Abstract:
BACKGROUND:Long-term use of immunosuppressants is associated with significant morbidity and mortality in transplant recipients. A simple whole blood assay that has U.S. Food and Drug Administration clearance directly assesses the net state of immune function of allograft recipients for better individualization of therapy. A meta-analysis of 504 solid organ transplant recipients (heart, kidney, kidney-pancreas, liver and small bowel) from 10 U.S. centers was performed using the Cylex ImmuKnow assay. METHODS:Blood samples were taken from recipients at various times posttransplant and compared with clinical course (stable, rejection, infection). In this analysis, 39 biopsy-proven cellular rejections and 66 diagnosed infections occurred. Odds ratios of infection or rejection were calculated based on measured immune response values. RESULTS:A recipient with an immune response value of 25 ng/ml adenosine triphosphate (ATP) was 12 times (95% confidence of 4 to 36) more likely to develop an infection than a recipient with a stronger immune response. Similarly, a recipient with an immune response of 700 ng/ml ATP was 30 times (95% confidence of 8 to 112) more likely to develop a cellular rejection than a recipient with a lower immune response value. Of note is the intersection of odds ratio curves for infection and rejection in the moderate immune response zone (280 ng/ml ATP). This intersection of risk curves provides an immunological target of immune function for solid organ recipients. CONCLUSION:These data show that the Cylex ImmuKnow assay has a high negative predictive value and provides a target immunological response zone for minimizing risk and managing patients to stability.
journal_name
Transplantationjournal_title
Transplantationauthors
Kowalski RJ,Post DR,Mannon RB,Sebastian A,Wright HI,Sigle G,Burdick J,Elmagd KA,Zeevi A,Lopez-Cepero M,Daller JA,Gritsch HA,Reed EF,Jonsson J,Hawkins D,Britz JAdoi
10.1097/01.tp.0000234837.02126.70subject
Has Abstractpub_date
2006-09-15 00:00:00pages
663-8issue
5eissn
0041-1337issn
1534-6080pii
00007890-200609150-00011journal_volume
82pub_type
杂志文章,meta分析相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:The purpose of this study is to examine the effects of the coronavirus disease 2019 (COVID-19) pandemic on adult lung transplants and report practice changes in the United States. METHODS:A retrospective analysis of a public dataset from the United Network for Organ Sharing was performed regarding adult lun...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003522
更新日期:2021-01-01 00:00:00
abstract::The aim of this study was to assess the feasibility of detecting anti-HLA antibodies in eluates from needle core biopsies of renal transplants with chronic allograft nephropathy. Two methods of screening, the enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FlowPRA) were compared. Twenty renal transplants...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000156164.54216.de
更新日期:2005-05-27 00:00:00
abstract:BACKGROUND:A recent clinical study demonstrated that in renal allografts preserved in the cold apoptosis occurred soon after reperfusion. The mode of cell death during cold storage is generally considered necrotic. Whether apoptosis occurs as a part of cold storage is uncertain. The objective was to determine in human ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200109150-00010
更新日期:2001-09-15 00:00:00
abstract:BACKGROUND:The role of asymptomatic bacteriuria in kidney transplant recipients is unknown. There is no clear evidence of its effect on transplanted kidney. METHODS:We studied urine cytokines profile among kidney transplant recipients with bacteriuria found in screening examination. Urine cultures were collected in 26...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000226072.20185.f8
更新日期:2006-06-27 00:00:00
abstract:BACKGROUND:Cardiovascular disease remains epidemic in transplant recipients, despite aggressive treatment of cardiovascular risk factors. Thus, novel risk factors could play a role in the genesis of cardiovascular events in this population. METHODS:We evaluated the impact of early posttransplant anemia on cardiovascul...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000084872.26360.C5
更新日期:2003-09-15 00:00:00
abstract:BACKGROUND:New insights into mechanisms of injury in orthotopic liver transplantation (OLT) often come from experiments in small animal models. Mice are particularly suitable because of the growing availability of gene-altered animals and specific antibodies. A validated model of OLT in mice is not available and, in pa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200211150-00008
更新日期:2002-11-15 00:00:00
abstract:BACKGROUND:Whether cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) at prophylaxis cessation predicts D+/R+ kidney transplants at risk of late-onset CMV infection after receiving distinct induction therapies is still not well characterized. METHODS:We prospectively assessed CMV-specific CMI predicting late-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002421
更新日期:2018-11-01 00:00:00
abstract::Retrospectively we analyzed the histocompatibility data and clinical results of bone marrow transplantation in 51 patients who received marrow from unrelated donors (UD) from 1977 to 1987 at one of four UK BMT centers. We compared the results with those obtained in 51 transplants carried out at the same centers using ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00007890-199003000-00015
更新日期:1990-03-01 00:00:00
abstract::The requirement for effective, minimally toxic immunosuppression remains a major obstacle to performing human composite tissue allotransplantation. The skin component of composite tissue (e.g., limb) allografts is especially antigenic, necessitating toxic immunosuppressant doses to prevent or reverse acute rejection. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199402150-00020
更新日期:1994-02-01 00:00:00
abstract::The potent immunosuppressive action of rabbit antithymocyte globulin (RATG) in allotransplant recipients has been recognized for many years. Some of the antibody specificities and immunoregulatory effects of RATG have been described, but a comprehensive definition of RATG components has not been reported previously. I...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199403150-00010
更新日期:1994-03-15 00:00:00
abstract:BACKGROUND:Delayed graft function (DGF) is associated with acute tubular necrosis. In this setting, surviving tubular cells may proliferate and replace injured cells. CD133Pax-2cells may play a role in the regeneration of tubular damage. The aim of this study was to demonstrate the presence of these cells in human kidn...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816a8891
更新日期:2008-04-27 00:00:00
abstract:BACKGROUND:It is unclear to what extent cancer history affects posttransplantation mortality in solid organ transplant recipients. METHODS:We identified a Swedish population-based cohort of solid organ transplant recipients in the National Patient Register 1970 to 2008 and linked it to the Cancer and Cause-of-Death Re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829854b7
更新日期:2013-08-15 00:00:00
abstract:BACKGROUND:The shortage of livers for transplantation has prompted transplant centers to seek alternatives to conventional cadaveric liver transplantation. Left lateral segmentectomy from living donors has proven to be a safe operation for the donor with excellent results in the pediatric population. Left lobectomy, co...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199909270-00012
更新日期:1999-09-27 00:00:00
abstract::Zero-time kidney biopsies, obtained at time of transplantation, are performed in many transplant centers worldwide. Decisions on kidney discard, kidney allocation, and choice of peritransplant and posttransplant treatment are sometimes based on the histological information obtained from these biopsies. This comprehens...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001018
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Exact knowledge of biliary anatomy is essential in living donor liver transplantation. The purpose of this study was to evaluate the accuracy of pretransplant magnetic resonance cholangiography (MRC) in depicting the biliary anatomy in comparison with intraoperative cholangiography (IOC). MATERIALS AND METHO...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31821c1e33
更新日期:2011-07-15 00:00:00
abstract::Immunomodulatory properties are attributed to apoptotic cells. These properties have been used to modulate allogeneic immune responses in experimental transplantation settings. In independent studies, apoptotic cell infusion has been shown to favor hematopoietic cell engraftment, to increase heart graft survival, and ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000269113.59857.d6
更新日期:2007-07-15 00:00:00
abstract::Mouse thyroid tissue was dissociated with collagenase, fixed in periodate-lysine-paraformaldehyde (PLP), and further dissociated with EDTA and trypsin to yield cell suspensions containing mainly follicle epithelial cells and vascular endothelial cells. H-2 complex antigens were detected on the vascular endothelial cel...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198008000-00013
更新日期:1980-08-01 00:00:00
abstract::Conjugation of dextran-coated superparamagnetic iron oxide (SPIO) particles with transactivator protein (Tat)-peptide and fluorescein isothiocyanate (FITC) allows cells to readily uptake SPIO particles. This makes possible high-resolution, real-time imaging of these cells by magnetic resonance imaging (MRI). First, we...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000090164.42732.47
更新日期:2003-10-15 00:00:00
abstract::Intestinal transplantation has become the treatment of choice for patients who are experiencing life-threatening complications of intestinal failure. Early attempts with intestinal transplantation were unsuccessful as a consequence of both technical and immunologic failures. The introduction of tacrolimus provided the...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000126931.23349.15
更新日期:2004-05-15 00:00:00
abstract::BACKGROUND.: Reduced levels of serum adiponectin, an adipokine, are associated with cardiovascular and obesity-related diseases; however, relations between adiponectin and hypertension are unclear. METHODS.: This cross-sectional study examined adiponectin and ambulatory blood pressure monitoring (ABPM) in 33 pediatric...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b9e1ec
更新日期:2009-10-27 00:00:00
abstract::Focal segmental glomerulosclerosis (FSGS) is the primary renal disease in approximately one-tenth of pediatric patients receiving a renal allograft. Recurrence of proteinuria after renal transplantation is observed in approximately 30% of patients and negatively impacts graft survival. Risk factors for recurrence are ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000187110.25512.82
更新日期:2005-09-27 00:00:00
abstract::Patients awaiting a renal transplant were given 1 HLA-DR antigen-matched blood in order to compare the sensitization and graft outcome of these patients with those of control patients, who had been given random blood before transplantation. No differences in sensitization, measured by the formation of HLA antibodies, ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-10-15 00:00:00
abstract::Preexisting diabetes mellitus (DM) has been regarded as a contraindication to heart transplantation (HT). This prejudice has been based upon concern over increased infection rates and worsening DM with the initiation of prednisone immunosuppression. To better evaluate these suppositions, we reviewed our experience wit...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199002000-00015
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Ventricular assist devices (VADs) are increasingly being used in pediatric patients to provide long-term cardiac support. One potential complication of VAD therapy is the development of antibodies directed against human leukocyte antigens (HLA). This phenomenon has not been well described with the Berlin Hea...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182925242
更新日期:2013-06-27 00:00:00
abstract:BACKGROUND:Bone complications after hematopoietic stem-cell transplantation (HSCT) are relatively frequent. Evaluation of biomarkers of bone turnover and dual energy x-ray absorptiometry (DEXA) are not known in this context. METHODS:We prospectively evaluated bone mineral density, biomarkers of bone turnover, and the ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181d84c8e
更新日期:2010-06-15 00:00:00
abstract::The effect of the tritiated thymidine (3H-TdR) suicide technique on the ability of donor cells to induce fatal graft-versus-host disease (GVHD) was studied. C57BL/6 (H-2b) spleen cells were stimulated in vitro with irradiated BALB/c (H-2d) Moloney lymphoma cells in mixed culture and 3H-TdR of high-specific activity ad...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00001
更新日期:1977-04-01 00:00:00
abstract::In 33 renal allograft recipient-donor pairs, B and T lymphocyte complement-dependent cytotoxicity crossmatches and mixed lymphocyte culture (MLC) blocking experiments were performed and the results were correlated with graft outcome. MLC blocking particularly in the unidirectional culture against donor-stimulating cel...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197804000-00002
更新日期:1978-04-01 00:00:00
abstract::Renal transplant recipients are at risk of severe morbidity and mortality from CMV disease. We have undertaken routine surveillance for CMV shedding on 133 transplant recipients, using a rapid culture technique, in order to assess the incidence of CMV infection and disease in these patients and to assess the prognosti...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199307000-00019
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:The use of kidneys from non-heartbeating donors (NHB) remains controversial. An increased incidence of delayed primary function and primary nonfunction is common. We report a characteristic syndrome of transaminitis and thrombocytopenia after NHB renal transplantation, which may be predictive of graft outcom...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199705270-00005
更新日期:1997-05-27 00:00:00
abstract:BACKGROUND:New strategies for improving durable functional islet mass will be instrumental in facilitating islet transplantation as a cure for type 1 diabetes mellitus. The ability to transfer immunoregulatory or cytoprotective genes into pancreatic islets may enhance survival. Adenoviral vectors (Ad5) have been used w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000066361.02042.CA
更新日期:2003-07-15 00:00:00