Abstract:
BACKGROUND:Extended partial hepatectomy (PH) in patients is leading to portal hyperperfusion but reduced hepatic arterial perfusion (HAP), and is invariably causing focal hepatic venous outflow obstruction (FHVOO). We observed in a rat model that PH in combination with right median hepatic vein ligation (RMHV-L) caused confluent parenchymal necrosis interspersed with viable portal tracts in the obstructed territory and large sinusoidal vascular canals in the border zone. Lack of HAP impaired the spontaneous course of recovery in terms of enlarged parenchymal necrosis, delayed regeneration, and the absence of draining vascular canals. We aimed to investigate whether pharmacological intervention modulates the imbalance between portal venous and hepatic arterial inflow, aggravates the liver damage, and delays the recovery process after FHVOO in liver-resected rats. METHODS:Male Lewis rats were subjected to 70% PH and RMHV-L. Molsidomine or NG-nitro-L-arginine methyl ester (L-NAME) or saline were applied daily. Hepatic damage, microcirculation, regeneration, and vascular remodeling were evaluated at postoperative days 1, 2, and 7. Animals subjected to RMHV-L only were used as "no HAP" control. RESULTS:Significant increase of portal venous inflow with a concomitant decrease in HAP was observed in all groups after PH. Molsidomine treatment did neither affect hepatic hemodynamics nor the spontaneous recovery. In contrast, L-NAME treatment further decreased HAP which impaired hepatic microcirculation, aggravated parenchymal damage, decelerated recovery, and impaired the formation of sinusoidal canals. CONCLUSIONS:Reduction of HAP through inhibition of nitric oxide production worsened the recovery from FHVOO. Drugs increasing HAP need to be evaluated to reverse the hyperperfusion-induced impairment of the spontaneous course after FHVOO.
journal_name
Transplantationjournal_title
Transplantationauthors
Huang H,Deng M,Jin H,Liu A,Dahmen U,Dirsch Odoi
10.1097/TP.0000000000000089subject
Has Abstractpub_date
2014-05-27 00:00:00pages
1009-18issue
10eissn
0041-1337issn
1534-6080journal_volume
97pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:New insights into mechanisms of injury in orthotopic liver transplantation (OLT) often come from experiments in small animal models. Mice are particularly suitable because of the growing availability of gene-altered animals and specific antibodies. A validated model of OLT in mice is not available and, in pa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200211150-00008
更新日期:2002-11-15 00:00:00
abstract:BACKGROUND:An elevated terminal creatinine is frequently used as a reason for organ refusal in pediatric kidney transplantation. There is increasing evidence that adults who receive kidneys from donors with moderate to severe acute kidney injury (AKI) have similar outcomes to recipients who receive kidneys from donors ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002827
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:To reduce the side effects of long-term immunosuppressive therapy, stable renal transplant patients were routinely converted from cyclosporine to either azathioprine or mycophenolate mofetil. Thereafter, the azathioprine and mycophenolate mofetil dose was reduced to 75% at 4 months and to 50% at 8 months aft...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2000-07-15 00:00:00
abstract:BACKGROUND:Uterus transplantation is a treatment for absolute uterine infertility and can be performed with living and deceased donors. Given the safety and increased utilization of robotic assistance with other gynecologic and transplant donor operations, we adopted a robot-assisted approach to donor hysterectomy. Thi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003211
更新日期:2021-01-01 00:00:00
abstract::Preexisting diabetes mellitus (DM) has been regarded as a contraindication to heart transplantation (HT). This prejudice has been based upon concern over increased infection rates and worsening DM with the initiation of prednisone immunosuppression. To better evaluate these suppositions, we reviewed our experience wit...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199002000-00015
更新日期:1990-02-01 00:00:00
abstract::The association of renal vein thrombosis and membranous glomerulopathy in native kidneys has been well documented. However, this association has only occasionally been described following renal transplantation. A review of 693 renal transplant recipients revealed 77 (11%) in whom persistent, heavy proteinuria (greater...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:New strategies for improving durable functional islet mass will be instrumental in facilitating islet transplantation as a cure for type 1 diabetes mellitus. The ability to transfer immunoregulatory or cytoprotective genes into pancreatic islets may enhance survival. Adenoviral vectors (Ad5) have been used w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000066361.02042.CA
更新日期:2003-07-15 00:00:00
abstract:BACKGROUND:Recently the United Network for Organ Sharing (UNOS) began a pilot study to evaluate prospectively the merits of an allocation of cadaveric kidneys based on broader classes of HLA antigens, called cross-reactive groups (CREG). The objectives of the pilot study consider patient outcomes, but not the potential...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200008150-00024
更新日期:2000-08-15 00:00:00
abstract:BACKGROUND:Organ transplantation has been successfully practiced for decades, but the outcome of cell transplantation remains disappointing. This is the case in animal models; liver allografts in mice are spontaneously accepted without requirement of immunosuppression, whereas hepatocyte transplants in the same combina...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818bfd13
更新日期:2008-12-15 00:00:00
abstract::The NOD mouse develops immune-mediated diabetes mellitus characterized by T cell infiltration and destruction of pancreatic islet tissue. We wished to determine whether one contributing factor was an abnormality of the NOD pancreas that caused it to elicit an attack by NOD T cells. Therefore we constructed mice that h...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199206000-00032
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to examine the utility of the random urine protein to creatinine ratio (P/C) in evaluation and longitudinal management of proteinuria in adult renal transplant recipients with or without overt nephropathy in an outpatient clinic. METHODS:A total of 289 adult renal transplant re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200110270-00021
更新日期:2001-10-27 00:00:00
abstract:BACKGROUND:Although the value of duodenal histology as a means to diagnose acute rejection in pancreaticoduodenal allografts has been validated, it is not known how the duodenum responds to antirejection treatment in comparison with the pancreas. METHODS:Diabetic Lewis rats received a pancreaticoduodenal allograft. Cy...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200201270-00008
更新日期:2002-01-27 00:00:00
abstract:BACKGROUND:Hemophagocytic syndrome (HPS) is a serious hematological disorder caused by activated T lymphocytes in immunologically compromised patients. There is no report of HPS in liver transplant recipients. METHODS:Among 135 patients who underwent living-related liver transplantation between June 1990 and October 2...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200112150-00024
更新日期:2001-12-15 00:00:00
abstract::T lymphocyte subsets, mitogenic response, and immunoglobulin levels were studied in peripheral blood from 95 thalassemic patients before and at different times after bone marrow transplantation. With the exception of patients receiving more than 100 transfusion units before transplant, who showed an increased percenta...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198809000-00012
更新日期:1988-09-01 00:00:00
abstract::Renal transplant recipients are at risk of severe morbidity and mortality from CMV disease. We have undertaken routine surveillance for CMV shedding on 133 transplant recipients, using a rapid culture technique, in order to assess the incidence of CMV infection and disease in these patients and to assess the prognosti...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199307000-00019
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:The currently used macrolide immunosuppressants, i.e., cyclosporine and tacrolimus, exert considerable nephrotoxicity. We aimed to avoid the nephrotoxic effects by applying a cyclosporine-free regimen for the induction as well as for the maintenance treatment of renal allograft recipients using mycophenolate...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199807150-00007
更新日期:1998-07-15 00:00:00
abstract:BACKGROUND:Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). METHODS:We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We com...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e3182394cb3
更新日期:2012-01-15 00:00:00
abstract::In the DA-to-Lewis renal allograft model, donor whole blood enhanced renal allograft survival (14.5 +/- 7.6 days versus 6.9 +/- 0.6 days in controls [P less than 0.01]). The effect of individual cell components given in numbers equivalent to those present in the enhancing volumes of donor whole blood was studied. Immu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198409000-00003
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) still limits survival after heart transplantation. Currently available noninvasive tests are of inferior value to detect CAV, and thus invasive coronary angiography (ICA) is frequently performed. Cardiac dual-source computed tomography calcium scoring (DSCTCS) offers the ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318225281d
更新日期:2011-08-27 00:00:00
abstract::Idarubicin was conjugated to anti-Ly-2.1 and anti-L3T4 monoclonal antibodies. These conjugates were used to investigate their effects on skin graft survival in mice. Several donor and recipient combinations were used so that the effect of individual or mixtures of conjugates on class I and class II antigenic differenc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198907000-00018
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:The objective of this study was to investigate purine nucleotide metabolism in peripheral blood mononuclear cells (PBMC) of cardiac transplant recipients switched from azathioprine to mycophenolate mofetil (MMF). METHODS:Concentrations of guanosine 5'triphosphate (GTP) and adenosine 5'triphosphate (ATP), th...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000225759.54343.23
更新日期:2006-07-15 00:00:00
abstract:BACKGROUND:Metrics for evaluating low-quality kidneys have failed to predict outcomes or reduce the kidney refusal and discard rates. Kidneys from extended-criteria donors (ECDs) and kidneys with ≥85% kidney donor profile indexes (KDPIs) might have different sensitivities to the proinflammatory milieu generated by brai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003048
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Sirolimus (Rapamune, rapamycin, RAPA) is a potent immunosuppressive drug that has reduced the rate of acute rejection episodes by more than 40% in phase III trials when added to an immunosuppression regimen of cyclosporine (CsA) and prednisone. However, RAPA treatment tends to increase lipid levels, particul...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200110150-00011
更新日期:2001-10-15 00:00:00
abstract:BACKGROUND:Geographic variation in kidney transplantation rates in the United States has been described previously but remains unexplained by age, race, sex, or socioeconomic status differences. Geographic variations in the concentration of poverty appear to impact end-stage renal disease care and potentially access to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000125
更新日期:2014-09-27 00:00:00
abstract::A cadaveric renal transplant was performed on a 63-year-old woman. The donor renal artery and vein were anastomosed to the recipient external iliac vessels using the vascular clipping system. These vascular anastomoses were performed with four stay sutures and several clips for each anastomosis, without a continuous v...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199610270-00024
更新日期:1996-10-27 00:00:00
abstract:BACKGROUND:Hyperacute rejection (HAR) of pig-to-primate discordant xenografts is caused by the deposition of preexisting natural antibodies that recognize Galalpha1-3Gal (alphaGal)-terminating oligosaccharides on glycoproteins and glycolipids, followed by complement-mediated lysis of the graft's endothelium. In vitro, ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802150-00009
更新日期:1998-02-15 00:00:00
abstract:BACKGROUND:The urinary CXC chemokine ligand (CXCL)10 detects renal transplant inflammation noninvasively, but has limited sensitivity and specificity. In this study, we performed urinary proteomic analysis to identify novel biomarkers that may improve the diagnostic performance of urinary CXCL10 for detecting alloimmun...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000867
更新日期:2016-03-01 00:00:00
abstract::Increased QT dispersion (QTd), predicting patients with risk of malignant arrhythmia, have recently been reported in hemodialysis patients (HDp). In this prospective study, we aimed to investigate changes in QTd and signal averaged-ECG (SAECG) in HDp after transplantation. Twenty-seven HDp (M/F:18/9, mean age 30+/-8 y...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-200111150-00009
更新日期:2001-11-15 00:00:00
abstract::We examined the cytokine profiles associated with tolerance and rejection using the mouse model of neonatal tolerance. BALB/c mice primed with CAF1 splenocytes during the neonatal stage showed increased A/J skin graft survival of > 60 days and failed to develop anti-A/J cytotoxic responses, but rejected third-party C5...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199504150-00002
更新日期:1995-04-15 00:00:00
abstract::In human organ transplantation, the correct diagnosis of rejection may be difficult using clinical and/or histopathologic criteria, and immunologic assays should therefore be considered. We have applied monoclonal antibodies in 2-color flow cytometric (FACS) analysis to study phenotypic patterns of kidney-infiltrating...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198905000-00014
更新日期:1989-05-01 00:00:00