Abstract:
BACKGROUND:A kidney transplant recipient inadvertently contracted donor-origin melanoma, which was found to be very advanced at presentation. Withdrawal of immunosuppression failed to induce rejection, and interferon-alpha was required. When florid allograft rejection was in progress, the allograft was removed, before it was recognized that the transplanted melanoma was not being simultaneously rejected. METHODS:Subsequent immunotherapy was required, which largely recapitulated treatment of recognized value in autologous melanoma and included interferon-alpha, use of cultured melanoma cells as tumor vaccine, pooled allogeneic cell vaccination, and adoptive immunotherapy using lymphokine-activated killer cells. RESULTS:Prolonged immunotherapy eradicated the widespread malignancy, and the patient went on to a successful second renal transplant, with follow-up of over 24 months. CONCLUSIONS:This unique case demonstrates the successful cure of advanced transplanted melanoma through the use of immunotherapy, which did not require sophisticated tumor vaccine technology, and successful retransplantation.
journal_name
Transplantationjournal_title
Transplantationauthors
Suranyi MG,Hogan PG,Falk MC,Axelsen RA,Rigby R,Hawley C,Petrie Jdoi
10.1097/00007890-199809150-00020subject
Has Abstractpub_date
1998-09-15 00:00:00pages
655-61issue
5eissn
0041-1337issn
1534-6080journal_volume
66pub_type
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