High incidence of monoclonal immunoglobulins in patients after liver or heart transplantation.


:Sera from 56 recipients of liver or heart transplants were investigated for monoclonal immunoglobulins (mIg) by immunofixation electrophoresis (IFE) at different times during 4 years after transplantation. Transient, changing, or stable mIgs were found in 18 patients. A significantly increased mIg incidence was observed in heart Tx patients, patients over 40 years of age, and those receiving azathioprine or antithymocyte globulin in addition to prednisolone and cyclosporine as immunosuppressive treatment. No correlations could be found between the presence of mIg and the number of rejection episodes or intercurrent infections. Such serum mIg represent monoclones of at least 1 x 10(9) cells of B lymphocyte lineage that apparently proliferate without adequate suppressive control. Since immunosuppressed allograft recipients are at risk of developing B cell lymphomas, such monoclones may be regarded as prelymphomas necessitating a careful follow-up in these patients.






Peest D,Schaper B,Nashan B,Wonigeit K,Raude E,Pichlmayr R,Haverich A,Deicher H




Has Abstract


1988-09-01 00:00:00












  • Propagation of lymphocytes infiltrating human liver allografts. Correlation with histologic diagnosis of rejection.

    abstract::In this study, we have investigated whether lymphocyte growth from 196 liver transplant biopsies is correlated with the histologic diagnosis of graft rejection. One fragment of each biopsy was cultured in IL-2 to expand activated T cells, and the remainder of the biopsy was analyzed histologically. A significantly hig...


    pub_type: 杂志文章


    authors: Saidman SL,Demetris AJ,Zeevi A,Duquesnoy RJ

    更新日期:1990-01-01 00:00:00

  • Over 500 solitary pancreas transplants in nonuremic patients with brittle diabetes mellitus.

    abstract:BACKGROUND:A pancreas transplant alone (PTA) in a nonuremic patient with brittle diabetes mellitus remains a rare procedure because the tradeoff for insulin independence is lifelong immunosuppression. METHODS:Herein we report our results at the University of Minnesota of 513 PTAs from December 17, 1966, through Decemb...


    pub_type: 杂志文章


    authors: Gruessner RW,Sutherland DE,Kandaswamy R,Gruessner AC

    更新日期:2008-01-15 00:00:00

  • ABO compatibility and acute graft-versus-host disease following allogeneic bone marrow transplantation.

    abstract::If ABO antigens/antibodies play any role in the pathogenesis of acute graft-versus-host disease (GVHD), one would expect the highest incidence of GVHD in recipients of minor ABO-mismatched grafts, followed by ABO-matched grafts, and the lowest incidence in major ABO-mismatched transplants. To test this hypothesis 174 ...


    pub_type: 杂志文章


    authors: Bacigalupo A,Van Lint MT,Occhini D,Margiocco M,Ferrari G,Pittaluga PA,Frassoni F,Peralvo J,Lercari G,Carubia F

    更新日期:1988-06-01 00:00:00

  • Utility in Treating Kidney Failure in End-Stage Liver Disease With Simultaneous Liver-Kidney Transplantation.

    abstract:BACKGROUND:Simultaneous liver-kidney (SLK) transplantation plays an important role in treating kidney failure in patients with end-stage liver disease. It used 5% of deceased donor kidney transplanted in 2015. We evaluated the utility, defined as posttransplant kidney allograft lifespan, of this practice. METHODS:Usin...


    pub_type: 杂志文章


    authors: Cheng XS,Stedman MR,Chertow GM,Kim WR,Tan JC

    更新日期:2017-05-01 00:00:00

  • The Impact of Performance Status on Length of Hospital Stay and Clinical Complications Following Liver Transplantation.

    abstract:BACKGROUND:Impaired pretransplant performance status (PS) is associated with chronic liver disease (CLD). We studied its impact on hospital length of stay (LOS), complications and readmissions in the first year after liver transplantation. METHOD:The Standard National Liver Transplant Registry was linked to a hospital...


    pub_type: 杂志文章


    authors: Wallace D,Cowling TE,Walker K,Suddle A,Gimson A,Rowe I,Callaghan C,Heaton N,van der Meulen J,Bernal W

    更新日期:2020-10-08 00:00:00

  • Impact of extracorporeal membrane oxygenation or mechanical ventilation as bridge to combined heart-lung transplantation on short-term and long-term survival.

    abstract:BACKGROUND:Extracorporeal membrane oxygenation (ECMO) and mechanical ventilation (MV) can be used as a bridge to heart-lung transplantation (HLT). The goal of this study was to determine if pretransplantation ECMO or MV affects survival in HLT. METHODS:The United Network for Organ Sharing database was reviewed for all...


    pub_type: 杂志文章


    authors: Jayarajan SN,Taghavi S,Komaroff E,Brann S,Horai T,Cordova F,Patel N,Guy TS,Toyoda Y

    更新日期:2014-01-15 00:00:00

  • Benefit of Neoral C2 monitoring in de novo cardiac transplant recipients receiving basiliximab induction.

    abstract:BACKGROUND:For cyclosporine (CsA), 2-hr postdose level (C2) is the best single time point predictor of the area under the curve and a critical measure for effective dosing. The therapeutic CsA microemulsion (Neoral) C2 range in de novo heart transplant patients remains to be determined. PURPOSE:The purpose of this stu...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Cantarovich M,Ross H,Arizón JM,Gómez MA,Straatman L,Orús J,Alonso-Pulpón L,Molina BD,Wang S,Lage E,Crespo MG,Manito N,Howlett J,Haddad H,Motown Study Group.

    更新日期:2008-04-15 00:00:00

  • First in man renal transplantation after ex vivo normothermic perfusion.

    abstract:BACKGROUND:Normothermic perfusion is an alternative but little studied method of organ preservation. Herein, we report the first case of ex vivo normothermic renal transplant perfusion in man. METHODS:The 62-year-old extended criteria donor died of an intracranial hemorrhage and had undergone cardiopulmonary resuscita...


    pub_type: 杂志文章


    authors: Hosgood SA,Nicholson ML

    更新日期:2011-10-15 00:00:00

  • Accelerated rejection of H-2-incompatible skin allografts in the absence of specific cytotoxic antibodies.

    abstract::Second-set rejection is generally considered to be mediated by cytotoxic humoral antibodies. A few discordant data have been reported, however. To address this question, we have taken advantage of a model in which specific cytotoxic alloantibodies are not produced although transplantation cellular immunity develops. F...


    pub_type: 杂志文章


    authors: Aitouche A,Touraine JL

    更新日期:1993-09-01 00:00:00

  • Chronic cyclosporine-induced nephropathy in the rat. A medullary ray and inner stripe injury.

    abstract::Cyclosporine CsA nephrotoxicity was examined in male Sprague-Dawley rats with or without prior uninephrectomy, injected daily with 12.5 mg/kg CsA, and fed a salt-depleted or normal diet for 3-10 weeks. Control rats received the CsA vehicle. CsA induced a fall in creatinine clearance in salt-depleted rats, from 1.3 +/-...


    pub_type: 杂志文章


    authors: Rosen S,Greenfeld Z,Brezis M

    更新日期:1990-02-01 00:00:00

  • The role of self-expandable metallic stents for the treatment of airway complications after lung transplantation.

    abstract:BACKGROUND:Airway complications continue to be an important source of morbidity and mortality after lung transplantation (LTx). Different approaches have been used for their nonsurgical management. We describe our experience using self-expandable metallic stents (SEMSs) in patients with airway complications post-LTx. ...


    pub_type: 杂志文章


    authors: Saad CP,Ghamande SA,Minai OA,Murthy S,Pettersson G,DeCamp M,Mehta AC

    更新日期:2003-05-15 00:00:00

  • The effect of verapamil in reducing the severity of acute tubular necrosis in canine renal autotransplants.

    abstract::Calcium channel blockade has been shown to prevent warm renal ischemic damage. The ability of verapamil to decrease the severity of acute tubular necrosis (ATN) after 24-hr cold storage and autotransplantation was studied in a randomized paired study of 12 dogs. Experimental animals pretreated with intraarterial verap...


    pub_type: 杂志文章


    authors: Agatstein EH,Farrer JH,Kaplan LM,Randazzo RF,Glassock RJ,Kaufman JJ

    更新日期:1987-09-01 00:00:00

  • KIR/HLA ligand incompatibility in kidney transplantation.

    abstract:BACKGROUND:The polymorphic family of killer-cell immunoglobulin-like receptors (KIRs) consists of activating and inhibitory receptors expressed by natural killer (NK) cells and effector T cells that recognize human leukocyte antigen (HLA) class I ligands. It has been suggested that KIR/HLA incompatibility exerts benefi...


    pub_type: 杂志文章


    authors: Kunert K,Seiler M,Mashreghi MF,Klippert K,Schönemann C,Neumann K,Pratschke J,Reinke P,Volk HD,Kotsch K

    更新日期:2007-12-15 00:00:00

  • Impact of renal posttransplantation amputation on allograft outcomes: a study of United States renal data system.

    abstract:BACKGROUND:The prevalence of renal posttransplantation amputation and its impact on allograft and patient survival have not been widely reported. METHODS:We used an incident cohort of patients who underwent renal transplantation between June 2004 and September 2009. Amputation data were obtained using Medicare institu...


    pub_type: 杂志文章


    authors: Brar A,Jindal RM,Sumrani N,John D,Mondal Z,Tedla F,Salifu MO

    更新日期:2013-05-27 00:00:00

  • Extensively drug-resistant Pseudomonas aeruginosa bacteremia in solid organ transplant recipients.

    abstract:BACKGROUND:We sought to determine the risk factors, molecular epidemiology, antibiotic therapy, and outcomes of bacteremia because of extensively drug-resistant (XDR) Pseudomonas aeruginosa in solid organ transplant (SOT) recipients. METHODS:All episodes of bacteremia occurring in SOT recipients were prospectively doc...


    pub_type: 杂志文章


    authors: Bodro M,Sabé N,Tubau F,Lladó L,Baliellas C,González-Costello J,Cruzado JM,Carratalà J

    更新日期:2015-03-01 00:00:00

  • A New Life: Motherhood After Heart Transplantation. A Single-center Experience and Review of Literature.

    abstract:BACKGROUND:Pregnancy after heart transplantation (HTx) may expose the recipient to hemodynamic and immunologic risks and the newborn to toxic effects of immunosuppressive therapy. Adequate preconception counseling is crucial to identify optimal timing and to modify immunosuppressive therapy to minimize risks for both t...


    pub_type: 杂志文章,评审


    authors: Macera F,Occhi L,Masciocco G,Varrenti M,Frigerio M

    更新日期:2018-09-01 00:00:00

  • Clinical Trials for Immunosuppression in Transplantation: The Case for Reform and Change in Direction.

    abstract::Currently trials of immunosuppression in transplantation are in decline because their objectives remain focused on improving acute rejection rates and graft survival in the first 12 months. With 1 year renal graft survival rates of greater than 90% the best that can be hoped for is noninferiority trial outcomes compar...




    authors: OʼConnell PJ,Kuypers DR,Mannon RB,Abecassis M,Chadban SJ,Gill JS,Murphy B,Nickerson PW,Schold JD,Stock PG,Seron D,Alloway RR,Bromberg JS,Budde K,Jordan SC,Legendre C,Lefaucheur C,Sarwall M,Segev DL,Stegall MD,Tull

    更新日期:2017-07-01 00:00:00

  • Acute tubular necrosis after renal transplantation.

    abstract::We evaluated the influence of dialysis requiring acute tubular necrosis on patient survival, and kidney survival and function in all 182 patients who needed dialysis immediately after transplantation at the University of Minnesota Hospitals. When compared to matched control patients not requiring dialysis, there was n...


    pub_type: 杂志文章


    authors: Brophy D,Najarian JS,Kjellstrand CM

    更新日期:1980-03-01 00:00:00

  • The effect of organ-specific CD26/DPP IV enzymatic activity inhibitor-preconditioning on acute pulmonary allograft rejection.

    abstract:BACKGROUND:Systemic inhibition of serum CD26/dipeptidylpeptidase (DPP IV) enzymatic activity abrogated acute rejection of pulmonary allografts, whereas organ-specific inhibition ameliorated ischemia/reperfusion injury in syngeneic transplants. Here, we analyze the effect of allograft-specific inhibitor preconditioning ...


    pub_type: 杂志文章


    authors: Jungraithmayr W,Oberreiter B,De Meester I,Wiedl T,Inci I,Bain M,Augustyns K,Hillinger S,Scharpé S,Weder W,Korom S

    更新日期:2009-08-27 00:00:00

  • "Striped" pattern of medullary ray fibrosis in allograft biopsies from kidney transplant recipients maintained on tacrolimus.

    abstract:BACKGROUND:A striped pattern of fibrosis has been described in the kidneys of patients undergoing long-term cyclosporine or tacrolimus therapy. This lesion is frequently misconstrued as being specific for drug toxicity. METHODS:We performed clinicopathologic correlation on 18 patients with striped fibrosis identified ...


    pub_type: 杂志文章


    authors: Dell'Antonio G,Randhawa PS

    更新日期:1999-02-15 00:00:00

  • Induction of hyperacute rejection of skin allografts by CD8+ lymphocytes.

    abstract:BACKGROUND:Second-set rejection is generally regarded as a phenomenon mainly mediated by humoral cytotoxic antibodies, although a few discordant data have been presented. In the reported experiments, we have taken advantage of the absence of production of specific cytotoxic alloantibodies contrasting with the normal de...


    pub_type: 杂志文章


    authors: Yoshimura R,Chargui J,Aitouche A,Veyron P,Touraine JL

    更新日期:2000-04-15 00:00:00

  • Pancreas after living donor kidney versus simultaneous pancreas-kidney transplant: an analysis of the organ procurement transplant network/united network of organ sharing database.

    abstract:BACKGROUND:One of the alternative options to simultaneous pancreas-kidney transplantation (SPKT) for type I diabetics with renal failure is sequential transplant of a living donor kidney followed by a deceased donor pancreas transplant (pancreas after living donor kidney transplant [PALK]). We retrospectively compared ...


    pub_type: 杂志文章


    authors: Poommipanit N,Sampaio MS,Cho Y,Young B,Shah T,Pham PT,Wilkinson A,Danovitch G,Bunnapradist S

    更新日期:2010-06-27 00:00:00

  • Flow cross-matching identifies patients at risk for postoperative elaboration of cytotoxic antibodies.

    abstract:BACKGROUND:Cytotoxic IgG against class I antigens can contribute to renal dysfunction or failure after transplantation. However, the clinical relevance of IgG measured by flow cytometric cross-matching is controversial. This study correlated pre- and postoperative flow reactivity with clinical outcome among renal trans...


    pub_type: 杂志文章


    authors: Kimball P,Rhodes C,King A,Fisher R,Ham J,Posner M

    更新日期:1998-02-15 00:00:00

  • In situ hybridization utilizing a Y chromosome DNA probe. Use as a cell marker for hepatocellular transplantation.

    abstract::Research in hepatocellular gene therapy requires a consistently reproducible cell marker to detect transplanted hepatocytes. We have used a Y-specific genomic DNA probe to accomplish this goal. This technique enables the identification of transplanted male cells in recipient female tissues. Donor hepatocytes from male...


    pub_type: 杂志文章


    authors: Eckert JW,Buerkle CJ,Major AM,Finegold MJ,Brandt ML

    更新日期:1995-01-15 00:00:00

  • Recipients' perceptions of their transplanted kidneys.

    abstract:BACKGROUND:The literature indicates few studies on kidney patients' perception of the donor kidney. In light of this fact, we decided to explore this issue with adult patients. METHODS:We carried out a phenomenological study with 40 adult kidney patients. RESULTS:In this study, three main themes became apparent: the ...


    pub_type: 杂志文章


    authors: Buldukoglu K,Kulakac O,Kececioglu N,Alkan S,Yilmaz M,Yucetin L

    更新日期:2005-08-27 00:00:00

  • Mapping and transcriptional properties of RT1 class II region genes.

    abstract::The class II region of major histocompatibility complex of the rat. Rattus norvegicus (RT1) consists of RT1.B, RT1.D, and RT1.H subregions. The gene order around the H subregion was determined as RT1.A--H beta-H alpha--B by RFLP analysis of naturally occurring intra-RT1 recombinant rats with HLA DP probes. A unique re...


    pub_type: 杂志文章


    authors: Fujii H,Kakinuma M,Yoshiki T,Natori T

    更新日期:1991-08-01 00:00:00

  • Time-response studies of the cellular immune response to cell membrane antigens.

    abstract::It was the objective of these experiments to study the time-related changes in the responsiveness of the cellular elements of the immune system following contact with single non-H-2 or multiple H-2 histocompatibility antigens. The reactivity of spleen cells from mice that received injections of spleen cells bearing H-...


    pub_type: 杂志文章


    authors: Graff RJ,Kurtz ME,Russell H,Martin-Morgan D

    更新日期:1988-02-01 00:00:00

  • Anti-CD20 monoclonal antibody (rituximab) therapy for acute cardiac humoral rejection: a case report.

    abstract::Humoral or antibody-mediated rejection in cardiac transplant recipients is mediated by donor-specific cytotoxic antibodies and is histologically defined by linear deposits of immunoglobulin and complement in the myocardial capillaries. Antibody-mediated rejection often is accompanied by hemodynamic compromise and is a...


    pub_type: 杂志文章


    authors: Aranda JM Jr,Scornik JC,Normann SJ,Lottenberg R,Schofield RS,Pauly DF,Miles M,Hill JA,Sleasman JW,Skoda-Smith S

    更新日期:2002-03-27 00:00:00

  • Reconstitution of (BALB/c x B6)F1 normal mice with stem cells and thymus from nonobese diabetic mice results in autoimmune insulitis of the normal hosts' pancreases.

    abstract::The NOD mouse develops immune-mediated diabetes mellitus characterized by T cell infiltration and destruction of pancreatic islet tissue. We wished to determine whether one contributing factor was an abnormality of the NOD pancreas that caused it to elicit an attack by NOD T cells. Therefore we constructed mice that h...


    pub_type: 杂志文章


    authors: Stein PH,Rees MA,Singer A

    更新日期:1992-06-01 00:00:00

  • Efficient gene transfer to pancreatic islets mediated by adenoviral vectors.

    abstract::Genetic manipulation of pancreatic islets before transplantation has the potential to alter cellular immunity as well as islet function. The purpose of this study was to examine the feasibility of gene transfer to islets, using replication-defective adenoviral vectors. Newborn mouse islets were infected with AdHCMVsp1...


    pub_type: 杂志文章


    authors: Csete ME,Benhamou PY,Drazan KE,Wu L,McIntee DF,Afra R,Mullen Y,Busuttil RW,Shaked A

    更新日期:1995-01-27 00:00:00