Novel antibodies to the donor stem cell population CD34+/VEGFR-2+ are associated with rejection after hematopoietic stem cell transplantation.

abstract：BACKGROUND:Antibody-mediated rejection (AMR) remains associated with reduced kidney graft survival and no clear prognostic marker is available. METHODS:We investigated whether donor-specific antibodies (DSA) ability to bind C1q in comparison with AMR C4d status, both indirect signs of complement activation, improve ri...

journal_title：Transplantation

authors： Malheiro J,Santos S,Tafulo S,Dias L,Martins S,Fonseca I,Almeida M,Pedroso S,Beirão I,Castro-Henriques A,Cabrita A

更新日期：2018-11-01 00:00:00

abstract：:A laparoscopic live-donor nephrectomy was performed on a 40-year-old man. The kidney was removed intact via a 9-cm infraumbilical midline incision. Warm ischemia was limited to less than 5 min. Immediately upon revascularization, the allograft produced urine. By the second postoperative day, the recipient's serum crea...

journal_title：Transplantation

authors： Ratner LE,Ciseck LJ,Moore RG,Cigarroa FG,Kaufman HS,Kavoussi LR

更新日期：1995-11-15 00:00:00

abstract：:We performed a multicenter study to investigate the problem of cadaver kidney transplants that never achieve function, or that recover after a period of delayed function, and we used multivariate techniques to model the results. Sixty-nine patients who received cadaver kidney transplants that never functioned (NF) wer...

journal_title：Transplantation

authors： Halloran P,Aprile M

更新日期：1988-01-01 00:00:00

abstract：:Donor-specific blood transfusion (DSBT) in animals and humans can either promote subsequent renal graft survival or lead to sensitization and graft rejection. Using a rat renal allograft model, we have examined whether the effects of DSBT on renal allograft outcome and IgG alloantibody responses are linked to the host...

journal_title：Transplantation

authors： Wasowska B,Baldwin WM 3rd,Howell DN,Sanfilippo F

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Extended partial hepatectomy (PH) in patients is leading to portal hyperperfusion but reduced hepatic arterial perfusion (HAP), and is invariably causing focal hepatic venous outflow obstruction (FHVOO). We observed in a rat model that PH in combination with right median hepatic vein ligation (RMHV-L) caused...

journal_title：Transplantation

authors： Huang H,Deng M,Jin H,Liu A,Dahmen U,Dirsch O

更新日期：2014-05-27 00:00:00

abstract：:World Kidney Day on March 8, 2012, provides a chance to reflect on the success of kidney transplantation as a therapy for end-stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost-effectiveness. Anything that is both cheaper and better, but ...

journal_title：Transplantation

authors： Garcia GG,Harden P,Chapman J,World Kidney Day Steering Committee 2012.

更新日期：2012-02-27 00:00:00

abstract：BACKGROUND:We developed a nonviral gene transfer method using rapid injection of naked DNA targeting the liver and applied it in a rat model of liver transplantation. METHODS:Inbred Dark Agouti and Lewis rats were used. To test the efficacy and adverse effects of systemic or local (catheter-based) injection, different...

journal_title：Transplantation

authors： Inoue S,Hakamata Y,Kaneko M,Kobayashi E

更新日期：2004-04-15 00:00:00

abstract：BACKGROUND:There are limited experimental data on the nature of the humoral response elicited in humans against pig antigens. In this study, we have examined the xenoantibody (XAb) response in eight patients with acute liver failure exposed to pig hepatocytes after treatment with the bioartificial liver (BAL). METHODS...

journal_title：Transplantation

authors： Baquerizo A,Mhoyan A,Kearns-Jonker M,Arnaout WS,Shackleton C,Busuttil RW,Demetriou AA,Cramer DV

更新日期：1999-01-15 00:00:00

abstract：:H-1-incompatible rat renal allograft survival rates are strongly influenced by the non-major histocompatibility system (MHS) genes. The same H-1 (MHS) incompatibility tested on four different non-MHS backgrounds gave widely differing results ranging from 11 to 60% fractional survival between the best and the poorest (...

journal_title：Transplantation

authors： Paris AM,Bishop C,Festenstein H,Gunther E

更新日期：1978-05-01 00:00:00

abstract：:The psychosocial and psychiatric impact of donating bone marrow (BM) has received little study. This mail questionnaire study of bone marrow donors whose recipient had survived more than one year post-BMT was undertaken to document the psychosocial consequences of donation on "successful" BM donors. Demographic, mood ...

journal_title：Transplantation

authors： Wolcott DL,Wellisch DK,Fawzy FI,Landsverk J

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:LCP-Tacro is an extended-release formulation of tacrolimus designed for once-daily dosing. Phase 1 studies demonstrated greater bioavailability to twice-daily tacrolimus capsules and no new safety concerns. METHODS:In this phase 2 study, adult stable kidney transplant patients on tacrolimus capsules (Progra...

journal_title：Transplantation

authors： Gaber AO,Alloway RR,Bodziak K,Kaplan B,Bunnapradist S

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...

journal_title：Transplantation

authors： Sola E,Gonzalez-Molina M,Cabello M,Burgos D,Ramos J,Gutierrez C,Lopez V,Soler J,de la Vega E,Hernandez D

更新日期：2010-03-27 00:00:00

abstract：BACKGROUND:Mixed allogeneic hematopoietic chimerism has previously been reliably achieved and shown to induce tolerance to fully MHC-mismatched allografts in mice and monkeys. However, the establishment of hematopoietic chimerism has been difficult to achieve in the discordant pig-to-primate xenogeneic model. METHODS:...

journal_title：Transplantation

authors： Sablinski T,Emery DW,Monroy R,Hawley RJ,Xu Y,Gianello P,Lorf T,Kozlowski T,Bailin M,Cooper DK,Cosimi AB,Sachs DH

更新日期：1999-04-15 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Kidney transplant graft survival is almost uniformly superior for initial transplants compared to repeat transplants. We investigate the association between first second kidney transplant graft survival in patients who underwent initial transplant during their pediatric years whether age at se...

journal_title：Transplantation

authors： Gupta M,Wood A,Mitra N,Furth SL,Abt PL,Levine MH

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Cidofovir has antiviral activity against a wide spectrum of DNA viruses. Several small studies have focused on the efficacy of topical cidofovir in various viral-induced diseases. We report a systemic complication of such therapy. CASE REPORT:A bone marrow transplant recipient with chronic renal failure dev...

journal_title：Transplantation

authors： Bienvenu B,Martinez F,Devergie A,Rybojad M,Rivet J,Bellenger P,Morel P,Gluckman E,Lebbé C

更新日期：2002-02-27 00:00:00

abstract：BACKGROUND:For certain uremic, diabetic patients, a sequential transplant of a kidney (usually from a living donor) followed by a cadaver pancreas has become an attractive option. But how long to wait after the kidney transplant before proceeding with a pancreas transplant is unclear. We studied outcomes in recipients ...

journal_title：Transplantation

authors： Humar A,Sutherland DE,Ramcharan T,Gruessner RW,Gruessner AC,Kandaswamy R

更新日期：2000-10-27 00:00:00

abstract：:The interactions of rapamycin (Rapa), CsA, and donor-specific transfusion (DST) were examined in an ACI to Lewis rat heterotopic cardiac allograft model. Survival data were truncated at 175 days for the purpose of statistical comparisons. Vehicle (Veh)-treated animals rejected at a mean of 7.3 +/- 0.2 days. Treatment ...

journal_title：Transplantation

authors： Davies CB,Madden RL,Alexander JW,Cofer BR,Fisher RA,Anderson P

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA). METHODS:Peripheral blood mononuclear cells from SLA identical wild type (WT), α1, 3-galactos...

journal_title：Transplantation

authors： Martens GR,Reyes LM,Li P,Butler JR,Ladowski JM,Estrada JL,Sidner RA,Eckhoff DE,Tector M,Tector AJ

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Ventricular assist devices (VADs) are increasingly being used in pediatric patients to provide long-term cardiac support. One potential complication of VAD therapy is the development of antibodies directed against human leukocyte antigens (HLA). This phenomenon has not been well described with the Berlin Hea...

journal_title：Transplantation

authors： O'Connor MJ,Harville TO,Rhodes-Clark B,Pye SE,Knecht KR,Imamura M,Frazier EA,Morrow WR

更新日期：2013-06-27 00:00:00

abstract：:The aim of this study was to assess the efficacy of an enteral diet fortified with arginine, RNA, and fish oil (Impact), alone and in combination with cyclosporine (CsA) and donor-specific transfusion (DST) on allograft survival in the ACI:Lewis rat cardiac transplant model. Animals were fed ad libitum with either sta...

journal_title：Transplantation

authors： Levy AE,Alexander JW

更新日期：1995-10-27 00:00:00

abstract：BACKGROUND:The genetic modification of pigs is a powerful strategy that may ultimately enable successful xenotransplantation of porcine organs into humans. METHODS:Transgenic pigs were produced by microinjection of gene constructs for human complement regulatory proteins CD55 and CD59 and the enzyme alpha1,2-fucosyltr...

journal_title：Transplantation

authors： Cowan PJ,Aminian A,Barlow H,Brown AA,Chen CG,Fisicaro N,Francis DM,Goodman DJ,Han W,Kurek M,Nottle MB,Pearse MJ,Salvaris E,Shinkel TA,Stainsby GV,Stewart AB,d'Apice AJ

更新日期：2000-06-27 00:00:00

abstract：:A novel method for quantifying the fatty change of the graft liver by characterizing the optical property of the tissue was introduced. A wide range of lipid content in the rat liver was obtained by using different feeding regimens, with lipotropic chow (choline/methionine deficient or low chow). The liver was removed...

journal_title：Transplantation

authors： Kitai T,Beauvoit B,Chance B

更新日期：1996-09-15 00:00:00

abstract：:A non-complement-binding monoclonal antibody, TA-1, recognizing determinants on human T lymphocytes, was linked to the plant seed toxin ricin, either the intact molecule or purified ricin A chain. Peripheral blood lymphocytes were pretreated with conjugate for 2 hr, washed, and then measured in vitro for T cell prolif...

journal_title：Transplantation

authors： Vallera DA,Quinones RR,Azemove SM,Soderling CC

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:AGI-1096 is a novel phenolic intracellular antioxidant with anti-inflammatory and antiproliferative properties. In vitro, AGI-1096 inhibited the inducible expression of vascular cell adhesion molecule (VCAM)-1, E-selectin, and monocyte chemoattractant protein (MCP)-1 in endothelial cells and tumor necrosis f...

journal_title：Transplantation

authors： Murata S,Sundell CL,Lijkwan MA,Balsam LB,Hammainen P,Coleman C,York C,Luchoomun J,Suen KL,Howard R,Somers PK,Morris RE,Robbins RC

更新日期：2004-05-27 00:00:00

abstract：BACKGROUND:Natural antibodies that bind the carbohydrate antigen Galalpha1-3Galbeta1-4GlcNAc-R (alphaGal) mediate rigorous rejection of porcine xenografts and represent a major immunological hurdle to successful discordant xenotransplantation. However, little is known about how production of antibodies specific for alp...

journal_title：Transplantation

authors： Cretin N,Iacomini J

更新日期：2002-05-27 00:00:00

abstract：BACKGROUND:Graft failure related to acute and chronic rejection remains an important problem in transplantation. An association has been reported between microchimerism and the development of tolerance. Since it has been established that cells of fetal origin can be found in maternal tissues long after parturition, and...

journal_title：Transplantation

authors： Miles CD,Schaubel DE,Liu D,Port FK,Rao PS

更新日期：2008-05-27 00:00:00

abstract：:The histopathological changes and the course of graft-versus-host (GVH) disease were studied in the rat model of small-bowel transplantation using the Lewis----LBN-F1 strain combination. Allograft-induced GVH disease led to the recipients' death from enteritis, dermatitis and emaciation after 14.4 +/- 2.9 days (hetero...

journal_title：Transplantation

authors： Schraut WH,Lee KK,Dawson PJ,Hurst RD

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders...

journal_title：Transplantation

authors： St Peter SD,Imber CJ,Jones DC,Fuggle SV,Watson CJ,Friend PJ,Marshall SE

更新日期：2002-09-27 00:00:00

abstract：:In human organ transplantation, the correct diagnosis of rejection may be difficult using clinical and/or histopathologic criteria, and immunologic assays should therefore be considered. We have applied monoclonal antibodies in 2-color flow cytometric (FACS) analysis to study phenotypic patterns of kidney-infiltrating...

journal_title：Transplantation

authors： Tötterman TH,Hanås E,Bergström R,Larsson E,Tufveson G

更新日期：1989-05-01 00:00:00

abstract：:The effect of prophylactic i.v. administration of high doses of human gamma-immunoglobulin (IgG) on kidney graft survival was investigated in rhesus monkeys treated with azathioprine and prednisolone. In nontransfused recipients not treated with IgG (controls), graft survival ranged from 9 to 22 days; if nontreated an...

journal_title：Transplantation

authors： Borleffs JC,Marquet RL,de By-Aghai Z,Dolkart RE,Persijn GG,Balner H

更新日期：1982-01-01 00:00:00