Abstract:
:Hepatic artery thrombosis is a continuing source of morbidity and mortality following orthotopic liver transplantation. The cornerstone of therapy has been urgent retransplantation that is limited by organ availability. For this reason we developed a policy of urgent revascularization for allograft rescue. Hepatic artery thrombosis developed following 15 transplants of which 11 underwent urgent rearterialization. The diagnosis was made a mean of 4.8 days (range 1-10) following transplantation. Duplex ultrasonography was diagnostic in all patients and confirmed by angiography in 4 (36%). Three patients with hepatic artery thrombosis were identified following screening ultrasonography and were clinically unsuspected. Upon reexploration, a specific technical reason for hepatic artery was found in 4 patients (36%). Twelve arterial revascularization procedures were performed in 11 patients including: thrombectomy alone (n = 4); revision of anastomosis with thrombectomy (n = 5); and thrombectomy with placement of vascular conduit (n = 3). Following revascularization, 8 patients maintained hepatic artery patency. Three patients eventually required retransplantation secondary to biliary sepsis. Biliary tract complications developed in 6 patients, at a mean of 23 days following revascularization and included: breakdown of the biliary anastomosis (n = 4); stricture (n = 1); and sludge formation (n = 1). The overall graft and patient survival are 74% and 82% respectively, with a mean follow-up of 6.8 months. Hepatic allograft rescue with the use of urgent revascularization following hepatic artery thrombosis appears to be an effective means of either avoiding retransplantation or providing a bridge until a suitable donor becomes available.
journal_name
Transplantationjournal_title
Transplantationauthors
Langnas AN,Marujo W,Stratta RJ,Wood RP,Li SJ,Shaw BWdoi
10.1097/00007890-199101000-00013subject
Has Abstractpub_date
1991-01-01 00:00:00pages
86-90issue
1eissn
0041-1337issn
1534-6080journal_volume
51pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:The deceased donor score (DDS), expanded criteria donor (ECD) definition, and resistive index (RI) were developed for pretransplant evaluation of donors. DDS and ECD are determined by a calculation of risk from donor variables, while RI is determined from flow characteristics of kidneys during machine preser...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173798.04043.af
更新日期:2005-10-15 00:00:00
abstract::Sprague-Dawley rats were treated for 14 days with rapamycin (RAP; 1.5 mg/kg/day i.p.), cyclosporine (15 mg/kg/day by gavage), both drugs in combination, or appropriate drug vehicles. Hematological parameters and biochemical indices of renal and hepatic function were determined throughout the experimental period, at th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199108000-00004
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:A new vascularized concordant xenotransplant model using the Chinese hamster as donor and mouse as recipient species is reported. This model takes advantage of the wealth of informative immune reagents and knockout and transgenic backgrounds available for the mouse. METHODS:Heterotopic auxillary cardiac tra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199906150-00016
更新日期:1999-06-15 00:00:00
abstract:BACKGROUND:Tacrolimus (Tac) and mycophenolate mofetil (MMF) are newly approved immunosuppressive agents. However, the safety and efficacy of the combination of MMF and Tac in primary liver transplantation has not been determined. METHODS:An Institutional Review Board-approved, open-label prospective randomized protoco...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199811270-00024
更新日期:1998-11-27 00:00:00
abstract:BACKGROUND:A recent proposal supports the elimination of allocation points for human leukocyte antigen (HLA) mismatches (MM) in cadaveric kidney transplantation. The intent is to increase access for some racial groups that might be disadvantaged by the representation of race-specific HLA in a largely white donor pool. ...
journal_title:Transplantation
pub_type: 评论,杂志文章
doi:10.1097/00007890-200212150-00024
更新日期:2002-12-15 00:00:00
abstract:BACKGROUND:Human intravenous immunoglobulin G delayed xenogeneic hyperacute rejection (HAR) in the guinea pig-to-rat combination. We investigated the respective roles of the Fc and Fab fragments of the IgG molecule in this inhibitory effect. METHODS:By using a guinea pig-to-rat heart transplantation model, the efficie...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199808150-00018
更新日期:1998-08-15 00:00:00
abstract:BACKGROUND:The objective of this study was to investigate purine nucleotide metabolism in peripheral blood mononuclear cells (PBMC) of cardiac transplant recipients switched from azathioprine to mycophenolate mofetil (MMF). METHODS:Concentrations of guanosine 5'triphosphate (GTP) and adenosine 5'triphosphate (ATP), th...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000225759.54343.23
更新日期:2006-07-15 00:00:00
abstract:BACKGROUND:The results of the transplantation of marginal donor kidneys remain controversial. This study aimed to investigate the impact of donor risk factors as predictors of kidney-graft outcome. METHODS:Allograft failure risk factors were studied in 7,209 cadaveric kidney-transplant recipients reporting to the Etab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000044171.97375.61
更新日期:2003-02-15 00:00:00
abstract:BACKGROUND:T lymphocyte activation mediated by CD28 costimulation plays a critical role in graft rejection. Plant alkaloid tetrandrine, purified from a Chinese antirheumatic herb, is a potent immunosuppressant. Here, we examined its effects on several CD28-costimulated T-cell activities. In addition, such effects were ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199911150-00027
更新日期:1999-11-15 00:00:00
abstract:BACKGROUND:Several single nucleotide polymorphisms (SNPs) in the multidrug resistance (MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) absorption in renal transplant patients. METHODS:An analysis of CsA absorption measured by the dose- and weight-adjusted 4 hr area under the time-co...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000264197.88129.2e
更新日期:2007-05-27 00:00:00
abstract:BACKGROUND:Sirolimus (rapamycin) is a potent immunosuppressant with a mechanism of action different from cyclosporine (CsA) or tacrolimus. METHODS:In 11 European centers, first cadaveric renal allograft recipients were randomized to CsA (n=42) or sirolimus (n=41). Dosing of these agents was concentration-controlled an...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199904150-00017
更新日期:1999-04-15 00:00:00
abstract:BACKGROUND:Intrahepatic bile duct strictures are a serious complication after non-heart-beating (NHB) liver transplantation. Bile salt toxicity has been identified as an important factor in the pathogenesis of bile duct injury and cholangiopathies. The role of bile salt toxicity in the development of biliary strictures...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318170f5f7
更新日期:2008-06-15 00:00:00
abstract:BACKGROUND:Langerhans cells (LCs) are self-renewing epidermal myeloid cells that can migrate and mature into dendritic cells. Recipient LCs that survive cytotoxic therapy given in preparation for allogeneic hematopoietic cell transplantation may prime donor T cells to mediate cutaneous graft-versus-host disease (GVHD)....
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/TP.0000000000000097
更新日期:2014-09-15 00:00:00
abstract:BACKGROUND:Obliterative bronchiolitis (OB), chronic allograft rejection of the lung, is a major cause of morbidity and mortality after lung transplantation. Previous studies using the heterotopic mouse trachea model of chronic airway rejection have shown a T cell infiltrate composed of CD4+ and CD8+ T cells. The goal o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002150-00016
更新日期:2000-02-15 00:00:00
abstract::Rat, hamster, and rabbit islets were transplanted into diabetic C57BL/B6 mice. The effect on islet xenograft survival of low-temperature culture of the donor islets, alpha L3T4 treatment of the recipients for seven days, and transplantation of the grafts either in the renal capsule or in the liver via the portal vein ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198905000-00002
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Chronic cyclosporine (CsA) nephropathy, which has been unequivocally documented in recipients of heart, heart-lung, liver, or bone marrow transplants, as well as in nontransplant situations, usually results in a progressive deterioration of renal function. In this study, we assessed the potential reversibili...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199803150-00010
更新日期:1998-03-15 00:00:00
abstract::Vascularized xenografts are rejected acutely and hyperacutely in concordant or discordant combinations, respectively. We investigated the impact of the donor-recipient combination on the rejection of arterial xenografts, analyzing the cellular and extracellular matricial compartments. Aortic xenografts were performed ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199609270-00017
更新日期:1996-09-27 00:00:00
abstract:BACKGROUND:The impact of community-acquired respiratory virus (CARV) infections on bronchiolitis obliterans syndrome (BOS) and outcome after lung transplantation (LTx) and diagnostic techniques were prospectively evaluated. METHODS:A single-center prospective cohort study was performed in LTx-outpatients between Octob...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a4857d
更新日期:2009-05-27 00:00:00
abstract::Several approaches have been attempted to manage renal allograft dysfunction in cyclosporine-prednisone (CsA-Pred)-treated patients. Conversion to conventional therapy and perioperative triple drug have been associated with high rates of acute rejection episodes, infections, or neoplasms. We report our experience in d...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199108000-00017
更新日期:1991-08-01 00:00:00
abstract::Islet isolation is a time-consuming process. Islet yields vary, and previous in vitro studies suggest that Ficoll may be an islet toxin. Here, we describe an alternative, Ficoll-free method to purify murine islets by filtration through a cell strainer. Collagenase digestion of pancreata was carried out using standard ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200209270-00023
更新日期:2002-09-27 00:00:00
abstract::T cells must be activated before they can elicit damage to allografts, through interaction of their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. Signaling through accessory molecules or costimulatory molecules is a critical way for the immune system to fine tune T cell activation. An...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e31826d4672
更新日期:2013-02-27 00:00:00
abstract:BACKGROUND:The clinical significance of HLA-directed antibodies newly detected after transplantation (HT) is controversial. METHODS:Seventy-one HT recipients consented to enroll. Mean follow-up time was 28 months (range 6-48). Panel reactive antibody (PRA) analysis was performed on posttransplant sera (2 weeks, 1, 2, ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000180564.14050.49
更新日期:2005-10-27 00:00:00
abstract:BACKGROUND:Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA). METHODS:Peripheral blood mononuclear cells from SLA identical wild type (WT), α1, 3-galactos...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001646
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Combined transplantation of the lungs and liver is indicated for patients who would not be expected to survive transplantation of either organ alone. No single center has accumulated a significant experience, and as a result the expectations for this operation in the current era are unknown. METHODS:Patient...
journal_title:Transplantation
pub_type: 杂志文章,meta分析,评审
doi:10.1097/01.tp.0000165717.23652.09
更新日期:2005-11-15 00:00:00
abstract:BACKGROUND:Leflunomide is a novel immunosuppressive agent with promising activity for xenotransplantation. It is not clear yet which mechanisms of action of leflunomide are responsible for that. METHODS:In a hamster-to-C57BL/6 nude mouse heart transplantation model, a 2-week course of leflunomide was used after transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000147464.63188.4b
更新日期:2005-01-27 00:00:00
abstract::The concept of islet exhaustion maintains that exposure of pancreatic islets to hyperglycemia and other stresses leads to islet dysfunction and irreparable damage. The process of pancreatic transplantation places many stresses on islets (e.g., counter-regulatory hormones, steroids, cyclosporine toxicity). As practiced...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198907000-00006
更新日期:1989-07-01 00:00:00
abstract::Two technical modifications have been suggested for whole-pancreas transplantation with bladder drainage. The duodenal button technique (DB [Madison]) and the duodenal segment technique (DS [Iowa]) are the most commonly performed procedures (1,2). From December 1985 until May 1988 we performed 32 combined pancreas-kid...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00026
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:A kidney transplant recipient inadvertently contracted donor-origin melanoma, which was found to be very advanced at presentation. Withdrawal of immunosuppression failed to induce rejection, and interferon-alpha was required. When florid allograft rejection was in progress, the allograft was removed, before ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199809150-00020
更新日期:1998-09-15 00:00:00
abstract:BACKGROUND:The objectives of this study are to investigate the impact of cytomegalovirus (CMV) donor (D)/recipient (R) serostatus on kidney transplant outcomes in recipients who received CMV prophylaxis and to investigate the association of individual antiviral agents (acyclovir, ganciclovir, and valganciclovir) with o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181f7c053
更新日期:2010-11-27 00:00:00
abstract:BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001005
更新日期:2016-10-01 00:00:00