Abstract:
BACKGROUND:We began a clinical trial in African Americans comparing sirolimus-tacrolimus to standard immunosuppression. We report two African American male living donor kidney recipients who developed acute renal failure after exposure to sirolimus-tacrolimus. METHODS:Both patients received similar doses of sirolimus and tacrolimus to achieve target levels of 5 to 15 ng/mL and prednisone in tapering doses. Renal function and tacrolimus and sirolimus levels were systematically monitored. RESULTS:Although both kidneys functioned immediately, acute oliguric renal failure developed approximately 2 weeks after transplantation. Transplant kidney biopsy showed acute tubular necrosis in patient 2. Sirolimus-tacrolimus was then stopped in both patients. Both patients required temporary hemodialysis. Renal function returned 2 weeks later and was normal 2 months after transplantation on tacrolimus plus mycophenolate mofetil. CONCLUSION:Combination sirolimus-tacrolimus may cause nephrotoxicity in some patients by mechanisms that are presently unexplained.
journal_name
Transplantationjournal_title
Transplantationauthors
Lawsin L,Light JAdoi
10.1097/00007890-200301150-00029subject
Has Abstractpub_date
2003-01-15 00:00:00pages
157-60issue
1eissn
0041-1337issn
1534-6080journal_volume
75pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::BACKGROUND.: Reduced levels of serum adiponectin, an adipokine, are associated with cardiovascular and obesity-related diseases; however, relations between adiponectin and hypertension are unclear. METHODS.: This cross-sectional study examined adiponectin and ambulatory blood pressure monitoring (ABPM) in 33 pediatric...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b9e1ec
更新日期:2009-10-27 00:00:00
abstract:BACKGROUND:Pancreatic islets are avascular immediately after transplantation and depend on revascularization. Recently, the authors found decreased vascular density in mouse islets 1 month after implantation into nondiabetic recipients. This study investigated possible differences in revascularization between islets im...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000052592.92966.FE
更新日期:2003-03-15 00:00:00
abstract::Long-term graft survival is mainly influenced by early graft rejection and posttransplant graft function. The ability of both complement-dependent cytotoxicity cross-match (CDC) and flow cytometry cross-match (FCXM) to predict acute rejection episodes has been evaluated by cross-matching 40 patients who received cadav...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199702270-00012
更新日期:1997-02-27 00:00:00
abstract:BACKGROUND:Strong correlations have been described between persistently elevated proportions of CD57+ (CD28-) CD8+high T lymphocytes and cytomegalovirus (CMV) infection, in healthy individuals as well as in transplant patients. We investigated whether secondary exposure to CMV triggers recall responses within the CD8 T...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199703150-00014
更新日期:1997-03-15 00:00:00
abstract:BACKGROUND:Matrix metalloproteinases (MMPs) play a key role in extracellular matrix remodeling events associated with hepatic regeneration after partial hepatectomy. We therefore hypothesized that urinary MMPs and their endogenous tissue inhibitors of matrix metalloproteinases (TIMPs) might also provide important infor...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000137935.81103.a2
更新日期:2004-10-27 00:00:00
abstract::The frequencies of circulating donor-reactive cytotoxic lymphocyte precursors (CLP) and Il-2-producing helper lymphocyte precursors (HLP) were determined by limiting dilution analysis in 19 kidney allograft recipients before and at various intervals (up to 2 years) after transplantation. A significant, selective, and ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199309000-00025
更新日期:1993-09-01 00:00:00
abstract::The influence of continuous immunosuppression on the immune system of 2 neonates born to heart-lung transplant recipients was analyzed. T cells, T cell subpopulations, B cells and cyclosporine levels were measured in maternal and cord blood at the time of delivery. Cyclosporine, both parent compound, and metabolites w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198908000-00008
更新日期:1989-08-01 00:00:00
abstract::Longitudinal studies over an eight-month period have been performed to follow the T killer response restoration after allogeneic bone marrow transplantation (BMT). The capacity of the patient's peripheral blood mononuclear cells (PBM) to develop cytotoxic effector cells directed either against allogeneic cells or agai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198708000-00024
更新日期:1987-08-01 00:00:00
abstract::In liver allograft rejection, interlobular bile ducts are thought to be the main target of rejection. In contrast, in other organ allografts the capillary bed of the graft appears to be the primary target. To determine whether portal tract microvasculature is destroyed in liver allografts during rejection, we have ide...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199307000-00012
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:The need to find a safe, effective liver support system for patients with fulminant hepatic failure (FHF) continues to be unmet. A system using immortalized human hepatocytes was originally developed in the early 1990s. A modified version of the initial extracorporeal liver-assist device (ELAD) was recently ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-200212270-00016
更新日期:2002-12-27 00:00:00
abstract::Antigenic requirements for the induction of T cell-independent primary splenic IgM antibody responses (plaque-forming cell responses) to H-2Dd alloantigens were studied. Results show that some functional activity or structural property of the donor cells is required for immunogenicity, because antigens are not active ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198302000-00014
更新日期:1983-02-01 00:00:00
abstract::Histoincompatible-complete radiation chimeras, after resolving acute graft-versus-host disease (GVHD), establish specific tolerance to host and donor alloantigens. This tolerance can be perturbed with immunosuppressive agents and infusions of small numbers of donor-type cells, with infusions of massive numbers of dono...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198109000-00005
更新日期:1981-09-01 00:00:00
abstract::In light of the transplant community's efforts to increase living donation, preserving donor autonomy is essential. Understanding how often and the reasons why potential living kidney donors opt out of the donor evaluation process for nonmedical reasons is important for assessing donor voluntariness. The experiences o...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001408
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:In response to a longstanding Federal mandate to minimize the role of geography in access to transplant in the United States, we assessed whether patient travel distance was associated with lung transplant outcomes. We focused on the posttransplant time period, when the majority of patient visits to a transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003129
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Short-term outcomes using steroid-free immunosuppression after renal transplantation have been promising. No studies have examined the incidence of and reasons for steroid-avoidance protocol failures. METHODS:We present a single-center analysis of steroid-free immunosuppression failures among 129 pediatric ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a5df60
更新日期:2009-06-15 00:00:00
abstract:BACKGROUND:Diarrhea is a frequent complication of solid organ transplantation. Cryptosporidiosis is classically reported in patients with acquired immunodeficiency syndrome and emerged as a cause of persistent diarrhea in solid organ transplant patients. METHODS:Through the ANOFEL Cryptosporidium National Network and ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001503
更新日期:2017-04-01 00:00:00
abstract::A series of three synthetic peptides spanning H-2E alpha k chain residues (90-110), (110-130), and (130-150) were synthesized and purified. Mice representative of H-2E- (B6, B10, B10.M, B10.Q, B10.S) and H-2E+ (B10.D2, B10.K, B10.RIII) were immunized with individual peptides and lymph node cells challenged in vitro. B...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199211000-00029
更新日期:1992-11-01 00:00:00
abstract::Multiple variations of the basic lymphocytotoxicity test have been reported to increase test sensitivity. Although these modifications are used routinely in crossmatch tests, as required by federal regulation, there has been no methodical assessment of the relative sensitivities and specificities of these techniques w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199509000-00016
更新日期:1995-09-15 00:00:00
abstract:BACKGROUND:Translational research in a relevant preclinical model is recommended before Treg-inducing protocols can be implemented in humans. We have characterized rhesus monkey CD25 cells phenotypically and functionally. METHODS:The phenotype of CD4(+)CD25(high) cells was determined by FACS, focusing on established m...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816b15b9
更新日期:2008-04-27 00:00:00
abstract:BACKGROUND:The depletion of differential B cell and xenoreactive natural antibodies (XNA) by anti-delta and anti-mu injections was analyzed in adult mice. Sequential treatment with anti-delta and then anti-mu induces a complete depletion of B cells and XNA and represents a potential approach to induce xenograft toleran...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199912150-00017
更新日期:1999-12-15 00:00:00
abstract::The effect of cyclosporine and metabolite 17 (M17) as well as other CsA-related compounds (CsG, dihydro-CsC, dihydro-CsD, CsH, B5.49, and H7.94) was tested on T lymphocyte clone proliferation. In these experiments, antigen and interleukin 2 (IL-2) dependent long-term T lymphocyte clones derived from a rejected human k...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198712000-00019
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:In live donor liver transplantation portal flush only of the graft is done on the bench. There are no data on antegrade arterial flush along with portal flush of the graft. METHODS:Consecutive patients undergoing elective right lobe live donor liver transplantation were block-randomized to receive either po...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000002088
更新日期:2018-04-01 00:00:00
abstract::The generation of Gal knockout (KO) pigs is likely to be an important advance in xenotransplantation. However, recent reports suggesting that expression of Gal may not be completely eliminated raise the possibility of a continuing anti-Gal immune response. The authors used a Gal-mismatched skin graft model to study ce...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000116420.17173.e4
更新日期:2004-03-15 00:00:00
abstract::Retrospectively we analyzed the histocompatibility data and clinical results of bone marrow transplantation in 51 patients who received marrow from unrelated donors (UD) from 1977 to 1987 at one of four UK BMT centers. We compared the results with those obtained in 51 transplants carried out at the same centers using ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00007890-199003000-00015
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Urolithiasis occurs in approximately 6% of adult kidney transplant (KTx) recipients. Limited data are available on urolithiasis after pediatric KTx. We report the incidence, management of, and risk factors for stone development in children after KTx. METHODS:We reviewed the medical records of 399 children w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000139543.56886.de
更新日期:2004-11-15 00:00:00
abstract::In the USA approximately 10% of candidates for renal transplantation have serum antibodies to hepatitis C (HCV). To assess the possible impact of HCV infection on early posttransplant events we assessed allograft complications during the first 6 months following renal transplantation in three groups of adult renal all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199610270-00004
更新日期:1996-10-27 00:00:00
abstract::We reviewed coded autopsy material from 71 dogs, 46 receiving allogeneic and 25 receiving autologous bone marrow transplants, to evaluate the hypothesis that lymphocytic bronchitis is associated with severe acute graft-versus-host disease (GVHD). We found no significant correlation between the presence of lymphocytic ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198403000-00003
更新日期:1984-03-01 00:00:00
abstract::Anti-CD3 mAbs are potent inhibitors of T cell function; however, administration of mitogenic mAb can cause significant morbidity secondary to T cell activation and cytokine release. Nonmitogenic anti-CD3 mAb is immunosuppressive in mice without inducing detectable morbidity, and may thus be preferable for in vivo T ce...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-12-15 00:00:00
abstract:BACKGROUND:Recent studies have described submandibular gland allografts in animal models; however, the amount of saliva secretion or nervous regeneration in those animals have not been reported. Herein, we investigated saliva secretion from submandibular gland allografts in beagle dogs. METHODS:Using a vascularized su...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000258598.27904.d7
更新日期:2007-03-27 00:00:00
abstract:BACKGROUND:Extracorporeal membrane oxygenation (ECMO) and mechanical ventilation (MV) can be used as a bridge to heart-lung transplantation (HLT). The goal of this study was to determine if pretransplantation ECMO or MV affects survival in HLT. METHODS:The United Network for Organ Sharing database was reviewed for all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a860b8
更新日期:2014-01-15 00:00:00