Rejection of murine cardiac allografts. II. Evidence that splenocytes bearing Lyt2 inhibit responsiveness in long-term heart graft recipients.

abstract：BACKGROUND:Diagnosing acute rejection (AR) in kidney transplant recipients typically requires an invasive kidney biopsy. A previous study has suggested that expression of five genes in peripheral blood can indicate the presence of AR in American pediatric kidney transplant recipients. This study aims to validate if the...

journal_title：Transplantation

authors： Lee A,Jeong JC,Choi YW,Seok HY,Kim YG,Jeong KH,Moon JY,Lee TW,Ihm CG,Jeon HJ,Koo TY,Ahn C,Lim SJ,Yang J,Lee SH

更新日期：2014-10-15 00:00:00

abstract：BACKGROUND:We are presently investigating the therapeutic potential of herpes simplex-thymidine kinase-expressing donor T cells in the setting of a T cell-depleted allogeneic bone marrow transplantation. The generation, expansion, and selection of the gene-modified T cells require a 12-day ex vivo culture period in hig...

journal_title：Transplantation

authors： Contassot E,Murphy W,Angonin R,Pavy JJ,Bittencourt MC,Robinet E,Reynolds CW,Cahn JY,Hervé P,Tiberghien P

更新日期：1998-05-27 00:00:00

abstract：BACKGROUND:Immunosuppressive regimens for kidney transplantation which reduce the long-term burden of immunosuppression are attractive, but little data are available to judge the safety and efficacy of the different strategies used. We tested the hypothesis that the simple, cheap, regimen of alemtuzumab induction combi...

journal_title：Transplantation

authors： Chan K,Taube D,Roufosse C,Cook T,Brookes P,Goodall D,Galliford J,Cairns T,Dorling A,Duncan N,Hakim N,Palmer A,Papalois V,Warrens AN,Willicombe M,McLean AG

更新日期：2011-10-15 00:00:00

abstract：:Multiple variations of the basic lymphocytotoxicity test have been reported to increase test sensitivity. Although these modifications are used routinely in crossmatch tests, as required by federal regulation, there has been no methodical assessment of the relative sensitivities and specificities of these techniques w...

journal_title：Transplantation

authors： Zachary AA,Klingman L,Thorne N,Smerglia AR,Teresi GA

更新日期：1995-09-15 00:00:00

abstract：BACKGROUND:Globalization and migration patterns have increased the number of donors from countries with high incidence rates of tuberculosis (TB) in low incidence countries, with the subsequent increase in risk of TB transmission to the recipients. METHODS:Retrospective cohort study, including all actual deceased dono...

journal_title：Transplantation

authors： Coll E,Torre-Cisneros J,Calvo R,Garrido G,Matesanz R

更新日期：2013-07-27 00:00:00

abstract：:Antigenic requirements for the induction of T cell-independent primary splenic IgM antibody responses (plaque-forming cell responses) to H-2Dd alloantigens were studied. Results show that some functional activity or structural property of the donor cells is required for immunogenicity, because antigens are not active ...

journal_title：Transplantation

authors： Nakashima I,Clark EA,Lake P,Kato N,Nagase F,Mizoguchi K,Isobe KI,Saito M

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:Human islet transplantation is a great potential therapy for type I diabetes. To investigate islet graft survival and function, we recently showed the improved effects after co-culture and co-transplantation with vascular endothelial cells (ECs) in diabetic rats. METHODS:ECs were isolated, and the viability...

journal_title：Transplantation

authors： Pan X,Xue W,Li Y,Feng X,Tian X,Ding C

更新日期：2011-12-15 00:00:00

abstract：BACKGROUND:Significant disparity exists in the United Kingdom between the need for organ transplant and supply of deceased donor organs. In the recent years, efforts to increase donation has improved the rate of mainly deceased donors after circulatory death and from older donors. The rate of donation from pediatric po...

journal_title：Transplantation

authors： Dave RV,Hakeem AR,Dawrant MJ,Ecuyer CL,Lewington AJ,Attia MS,Hostert L,Finlay E,Ahmad N

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:We previously showed that bortezomib (BTZ) partially depletes plasma cells, yet has limited efficacy for desensitization in kidney transplant candidates when up to 16 doses is given. METHODS:This study aimed to determine the safety and efficacy of 32 doses of BTZ (1.3 mg/m of body surface area) in 10 highly...

journal_title：Transplantation

authors： Moreno Gonzales MA,Gandhi MJ,Schinstock CA,Moore NA,Smith BH,Braaten NY,Stegall MD

更新日期：2017-06-01 00:00:00

abstract：:Retrospective mixed leukocyte culture studies were performed in eight patients who had either rejected their marrow grafts or experienced graft-versus-host disease and in seven patients with successful marrow engraftment. In tests of pre-and post-transplant lymphocytes we found no evidence that rejection or graft-vers...

journal_title：Transplantation

authors： Opelz G,Gale RP

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:Although inactivated vaccines are recommended for immunocompromized patients, efficacy and safety of diphtheria and tetanus immunization in renal transplant recipients have received little attention so far. The aim of the study was to investigate the response to a standard diphtheria and tetanus booster vacc...

journal_title：Transplantation

authors： Enke BU,Bökenkamp A,Offner G,Bartmann P,Brodehl J

更新日期：1997-07-27 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the utility of the random urine protein to creatinine ratio (P/C) in evaluation and longitudinal management of proteinuria in adult renal transplant recipients with or without overt nephropathy in an outpatient clinic. METHODS:A total of 289 adult renal transplant re...

journal_title：Transplantation

authors： Torng S,Rigatto C,Rush DN,Nickerson P,Jeffery JR

更新日期：2001-10-27 00:00:00

abstract：BACKGROUND:The role of CD20+ B cells in renal allograft rejection has been reappreciated. Importantly, recent studies suggest a relation between CD20+ B cell aggregates and poorer clinical outcome. In the present study, we attempted to confirm these early reports in a tightly controlled patient population and to differ...

journal_title：Transplantation

authors： Scheepstra C,Bemelman FJ,van der Loos C,Rowshani AT,van Donselaar-Van der Pant KA,Idu MM,ten Berge IJ,Florquin S

更新日期：2008-09-27 00:00:00

abstract：:Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the ex...

journal_title：Transplantation

authors： Benke K,Sayour AA,Mátyás C,Ágg B,Németh BT,Oláh A,Ruppert M,Hartyánszky I,Szabolcs Z,Radovits T,Merkely B,Szabó G

更新日期：2017-03-01 00:00:00

abstract：:In a murine strain combination disparate in both H-2 antigens and minor histocompatibility antigens consisting of C57BL/6 (B6; H-2b, Mls-1b) mice as recipients and AKR/J (AKR; H-2k, Mls-1a) mice as donors, we reported that the administration of anti-TCR-alpha beta mAb nonspecifically suppresses the ability to reject a...

journal_title：Transplantation

authors： Nomoto K,Yung-Yun K,Omoto K,Umesue M,Murakami Y,Matsuzaki G,Nomoto K

更新日期：1995-02-15 00:00:00

abstract：:It was the objective of these experiments to study the time-related changes in the responsiveness of the cellular elements of the immune system following contact with single non-H-2 or multiple H-2 histocompatibility antigens. The reactivity of spleen cells from mice that received injections of spleen cells bearing H-...

journal_title：Transplantation

authors： Graff RJ,Kurtz ME,Russell H,Martin-Morgan D

更新日期：1988-02-01 00:00:00

abstract：:We have studied organ allograft survival in rhesus monkeys conditioned with myeloablative total-body irradiation and T cell-depleted autologous bone marrow transplantation then given a heterotopic MHC-mismatched cardiac allograft in the immediate postmyeloablative period. This model has enabled us to investigate the r...

journal_title：Transplantation

authors： Moses RD,Sundeen JT,Orr KS,Roberts RR,Gress RE

更新日期：1989-11-01 00:00:00

abstract：:Two patients at our institution underwent single lung transplantation. The procedure and the patient's postoperative course were uncomplicated in each case. Pathological examination of each pneumonectomy specimen revealed a well-differentiated adenocarcinoma; both were less than 1 cm in size. The remainder of each lun...

journal_title：Transplantation

authors： Svendsen CA,Bengtson RB,Park SJ,Shumway SJ

更新日期：1998-10-27 00:00:00

abstract：BACKGROUND:Although the clinical features of early hepatic artery thrombosis (HAT) are well defined, the features of delayed (more than 4 weeks after transplantation) hepatic artery thrombosis are less clearly defined. The aim of our study was to identify risk factors, clinical presentation, and outcome of management o...

journal_title：Transplantation

authors： Bhattacharjya S,Gunson BK,Mirza DF,Mayer DA,Buckels JA,McMaster P,Neuberger JM

更新日期：2001-06-15 00:00:00

abstract：:The effect of pretreatment with cyclosporine on liver preservation was studied using a rat liver transplant model. In a preliminary 1-week survival study, 59 liver transplants were performed. In group A, neither donors nor recipients were treated. In group B, the recipients were pretreated by a 3-day course of CsA (10...

journal_title：Transplantation

authors： Goto S,Kim YI,Shimada T,Kawano K,Kobayashi M

更新日期：1991-10-01 00:00:00

abstract：:In recent years there have been major advances in the technology for the detection and definition of human leukocyte antigen antibodies. In this overview we describe the evolution in laboratory technology, the techniques currently available and consider their application in antibody specificity definition and in under...

journal_title：Transplantation

authors： Fuggle SV,Martin S

更新日期：2008-08-15 00:00:00

abstract：:OKT3, an anti-CD3 MAB, depletes T cells in vivo and is among the most potent inhibitors of acute allograft rejection. The mechanism of this inhibition is unknown. The present studies investigate whether anti-CD3 antibodies have the ability to crosslink CD3 on two different cells and induce TCR-dependent antibody-bridg...

journal_title：Transplantation

authors： Wong JT,Eylath AA,Ghobrial I,Colvin RB

更新日期：1990-10-01 00:00:00

abstract：:Two infants born to mothers who had been given a renal transplant and who were receiving azathioprine and prednisone have been followed up for over 2 years. Initially both had lower than normal lymphocyte counts and cortisol levels. Chromosomal aberrations similar to those found in the lymphocytes of the mothers were ...

journal_title：Transplantation

authors： Price HV,Salaman JR,Laurence KM,Langmaid H

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:Thymoglobulin given before allo-hematopoietic stem-cell transplantation (HSCT) from unrelated donors reduces acute graft-versus-host disease (GvHD), but the optimal dose is unknown. METHOD:Four different doses of Thymoglobulin were given to 162 patients with hematologic malignancies undergoing unrelated don...

journal_title：Transplantation

authors： Remberger M,Svahn BM,Mattsson J,Ringdén O

更新日期：2004-07-15 00:00:00

abstract：:Disseminated varicella-zoster (VZV) infection is a rare complication after renal allotransplantation in adults. We report four patients, among them one with combined VZV and cytomegalovirus infection. The main complications were hepatitis, pneumonitis, and disseminated intravascular coagulation. A review of the litera...

journal_title：Transplantation

authors： Fehr T,Bossart W,Wahl C,Binswanger U

更新日期：2002-02-27 00:00:00

abstract：:Hemorrhagic cystitis (HC) is a major cause of morbidity after BMT; we have analyzed its incidence, risk factors, and complications in 977 patients undergoing BMT between 1974 and 1988. Despite vigorous hydration and frequent voiding in all patients receiving cyclophosphamide, 135/977 (15% by Kaplan-Meier projection) d...

journal_title：Transplantation

authors： Sencer SF,Haake RJ,Weisdorf DJ

更新日期：1993-10-01 00:00:00

abstract：:Cell surface markers of isolated graft-infiltrating cells (GIC) were studied, and functional in vitro assays performed in 8 cases of acute irreversible rejection of human renal allografts. The GIC were mostly activated T cells (OKT11+, OKT3+, Ia+), with predominance of the cytotoxic/suppressor T cell phenotype (OKT8+)...

journal_title：Transplantation

authors： Charpentier BM,Bach MA,Lang P,Martin B,Fries D

更新日期：1987-07-01 00:00:00

abstract：:Nine recombinant H-2 mouse strains with crossovers in the I region between I-E-negative haplotypes f,q and I-E-positive haplotypes p,k were examined for I-E expression by microcytotoxicity dye exclusion assay. These recombinants were found to be negative for I-E expression. There are two possible genotypes in these re...

journal_title：Transplantation

authors： Lafuse WP,Savarirayan S,McCormick JF,David CS

更新日期：1987-02-01 00:00:00

abstract：:Intestinal transplantation has become the treatment of choice for patients who are experiencing life-threatening complications of intestinal failure. Early attempts with intestinal transplantation were unsuccessful as a consequence of both technical and immunologic failures. The introduction of tacrolimus provided the...

journal_title：Transplantation

authors： Langnas AN

更新日期：2004-05-15 00:00:00

abstract：BACKGROUND:According to a pooled analysis of three randomized clinical studies concerning the prevention of acute rejection in cadaveric renal transplantation, mycophenolate mofetil (MMF) proved superior to azathioprine or placebo in conjunction with cyclosporine (CsA) and steroids. MMF-treated patients showed reduced ...

journal_title：Transplantation

authors： Kim YS,Moon JI,Kim SI,Park K

更新日期：1999-08-27 00:00:00