A simplified model for heterotopic rat heart transplantation.

Abstract:

:A technique for simplified heterotopic rat heart transplantation having only aorto-aortic anastomosis is presented. The heterotopic rt heart survives and functions well when one lung lobe is attached t the transplantation and functions as a reservoir. Iso- and allotransplants are compared by electrocardiogram (ECG) determination and histological examination. Isotransplants exhibited normal heart and lung throughout the 6-month observation period. allotransplants ceased to function by the 16th postoperative day, with the cessation of palpable heart beat over the abdominal wall by the 10th postoperative day. This simplified heterotopic rat heart transplantation model can be operated by nonsurgeons in an unhurried manner with minimal training in microvascular surgery, and can be applied to various transplantation immunological studies.

journal_name

Transplantation

journal_title

Transplantation

authors

Lee S,Macedo AR,Curtis GP,Lee D,Orloff MJ

doi

10.1097/00007890-198204000-00020

subject

Has Abstract

pub_date

1982-04-01 00:00:00

pages

438-42

issue

4

eissn

0041-1337

issn

1534-6080

journal_volume

33

pub_type

杂志文章
  • Characterization of antiidiotypic antibodies to donor HLA that develop after liver transplantation.

    abstract::Several studies have reported the development of antiidiotypic antibodies to anti-HLA alloantibodies in renal allograft transplant recipients, postulating their potential beneficial role in allograft survival. In order to evaluate the role of anti-HLA antiidiotypic antibodies in human liver transplant recipients and t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199308000-00037

    authors: Chauhan B,Phelan DL,Marsh JW,Mohanakumar T

    更新日期:1993-08-01 00:00:00

  • Results of a prospective randomized trial of sirolimus conversion in kidney transplant recipients on early corticosteroid withdrawal.

    abstract:BACKGROUND:The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. METHODS:The aim of this study was to determine the outcome of a prospective randomized trial...

    journal_title:Transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/TP.0b013e31822805d7

    authors: Heilman RL,Younan K,Wadei HM,Mai ML,Reddy KS,Chakkera HA,Gonwa TA

    更新日期:2011-10-15 00:00:00

  • Comparative analysis of the DST and Imuran-plus-DST protocols for live donor renal transplantation.

    abstract::We have done a comparative analysis of two consecutive clinical trials at our center: the first in 56 patients who received blood transfusions from their prospective donors (DST group), and the second in 36 patients who received such transfusions while they were taking Imuran in an attempt to reduce the incidence of s...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198336060-00009

    authors: Glass NR,Miller DT,Sollinger HW,Belzer FO

    更新日期:1983-12-01 00:00:00

  • Developing Statistical Models to Assess Transplant Outcomes Using National Registries: The Process in the United States.

    abstract::Created by the US National Organ Transplant Act in 1984, the Scientific Registry of Transplant Recipients (SRTR) is obligated to publicly report data on transplant program and organ procurement organization performance in the United States. These reports include risk-adjusted assessments of graft and patient survival,...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000000891

    authors: Snyder JJ,Salkowski N,Kim SJ,Zaun D,Xiong H,Israni AK,Kasiske BL

    更新日期:2016-02-01 00:00:00

  • The effect of agents which modulate levels of the cyclic nucleotides on human lymphotoxin secretion and activity in vitro.

    abstract::The ability of concanavalin-A (Con-A) to activate lymphocytes to secrete human lymphotoxin (LT) was tested in the presence of agents known to modify the intracellular levels of cyclic nucleotides (cAMP and cGMP). Lymphocytes were treated with these agents at different stages of activation: (1) during the first encount...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197510000-00010

    authors: Prieur AM,Granger GA

    更新日期:1975-10-01 00:00:00

  • Novel Therapeutic Approaches to Allosensitization and Antibody-mediated Rejection.

    abstract::Modification of pathogenic antibodies for autoimmune diseases illuminated the biologic relevance of B cells, plasma cells, and pathogenic antibodies in autoimmunity. They have also rejuvenated interest in how B cells mediate multiple effector functions that include antibody production, antigen presentation to T cells,...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000002462

    authors: Jordan SC,Ammerman N,Choi J,Huang E,Peng A,Sethi S,Najjar R,Toyoda M,Lim K,Louie S,Vo A

    更新日期:2019-02-01 00:00:00

  • Immunohistochemical study of actin binding protein (p55) in the human kidney.

    abstract:BACKGROUND:In clinical transplantation, "passenger" dendritic cells (DCs) in the allograft have been thought to induce allograft rejection. However, the presence of DCs in the normal human kidney is controversial. Most reports have relied on the examination of MHC class I and II antigen expression in combination with D...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199804150-00025

    authors: Sonderbye L,Meehan S,Palsson R,Ahsan N,Ladefoged J,Langhoff E

    更新日期:1998-04-15 00:00:00

  • Metabolic syndrome and atherosclerotic events in renal transplant recipients.

    abstract:BACKGROUND:Metabolic syndrome (MS) is a known cardiovascular risk factor in the general population. We explored the influence of MS on the occurrence of atherosclerotic events (AEs) after renal transplantation. METHODS:Three hundred thirty-seven renal transplant recipients were included in the study. Various parameter...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000266898.93894.3d

    authors: Courivaud C,Kazory A,Simula-Faivre D,Chalopin JM,Ducloux D

    更新日期:2007-06-27 00:00:00

  • Monocyte-derived dendritic cell precursors facilitate tolerance to heart allografts after total lymphoid irradiation.

    abstract:BACKGROUND:Previous studies have shown that posttransplant total lymphoid irradiation, anti-thymocyte globulin, and an intravenous donor blood cell infusion induce tolerance to ACI heart allografts in Lewis rat hosts. METHODS:In the current study, fresh ACI monocytes and dendritic cell precursors, derived from short-t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199811270-00004

    authors: Hayamizu K,Huie P,Sibley RK,Strober S

    更新日期:1998-11-27 00:00:00

  • Nitric oxide synthase activity in renal ischemia-reperfusion injury in the rat: implications for renal transplantation.

    abstract::Cadaveric kidney transplants with delayed graft function have poorer graft survival by an unknown mechanism. Nitric oxide, produced by nitric oxide synthase (NOS), has a proven role in both recovery of ischemia and promotion of rejection. We therefore wished to study the patterns of NOS activity in a model of renal is...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199702270-00002

    authors: Shoskes DA,Xie Y,Gonzalez-Cadavid NF

    更新日期:1997-02-27 00:00:00

  • Thrombolysis and endovascular stent placement for inferior vena caval thrombosis in a liver transplant recipient.

    abstract:BACKGROUND:Vascular complications remain an important cause of postoperative morbidity in liver transplant patients. Herein, we present an unusual case of nonanastomotic inferior vena cava (IVC) stenosis in a patient with a "piggyback" caval anastomosis. METHODS:A 59-year-old woman underwent liver transplantation usin...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199711150-00020

    authors: Orons PD,Hari AK,Zajko AB,Marsh JW

    更新日期:1997-11-15 00:00:00

  • Acute tubular necrosis after renal transplantation.

    abstract::We evaluated the influence of dialysis requiring acute tubular necrosis on patient survival, and kidney survival and function in all 182 patients who needed dialysis immediately after transplantation at the University of Minnesota Hospitals. When compared to matched control patients not requiring dialysis, there was n...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198003000-00016

    authors: Brophy D,Najarian JS,Kjellstrand CM

    更新日期:1980-03-01 00:00:00

  • Frequency analysis of donor-reactive cytotoxic T lymphocyte precursors in in allograft recipients. Lack of correlation with clinical outcome.

    abstract::The frequency of donor-reactive and of third party-reactive cytotoxic T lymphocyte precursors (CTLp) was determined by limiting dilution analysis in the peripheral blood of 13 liver allograft recipients before (pre-tpx) and at various intervals (4 to 22 months) after (post-tpx) transplantation. In 6 of 13 patients wit...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Eberspächer ML,Otto G,Herfarth C,Kabelitz D

    更新日期:1994-06-27 00:00:00

  • Recipient-reactive antibodies occur during development of acute graft-versus-host reaction after small bowel transplantation.

    abstract::After small bowel transplantation, not only rejection but also graft-versus-host reaction (GVHR) may occur. Donor T lymphocytes, transferred together with the graft, are a prerequisite for the development of GVHR. So far, however, little is known about the effector mechanisms in acute GVHR. It can be assumed that not ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199608150-00007

    authors: Johnsson C,Bengtsson M,Tufveson G

    更新日期:1996-08-15 00:00:00

  • Non-major histocompatibility system immunogenetic influences in rat renal allograft survival.

    abstract::H-1-incompatible rat renal allograft survival rates are strongly influenced by the non-major histocompatibility system (MHS) genes. The same H-1 (MHS) incompatibility tested on four different non-MHS backgrounds gave widely differing results ranging from 11 to 60% fractional survival between the best and the poorest (...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197805000-00006

    authors: Paris AM,Bishop C,Festenstein H,Gunther E

    更新日期:1978-05-01 00:00:00

  • VEGF-A and -C but not -B mediate increased vascular permeability in preserved lung grafts.

    abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent endothelial cell growth and permeability factor, expressed in the lung. Overexpression of VEGF is associated with increased vascular permeability in the early stage of acute lung injury in mice. The role of various forms of VEGF in transplantation-induced...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200206150-00003

    authors: Abraham D,Taghavi S,Riml P,Paulus P,Hofmann M,Baumann C,Kocher A,Klepetko W,Aharinejad S

    更新日期:2002-06-15 00:00:00

  • ICAM-1 induction on hepatocytes as a marker for immune activation of acute liver allograft rejection.

    abstract::Intercellular adhesion molecule-1 (ICAM-1) induction on hepatocytes was investigated in relation to acute liver allograft rejection, CMV infection, and systemic bacterial infections. Twenty-four liver transplant recipients underwent an episode of acute rejection, 13 developed a symptomatic clinical CMV infection, and ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199312000-00041

    authors: Lautenschlager IT,Höckerstedt KA

    更新日期:1993-12-01 00:00:00

  • High Tacrolimus Clearance Is a Risk Factor for Acute Rejection in the Early Phase After Renal Transplantation.

    abstract:BACKGROUND:Patients with high tacrolimus clearance eliminate more drug within a dose interval compared with those with low clearance. Delays in dosing time will result in transient periods of lower concentrations in high versus low clearance patients. Transient subtherapeutic tacrolimus concentrations may induce acute ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001796

    authors: Egeland EJ,Robertsen I,Hermann M,Midtvedt K,Størset E,Gustavsen MT,Reisæter AV,Klaasen R,Bergan S,Holdaas H,Hartmann A,Åsberg A

    更新日期:2017-08-01 00:00:00

  • Increased infections in liver transplant recipients with recurrent hepatitis C virus hepatitis.

    abstract::Infectious complications in patients with recurrent hepatitis C virus (HCV) hepatitis after liver transplantation were prospectively assessed and compared with those of all other liver transplant recipients without HCV hepatitis operated on during the same period. Major infections occurred in 64% (14/22) of the patien...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199602150-00014

    authors: Singh N,Gayowski T,Wagener MM,Marino IR

    更新日期:1996-02-15 00:00:00

  • Immunologic diagnosis of kidney rejection using FACS analysis of graft-infiltrating functional and activated T and NK cell subsets.

    abstract::In human organ transplantation, the correct diagnosis of rejection may be difficult using clinical and/or histopathologic criteria, and immunologic assays should therefore be considered. We have applied monoclonal antibodies in 2-color flow cytometric (FACS) analysis to study phenotypic patterns of kidney-infiltrating...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198905000-00014

    authors: Tötterman TH,Hanås E,Bergström R,Larsson E,Tufveson G

    更新日期:1989-05-01 00:00:00

  • Assessing relative risks of infection and rejection: a meta-analysis using an immune function assay.

    abstract:BACKGROUND:Long-term use of immunosuppressants is associated with significant morbidity and mortality in transplant recipients. A simple whole blood assay that has U.S. Food and Drug Administration clearance directly assesses the net state of immune function of allograft recipients for better individualization of thera...

    journal_title:Transplantation

    pub_type: 杂志文章,meta分析

    doi:10.1097/01.tp.0000234837.02126.70

    authors: Kowalski RJ,Post DR,Mannon RB,Sebastian A,Wright HI,Sigle G,Burdick J,Elmagd KA,Zeevi A,Lopez-Cepero M,Daller JA,Gritsch HA,Reed EF,Jonsson J,Hawkins D,Britz JA

    更新日期:2006-09-15 00:00:00

  • Response to diphtheria and tetanus booster vaccination in pediatric renal transplant recipients.

    abstract:BACKGROUND:Although inactivated vaccines are recommended for immunocompromized patients, efficacy and safety of diphtheria and tetanus immunization in renal transplant recipients have received little attention so far. The aim of the study was to investigate the response to a standard diphtheria and tetanus booster vacc...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199707270-00010

    authors: Enke BU,Bökenkamp A,Offner G,Bartmann P,Brodehl J

    更新日期:1997-07-27 00:00:00

  • N-acetylcysteine ameliorates reperfusion injury after warm hepatic ischemia.

    abstract::Glutathione is important in cellular defense against oxidative stress. We postulated that administration of N-acetylcysteine (NAC), a glutathione precursor, might help maintain or replenish hepatic glutathione stores, thereby reducing reperfusion injury in liver grafts after warm ischemia. Eighteen pigs were subjected...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199501150-00002

    authors: Fukuzawa K,Emre S,Senyuz O,Acarli K,Schwartz ME,Miller CM

    更新日期:1995-01-15 00:00:00

  • Five-year follow-up of two siblings with aspartylglucosaminuria undergoing allogeneic stem-cell transplantation from unrelated donors.

    abstract:BACKGROUND:Aspartylglucosaminuria is a rare, inherited lysosomal disease characterized by a slowly progressive mental retardation and coarse facial and body features. With the intent to provide the deficient enzyme aspartylglucosaminidase, allogeneic stem-cell transplantation (ASCT) has been attempted. Only a few cases...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200408150-00015

    authors: Malm G,Månsson JE,Winiarski J,Mosskin M,Ringdén O

    更新日期:2004-08-15 00:00:00

  • Comparative outcome analysis of ABO-incompatible and positive crossmatch renal transplantation: a single-center experience.

    abstract:BACKGROUND:ABO-incompatible (ABOi) and positive crossmatch (XM) renal transplants pose special immunologic challenges. It is important to compare outcomes, study resource utilization, and attempt to risk stratify patients in these higher risk transplant settings. METHODS:We compared apheresis utilization and transplan...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181a76ae1

    authors: Padmanabhan A,Ratner LE,Jhang JS,Duong JK,Markowitz GS,Vasilescu ER,Crew RJ,Schwartz J

    更新日期:2009-06-27 00:00:00

  • Posttransplant deaths and factors that influence the mortality rate in North American children.

    abstract::Of 2457 patients in the North American Pediatric Renal Transplant Cooperative Study registry who were followed for 5481 patient-years after the index transplantation, we observed 136 deaths, for an average annual rate of 24.8 deaths per 1000 patient-years. Death resulted primarily from infection (n = 55, 40%), cardiov...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Tejani A,Sullivan EK,Alexander S,Fine R,Harmon W,Lilienfeld D

    更新日期:1994-02-27 00:00:00

  • Studies on the induction and expression of T cell-mediated immunity. V. Lectin-induced nonspecific cell-mediated cytotoxicity by alloimmune lymphocytes.

    abstract::Murine lymphoid cells sensitized against allografts express two types of cytotoxicity measured in vitro in short-term assays of 2 to 3 hr by 51Cr release. One type of cytotoxicity is specific against target cells carrying the sensitizing alloantigens, and the other type is nonspecific against both syngeneic and unrela...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197602000-00002

    authors: Bonavida B,Bradley TP

    更新日期:1976-02-01 00:00:00

  • Imaging molecular and cellular events in transplantation.

    abstract::Imaging methods such as nuclear medicine (including positron emission tomography), magnetic resonance imaging, ultrasound, and optical imaging can be used to provide information about the expression of genes, and the location of molecules and cells in intact animals or patients. In the setting of transplantation, this...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.tp.0000235530.80305.d2

    authors: George AJ,Bhakoo KK,Haskard DO,Larkman DJ,Reynolds PR

    更新日期:2006-11-15 00:00:00

  • Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapy.

    abstract:BACKGROUND:There is growing interest in new therapeutic options for the treatment of end-stage liver diseases. In addition to mechanical devices supporting liver function, such as bioreactors, the transplantation of hepatocyte-like cells derived from (adult) stem cells offer great perspectives. We have generated hepato...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000157362.91322.82

    authors: Ruhnke M,Nussler AK,Ungefroren H,Hengstler JG,Kremer B,Hoeckh W,Gottwald T,Heeckt P,Fandrich F

    更新日期:2005-05-15 00:00:00

  • Reduced fibrin deposition and intravascular thrombosis in hDAF transgenic pig hearts perfused with tirofiban.

    abstract:BACKGROUND:Solid organ xenograft rejection is associated with vascular injury resulting at least in part in platelet activation, and rejected xenografts invariably demonstrate intravascular thrombosis and interstitial hemorrhage. Complement activation plays a prominent role in platelet-endothelial interaction. We teste...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000295742.45413.dc

    authors: Brandl U,Jöckle H,Erhardt M,Michel S,Burdorf L,Brenner P,Bittmann I,Rössle M,Mordstein V,Hammer C,Thein E,Reichart B,Schmoeckel M

    更新日期:2007-12-27 00:00:00