Abstract:
BACKGROUND:Evidence on prevalence and correlates of pretransplant medication nonadherence (MNA) is limited. The present study explored self-reported prevalence and correlates of MNA before heart, liver, and lung transplantation. METHODS:This cross-sectional descriptive study included 174 patients: 69 lung, 33 heart, and 72 liver transplant candidates. MNA was assessed by self-report using the following question: "During the past 14 days, how often did you not take your medication?" Patients scoring once or higher on a five-point rating scale were considered to be nonadherent. Correlates of MNA explored were demographics, anxiety and depression (Hospital Anxiety and Depression Inventory), personality traits (NEO Personality Inventory-Revised), perceived health status (Euro-QOL), and social support (Social Support Questionnaire). RESULTS:Prevalence of pretransplant MNA was 16.7% and was comparable among the three groups. After correction for multiple comparisons (i.e., P=0.01), higher educational level (P=0.006) was related to MNA. Less severe depression (P=0.069), lower scores on the personality trait conscientiousness (P=0.021), and less received social support (P=0.062) tended to be related to MNA. Multiple logistic regression revealed that higher educational level (P=0.008), lower received social support (P=0.013), and lower conscientiousness (P=0.023) were independent predictors of pretransplant MNA. CONCLUSIONS:Several correlates of MNA allow identification of patients at risk for pretransplant MNA.
journal_name
Transplantationjournal_title
Transplantationauthors
Dobbels F,Vanhaecke J,Desmyttere A,Dupont L,Nevens F,De Geest Sdoi
10.1097/01.tp.0000158430.06507.87subject
Has Abstractpub_date
2005-06-15 00:00:00pages
1588-95issue
11eissn
0041-1337issn
1534-6080pii
00007890-200506150-00019journal_volume
79pub_type
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