Neutrophil elastase enhances intercellular adhesion molecule-1 expression.

Abstract:

BACKGROUND:Elastase released from activated neutrophils is an important mediator of inflammatory tissue damage. We investigated the effect of human neutrophil elastase (NE) inhibitor (ONO-5046) on reperfusion injury after pancreaticoduodenal transplantation in rats by measuring the expression of intercellular adhesion molecule-1 (ICAM-1). Additional in vitro experiments were conducted to investigate the effect of NE on ICAM-1 mRNA transcription in a rat endothelial cell line (WK-5) and human umbilical vein endothelial cells (HUVEC). METHODS:In an in vivo experiment, male Wistar rats were transplanted with syngeneic pancreaticoduodenal grafts. An NE inhibitor, ONO-5046, was injected intravenously 5 min before vascular clamping and immediately after reperfusion at a dose of 10 mg/kg. ICAM-1 expression was determined by immunostaining and Northern analysis. In in vitro experiments, the effects of NE and chemical agents on ICAM-1 mRNA transcripts were determined in WK-5 cells and HUVEC. RESULTS:Pretreatment with ONO-5046 decreased ICAM-1 immunostaining in the pancreatic graft and inhibited the increase in ICAM-1 mRNA levels in grafts after reperfusion. ICAM-1 mRNA levels in WK-5 cells and HUVEC showed stimulation by NE, while ONO-5046 inhibited this increase. Calcium ionophore (A23187) augmented NE stimulation of ICAM-1 mRNA levels in these cells. In contrast, a phospholipase C inhibitor (U73122) blunted NE induction of ICAM-1 mRNA, and either calcium chelator (TMB-8) or a nuclear factor-kappa B inhibitor (pyrrolidine dithiocarbamate) completely inhibited induction. CONCLUSION:These results indicate that NE stimulates ICAM-1 expression in pancreatic grafts via intracellular Ca2+ influx and a phospholipase C signal transduction.

journal_name

Transplantation

journal_title

Transplantation

authors

Yamaguchi Y,Matsumura F,Wang FS,Akizuki E,Liang J,Matsuda T,Okabe K,Ohshiro H,Horiuchi T,Yamada S,Mori K,Ogawa M

doi

10.1097/00007890-199806270-00014

subject

Has Abstract

pub_date

1998-06-27 00:00:00

pages

1622-8

issue

12

eissn

0041-1337

issn

1534-6080

journal_volume

65

pub_type

杂志文章
  • Enhancement of allograft survival by donor-specific transfusion one day prior to transplant. Importance of timing and specificity when DST is given with cyclosporine.

    abstract::Donor-specific transfusion effects were studied in the ACI-to-Lewis rat heterotopic heart allograft model using cyclosporine immunosuppression. Low-dose CsA for 1 week plus a single fresh or stored DST given 1 day before allografting significantly prolonged graft survival over CsA therapy alone (median survival time 2...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199109000-00032

    authors: Brunson ME,Tchervenkov JI,Alexander JW

    更新日期:1991-09-01 00:00:00

  • Comparison of specific radioimmunoassays for cyclosporine.

    abstract::This study compares two recently introduced radioimmunoassay kits involving specific monoclonal antibodies to cyclosporine. One kit (Sandimmun) involved 3H-labeled CsA (3H-CsA) as tracer and the other (CY-CLO-Trac-SP) involved a 125I-labeled conjugated derivative of CsA. The kits were nearly equivalent in method perfo...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198904000-00019

    authors: Sgoutas DS,Hammarstrom M

    更新日期:1989-04-01 00:00:00

  • Urine cytokines profile in renal transplant patients with asymptomatic bacteriuria.

    abstract:BACKGROUND:The role of asymptomatic bacteriuria in kidney transplant recipients is unknown. There is no clear evidence of its effect on transplanted kidney. METHODS:We studied urine cytokines profile among kidney transplant recipients with bacteriuria found in screening examination. Urine cultures were collected in 26...

    journal_title:Transplantation

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    doi:10.1097/01.tp.0000226072.20185.f8

    authors: Ciszek M,Paczek L,Bartłomiejczyk I,Mucha K

    更新日期:2006-06-27 00:00:00

  • Renal transplantation in multiple myeloma. Case report and review of the literature.

    abstract::A patient with end-stage renal disease and known benign monoclonal gammopathy underwent kidney transplantation at Westchester County Medical Center, Valhalla, NY. After surgery, during routine follow-up, the patient had laboratory evidence of frank multiple myeloma. However, she did not show any clinical signs or symp...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/00007890-199612150-00008

    authors: Dagher F,Sammett D,Abbi R,Tomasula JR,Delaney V,Butt KM

    更新日期:1996-12-15 00:00:00

  • Evaluation and clinical significance of circulating immune complexes after renal transplantation.

    abstract::Using C1q binding, Kg binding, and Raji cell radioimmunoassays, the relationship between renal allograft rejection and the circulating immune complexes was examined in 90 patients with renal transplants. The data showed that there was a significant quantitative correlation between C1q-binding and Raji-cell-binding act...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198308000-00009

    authors: Fukuda M

    更新日期:1983-08-01 00:00:00

  • Evidence for the involvement of host-derived OKT8-positive T cells in the rejection of T-depleted, HLA-identical bone marrow grafts.

    abstract::The recent introduction of a variety of techniques for removing T cells from bone marrow grafts has reduced the incidence of graft-versus-host disease (GVHD)-associated morbidity and mortality. Whether this advance will be translated into improved patient survival is unclear at present, mainly because these procedures...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198704000-00009

    authors: Bunjes D,Heit W,Arnold R,Schmeiser T,Wiesneth M,Carbonell F,Porzsolt F,Raghavachar A,Heimpel H

    更新日期:1987-04-01 00:00:00

  • The successful allotransplantation of neonatal rat islets across multiple combined major and minor histocompatibility barriers.

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198712000-00003

    authors: Serie JR,Hegre OD,Eide CR,Weinhaus AJ,Marshall S

    更新日期:1987-12-01 00:00:00

  • Effect of preprocurement ventilation on lungs donated after cardiac death in a canine lung transplantation model.

    abstract:BACKGROUND:One method of countering chronic lung donor shortages is the practice of donation after cardiac death (DCD). However, this technique inevitably leads to pulmonary dysfunction related to warm ischemia. One promising method of alleviating this problem is ventilation. However, it can rarely be initiated from th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31822d87c6

    authors: Sakamoto J,Chen F,Yamada T,Nakajima D,Ohsumi A,Kikuchi R,Zhao X,Fujinaga T,Shoji T,Sakai H,Bando T,Date H

    更新日期:2011-10-27 00:00:00

  • The presence of activated donor HLA class I-reactive T lymphocytes is associated with rejection of corneal grafts.

    abstract::Although the cornea is considered to be an immunological privileged site, corneal transplantation can result in immunological rejection followed by graft failure, especially in patients with vascularized corneas. Several studies suggest a beneficial effect of matching for the HLA class I antigens on corneal graft surv...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199504150-00021

    authors: Roelen DL,van Beelen E,van Bree SP,van Rood JJ,Völker-Dieben HJ,Claas FH

    更新日期:1995-04-15 00:00:00

  • Screening for de novo anti-human leukocyte antigen antibodies in nonsensitized kidney transplant recipients does not predict acute rejection.

    abstract:BACKGROUND:The purpose of this study was to determine whether screening for anti-human leukocyte antigen (HLA) antibodies (Abs) could predict development of acute rejection (AR) before clinical evidence of kidney allograft dysfunction in nonsensitized recipients. METHODS:Eighty-four non-HLA identical kidney transplant...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181c3503e

    authors: Gill JS,Landsberg D,Johnston O,Shapiro RJ,Magil AB,Wu V,Tinckam K,Keown P

    更新日期:2010-01-27 00:00:00

  • Respiratory tract viral infections in bone marrow transplant patients.

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000072012.26176.58

    authors: Raboni SM,Nogueira MB,Tsuchiya LR,Takahashi GA,Pereira LA,Pasquini R,Siqueira MM

    更新日期:2003-07-15 00:00:00

  • Noninvasive prognostication of polyomavirus BK virus-associated nephropathy.

    abstract:BACKGROUND:BK virus-associated nephropathy (BKVN) is associated with an increased risk of graft failure. METHODS:Levels of mRNAs encoding proteins implicated in inflammation and fibrosis were measured in urine collected at the time of biopsy diagnosis of BKVN in 29 kidney graft recipients and analyzed for prognosticat...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31829acb38

    authors: Dadhania D,Snopkowski C,Muthukumar T,Lee J,Ding R,Sharma VK,Christos P,Bang H,Kapur S,Seshan SV,Suthanthiran M

    更新日期:2013-07-27 00:00:00

  • The effect of chronic graft-versus-host disease on B cell development.

    abstract::Chronic graft-versus-host disease often results in a combined deficiency of humoral and cell-mediated immunity. Clinical and experimental studies have suggested that the decrease in B cell responsiveness is due to a failure of B cell production in the bone marrow, intrinsic B cell defects, excessive suppressor T cell ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199303000-00025

    authors: Schreiber KL,Forman J

    更新日期:1993-03-01 00:00:00

  • Cell transplantation of genetically altered cells on biodegradable polymer scaffolds in syngeneic rats.

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199308000-00033

    authors: Gilbert JC,Takada T,Stein JE,Langer R,Vacanti JP

    更新日期:1993-08-01 00:00:00

  • Thymectomy impairs but does not uniformly abrogate long-term acceptance of semi-identical liver allograft in inbred miniature Swine temporarily treated with FK506.

    abstract:BACKGROUND:Long-term acceptance of semi-identical orthotopic liver transplants (OLTs) in inbred swine is induced by a 12-day course of FK506. To study whether acceptance is attributable to central or peripheral immune mechanisms, the effect of complete thymectomy was determined. METHODS:Total thymectomy was performed ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000121762.47432.15

    authors: Uryuhara K,Ambiru S,Dehoux JP,Oike F,Talpe S,Gianello P

    更新日期:2004-04-27 00:00:00

  • Mechanisms of acquired thymic unresponsiveness to renal allografts. Thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy.

    abstract::We have recently shown that a single intrathymic injection of synthetic 25mer peptides, representing full sequences of the hypervariable domain of RT1.BuB (4 peptides) and RT1.Du beta (4 peptides) WF class II MHC molecules, 48 hr before transplantation induces donor-specific unresponsiveness to WF rat renal allografts...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Sayegh MH,Perico N,Gallon L,Imberti O,Hancock WW,Remuzzi G,Carpenter CB

    更新日期:1994-07-27 00:00:00

  • Exercise training in solid organ transplant recipients: a systematic review and meta-analysis.

    abstract:BACKGROUND:Exercise training is effective in improving the cardiovascular risk profiles of nontransplanted patients, but the health benefits and potential harms of routine exercise training after solid organ transplantation are unclear. This study aims to assess the health benefits and harms of supervised exercise trai...

    journal_title:Transplantation

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/TP.0b013e31827a3d3e

    authors: Didsbury M,McGee RG,Tong A,Craig JC,Chapman JR,Chadban S,Wong G

    更新日期:2013-03-15 00:00:00

  • Parvovirus B19 infection-related complications in renal transplant recipients: treatment with intravenous immunoglobulin.

    abstract:BACKGROUND:Chronic red cell aplasia can develop in immunocompromised patients including transplant recipients infected with parvovirus B19 (PV B19). Renal involvement with PV B19 infection is not well-recognized. METHODS:We diagnosed erythroid hypoplasia associated with PV B19 infection in three renal transplant recip...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199712270-00037

    authors: Moudgil A,Shidban H,Nast CC,Bagga A,Aswad S,Graham SL,Mendez R,Jordan SC

    更新日期:1997-12-27 00:00:00

  • Development of IgA deficiency after bone marrow transplantation. The influence of acute and chronic graft-versus-host disease.

    abstract::Serum IgA levels were monitored at 3, 6, 12, and 24 months after BMT in 131 allogeneic and 3 syngeneic bone marrow transplant recipients. In general, IgA levels were low during the first 6 months and did not return to normal levels until 1-2 years after transplantation. Children (less than 15 years) had lower IgA leve...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199009000-00012

    authors: Abedi MR,Hammarström L,Ringdén O,Smith CI

    更新日期:1990-09-01 00:00:00

  • Human heart endothelial-cell-restricted allorecognition.

    abstract::We studied the reactivity of cardiac graft-infiltrating cells, cultured from endomyocardial biopsy specimens, toward heart endothelial cells (Hec). In two cases, Hec derived from the specific donor heart or Hec compatible with the donor were lysed, but not the syngeneic B cell line. A vessel-derived endothelial cell l...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199608150-00017

    authors: Jutte NH,Knoop CJ,Heijse P,Balk AH,Mochtar B,Claas FH,Weimar W

    更新日期:1996-08-15 00:00:00

  • Characteristics of dendritic cells in rat liver.

    abstract::The properties of rat liver dendritic cells (DC) were analyzed after collagenase digestion of the tissue and enrichment with density gradient centrifugation. The liver macrophages (Kupffer cells) were eliminated by adherence before the gradient centrifugation. The morphology of isolated DC in May-Grunwald-Giemsa (MGG)...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198805000-00019

    authors: Lautenschlager I,Halttunen J,Häyry P

    更新日期:1988-05-01 00:00:00

  • Pharmacokinetics of methylprednisolone and rejection episodes in kidney transplant patients.

    abstract::Rejection crises after kidney transplantation could be associated with individual variability of pharmacokinetic parameters of steroids. We therefore investigated the individual pharmacokinetics of methylprednisolone on day 2 (60 mg intravenously) and day 4 (60 mg per os) in 40 patients after kidney transplantation. M...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199508270-00005

    authors: Keller F,Hemmen T,Schöneshöfer M,Schwarz A,Offermann G

    更新日期:1995-08-27 00:00:00

  • Renal transplant from very old donors: how far can we go?

    abstract:BACKGROUND:The organ shortage has led many transplant centers to accept kidneys from old, suboptimal deceased donors, and make increasing use of old-for-old allocation systems. We report the experience of an Italian transplant center in the utilization of "ultra-old" (>75 years old) donors. METHODS:Sixty grafts from d...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181a6b4ff

    authors: Collini A,Kalmar P,Dhamo A,Ruggieri G,Carmellini M

    更新日期:2009-06-27 00:00:00

  • Kidney transplantation with minimized maintenance: alemtuzumab induction with tacrolimus monotherapy--an open label, randomized trial.

    abstract:BACKGROUND:Immunosuppressive regimens for kidney transplantation which reduce the long-term burden of immunosuppression are attractive, but little data are available to judge the safety and efficacy of the different strategies used. We tested the hypothesis that the simple, cheap, regimen of alemtuzumab induction combi...

    journal_title:Transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/TP.0b013e31822ca7ca

    authors: Chan K,Taube D,Roufosse C,Cook T,Brookes P,Goodall D,Galliford J,Cairns T,Dorling A,Duncan N,Hakim N,Palmer A,Papalois V,Warrens AN,Willicombe M,McLean AG

    更新日期:2011-10-15 00:00:00

  • Evaluation of Low- Versus High-dose Valganciclovir for Prevention of Cytomegalovirus Disease in High-risk Renal Transplant Recipients.

    abstract:BACKGROUND:Despite proven efficacy of prolonged cytomegalovirus (CMV) prophylaxis using valganciclovir 900 mg/day, some centers use 450 mg/day due to reported success and cost savings. This multicenter, retrospective study compared the efficacy and safety of 6 months of low-dose versus high-dose valganciclovir prophyla...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1097/TP.0000000000000570

    authors: Gabardi S,Asipenko N,Fleming J,Lor K,McDevitt-Potter L,Mohammed A,Rogers C,Tichy EM,Weng R,Lee RA

    更新日期:2015-07-01 00:00:00

  • Accommodation: does it apply to human leukocyte antigens?

    abstract::The term "accommodation" was invoked to describe endothelial cell resistance to antibody-mediated rejection after ABO-incompatible kidney or experimental xenograft transplantation. Currently, there is much interest in how to achieve successful human leukocyte antigen (HLA)-incompatible allograft transplantation in HLA...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31823f468c

    authors: Rose ML,West LJ

    更新日期:2012-02-15 00:00:00

  • Management of posttransplant lymphoproliferative disease in pediatric liver transplant recipients receiving primary tacrolimus (FK506) therapy.

    abstract:BACKGROUND:Posttransplant lymphoproliferative disease (PTLD) after pediatric liver transplantation has been associated with high mortality rates. METHODS:The present study examined 282 consecutive pediatric liver transplant recipients from October 1989 to June 1996 who received primary tacrolimus immunosuppression. Th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199810270-00014

    authors: Cacciarelli TV,Green M,Jaffe R,Mazariegos GV,Jain A,Fung JJ,Reyes J

    更新日期:1998-10-27 00:00:00

  • The effects of inhaled nitric oxide, gabexate mesilate, and retrograde flush in the lung graft from non-heart beating minipig donors.

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200005270-00008

    authors: Luh SP,Tsai CC,Shau WY,Chen JS,Kuo SH,Lin-Shiau SY,Lee YC

    更新日期:2000-05-27 00:00:00

  • Sensitization with xenogeneic tissues alters the heavy chain repertoire of human anti-Galalpha1-3Gal antibodies.

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000162976.07023.6d

    authors: Yu PB,Parker W,Nayak JV,Platt JL

    更新日期:2005-07-15 00:00:00

  • Early indices of warm ischemic damage in autotransplanted canine kidneys preserved by simple hypothermic storage.

    abstract::After measurement of normal renal function, dog kidneys (n = 52) were subjected to 3, 15, or 30 min of normothermic warm ischemia (WI). After 24 hr of preservation by simple hypothermic storage (SHS) in a modified Collins solution, autotransplant was done and renal function was again measured beginning at 1 hr. Compar...

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    pub_type: 杂志文章

    doi:10.1097/00007890-198611000-00003

    authors: Gregg CM,Lai MK,Mandour WA,Linke CA

    更新日期:1986-11-01 00:00:00