Abstract:
:Flow cytometry (FC) T and B cell crossmatches were done retrospectively for 38 cadaver renal transplant recipients (29 first and 9 retransplants--minimum follow-up 12 months) using both current pretransplant serum and peak-reactive sera. An increase in median fluorescence intensity (channel shift) and/or an increase in the number of donor T and/or B cells binding antibody in test sera occurred in 23 cases. These 23 patients experienced a greater number of reversible rejection episodes as compared with patients with negative FC crossmatches (65% vs. 33%), P = 0.031. Graft outcome, however, was not different in the two groups. Thus, a positive FC crossmatch allows for the detection of subliminal levels of donor presensitization and is associated with a greater number of rejection episodes. A positive FC crossmatch is not predictive of ultimate graft loss.
journal_name
Transplantationjournal_title
Transplantationauthors
Lazda VA,Pollak R,Mozes MF,Jonasson Odoi
10.1097/00007890-198803000-00012subject
Has Abstractpub_date
1988-03-01 00:00:00pages
562-5issue
3eissn
0041-1337issn
1534-6080journal_volume
45pub_type
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