False-negative results in anti-HLA antibody detection by Sangstat ELISA: complement dependent cytotoxicity is not yet obsolete.

abstract：BACKGROUND:The need to find a safe, effective liver support system for patients with fulminant hepatic failure (FHF) continues to be unmet. A system using immortalized human hepatocytes was originally developed in the early 1990s. A modified version of the initial extracorporeal liver-assist device (ELAD) was recently ...

journal_title：Transplantation

authors： Millis JM,Cronin DC,Johnson R,Conjeevaram H,Conlin C,Trevino S,Maguire P

更新日期：2002-12-27 00:00:00

abstract：BACKGROUND:We sought to determine the risk factors, molecular epidemiology, antibiotic therapy, and outcomes of bacteremia because of extensively drug-resistant (XDR) Pseudomonas aeruginosa in solid organ transplant (SOT) recipients. METHODS:All episodes of bacteremia occurring in SOT recipients were prospectively doc...

journal_title：Transplantation

authors： Bodro M,Sabé N,Tubau F,Lladó L,Baliellas C,González-Costello J,Cruzado JM,Carratalà J

更新日期：2015-03-01 00:00:00

abstract：:Hepatic artery thrombosis is a continuing source of morbidity and mortality following orthotopic liver transplantation. The cornerstone of therapy has been urgent retransplantation that is limited by organ availability. For this reason we developed a policy of urgent revascularization for allograft rescue. Hepatic art...

journal_title：Transplantation

authors： Langnas AN,Marujo W,Stratta RJ,Wood RP,Li SJ,Shaw BW

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The influence of the graft composition on the clinical outcome after allogeneic peripheral blood stem cell (PBSC) transplantation is not well established. METHODS:The cellular composition of the apheretic products obtained from 63 human leukocyte antigen-identical siblings was prospectively correlated with ...

journal_title：Transplantation

authors： Iori AP,Torelli GF,De Propris MS,Milano F,Pupella S,Gozzer M,Mancini F,Milani ML,Intoppa S,Cerretti R,Lucarelli B,Valle V,Malandruccolo L,Iannella E,Arleo E,Guarini A,Foà R

更新日期：2008-02-15 00:00:00

abstract：BACKGROUND:The novel agent sirolimus (SRL; Rapamune; rapamycin) inhibits the immune response by a mechanism distinct from those of calcineurin antagonists or antimetabolites. This randomized, controlled, multicenter, single blind, phase II trial examined the combination of SRL, steroids, and full versus reduced doses o...

journal_title：Transplantation

authors： Kahan BD,Julian BA,Pescovitz MD,Vanrenterghem Y,Neylan J

更新日期：1999-11-27 00:00:00

abstract：:Spodoptera frugiperda (Sf9) insect cells secreted a class I MHC RT1.Aa heavy chain protein when infected with baculovirus that bore a construct that contained a honeybee melittin secretion (ms) signal attached to RT1.Aa cDNA. The RT1.Aa heavy chain protein in the culture supernatant and cell lysate immunoprecipitated ...

journal_title：Transplantation

authors： Wang M,Stepkowski SM,Wang ME,Tian L,Qu X,Tu Y,He G,Kahan BD

更新日期：1996-02-15 00:00:00

abstract：:CD4+ cells from CsA-treated DA rats with long-surviving PVG heart allografts specifically suppress the capacity of naive CD4+ cells to restore allograft rejection in irradiated DA rats, but have normal donor-specific alloreactivity in MLC. CD4+ suppressor cells from CsA-treated DA rats cultured for 3 days against eith...

journal_title：Transplantation

authors： Pearce NW,Spinelli A,Gurley KE,Hall BM

更新日期：1993-02-01 00:00:00

abstract：:Kidney transplantation in elderly patients is a good therapeutic option, but the incidence of infections compared to younger patients must be studied. Case and control study was performed with 40 cases (patients older than 65) and 40 controls (younger than 65) receiving a kidney transplant between January 2000 and Aug...

journal_title：Transplantation

authors： Trouillhet I,Benito N,Cervera C,Rivas P,Cofán F,Almela M,Angeles Marcos M,Puig de la Bellacasa J,Pumarola T,Oppenheimer F,Moreno-Camacho A

更新日期：2005-10-15 00:00:00

abstract：:Previously, we demonstrated that the dose-normalized tacrolimus blood concentration after renal transplantation was associated with a single nucleotide polymorphism (SNP) in the CYP3AP1 gene, probably through linkage with an SNP in the CYP3A5 gene. Individuals with at least one CYP3A5*1 allele synthesize CYP3A5 and CY...

journal_title：Transplantation

authors： Macphee IA,Fredericks S,Mohamed M,Moreton M,Carter ND,Johnston A,Goldberg L,Holt DW

更新日期：2005-02-27 00:00:00

abstract：BACKGROUND:Evidence on prevalence and correlates of pretransplant medication nonadherence (MNA) is limited. The present study explored self-reported prevalence and correlates of MNA before heart, liver, and lung transplantation. METHODS:This cross-sectional descriptive study included 174 patients: 69 lung, 33 heart, a...

journal_title：Transplantation

authors： Dobbels F,Vanhaecke J,Desmyttere A,Dupont L,Nevens F,De Geest S

更新日期：2005-06-15 00:00:00

abstract：:In the present study the functional and morphologic effects of two pulmoplegic solutions are evaluated. Single left-lung allotransplantation with ligation of the right pulmonary artery was performed in 15 piglets (13-20 kg). The lungs were preserved after donor prostaglandin E-1 treatment with single pulmonary artery ...

journal_title：Transplantation

authors： Lehtola A,Harjula A,Heikkilä L,Hämmäinen P,Taskinen E,Kurki T,Salmenperä M,Mattila S

更新日期：1990-06-01 00:00:00

abstract：:We retrospectively investigated the impact of pancreas transplantation on cardiovascular disease risk factors in patients with type 1 diabetic end-stage renal disease (ESRD). Two cohorts of patients, 44 simultaneous pancreas and kidney transplant patients (SPK) and 30 kidney transplant-alone patients (KTA), were inclu...

journal_title：Transplantation

authors： Luan FL,Miles CD,Cibrik DM,Ojo AO

更新日期：2007-08-27 00:00:00

abstract：BACKGROUND:To determine the prevalence of GB virus-C/hepatitis G virus (GBV-C/HGV) infection in liver transplant recipients transplanted for non-hepatitis C virus indications, 44 patients transplanted for cryptogenic, autoimmune, hepatitis B, or cholestatic liver disease and 91 non-liver transplantation (LT) patients w...

journal_title：Transplantation

authors： Dickson RC,Qian KP,Lau JY

更新日期：1997-06-15 00:00:00

abstract：:Despite growing evidence that reactive oxygen species are responsible for deleterious effects of ischemia-reperfusion (I/R) injury of the liver, there exists, until now, no reliable antioxidant therapeutics applicable in the clinical setting. We investigated the effects of free radical scavenger, 3-methyl-1-phenyl-2-p...

journal_title：Transplantation

authors： Ninomiya M,Shimada M,Harada N,Shiotani S,Hiroshige S,Soejima Y,Suehiro T,Sugimachi K

更新日期：2002-11-27 00:00:00

abstract：:Pre- and post transplant sera from 51 cases of bone marrow transplants performed for severe aplastic anemia were tested on monocytes (M) and corresponding B cells (B) from a panel of unrelated donors. One-third of the sera were cytotoxic for B and M either from different or from the same individuals, while 45% reacted...

journal_title：Transplantation

authors： Gluckman JC,Gluckman E,Azogui O,Guillet J,Baldwin WM,Devergie A,Chapuis F,Brisson E,Andersen E,Dausset J

更新日期：1982-06-01 00:00:00

abstract：:The aim of this study was to assess the feasibility of detecting anti-HLA antibodies in eluates from needle core biopsies of renal transplants with chronic allograft nephropathy. Two methods of screening, the enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FlowPRA) were compared. Twenty renal transplants...

journal_title：Transplantation

authors： Martin L,Guignier F,Bocrie O,D'Athis P,Rageot D,Rifle G,Justrabo E,Mousson C

更新日期：2005-05-27 00:00:00

abstract：BACKGROUND:Innate immunity plays a role in controlling adaptive immune responses. METHODS:We investigated the clinical relevance of single nucleotide polymorphisms in 22 genes encoding innate, secreted, and signaling pattern recognition receptors in a total of 520 donor-recipient pairs of postmortem, human leukocyte a...

journal_title：Transplantation

authors： Eikmans M,de Canck I,van der Pol P,Baan CC,Haasnoot GW,Mallat MJ,Vergunst M,de Meester E,Roodnat JI,Anholts JD,van Thielen M,Doxiadis II,de Fijter JW,van der Linden PJ,van Beelen E,van Kooten C,Kal-van Gestel JA,Peeters

更新日期：2012-09-15 00:00:00

abstract：BACKGROUND:Orthotopic liver transplantation (OLT) has been associated with major blood loss and the need for blood product transfusions. During the last decade, improved surgical and anesthetic management has reduced intraoperative blood loss and blood product transfusions. A first report from our group published in 20...

journal_title：Transplantation

authors： Massicotte L,Denault AY,Beaulieu D,Thibeault L,Hevesi Z,Nozza A,Lapointe R,Roy A

更新日期：2012-06-27 00:00:00

abstract：:Complement plays important roles in both ischemia-reperfusion injury (IRI) and antibody-mediated rejection (AMR) of solid organ allografts. One approach to possibly improve outcomes after transplantation is the use of C1 inhibitor (C1-INH), which blocks the first step in both the classical and lectin pathways of compl...

journal_title：Transplantation

authors： Berger M,Lefaucheur C,Jordan SC

更新日期：2019-09-01 00:00:00

abstract：:The aim of this study was to investigate excretion of urinary and pancreatic juice neopterin in patients after combined pancreas-kidney transplantation and to relate it to the clinical course. The study design was a prospective observation study. Thirty consecutive patients with end-stage diabetic disease received a s...

journal_title：Transplantation

authors： Tilg H,Königsrainer A,Krausler R,Aulitzky WE,Margreiter R,Reibnegger G,Wachter H,Huber C

更新日期：1992-04-01 00:00:00

abstract：:The prevalence of angiographically proven coronary artery disease (CAD) in adults with end-stage liver disease who undergo evaluation for liver transplantation is unknown; also it is unclear if cholestatic liver disease represents an independent risk factor. Patients with end-stage liver disease over age 50 having liv...

journal_title：Transplantation

authors： Carey WD,Dumot JA,Pimentel RR,Barnes DS,Hobbs RE,Henderson JM,Vogt DP,Mayes JT,Westveer MK,Easley KA

更新日期：1995-03-27 00:00:00

abstract：:Two infants born to mothers who had been given a renal transplant and who were receiving azathioprine and prednisone have been followed up for over 2 years. Initially both had lower than normal lymphocyte counts and cortisol levels. Chromosomal aberrations similar to those found in the lymphocytes of the mothers were ...

journal_title：Transplantation

authors： Price HV,Salaman JR,Laurence KM,Langmaid H

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:Successful pancreatic islet transplantation (PIT) has resulted in several transplant centers wanting to start PIT programs. PIT remains experimental and must be performed safely for its continued use. We describe the radiographic techniques used at our center and their results. METHODS:Between January 17, 2...

journal_title：Transplantation

authors： Goss JA,Soltes G,Goodpastor SE,Barth M,Lam R,Brunicardi FC,Froud T,Alejandro R,Ricordi C

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Avascular osteonecrosis (AVN) is a serious complication of allogeneic stem cell transplantation (SCT). Graft-versus-host disease and its treatment with steroids are the main risk factors; underlying diagnosis, age and gender are further risk factors. It has been speculated that low baseline bone mineral dens...

journal_title：Transplantation

authors： Schulte CM,Beelen DW

更新日期：2005-06-27 00:00:00

abstract：:Infectious complications in patients with recurrent hepatitis C virus (HCV) hepatitis after liver transplantation were prospectively assessed and compared with those of all other liver transplant recipients without HCV hepatitis operated on during the same period. Major infections occurred in 64% (14/22) of the patien...

journal_title：Transplantation

authors： Singh N,Gayowski T,Wagener MM,Marino IR

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:Circulating transthyretin (TTR) is derived from the liver, and orthotopic liver transplantation (OLT) is widely performed for variant TTR-associated familial amyloid polyneuropathy (FAP). The effect of OLT on FAP-related cardiac amyloid is of particular interest because wild-type TTR can itself be deposited ...

journal_title：Transplantation

authors： Stangou AJ,Hawkins PN,Heaton ND,Rela M,Monaghan M,Nihoyannopoulos P,O'Grady J,Pepys MB,Williams R

更新日期：1998-07-27 00:00:00

abstract：BACKGROUND:Donor-specific immune tolerance has been reported in isolated cases of kidney transplantation associated with bone marrow transplantation. The following is a description of a living donor liver transplantation for a hilar cholangiocarcinoma in a previous recipient of an allogeneic bone marrow transplant. ME...

journal_title：Transplantation

authors： Kadry Z,Mullhaupt B,Renner EL,Bauerfeind P,Schanz U,Pestalozzi BC,Studer G,Zinkernagel R,Clavien PA

更新日期：2003-09-27 00:00:00

abstract：BACKGROUND:Cold ischemia-reperfusion injury is unavoidable during organ transplantation, and prolonged preservation is associated with poorer function recovery. Cardiotrophin-1 (CT-1) is an IL-6 family cytokine with cytoprotective properties. This preclinical study in rats tested whether CT-1 mitigates cold renal ische...

journal_title：Transplantation

authors： García-Cenador B,Blanco-Gozalo V,López-Montañés D,Sanz Giménez-Rico JR,López-Novoa JM,López-Hernández FJ

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in the prevention of AVR and to determine whether a combination of LF15-0...

journal_title：Transplantation

authors： Wang H,Hosiawa KA,Garcia B,Shum JB,Dutartre P,Kelvin DJ,Zhong R

更新日期：2003-05-15 00:00:00

abstract：:Ranolazine is a new drug with a novel mode of action as a metabolic modulator and membrane stabilizer. In this prospective randomized double-blind trial, a porcine model of renal autotransplantation was used to assess the effects of this drug during preservation and reperfusion of kidneys cold-stored for 24 hr in phos...

journal_title：Transplantation

authors： Lodge JP,Lam FT,Perry SL,Giles GR

更新日期：1990-11-01 00:00:00