Abstract:
:Despite growing evidence that reactive oxygen species are responsible for deleterious effects of ischemia-reperfusion (I/R) injury of the liver, there exists, until now, no reliable antioxidant therapeutics applicable in the clinical setting. We investigated the effects of free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), using an isolated liver perfusion model to elucidate its possible therapeutic effects on hepatic warm I/R injury. Isolated livers from Wistar rats were reperfused for 120 min with an oxygenated Krebs-Henseleit bicarbonate buffer after 1 hr of warm ischemia. Addition of MCI-186 (1 mg/L) into the perfusate significantly improved portal flow, hepatic enzyme release into the perfusate, total bile production, histologic alteration, and malondialdehyde concentration but not sinusoidal endothelial cell function as assessed by the clearance of hyaluronic acid. MCI-186 seems to have protective effects against hepatic warm I/R injury by attenuating the damage of the hepatocyte, which is the major target of oxidative damage in this model.
journal_name
Transplantationjournal_title
Transplantationauthors
Ninomiya M,Shimada M,Harada N,Shiotani S,Hiroshige S,Soejima Y,Suehiro T,Sugimachi Kdoi
10.1097/00007890-200211270-00021subject
Has Abstractpub_date
2002-11-27 00:00:00pages
1470-2issue
10eissn
0041-1337issn
1534-6080journal_volume
74pub_type
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