FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation.

abstract：BACKGROUND:A quantitative model of immunosuppression was previously developed based on the rejection of the allogeneic A/J murine tumor sarcoma 1 (Sa1) in immunocompetent mice. Here, the model is used to evaluate the immunologic mechanisms of graft rejection and to determine the potential of this model to detect synerg...

journal_title：Transplantation

authors： Hammond-McKibben D,Saulnier M,Zhang J,Risher N,Lake P,Weetall M

更新日期：2005-04-27 00:00:00

abstract：:CD4+ cells from CsA-treated DA rats with long-surviving PVG heart allografts specifically suppress the capacity of naive CD4+ cells to restore allograft rejection in irradiated DA rats, but have normal donor-specific alloreactivity in MLC. CD4+ suppressor cells from CsA-treated DA rats cultured for 3 days against eith...

journal_title：Transplantation

authors： Pearce NW,Spinelli A,Gurley KE,Hall BM

更新日期：1993-02-01 00:00:00

abstract：:Patients who require cystectomy are usually treated with an ileal conduit or intestinal neobladder for urinary control. In some of them, however, the bowel segment cannot be used because of previous abdominal surgery or radiation treatment. Bladder transplantation from cadavers may be beneficial to these patients, if ...

journal_title：Transplantation

authors： Takeuchi K,Takechi S,Ohoka H,Yokoyama M,Iwata H,Takeuchi M,Matsuda S

更新日期：1997-04-15 00:00:00

abstract：BACKGROUND:Small bowel transplantation in children weighing less than 10 kg is hindered by the lack of size-matched donors. The ability to create reduced size small bowel grafts from adult cadaveric donors suitable for use in young children has been studied. METHODS:Volumetric assessment of computed tomography scans w...

journal_title：Transplantation

authors： Delrivière L,Muiesan P,Marshall M,Davenport M,Dhawan A,Kane P,Karani J,Rela M,Heaton N

更新日期：2000-04-15 00:00:00

abstract：BACKGROUND:Liver transplantation using ABO-incompatible grafts is rarely performed because the reported outcome is poorer than with compatible grafts. We report our positive experience with adult-to-adult living-donor liver transplant (LDLT) using ABO-incompatible grafts. METHODS:The immunosuppressive protocol consist...

journal_title：Transplantation

authors： Testa G,Vidanovic V,Chejfec G,Gangemi A,Iqpal R,Porubsky M,Pham T,Benedetti E

更新日期：2008-03-15 00:00:00

abstract：BACKGROUND:In response to recent studies, a better understanding of the risks of renal complications among African American and biologically related living kidney donors is needed. METHODS:We examined a database linking U.S. registry identifiers for living kidney donors (1987-2007) to billing claims from a private hea...

journal_title：Transplantation

authors： Lentine KL,Schnitzler MA,Garg AX,Xiao H,Axelrod D,Tuttle-Newhall JE,Brennan DC,Segev DL

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Immunosuppressive therapy is a risk factor for the increased incidence and metastatic progression of malignancies in organ graft recipients. Transforming growth factor (TGF)-beta(1) has been associated with tumor invasion and metastasis, and we have implicated cyclosporine-associated TGF-beta(1) hyperexpress...

journal_title：Transplantation

authors： Maluccio M,Sharma V,Lagman M,Vyas S,Yang H,Li B,Suthanthiran M

更新日期：2003-08-15 00:00:00

abstract：BACKGROUND:Previously, we identified an antimitogenic IgG antibody separated from sera of patients with known kidney transplant chronic rejection. This antibody inhibits individual patients' own unprimed T helper cell responses to alloantigens as well as a third-party mixed lymphocyte response, but does not inhibit aut...

journal_title：Transplantation

authors： Shoker AS,Okasha K,Sheridan DP,Kappel JE,Baltzan MA

更新日期：1997-09-27 00:00:00

abstract：BACKGROUND:Although the value of duodenal histology as a means to diagnose acute rejection in pancreaticoduodenal allografts has been validated, it is not known how the duodenum responds to antirejection treatment in comparison with the pancreas. METHODS:Diabetic Lewis rats received a pancreaticoduodenal allograft. Cy...

journal_title：Transplantation

authors： Mark W,Hechenleitner P,Dietze O,Klima G,Schneeberger S,Steurer W,Candinas D,Margreiter R,Königsrainer A

更新日期：2002-01-27 00:00:00

abstract：:Thymectomy of mice aged 6-8 weeks causes a disproportion of splenic T cell sets, the Ly123 set being relatively decreased and the Ly23 set relatively increased (Ly123 decrease: Ly23 increase). A similar disproportion of splenic T cell sets was found to occur spontaneously with advancing age (12-18 months). By PA-SRBC ...

journal_title：Transplantation

authors： Newcomb EW,Goldberg EH,de Sousa M,Goldstein G,Boyse EA,Scheid MP

更新日期：1985-11-01 00:00:00

abstract：:Two patients at our institution underwent single lung transplantation. The procedure and the patient's postoperative course were uncomplicated in each case. Pathological examination of each pneumonectomy specimen revealed a well-differentiated adenocarcinoma; both were less than 1 cm in size. The remainder of each lun...

journal_title：Transplantation

authors： Svendsen CA,Bengtson RB,Park SJ,Shumway SJ

更新日期：1998-10-27 00:00:00

abstract：BACKGROUND:Liver transplant (LT) for nonalcoholic steatohepatitis (NASH) related hepatocellular carcinoma (HCC) is not well characterized in the literature. The aim of the study was to examine characteristics and outcomes of patients who had LT for NASH-HCC (NASH) versus HCC from other liver diseases (non-NASH). METHO...

journal_title：Transplantation

authors： Sadler EM,Mehta N,Bhat M,Ghanekar A,Greig PD,Grant DR,Yao F,Sapisochin G

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Strong correlations have been described between persistently elevated proportions of CD57+ (CD28-) CD8+high T lymphocytes and cytomegalovirus (CMV) infection, in healthy individuals as well as in transplant patients. We investigated whether secondary exposure to CMV triggers recall responses within the CD8 T...

journal_title：Transplantation

authors： Hazzan M,Labalette M,Noel C,Lelievre G,Dessaint JP

更新日期：1997-03-15 00:00:00

abstract：BACKGROUND:One of the alternative options to simultaneous pancreas-kidney transplantation (SPKT) for type I diabetics with renal failure is sequential transplant of a living donor kidney followed by a deceased donor pancreas transplant (pancreas after living donor kidney transplant [PALK]). We retrospectively compared ...

journal_title：Transplantation

authors： Poommipanit N,Sampaio MS,Cho Y,Young B,Shah T,Pham PT,Wilkinson A,Danovitch G,Bunnapradist S

更新日期：2010-06-27 00:00:00

abstract：BACKGROUND:Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has demonstrated feasibility. The ethics of VCA have moved past doubts about the morality of attempting such transplants to how to conduct them ethically. METHODS:Leaders of each program performing and/or evaluating VCA ...

journal_title：Transplantation

authors： Caplan AL,Parent B,Kahn J,Dean W,Kimberly LL,Lee WPA,Rodriguez ED

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Machine perfusion (MP) has evolved as a promising approach for the ex situ preservation in organ transplantation. However, the literature on the use of MP in human vascularized composite allografts is scarce. The aim of this study was to evaluate the effects of hypothermic MP with an acellular perfusate in h...

journal_title：Transplantation

authors： Haug V,Kollar B,Tasigiorgos S,Endo Y,Kauke M,Safi AF,Veeramani A,Abdulrazzak O,Bausk B,Walt D,Pomahac B

更新日期：2020-09-01 00:00:00

abstract：:Athymic PVG-rnu/rnu (RT1c) rats were grafted with skin bearing isolated MHC disparities 7-14 days in advance of cell transfer. The ability of naive CD4+ or CD8+ thoracic duct lymphocytes to induce rejection was assessed by adoptive transfer of one or both T cell subsets into nude recipients bearing congenic PVG.r1 (MH...

journal_title：Transplantation

authors： Bell EB,Rejali D,Whitby EH,Sparshott SM,Yang CP

更新日期：1990-10-01 00:00:00

abstract：:Graft and patient survival rates were analyzed in 239 consecutive first cadaver renal transplants as a function of time of administration of blood transfusion and the number of units given. There was no statistically significant difference in patient survival in comparing patients who were never transfused, patients n...

journal_title：Transplantation

authors： Corry RJ,West JC,Hunsicker LG,Schanbacher BA,Lachenbruch PA

更新日期：1980-12-01 00:00:00

abstract：:OKT3, an anti-CD3 MAB, depletes T cells in vivo and is among the most potent inhibitors of acute allograft rejection. The mechanism of this inhibition is unknown. The present studies investigate whether anti-CD3 antibodies have the ability to crosslink CD3 on two different cells and induce TCR-dependent antibody-bridg...

journal_title：Transplantation

authors： Wong JT,Eylath AA,Ghobrial I,Colvin RB

更新日期：1990-10-01 00:00:00

abstract：:As a first step in the study of the possible relationship between the T/t and H-2 complexes, the H-2 antigenic composition of the strains carrying factors t12, tw32, tw2, tw8, t1, t0, t6, tw1, tw71, tw73, tw12, tw5, tw75, and t38 was studied by using a battery of antisera containing antibodies against inbred-derived H...

journal_title：Transplantation

authors： Hammerberg C,Klein J,Artzt K,Bennett D

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:Alpha-glutathione-S-transferase (alphaGST) has been suggested as a sensitive marker of acute cellular rejection in liver transplantation. This study evaluated the usefulness of alphaGST as a marker of acute rejection in comparison with standard liver function tests. METHODS:Daily measurements of liver funct...

journal_title：Transplantation

authors： Nagral A,Butler P,Sabin CA,Rolles K,Burroughs AK

更新日期：1998-02-15 00:00:00

abstract：BACKGROUND:After transplantation, donor dendritic cells (DC) migrating to the draining lymph node of the recipient are thought to play an important role in the initiation of graft rejection. In this study, we compared the in vivo migration of DC after allogeneic skin transplantation with that after congeneic skin trans...

journal_title：Transplantation

authors： Richters CD,van Gelderop E,du Pont JS,Hoekstra MJ,Kreis RW,Kamperdijk EW

更新日期：1999-03-27 00:00:00

abstract：BACKGROUND:The UK Kidney Fast-Track Scheme (KFTS) was introduced in 2012 to identify kidneys at high risk of discard and to rapidly facilitate transplantation. A retrospective analysis of kidneys transplanted through the KFTS was undertaken. METHODS:UK Transplant Registry data were collected on deceased donor kidneys ...

journal_title：Transplantation

authors： Callaghan CJ,Mumford L,Pankhurst L,Baker RJ,Bradley JA,Watson CJE

更新日期：2017-12-01 00:00:00

abstract：:A considerable amount of data indicates that transplanted patients are at increased risk for de novo and recurrent cancer. Treatment of this population is difficult. It remains unclear if the immunosuppressive therapy should be continued, tapered or even stopped or if immunosuppressive drugs with antiproliferative pro...

journal_title：Transplantation

authors： Andrassy J,Graeb C,Rentsch M,Jauch KW,Guba M

更新日期：2005-09-27 00:00:00

abstract：BACKGROUND:The need for renal replacement therapy (RRT) either before or after orthotopic liver transplant (OLTX) has been reported to be a poor prognostic indicator for survival. Use of continuous veno-venous hemodialysis (CVVHD) for RRT has been reported in three series of OLTX patients with high 90-day mortality rat...

journal_title：Transplantation

authors： Gonwa TA,Mai ML,Melton LB,Hays SR,Goldstein RM,Levy MF,Klintmalm GB

更新日期：2001-05-27 00:00:00

abstract：:This study investigates the possibility that the active enhancing properties of bone marrow (BM) cells may be related to Ia-like determinants on their surface membranes. Less chromium was released on a cell per cell basis from nucleated baboon BM cells used as targets in complement-dependent cytotoxicity than from lab...

journal_title：Transplantation

authors： Smit JA,Myburgh JA,Gaillard VJ

更新日期：1978-08-01 00:00:00

abstract：:Islet transplantation is currently being explored as a treatment for patients with type 1 diabetes. At present, the number of patients becoming insulin-independent is rapidly increasing world-wide applying the transplantation protocol originally described by the group in Edmonton. A hallmark in this procedure is repea...

journal_title：Transplantation

authors： Korsgren O,Nilsson B,Berne C,Felldin M,Foss A,Kallen R,Lundgren T,Salmela K,Tibell A,Tufveson G

更新日期：2005-05-27 00:00:00

abstract：BACKGROUND:Graft failure related to acute and chronic rejection remains an important problem in transplantation. An association has been reported between microchimerism and the development of tolerance. Since it has been established that cells of fetal origin can be found in maternal tissues long after parturition, and...

journal_title：Transplantation

authors： Miles CD,Schaubel DE,Liu D,Port FK,Rao PS

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:Antibody-mediated rejection (AMR) is a leading cause of morbidity and mortality after kidney transplantation. Early diagnosis and treatment of subclinical AMR based on the donor-specific antibody (DSA) testing may result in better outcomes. METHODS:We tested this hypothesis in 220 kidney transplant recipien...

journal_title：Transplantation

authors： Parajuli S,Joachim E,Alagusundaramoorthy S,Blazel J,Aziz F,Garg N,Muth B,Mohamed M,Mandelbrot D,Zhong W,Djamali A

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Hepatic ischemia-reperfusion (IR) injury is frequently followed by cholestatic liver disease. Cytokines released by Kupffer cells following hepatic IR injury may subsequently regulate hepatic transporter expression. The purpose of this study was to determine whether hepatic IR injury and the resultant Kupffe...

journal_title：Transplantation

authors： Tanaka Y,Chen C,Maher JM,Klaassen CD

更新日期：2006-07-27 00:00:00