Recipient-reactive antibodies occur during development of acute graft-versus-host reaction after small bowel transplantation.

abstract：BACKGROUND:The clinical symptoms, histological findings, and treatments for antibody-mediated rejection (AMR), which is the leading cause of graft loss in adult ABO-incompatible liver transplantation (ABO-I-LT), have rarely been discussed. METHODS:We performed adult living donor ABO-I-LT on six patients. We used anti-...

journal_title：Transplantation

authors： Morioka D,Togo S,Kumamoto T,Takeda K,Matsuo K,Inayama Y,Yamanaka S,Tanaka K,Endo I,Maegawa J,Shimada H

更新日期：2008-01-27 00:00:00

abstract：BACKGROUND:The current shortage of organ donors has led many centers to use marginal and nonheart-beating donors (NHBDs). Recent research has implicated the infiltration of lymphocytes as an important mediator of ischemia-reperfusion injury (IRI). FTY720 is an immunosuppressant that promotes lymphocyte sequestration in...

journal_title：Transplantation

authors： Delbridge MS,Shrestha BM,Raftery AT,El Nahas AM,Haylor JL

更新日期：2007-07-27 00:00:00

abstract：:We have studied organ allograft survival in rhesus monkeys conditioned with myeloablative total-body irradiation and T cell-depleted autologous bone marrow transplantation then given a heterotopic MHC-mismatched cardiac allograft in the immediate postmyeloablative period. This model has enabled us to investigate the r...

journal_title：Transplantation

authors： Moses RD,Sundeen JT,Orr KS,Roberts RR,Gress RE

更新日期：1989-11-01 00:00:00

abstract：:A controlled trial was carried out to assess the value of intensive plasma exchange in 27 renal transplant recipients with clinical and histological evidence of acute vascular rejection. In addition to standard immunosuppression, 13 patients received plasma exchange on six consecutive days at a mean exchange volume of...

journal_title：Transplantation

authors： Allen NH,Dyer P,Geoghegan T,Harris K,Lee HA,Slapak M

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...

journal_title：Transplantation

authors： Uchida H,Kobayashi E,Matsuda K,Mizuta K,Sugimoto K,Kawarasaki H,Hashizume K,Fujimura A

更新日期：1999-05-15 00:00:00

abstract：:We have analyzed HLA data from the UNOS registry on 20,230 patients on the renal waiting list in 1991 and 18,708 donors from 1988-1992. Significant differences were found in the distribution of HLA antigens for comparisons of the total donor pool and the various racial groups of patients as well as for inter- and intr...

journal_title：Transplantation

authors： Leffell MS,Steinberg AG,Bias WB,Machan CH,Zachary AA

更新日期：1994-11-27 00:00:00

abstract：BACKGROUND:The low efficiency of islet transplantation necessitating sequential transplantations with the use of 2 to 3 donors for a recipient has been a major obstacle facing clinical islet transplantation. We determined whether adenosine has any beneficial effects on preventing early loss of transplanted islets in th...

journal_title：Transplantation

authors： Nitta T,Itoh T,Matsuoka N,Mera T,Kojima D,Nakano M,Yamashita Y,Yasunami Y

更新日期：2009-07-15 00:00:00

abstract：:Over the last decade there have been major advances in all aspects of liver transplantation with the consequence that the number of patients who could benefit from the procedure is increasing. As a result, the number of patients listed for liver transplantation is growing while the donor pool is remaining constant or ...

journal_title：Transplantation

authors： Neuberger J,Ubel PA

更新日期：2000-11-27 00:00:00

abstract：:Although ELISA on purified HLA molecules for detecting anti-HLA antibody (P-S ELISA) does detect some antibodies previously missed by the conventional complement dependent cytotoxicity method (C Cytotox), HLA ELISA should not fail to detect antibodies already detected by the conventional reference method to be able to...

journal_title：Transplantation

authors： Pierquin A,Masson D,Toupance O,Tabary T,Bougy F,Bensa JC,Chanard J,Cohen JH

更新日期：1996-11-27 00:00:00

abstract：:Retrospective mixed leukocyte culture studies were performed in eight patients who had either rejected their marrow grafts or experienced graft-versus-host disease and in seven patients with successful marrow engraftment. In tests of pre-and post-transplant lymphocytes we found no evidence that rejection or graft-vers...

journal_title：Transplantation

authors： Opelz G,Gale RP

更新日期：1976-11-01 00:00:00

abstract：:Despite growing evidence that reactive oxygen species are responsible for deleterious effects of ischemia-reperfusion (I/R) injury of the liver, there exists, until now, no reliable antioxidant therapeutics applicable in the clinical setting. We investigated the effects of free radical scavenger, 3-methyl-1-phenyl-2-p...

journal_title：Transplantation

authors： Ninomiya M,Shimada M,Harada N,Shiotani S,Hiroshige S,Soejima Y,Suehiro T,Sugimachi K

更新日期：2002-11-27 00:00:00

abstract：BACKGROUND:To define whether immunosuppressive agents that block the interleukin (IL)-2 pathway could prevent activation-induced cell death of activated T cells in the graft, we measured expression of IL-2, IL-2 receptor alpha chain (CD25), IL-15, Fas, and Fas ligand by real time reverse transcription-polymerase chain ...

journal_title：Transplantation

authors： Baan CC,Balk AH,van Riemsdijk IC,Vantrimpont PJ,Maat AP,Niesters HG,Zondervan PE,van Gelder T,Weimar W

更新日期：2003-05-27 00:00:00

abstract：:We developed and applied a quantitative competitive polymerase chain reaction method to study the expression of various cytokine genes in Con A-stimulated murine splenocytes. This method relies on the use of competitive templates that differ from the target cytokine cDNA templates only by the introduction of a unique ...

journal_title：Transplantation

authors： Zheng XX,Strom TB,Steele AW

更新日期：1994-07-15 00:00:00

abstract：BACKGROUND:In France, the need for continuous monitoring of transplant center performance has recently become apparent. Cumulative sum (CUSUM) monitoring of transplantation is already been used to monitor transplant outcomes in the United Kingdom and in the United States. Because CUSUM monitoring can be applied by diff...

journal_title：Transplantation

authors： Alexandrine B,Savoye E,Pessione F,Cantrelle C,Jasseron C,Santin G,Bastien O,Legeai C

更新日期：2019-09-01 00:00:00

abstract：:The early detection of allograft rejection remains elusive after solitary pancreas transplantation (PTX). We have previously described a modified technique of cystoscopic transduodenal PTX biopsy using the Biopty gun under ultrasound guidance. During the last 2 years, we performed 24 solitary PTXs with prospective pro...

journal_title：Transplantation

authors： Stratta RJ,Taylor RJ,Grune MT,Sindhi R,Sudan D,Castaldo P,Cushing KA,Radio SJ,Wisecarver JL,Matamoros A

更新日期：1995-12-27 00:00:00

abstract：BACKGROUND:Longest bipolar length of the kidney graft is routinely measured for ultrasonographic assessment of graft size (GS), although the value of the graft length remains unclear. METHODS:In a single-center, observational study involving 319 deceased-donor kidney transplant recipients, we assessed variations in ab...

journal_title：Transplantation

authors： Černe S,Arnol M,Kandus A,Buturović-Ponikvar J

更新日期：2016-08-01 00:00:00

abstract：:Antigenic requirements for the induction of T cell-independent primary splenic IgM antibody responses (plaque-forming cell responses) to H-2Dd alloantigens were studied. Results show that some functional activity or structural property of the donor cells is required for immunogenicity, because antigens are not active ...

journal_title：Transplantation

authors： Nakashima I,Clark EA,Lake P,Kato N,Nagase F,Mizoguchi K,Isobe KI,Saito M

更新日期：1983-02-01 00:00:00

abstract：:The aim of this study was to assess the feasibility of detecting anti-HLA antibodies in eluates from needle core biopsies of renal transplants with chronic allograft nephropathy. Two methods of screening, the enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FlowPRA) were compared. Twenty renal transplants...

journal_title：Transplantation

authors： Martin L,Guignier F,Bocrie O,D'Athis P,Rageot D,Rifle G,Justrabo E,Mousson C

更新日期：2005-05-27 00:00:00

abstract：BACKGROUND:The potential risk of transmission of porcine endogenous retroviruses (PERV) from xenogeneic donors into humans has been widely debated. Because we were involved in a phase I/II clinical trial using a bioartificial liver support system (BLSS), we proceeded to evaluate the biosafety of this device. MATERIALS...

journal_title：Transplantation

authors： Kuddus R,Patzer JF 2nd,Lopez R,Mazariegos GV,Meighen B,Kramer DJ,Rao AS

更新日期：2002-02-15 00:00:00

abstract：BACKGROUND:Strong correlations have been described between persistently elevated proportions of CD57+ (CD28-) CD8+high T lymphocytes and cytomegalovirus (CMV) infection, in healthy individuals as well as in transplant patients. We investigated whether secondary exposure to CMV triggers recall responses within the CD8 T...

journal_title：Transplantation

authors： Hazzan M,Labalette M,Noel C,Lelievre G,Dessaint JP

更新日期：1997-03-15 00:00:00

abstract：:Gastrointestinal infection due to cytomegalovirus occurs frequently in liver transplant recipients. Upper gastrointestinal cytomegalovirus infection is associated with subjective complaints of nausea, a sense of abdominal fullness, and occasionally emesis and/or dysphagia. In order to determine whether these symptoms ...

journal_title：Transplantation

authors： Van Thiel DH,Gavaler JS,Schade RR,Chien MC,Starzl TE

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:The subclass of IgG antibodies contributes to their capability to activate complement. It is currently unknown whether the pretransplant IgG subclass composition allows distinguishing harmful from presumably irrelevant donor-specific human leukocyte antigen (HLA) antibodies (HLA-DSA) detected by single-antig...

journal_title：Transplantation

authors： Hönger G,Hopfer H,Arnold ML,Spriewald BM,Schaub S,Amico P

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:The shortage of cadaveric livers has sparked an interest in adult-to-adult living donor transplantation. Right lobe donor hepatectomy is frequently required to obtain a graft of adequate size for adult recipients. Careful donor selection is necessary to minimize complications and assure a functional graft. ...

journal_title：Transplantation

authors： Marcos A,Fisher RA,Ham JM,Olzinski AT,Shiffman ML,Sanyal AJ,Luketic VA,Sterling RK,Olbrisch ME,Posner MP

更新日期：2000-06-15 00:00:00

abstract：:Temperature is a key parameter in organ preservation that has been consistently linked to primary nonfunction (PNF). In this communication, and for the first time anywhere, continued and direct measurements of human liver intraparenchymal temperatures are reported in six clinical cases of orthotopic liver transplantat...

journal_title：Transplantation

authors： Villa R,Fondevila C,Erill I,Guimerà A,Bombuy E,Gómez-Suárez C,Sacristán JC,García-Valdecasas JC

更新日期：2006-02-15 00:00:00

abstract：:A laparoscopic live-donor nephrectomy was performed on a 40-year-old man. The kidney was removed intact via a 9-cm infraumbilical midline incision. Warm ischemia was limited to less than 5 min. Immediately upon revascularization, the allograft produced urine. By the second postoperative day, the recipient's serum crea...

journal_title：Transplantation

authors： Ratner LE,Ciseck LJ,Moore RG,Cigarroa FG,Kaufman HS,Kavoussi LR

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:Registry databases offer the statistical power to analyze differences in graft survival rates that may not be detected in randomized clinical trials. This study analyses 2-year graft survival using tacrolimus (tac) or cyclosporine (CsA) with mycophenolate mofetil (MMF) and steroids. METHODS:Data reported to...

journal_title：Transplantation

authors： Bunnapradist S,Daswani A,Takemoto SK

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Cyclosporine A (CsA)-associated oxidative stress has been proposed as an important mechanism of renal injury. This study was designed to examine whether N-acetylcysteine (NAC), a well-known antioxidant, affects Klotho, antiaging gene, expression and its signaling pathway in an experimental model of chronic C...

journal_title：Transplantation

authors： Piao SG,Kang SH,Lim SW,Chung BH,Doh KC,Heo SB,Jin L,Li C,Yang CW

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND:We began a clinical trial in African Americans comparing sirolimus-tacrolimus to standard immunosuppression. We report two African American male living donor kidney recipients who developed acute renal failure after exposure to sirolimus-tacrolimus. METHODS:Both patients received similar doses of sirolimus ...

journal_title：Transplantation

authors： Lawsin L,Light JA

更新日期：2003-01-15 00:00:00

abstract：BACKGROUND:Because CD4CD25Foxp3 regulatory T cells (Tregs) are essential for the maintenance of self-tolerance, significant interest surrounds the developmental cues for thymic-derived natural Tregs (nTregs) and periphery-generated adaptive Tregs (aTregs). In the transplant setting, the allograft may play a role in the...

journal_title：Transplantation

authors： Kim JI,O'connor MR,Duff PE,Zhao G,Lee KM,Eliades P,Deng S,Yeh H,Caton AJ,Markmann JF

更新日期：2011-04-15 00:00:00

abstract：BACKGROUND:Vascular complications remain an important cause of postoperative morbidity in liver transplant patients. Herein, we present an unusual case of nonanastomotic inferior vena cava (IVC) stenosis in a patient with a "piggyback" caval anastomosis. METHODS:A 59-year-old woman underwent liver transplantation usin...

journal_title：Transplantation

authors： Orons PD,Hari AK,Zajko AB,Marsh JW

更新日期：1997-11-15 00:00:00