Abstract:
:Electrolytic lesions were produced in the tuberal hypothalamus and amygdala of male Fischer and female BNLF1 rats, and in male Fischer and female BNLF1 rats that had received antecedent hypophysectomies. Skin grafts from Lewis rats survived less well on tuberal-lesioned male Fischer rats than similar grafts on sham-operated and amygdala-lesioned male Fischer rats. Lewis skin graft survival was also curtailed in male Fischer rats that had received hypophysectomies followed by tuberal lesions. These differences were not apparent across the male to female (H-Y) BNLF1 histocompatibility barrier. We conclude: (1) that tuberal hypothalamic lesions stimulate allograft reactivity in rats, (2)that this response is greater when the immunogenetic disparity between donor and host is greater, and (3) that the mechanism governing this response involves a direct neural pathway which bypasses the hypothalamic-hypophyseal axis.
journal_name
Transplantationjournal_title
Transplantationauthors
Dann JA,Wachtel SS,Rubin ALdoi
10.1097/00007890-197904000-00002subject
Has Abstractpub_date
1979-04-01 00:00:00pages
223-6issue
4eissn
0041-1337issn
1534-6080journal_volume
27pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::The calcineurin inhibitors (CNIs) have been the cornerstone of immunosuppressive therapy in recent years, though their association with dose-related nephrotoxicity is a major factor in the development of chronic allograft nephropathy in kidney transplant recipients. The novel proliferation signal inhibitor everolimus ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000162434.62591.f3
更新日期:2005-05-15 00:00:00
abstract::BACKGROUND.: Reduced levels of serum adiponectin, an adipokine, are associated with cardiovascular and obesity-related diseases; however, relations between adiponectin and hypertension are unclear. METHODS.: This cross-sectional study examined adiponectin and ambulatory blood pressure monitoring (ABPM) in 33 pediatric...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b9e1ec
更新日期:2009-10-27 00:00:00
abstract::We initiated a policy of using RSLT in critically ill patients in June of 1988. Since that time we have performed 30 RSLTs in 29 patients, including 28 children and 1 adult. The mean age of the children was 27 months (range 1 month to 10 years) with 14 (52%) being 1 year of age or less. The mean weight was 11.3 kg (ra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199202010-00023
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether screening for anti-human leukocyte antigen (HLA) antibodies (Abs) could predict development of acute rejection (AR) before clinical evidence of kidney allograft dysfunction in nonsensitized recipients. METHODS:Eighty-four non-HLA identical kidney transplant...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c3503e
更新日期:2010-01-27 00:00:00
abstract:BACKGROUND:Liver transplantation (LT) represents a curative treatment for small hepatocellular carcinoma (HCC). Potentially curable higher-stage HCC patients are denied LT due to the lack of cancer markers that predict progression and recurrence. METHODS:Thirty-eight candidates for LT with hepatitis C virus (HCV) cirr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000258643.05294.0b
更新日期:2007-04-15 00:00:00
abstract::Influenza vaccination has been strongly recommended for immunosuppressed renal transplant recipients. However, immunosuppression may lead to impaired antibody responses. We studied the antibody response to an inactivated trivalent influenza vaccine in 59 renal transplant recipients with life-sustaining kidney function...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198610000-00009
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptimal donor livers before implantation. Our aim was to assess the diagnostic accuracy of bile biochemistry for the assessment of bile duct injury (BDI). METHODS:In a preclinical study, 23 human donor livers underwent 6 hour...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002500
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:HMG-CoA reductase inhibitors play several roles in the maintenance of organ transplants. We investigated the role of pitavastatin, a potent and newly developed HMG-CoA reductase inhibitor, in cardiac allograft rejection and mechanism of graft arterial disease (GAD) suppression. METHODS:Balb/c mice hearts ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000259650.67061.16
更新日期:2007-04-27 00:00:00
abstract::In 33 renal allograft recipient-donor pairs, B and T lymphocyte complement-dependent cytotoxicity crossmatches and mixed lymphocyte culture (MLC) blocking experiments were performed and the results were correlated with graft outcome. MLC blocking particularly in the unidirectional culture against donor-stimulating cel...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197804000-00002
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:Proteinuria is associated with endothelial dysfunction (ED) and increased mortality. We investigated whether urinary protein excretion (UPE) is correlated with markers of ED and whether these markers affect the association of proteinuria with mortality in renal transplant recipients (RTR). METHODS:Six hundr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181903d25
更新日期:2008-12-27 00:00:00
abstract::Polymerase chain reaction (PCR) amplification of CMV DNA recovered from bronchial alveolar lavage (BAL) and peripheral blood samples was compared with tissue culture, cytology, and/or histology for the earlier detection of CMV pneumonitis in 12 recipients of single-lung or heart/lung transplants. In patients with conf...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199308000-00017
更新日期:1993-08-01 00:00:00
abstract::Prominent components of vascularized xenograft rejection such as platelet activation and microvascular thrombosis may be dependent upon thrombin generation in vivo. To study potential therapeutic benefits of a synthetic low-molecular-weight thrombin inhibitor, SDZ MTH 958, in hyperacute porcine heart rejection by huma...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603270-00003
更新日期:1996-03-27 00:00:00
abstract:BACKGROUND:Low-molecular-weight heparin (LMWH) has been shown to prolong survival of rat cardiac allografts independently from immunosuppressive treatment. Furthermore, long-term treatment reduces the development of chronic graft vascular disease after experimental heart transplantation. The aim of the present study wa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200107270-00007
更新日期:2001-07-27 00:00:00
abstract:BACKGROUND:Galbeta1-4GlcNAcalpha2-6 sialyltransferase (ST6GalI) is an acute phase reactant whose release from cells can be induced by proinflammatory cytokines. Because patients with chronic renal failure have high circulating levels of proinflammatory cytokines, we hypothesized that patients on the renal transplant wa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003150-00022
更新日期:2000-03-15 00:00:00
abstract::The pig has been considered unsuitable for experimental pancreatic transplantation. In order to develop a model for segmental transplantation, the vascular anatomy was studied in 41 pigs. No variation in venous drainage of the pancrease was found. In contrast, 3 variations of arterial supply were noted. In 29 of the p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00010
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Immunosuppressive regimens for kidney transplantation which reduce the long-term burden of immunosuppression are attractive, but little data are available to judge the safety and efficacy of the different strategies used. We tested the hypothesis that the simple, cheap, regimen of alemtuzumab induction combi...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e31822ca7ca
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:This study evaluates whether surgical strategies such as the portosystemic shunt and ischemic preconditioning can protect against hepatic and pulmonary injury associated with liver transplantation. METHODS:The effect of the portosystemic shunt, ischemic preconditioning, and both surgical procedures together...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000067529.82245.4E
更新日期:2003-07-27 00:00:00
abstract::Pre-existing alloantibodies against the mismatched HLA-A and HLA-B antigens of the donor, when present in current sera, are believed to be detrimental to kidney graft survival. When these antibodies are present only in historical sera, their immunoglobulin class has reported to be important with respect to the expecte...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199405150-00018
更新日期:1994-05-15 00:00:00
abstract::Chronic kidney disease is common in patients with multiple myeloma. Historically, individuals with end-stage renal disease and multiple myeloma did poorly with renal transplantation due to higher mortality rates from the malignancy itself or associated comorbidities. However, over the past 2 decades, there have been s...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000002449
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Human ehrlichiosis, a newly described zoonotic infection, can be classified as human monocytic ehrlichiosis (HME) or human granulocytic ehrlichiosis (HGE). Although the clinical manifestations of HME and HGE are similar, the type of leukocyte infected, the etiologic agent, and the tick vector are distinct. ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/00007890-199710270-00010
更新日期:1997-10-27 00:00:00
abstract::The proliferation and differentiation of donor hematopoietic progenitor cells in bone marrow transplantation (BMT) recipients is influenced by hematopoietic growth factors, which could derive from either T cells or adherent stromal bone marrow cells, or both. In this study of 20 BMT recipients, we asked whether T lymp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199004000-00010
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Combined treatments of mycophenolate mofetil (MMF) and losartan (LSRT) have synergistic effects on various renal diseases through their hemodynamic and anti-inflammatory effects. This study investigated whether MMF treatment is effective in inhibiting inflammatory processes in chronic cyclosporine A (CsA) ne...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000045034.48833.51
更新日期:2003-02-15 00:00:00
abstract::Portal vein thrombosis is the most common cause of portal hypertension in noncirrhotic patients. Variceal bleeding is difficult to treat in these patients, especially those with prehepatic diffuse portal mesenteric thrombosis. In a patient with refractory esophagogastroduodenal variceal bleeding as a result of diffuse...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000168344.16547.da
更新日期:2005-08-27 00:00:00
abstract::High levels of tumor necrosis factor-alpha, interleukin-2, and gamma-interferon appeared in the circulation of kidney transplant recipients after the first injection of the monoclonal antibody OKT3. This initial injection was systematically followed by fever. The three cytokines were released in all patients (n = 9), ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198904000-00008
更新日期:1989-04-01 00:00:00
abstract::BACKGROUND.: Rabbit antithymocyte globulins (rATGs) are known to convert CD4CD25FoxP3 T cells from healthy individuals to CD4CD25FoxP3 T cells. In this study, we investigated the effect of rATG on the induction of regulatory T cells (Tregs) from blood cells of patients with end-stage renal disease who are candidates f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c9cc7a
更新日期:2010-03-27 00:00:00
abstract::An increased frequency of kidney rejection has been reported in diabetic patients who have simultaneous pancreas and kidney transplantation compared with patients who have a kidney transplant alone. Kidney graft outcome is similar in the two groups. The mechanism for increased kidney graft rejection with a simultaneou...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199304000-00015
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:The inflammation response is modulated by the elaborated chemokine-chemokine receptor system, which also plays an important role in the development of acute rejection (AR). In this study, we hypothesized that functional genetic variants of some of these modulatory proteins might influence the outcome of AR. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000178378.53616.ca
更新日期:2005-11-15 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated that long-term tolerance of class I mismatched renal allografts in miniature swine is induced by a short course of cyclosporine (CyA), and that a total thymectomy 21 days before transplantation abrogates the induction of stable tolerance. We have now examined the effects of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199904270-00005
更新日期:1999-04-27 00:00:00
abstract::Endothelial cells, one of several in vivo host cells for cytomegalovirus (CMV), participate in solid organ allograft rejection in part through the expression of leukocyte adhesion molecules. The hypothesis that CMV infection alters the constitutive and induced expression of ELAM-1, ICAM-1, and VCAM-1 on infected human...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-12-27 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) infection after liver transplantation may occur in patients previously not exposed to the virus, but who receive an organ from a surface antigen (HBsAg)-negative, core antibody (HBcAb)-positive donor. The risk of HBV reactivation after liver transplantation in recipients that are HBsA...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200202150-00027
更新日期:2002-02-15 00:00:00