Ghanekar A,Bagli DJ,Robinson LA,Selzner M

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Tacrolimus is a potent immunosuppressive agent that provides higher freedom from acute and chronic rejection than cyclosporine after liver transplantation (LTx). Initially, a steroid-free state was observed in about 70% of patients at 1 year; this did not change over the next 5 years. The present study ident...

journal_title：Transplantation

authors： Jain A,Kashyap R,Marsh W,Rohal S,Khanna A,Fung JJ

更新日期：2001-04-27 00:00:00

abstract：:A severe shortage of organs is one of the major barriers facing transplantation today. One of the proposals designed to overcome this serious problem is to increase the use of genetically unrelated living kidney donors. Excellent results have been achieved with these volunteers and cogent arguments have been made that...

journal_title：Transplantation

authors： Spital A

更新日期：2000-04-27 00:00:00

abstract：BACKGROUND:Calcineurin is a ubiquitously expressed calcium-dependent phosphatase that is inhibited by the immunosuppressant drugs cyclosporine and tacrolimus. Measuring calcineurin activity in transplant patients has been complicated by a lack of consistent correlation between drug level and enzyme activity, particular...

journal_title：Transplantation

authors： Pena JA,Titus L,Jackson J,Kirk AD,Gooch JL

更新日期：2013-08-15 00:00:00