Upregulation of CD59: potential mechanism of accommodation in a large animal model.

abstract：:The frequency of donor-reactive and of third party-reactive cytotoxic T lymphocyte precursors (CTLp) was determined by limiting dilution analysis in the peripheral blood of 13 liver allograft recipients before (pre-tpx) and at various intervals (4 to 22 months) after (post-tpx) transplantation. In 6 of 13 patients wit...

journal_title：Transplantation

authors： Eberspächer ML,Otto G,Herfarth C,Kabelitz D

更新日期：1994-06-27 00:00:00

abstract：BACKGROUND:Prognostic models, which estimate survival probabilities, enable the survival benefit from a procedure to be assessed and allow the comparison of outcomes between centers. We therefore compared three models that estimate survival in the absence of transplantation for patients with alcoholic liver disease (AL...

journal_title：Transplantation

authors： Young TA,Neuberger J,Longworth L,Ratcliffe J,Buxton MJ,Cost-Effectiveness in Liver Transplantation Study Team.

更新日期：2003-11-27 00:00:00

abstract：:In recent years there have been major advances in the technology for the detection and definition of human leukocyte antigen antibodies. In this overview we describe the evolution in laboratory technology, the techniques currently available and consider their application in antibody specificity definition and in under...

journal_title：Transplantation

authors： Fuggle SV,Martin S

更新日期：2008-08-15 00:00:00

abstract：:Vascular endothelial cells (VEC) are clearly immunogenic and express antigens unique to vascular endothelial cells. The observation that peripheral blood monocytes also express this VEC antigen system made prospective testing feasible. Preformed antibody to the VEC/monocyte antigen system of the donor usually leads to...

journal_title：Transplantation

authors： Cerilli J,Brasile L,Galouzis T,Lempert N,Clarke J

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:T-cell receptor transgenic (TCR-tg) mouse models with direct CD4 alloreactivity will help elucidate mechanisms of transplant rejection and tolerance in vivo. Although such models exist, they are limited by unusual strain combinations or are based on model antigens. METHODS:A TCR-tg mouse with direct CD4 spe...

journal_title：Transplantation

authors： Brennan TV,Hoang V,Garrod KR,Liu FC,Hayden T,Kim J,Kang SM

更新日期：2008-01-27 00:00:00

abstract：:To determine the degree of graft versus host disease (GVHD) prophylaxis that might be necessary if cord blood (CB) transplantation is more widely applied, we compared human cord blood mononuclear cell (CBMC) and adult peripheral blood mononuclear cell (PBMC) proliferative responses and stimulatory capabilities; to exa...

journal_title：Transplantation

authors： Greenfeld JI,Noizat-Pirenne F,Hardy MA,Oluwole SF,Hesdorffer CA,Preti RA,De Groote D,Franchimont P

更新日期：1994-08-27 00:00:00

abstract：:The production and release of cytokines and their receptors are of critical importance in mediating graft injury. In order to evaluate the expression of cytokines in renal allograft biopsies, we performed immunocytochemical studies to detect activated cells positive for TNF-alpha, IFN-gamma, and IL-2R, using an alkali...

journal_title：Transplantation

authors： Noronha IL,Eberlein-Gonska M,Hartley B,Stephens S,Cameron JS,Waldherr R

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:To evaluate the long-term outcome of renal transplant patients with membranoproliferative glomerulonephritis (MPGN) type I and the impact of recurrence. METHODS:The outcomes of 68 renal transplants performed between 1976 and 2009 in 63 patients with MPGN were compared with those of 136 controls matched for ...

journal_title：Transplantation

authors： Moroni G,Casati C,Quaglini S,Gallelli B,Banfi G,Montagnino G,Messa P

更新日期：2011-06-15 00:00:00

abstract：BACKGROUND:The deceased donor score (DDS), expanded criteria donor (ECD) definition, and resistive index (RI) were developed for pretransplant evaluation of donors. DDS and ECD are determined by a calculation of risk from donor variables, while RI is determined from flow characteristics of kidneys during machine preser...

journal_title：Transplantation

authors： Nyberg SL,Baskin-Bey ES,Kremers W,Prieto M,Henry ML,Stegall MD

更新日期：2005-10-15 00:00:00

abstract：BACKGROUND:Immunosuppressive regimens for kidney transplantation which reduce the long-term burden of immunosuppression are attractive, but little data are available to judge the safety and efficacy of the different strategies used. We tested the hypothesis that the simple, cheap, regimen of alemtuzumab induction combi...

journal_title：Transplantation

authors： Chan K,Taube D,Roufosse C,Cook T,Brookes P,Goodall D,Galliford J,Cairns T,Dorling A,Duncan N,Hakim N,Palmer A,Papalois V,Warrens AN,Willicombe M,McLean AG

更新日期：2011-10-15 00:00:00

abstract：:Clearance studies were performed in 32 transplanted children treated with CsA in combination with low-dose prednisolone (CsA group), and the results were compared with those of 29 children transplanted earlier and treated with azathioprine and prednisolone (CIS group). Serum creatinine and urea levels 6 weeks and 1 ye...

journal_title：Transplantation

authors： Hoyer PF,Krohn HP,Offner G,Byrd DJ,Brodehl J,Wonigeit K,Pichlmayr R

更新日期：1987-04-01 00:00:00

abstract：:Modification of pathogenic antibodies for autoimmune diseases illuminated the biologic relevance of B cells, plasma cells, and pathogenic antibodies in autoimmunity. They have also rejuvenated interest in how B cells mediate multiple effector functions that include antibody production, antigen presentation to T cells,...

journal_title：Transplantation

authors： Jordan SC,Ammerman N,Choi J,Huang E,Peng A,Sethi S,Najjar R,Toyoda M,Lim K,Louie S,Vo A

更新日期：2019-02-01 00:00:00

abstract：:We developed a new and simplified donor-specific blood transfusion (DSBT) protocol for prospective kidney transplant recipients from one-haplotype-mismatched related donors. Prospective kidney donors gave 450 ml of blood in a quad-pack unit, and the blood was stored in a blood bank. Twenty-five patients were transfuse...

journal_title：Transplantation

authors： Cheigh JS,Suthanthiran M,Kaplan M,Evelyn M,Riggio RR,Fotino M,Schechter N,Wolf CF,Stubenbord WT,Stenzel KH

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:The use of anti-B-cell and T-cell immunosuppressive agents leads to only a few weeks' survival of mouse-to-rat cardiac xenografts. METHODS:BALB/c cardiac xenografts were transplanted to Lewis rats treated with cyclosporine (CsA) and/or cobra venom factor (CVF). RESULTS:CsA alone did not prolong xenograft s...

journal_title：Transplantation

authors： Koyamada N,Miyatake T,Candinas D,Mark W,Hechenleitner P,Hancock WW,Soares MP,Bach FH

更新日期：1998-05-15 00:00:00

abstract：BACKGROUND:Simultaneous liver-kidney (SLK) transplantation plays an important role in treating kidney failure in patients with end-stage liver disease. It used 5% of deceased donor kidney transplanted in 2015. We evaluated the utility, defined as posttransplant kidney allograft lifespan, of this practice. METHODS:Usin...

journal_title：Transplantation

authors： Cheng XS,Stedman MR,Chertow GM,Kim WR,Tan JC

更新日期：2017-05-01 00:00:00

abstract：:Research in hepatocellular gene therapy requires a consistently reproducible cell marker to detect transplanted hepatocytes. We have used a Y-specific genomic DNA probe to accomplish this goal. This technique enables the identification of transplanted male cells in recipient female tissues. Donor hepatocytes from male...

journal_title：Transplantation

authors： Eckert JW,Buerkle CJ,Major AM,Finegold MJ,Brandt ML

更新日期：1995-01-15 00:00:00

abstract：BACKGROUND:Sirolimus (SRL) seems to impair renal recovery from ischemic injury in animal models and delayed graft function after clinical renal transplantation. This study determined the impact of SRL on renal recovery after ischemia-reperfusion injury in a rat kidney transplant model. METHODS:Syngeneic kidneys were p...

journal_title：Transplantation

authors： Fuller TF,Freise CE,Serkova N,Niemann CU,Olson JL,Feng S

更新日期：2003-12-15 00:00:00

abstract：BACKGROUND:Both T and B cells have been shown to be implicated in the pathogenesis of bronchiolitis obliterans syndrome, which is considered to represent chronic lung allograft rejection. However, the relative contributions of T cells and alloantibodies in the pathogenesis of the disease are still unknown. In this stud...

journal_title：Transplantation

authors： Higuchi T,Jaramillo A,Kaleem Z,Patterson GA,Mohanakumar T

更新日期：2002-09-15 00:00:00

abstract：:Differentiation between rejection and infection of lung allografts remains difficult. The effects of these two pathologic entities on the cytolytic activity of bronchoalveolar lavage (BAL) and PBL were investigated. Left lung allotransplantation was performed on 16 mongrel dogs of which 12 were available for complete ...

journal_title：Transplantation

authors： Nguyen DM,Mulder DS,Shennib H

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Elastase released from activated neutrophils is an important mediator of inflammatory tissue damage. We investigated the effect of human neutrophil elastase (NE) inhibitor (ONO-5046) on reperfusion injury after pancreaticoduodenal transplantation in rats by measuring the expression of intercellular adhesion ...

journal_title：Transplantation

authors： Yamaguchi Y,Matsumura F,Wang FS,Akizuki E,Liang J,Matsuda T,Okabe K,Ohshiro H,Horiuchi T,Yamada S,Mori K,Ogawa M

更新日期：1998-06-27 00:00:00

abstract：BACKGROUND:Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than for liver transplants performed for other causes of chronic liver disease. The factors responsible for the inferior outcome in HCV+ recipients, and whether they differ from factors associated with survival in HC...

journal_title：Transplantation

authors： Velidedeoglu E,Mange KC,Frank A,Abt P,Desai NM,Markmann JW,Reddy R,Markmann JF

更新日期：2004-06-27 00:00:00

abstract：BACKGROUND:Acute rejection of allografts remains a significant problem in clinical transplantation, and the fundamental mechanism underlying this rejection are as yet only poorly elucidated. Recently, DNA microarrays have come into use for the study of gene expression profiles, and we have taken advantage of this new t...

journal_title：Transplantation

authors： Saiura A,Mataki C,Murakami T,Umetani M,Wada Y,Kohro T,Aburatani H,Harihara Y,Hamakubo T,Yamaguchi T,Hasegawa G,Naito M,Makuuchi M,Kodama T

更新日期：2001-07-27 00:00:00

abstract：BACKGROUND:Historically, ex vivo physiological evaluation of cadaveric renal allografts has been limited to assessing perfusate flow (PF) during hypothermic perfusion preservation (HPP). Using a small animal model, we have previously described a method for continuous monitoring of glomerular filtration rate (GFR) durin...

journal_title：Transplantation

authors： Inman SR,Osgood RW,Plott WK,Richardson BF,Lewis RM

更新日期：1999-11-27 00:00:00

abstract：INTRODUCTION:The importance of HLA matching for renal transplantation outcomes has been appreciated for several decades. It has been hypothesized that as pharmacologic immunosuppression becomes stronger and more specific, the impact of HLA matching may be vanishing. Mycophenolate Mofetil (MMF) has been demonstrated to ...

journal_title：Transplantation

authors： Meier-Kriesche HU,Ojo AO,Leichtman AB,Magee JC,Rudich SM,Hanson JA,Cibrik DM,Kaplan B

更新日期：2001-02-15 00:00:00

abstract：BACKGROUND:Delayed xenograft rejection (DXR) remains a roadblock to successful xenotransplantation. A feature of DXR is early recruitment of monocytes to the xenograft. Naïve human monocytes can recognize and adhere to unstimulated porcine aortic endothelial cells (PAEC) more than human aortic endothelial cells, partly...

journal_title：Transplantation

authors： Greenwald AG,Jin R,Waddell TK

更新日期：2009-01-15 00:00:00

abstract：BACKGROUND:The role of human herpesvirus (HHV)-8 in the pathogenesis of multiple myeloma and its pre-malignant state of monoclonal gammopathy is unclear. HHV-8 is transmitted by organ transplantation, representing a unique model with which to investigate primary HHV-8 infection. METHODS:The authors studied the inciden...

journal_title：Transplantation

authors： Regamey N,Hess V,Passweg J,Hess C,Steiger J,Erb P,Cathomas G,Tamm M

更新日期：2004-05-27 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (HCMV) infection is associated with allograft vasculopathy and rejection. One potential mechanism is vascular injury from immunologically mediated processes. HCMV infection has been shown to increase the constitutive expression of intercellular adhesion molecule-1 (ICAM-1). The objectiv...

journal_title：Transplantation

authors： Burns LJ,Pooley JC,Walsh DJ,Vercellotti GM,Weber ML,Kovacs A

更新日期：1999-01-15 00:00:00

abstract：:Orthotopic liver allografts from BN donors to LEW recipients are spontaneously accepted, and the recipients develop donor-specific immunological unresponsiveness. This unresponsiveness may be mediated by suppressor T cells. Immunomagnetically purified splenic T cells from LEW rats bearing BN liver grafts were shown to...

journal_title：Transplantation

authors： Gassel HJ,Hutchinson IV,Engemann R,Morris PJ

更新日期：1992-12-01 00:00:00

abstract：:Precision medicine is an emerging integrative approach for disease prevention, early detection, and treatment which takes into account individual variability in genetic and other molecular measurements, medical history, environmental exposures, and lifestyle. The development and availability of genomic and other molec...

journal_title：Transplantation

authors： Sirota M,Sarwal MM

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Recently, TT virus (TTV) was discovered as a potential causative agent for non-A-E hepatitis. Little is known about the prevalence of TTV infection in renal transplant recipients. METHODS:One hundred and seventeen Brazilian renal transplant recipients and 100 normal subjects were examined to determine the p...

journal_title：Transplantation

authors： Yokosuka O,Ikeuchi T,Kanda T,Kawai S,Imazeki F,Saisho H,Mazzalli M,Filho GA,Nishimura NF,Soares EC

更新日期：2000-10-27 00:00:00