Abstract:
:Surgical site infection (SSI) is an important cause of morbidity after orthotopic liver transplantation (OLT). Perioperative antibiotic prophylaxis is one of the main modifiable risk factors. We prospectively investigated the epidemiology, risk factors, and prognosis of SSI in a cohort of 167 OLT. Two different schedules of antibiotic SSI prophylaxis were compared. Fifty-six episodes of SSI were included (0.34 episodes/patient). The SSI incidence among patients who received cefazolin and amoxicillin-clavulanate did not differ. Bacteria caused all episodes. The most common pathogen was Escherichia coli (21.25%), among which 47% were extended-spectrum beta-lactamase producers. The only risk factor for SSI was antibiotic therapy before OLT. Patients with SSI had a longer hospital and intensive care unit stay (P<0.05), but survival did not differ. In conclusion, SSI has a high incidence despite antibiotic perioperative prophylaxis; therefore, an integral perspective of SSI and a multifactorial approach other than antimicrobial prophylaxis are needed to prevent it.
journal_name
Transplantationjournal_title
Transplantationauthors
García Prado ME,Matia EC,Ciuro FP,Díez-Canedo JS,Sousa Martín JM,Porras López FM,de la Casa AC,Cisneros Herreros JMdoi
10.1097/TP.0b013e3181735407subject
Has Abstractpub_date
2008-06-27 00:00:00pages
1849-54issue
12eissn
0041-1337issn
1534-6080pii
00007890-200806270-00025journal_volume
85pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Rat lung allograft rejection is mediated by collagen type V (col(V)) specific T-helper-cell 17 (Th17) cells. Adoptive transfer of these cells is sufficient to induce rejection pathology in isografts, whereas tolerance to col(V) suppresses allograft rejection. Therefore, we tested whether regulatory T cells f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181bcde7b
更新日期:2009-12-27 00:00:00
abstract:BACKGROUND:A successful kidney transplant from a living-related donor (LRD) remains the most effective renal replacement therapy for children with end-stage renal failure. The use of LRD kidneys results in decreased time on dialysis, increased graft survival, and better function compared with kidneys transplanted from ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200007270-00008
更新日期:2000-07-27 00:00:00
abstract::The expression of some genes has been comparatively studied in transplanted rat liver and in liver reperfused after ischemia in situ. Experiments on protein synthesis by tissue slices from cold-stored or transplanted livers show that rat livers that retain a good capacity for protein synthesis during storage undergo a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199305000-00004
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Graft arterial disease (GAD) is a major cause of late graft loss after organ transplantation. Alloimmune responses and vascular remodeling eventually cause the transplant organ to develop GAD. In this study, we aimed to limit the development of GAD by inhibiting alloimmune responses and vascular smooth muscl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000576
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The risk of transmitting a hepatitis B virus (HBV) infection from donor kidneys with a past HBV serological profile may be negligible. Data on HBV transmission to kidney transplant recipients from donor organs that were anti-HBc/HBsAg in Italy has not been previously reported. Anti-HBc testing in cadaver org...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000189930.89031.1b
更新日期:2006-01-15 00:00:00
abstract::Although solid organ transplant results have improved significantly in recent decades, a pivotal cause of impaired long-term outcome is the development of antibody-mediated rejection (AMR), a condition characterized by the presence of donor specific antibodies to human leukocyte antigen (HLA) or non-HLA antigens. High...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003551
更新日期:2020-11-17 00:00:00
abstract::After measurement of normal renal function, dog kidneys (n = 52) were subjected to 3, 15, or 30 min of normothermic warm ischemia (WI). After 24 hr of preservation by simple hypothermic storage (SHS) in a modified Collins solution, autotransplant was done and renal function was again measured beginning at 1 hr. Compar...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198611000-00003
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Islet transplantation studies with diabetic rodents frequently use treatment with diabetogens such as alloxan or streptozotocin to render hosts hyperglycemic. These chemicals produce unwanted toxic side effects, which complicate interpretations of damage produced by hyperglycemia versus direct toxin-induced ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200204270-00024
更新日期:2002-04-27 00:00:00
abstract::The rat aortic transplant model was modified to investigate whether the vascular wall changes on chronic rejection are reversible. DA (RT1a) aortas were first transplanted to WF (RT1a) recipients. The first transplantation was accompanied, as described earlier, by an increase in intimal cellularity and thickness and t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199608270-00016
更新日期:1996-08-27 00:00:00
abstract:BACKGROUND:While previous surveys have demonstrated the psychological impact on living-related liver transplantation (LRLT) donors, such as anxiety, depression, ambivalence and anger, the details regarding the relevant factors that affect donors' psychological status have not been well described. METHODS:To evaluate e...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000287455.70815.9e
更新日期:2007-11-27 00:00:00
abstract:BACKGROUND:Skin-autofluorescence (skin-AF) noninvasively measures the tissue accumulation of advanced glycation end products (AGEs). AGEs are nephrotoxic and potential effectors of cardiovascular mortality. We investigated whether skin-AF predicted graft loss after kidney transplantation. METHODS:A total of 302 renal ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31819d3173
更新日期:2009-04-15 00:00:00
abstract::Acute antibody-mediated rejection (AAR) of mouse skin allografts was studied in nine donor-recipient combinations with increasing histoincompatibility ranging from an H-Y to a complete H-2 plus on-H-2 disparity. AAR was induced by the injection of specific alloantiserum along with a heterologous complement on day 7 af...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197709000-00002
更新日期:1977-09-01 00:00:00
abstract:BACKGROUND:The role of anti-human leukocyte antigen (HLA) donor-specific antibodies (DSA) detected by Luminex in the development of rejection is not fully understood. METHODS:A study including 369 patients who received transplants from deceased donors with a negative complement-dependent cytotoxicity crossmatch (XM) w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825ace2c
更新日期:2012-08-27 00:00:00
abstract:BACKGROUND:New-onset diabetes after transplantation (NODAT) increases infectious and cardiovascular complications and reduces patient and graft survival. We assessed the incidence and the risk factors for glucose metabolism abnormalities before and after kidney transplantation using an oral glucose tolerance test (OGTT...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31820f0877
更新日期:2011-04-15 00:00:00
abstract:BACKGROUND:Immunomodulatory protocols including intravenous immunoglobulin/rituximab (IVIG/R) are employed to decrease anti-human leukocyte antigen (HLA) antibody levels for patients broadly sensitized to HLA and increase chances for transplantation with a compatible deceased donor (DD). The aim of our study was to ide...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31821eab8a
更新日期:2011-07-15 00:00:00
abstract::A technique for orthotopic bone transplantation in mice has been developed. A section of recipient tibia was removed and replaced by a similar section from the donor animal. The graft was held in place by internal fixation. Bone healing was assessed clinically, histologically, radiologically, and by torsion testing. T...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00
abstract::The stability of HLA alloantibodies was studied in 128 antibody-positive, potential kidney transplant recipients over an average period of 3 years. Antibody detection was performed using an anti-human globulin-complement-dependent cytotoxicity technique. In this study, the specificity of antibodies was categorized as ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199703270-00015
更新日期:1997-03-27 00:00:00
abstract:BACKGROUND:Allogeneic bone marrow transplantation is under investigation for a range of nonmalignant indications, including tolerance induction through mixed chimerism. This strategy has so far been tested experimentally only in young recipients. Due to immunosenescence, older patients have an increase in memory T cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182954618
更新日期:2013-06-27 00:00:00
abstract:BACKGROUND:Human CD58 is an adhesion molecule that interacts with CD2 on lymphocytes. We describe here an antibody that blocks responses of human peripheral blood mononuclear cells (PBMCs) to porcine cells and reacts with a porcine protein with homology to CD58. METHODS:Antibodies were isolated with a screen for inhib...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000120377.57543.d8
更新日期:2004-04-27 00:00:00
abstract:BACKGROUND:The success of clinical xenotransplantation will depend on induction of xenotolerance. We have previously shown that combined xenothymus and vascularized xenoheart transplantation under the coverage of a tolerizing regimen (TR) can induce and maintain full xenotolerance. Here, induction/maintenance of xenoto...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000145522.26428.27
更新日期:2005-03-15 00:00:00
abstract::The current shortage of donor organs in liver transplantation has led experienced transplant centers to use more "marginal" grafts. The development of a reliable technique of bile collection gives access to hepatic bile from donors and recipients for bile analysis to characterize the grafts. Proton nuclear magnetic re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200109150-00020
更新日期:2001-09-15 00:00:00
abstract::Forty-three human liver allograft biopsies and normal liver were directly analyzed for inflammatory and immunoregulatory cytokine gene expression by polymerase chain reaction (PCR). IL-5 gene expression was predominantly present in biopsies from liver allografts with histopathological evidence of acute rejection. IL-2...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199202010-00035
更新日期:1992-02-01 00:00:00
abstract::The growing number of elderly patients with end-stage kidney disease awaiting transplantation has resulted in a corresponding rise in the number of elderly transplant recipients. In this paper, we review existing literature on age-related changes, transplant outcomes, and complications in the elderly in an attempt to ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000275423.69689.dc
更新日期:2007-08-15 00:00:00
abstract:BACKGROUND:The relationship between institutional case volume and clinical outcomes after living donor liver transplantation is not clarified. METHODS:We conducted a nationwide retrospective cohort study using the database of Korean National Healthcare Insurance Service. Between January 2007 and December 2016, 7073 ad...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002394
更新日期:2019-05-01 00:00:00
abstract::Published data on the guinea pig-to-rat hepatic xenotransplant model describe problems concerning poor graft reperfusion. To further investigate this phenomenon, orthotopic liver xenotransplantation between weight-matched guinea pigs and rats were performed using Kamada's technique. On reperfusion, all cases had porta...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199807150-00017
更新日期:1998-07-15 00:00:00
abstract::Although the cornea is considered to be an immunological privileged site, corneal transplantation can result in immunological rejection followed by graft failure, especially in patients with vascularized corneas. Several studies suggest a beneficial effect of matching for the HLA class I antigens on corneal graft surv...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199504150-00021
更新日期:1995-04-15 00:00:00
abstract:BACKGROUND:There are limited data on the outcome of transplant recipients with familial Mediterranean fever (FMF)-associated AA amyloidosis. The aim of the present study is to evaluate demographic, clinical, laboratory, and prognostic characteristics and outcome measures of these patients. METHODS:Eighty-one renal tra...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000003043
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Kidney paired donation (KPD) has emerged as a viable option for renal transplant candidates with incompatible living donors. The aim of this study was to assess the "performance" of a three-site KPD program that allowed screening of multiple donors per recipient. METHODS:We reviewed retrospectively the acti...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000054
更新日期:2014-08-15 00:00:00
abstract::Clinical transplantation of fetal porcine islet-like cell clusters (ICC) to kidney transplanted diabetic patients has shown both morphological and biochemical evidence of prolonged xenograft survival, but no effect was seen on the insulin requirement of the transplanted patients. One possible explanation for this rela...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199604270-00016
更新日期:1996-04-27 00:00:00
abstract:BACKGROUND:Early and late complications related to the pancreas after simultaneous kidney-pancreas transplantation (SKPT) frequently result in graft loss. The authors describe a surgical rescue technique that allows salvage of the pancreatic graft when surgical complications appear after the transplant. METHODS:Of 158...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000041784.27763.A9
更新日期:2003-01-27 00:00:00