Donor-specific antibody levels and three generations of crossmatches to predict antibody-mediated rejection in kidney transplantation.

abstract：BACKGROUND:Extracorporeal membrane oxygenation (ECMO) can be used to maintain oxygen delivery and provide hemodynamic support in case of circulatory and/or respiratory failure. Although the role of ECMO has emerged in the setting of adult liver transplantation (LT), data in children are limited. We aimed to describe th...

journal_title：Transplantation

authors： Ziogas IA,Johnson WR,Matsuoka LK,Rauf MA,Thurm C,Hall M,Bacchetta M,Godown J,Alexopoulos SP

更新日期：2020-08-13 00:00:00

abstract：BACKGROUND:Human CD58 is an adhesion molecule that interacts with CD2 on lymphocytes. We describe here an antibody that blocks responses of human peripheral blood mononuclear cells (PBMCs) to porcine cells and reacts with a porcine protein with homology to CD58. METHODS:Antibodies were isolated with a screen for inhib...

journal_title：Transplantation

authors： Crosby K,Yatko C,Dersimonian H,Pan L,Edge AS

更新日期：2004-04-27 00:00:00

abstract：:The mammalian target of rapamycin inhibitors (mTOR-I), drugs widely used in transplant medicine and oncology, exert their function by inhibiting a serine/threonine kinase with a pivotal role in cellular metabolism and in a wide range of eukaryotic biological/cellular functions and signaling networks. Additionally, as ...

journal_title：Transplantation

authors： Zaza G,Granata S,Caletti C,Signorini L,Stallone G,Lupo A

更新日期：2018-02-01 00:00:00

abstract：:We present the youngest successful patient with combined heart-lung-liver transplantation. The patient was a 2.5-year-old child with Alagille syndrome suffering from tetralogy of Fallot with pulmonary atresia and multiple aortopulmonary collaterals and familial cholestasis. ...

journal_title：Transplantation

authors： Gandhi SK,Reyes J,Webber SA,Siewers RD,Pigula FA

更新日期：2002-06-27 00:00:00

abstract：:The antibody response to the pregnancy-associated (Pa) antigen in the pregnant female segregated with the major histocompatibility complex (MHC) when the female progeny in the (PVG x WF)F1 x PVG testcross, in which the PVG strain is a low responder to Pa and the WF strain is a high responder, were mated to DA male rat...

journal_title：Transplantation

authors： Kunz HW,Gill TJ 3rd

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:During allograft rejection, up-regulation of cytokine-inducible nitric oxide synthase (iNOS) leads to the production of large amounts of nitric oxide (NO). The net effect of NO on the alloimmune response is, however, difficult to predict because of its diverse biological effects, which include potentially op...

journal_title：Transplantation

authors： Casey JJ,Wei XQ,Orr DJ,Gracie JA,Huang FP,Bolton EM,Liew FY,Bradley JA

更新日期：1997-08-27 00:00:00

abstract：BACKGROUND:Deciphering the mechanisms of tolerance and chronic rejection (CR) remains a major goal in transplantation. Data in rodents suggest that Toll-like receptors (TLR), regulators of innate immune responses, play a role in determining graft outcome. However, few studies have focused on TLR expression in human kid...

journal_title：Transplantation

authors： Braudeau C,Ashton-Chess J,Giral M,Dugast E,Louis S,Pallier A,Braud C,Moreau A,Renaudin K,Soulillou JP,Brouard S

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:Neighborhood poverty has been associated with worse outcomes after live donor kidney transplantation (LDKT), and prior work suggests that women with kidney disease may be more susceptible to the negative influence of poverty than men. As such, our goal was to examine whether poverty differentially affects wo...

journal_title：Transplantation

authors： Purnell TS,Luo X,Crews DC,Bae S,Ruck JM,Cooper LA,Grams ME,Henderson ML,Waldram MM,Johnson M,Segev DL

更新日期：2019-10-01 00:00:00

abstract：:In vitro studies have shown that calcium channel blockers (CCB) exert inhibitory effects on immunocompetent cells but conflicting results have been reported as to the translation of these effects into significant in vivo immunosuppression. In this study we evaluated the effects of the benzothiazepine-like calcium bloc...

journal_title：Transplantation

authors： Dumont L,Chen H,Daloze P,Xu D,Garceau D

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Cyclosporine (CsA) therapy must often be continued during pregnancy to maintain maternal health in such conditions as organ transplantation and autoimmune disease. This meta-analysis was performed to determine whether CsA exposure during pregnancy is associated with an increased risk of congenital malformati...

journal_title：Transplantation

authors： Bar Oz B,Hackman R,Einarson T,Koren G

更新日期：2001-04-27 00:00:00

abstract：:Subsets of T cells have been identified by the expression of different isoforms of CD45. Some T cells expressing CD45RA (gp220) have been characterized as "naive" in their response to antigens including alloantigens, whereas T cells expressing CD45RO (gp180) have been characterized as "memory" T cells. To examine the ...

journal_title：Transplantation

authors： Ibrahim S,Dawson DV,Sanfilippo F

更新日期：1995-03-15 00:00:00

abstract：:Pancreatic transplantation is intended to normalize carbohydrate metabolism in insulin-dependent diabetics by restoring endogenous insulin release, and it is usually performed together with kidney transplantation in patients with end-stage renal failure. A major problem in these patients is the daily control of the gr...

journal_title：Transplantation

authors： Secchi A,Pontiroli AE,Traeger J,Dubernard JM,Touraine JL,Ruitton A,Blanc N,Pozza G

更新日期：1983-04-01 00:00:00

abstract：:Requirements for sustained engraftment of fetal liver hematopoietic stem cells were evaluated in 45 dogs. Pretransplant preparative treatment with total-body irradiation, 14.7 Gy, permitted engraftment of DLA-compatible fetal liver cells. Radiation alone was inadequate in DLA-haploidentical or DLA-mismatched transplan...

journal_title：Transplantation

authors： Cain G,Stitzel K,Gale R,Champlin R

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Evidence on prevalence and correlates of pretransplant medication nonadherence (MNA) is limited. The present study explored self-reported prevalence and correlates of MNA before heart, liver, and lung transplantation. METHODS:This cross-sectional descriptive study included 174 patients: 69 lung, 33 heart, a...

journal_title：Transplantation

authors： Dobbels F,Vanhaecke J,Desmyttere A,Dupont L,Nevens F,De Geest S

更新日期：2005-06-15 00:00:00

abstract：:Thromboxane (Tx) plays a vital role in the dysfunction and ultimate rejection of MHC-disparate renal allografts. In addition to its potent vasoconstrictory properties, in vivo studies have implied that Tx is capable of promoting immune cytotoxic T cell function within transplants. In this study, we have examined the i...

journal_title：Transplantation

authors： Ruiz P,Rey L,Spurney R,Coffman T,Viciana A

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Pharmacokinetic modeling supports trough monitoring of everolimus, but prospective data comparing this approach versus mycophenolate mofetil (MMF) in de novo cardiac transplant recipients are currently unavailable. METHODS:In a 12-month multicenter open-label study, cardiac transplant patients received ever...

journal_title：Transplantation

authors： Lehmkuhl HB,Arizon J,Viganò M,Almenar L,Gerosa G,Maccherini M,Varnous S,Musumeci F,Hexham JM,Mange KC,Livi U,2411 Study Investigators.

更新日期：2009-07-15 00:00:00

abstract：:Frozen sections of lymph nodes from normal mice were examined by immunofluorescence with anti-T lymphocyte and anti-Ig reagents and by autoradiography following [3H]TdR administration. The scattered T lymphocytes present among B lymphocytes of primary follicles were found to be mostly nonproliferating; the few prolife...

journal_title：Transplantation

authors： Berman MA,Rafiei S,Gutman GA

更新日期：1981-11-01 00:00:00

abstract：:Nuclear imaging is used to evaluate renal allografts demonstrating delayed function after transplantation. Interpretation of the nuclear scan in the context of clinical data, provides helpful information in the management of the transplant recipient. The better quality of images obtained with technetium-99m mercaptoac...

journal_title：Transplantation

authors： Mange KC,Scheff A,Brayman K,Mozley D,Grossman RA,Naji A,Aradhye S

更新日期：1997-11-27 00:00:00

abstract：:We have analyzed HLA data from the UNOS registry on 20,230 patients on the renal waiting list in 1991 and 18,708 donors from 1988-1992. Significant differences were found in the distribution of HLA antigens for comparisons of the total donor pool and the various racial groups of patients as well as for inter- and intr...

journal_title：Transplantation

authors： Leffell MS,Steinberg AG,Bias WB,Machan CH,Zachary AA

更新日期：1994-11-27 00:00:00

abstract：:Hepatic artery thrombosis (HAT) after liver transplantation (LTx) usually mandates retransplantation. Prolonged preservation with Eurocollins solution has been associated with HAT. We reviewed our experience with 359 LTx patients to identify risk factors for HAT. All grafts were preserved in University of Wisconsin so...

journal_title：Transplantation

authors： Mor E,Schwartz ME,Sheiner PA,Menesses P,Hytiroglou P,Emre S,Kishikawa K,Chiodini S,Miller CM

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:After transplantation, donor dendritic cells (DC) migrating to the draining lymph node of the recipient are thought to play an important role in the initiation of graft rejection. In this study, we compared the in vivo migration of DC after allogeneic skin transplantation with that after congeneic skin trans...

journal_title：Transplantation

authors： Richters CD,van Gelderop E,du Pont JS,Hoekstra MJ,Kreis RW,Kamperdijk EW

更新日期：1999-03-27 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion (I/R) injury is the major cause of delayed renal graft function in kidney transplantation. To date, there are no effective therapeutic approaches for preventing I/R injury. We previously reported that treatment of animals with small interference RNA (siRNA) would prevent warm I/R injury ...

journal_title：Transplantation

authors： Zheng X,Zang G,Jiang J,He W,Johnston NJ,Ling H,Chen R,Zhang X,Liu Y,Haig A,Luke P,Jevnikar AM,Min WP

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Short-term outcomes using steroid-free immunosuppression after renal transplantation have been promising. No studies have examined the incidence of and reasons for steroid-avoidance protocol failures. METHODS:We present a single-center analysis of steroid-free immunosuppression failures among 129 pediatric ...

journal_title：Transplantation

authors： Sutherland S,Li L,Concepcion W,Salvatierra O,Sarwal MM

更新日期：2009-06-15 00:00:00

abstract：:Conjugation of dextran-coated superparamagnetic iron oxide (SPIO) particles with transactivator protein (Tat)-peptide and fluorescein isothiocyanate (FITC) allows cells to readily uptake SPIO particles. This makes possible high-resolution, real-time imaging of these cells by magnetic resonance imaging (MRI). First, we...

journal_title：Transplantation

authors： Kaufman CL,Williams M,Ryle LM,Smith TL,Tanner M,Ho C

更新日期：2003-10-15 00:00:00

abstract：:Nippostrongylus infection strongly stimulates TH2 activity in vivo. Given the evidence of cross regulation between TH2 and TH1 cells, and the link between TH1 activity and graft rejection, we examined the effects of Nippostrongylus infection on the fate of kidney allografts in rats. Both prior Nippostrongylus infectio...

journal_title：Transplantation

authors： Ledingham DL,McAlister VC,Ehigiator HN,Giacomantonio C,Theal M,Lee TD

更新日期：1996-01-27 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) is a strong predictor of cardiovascular disease, all-cause mortality, and renal allograft loss. Little is known about the effects of immunosuppressive and cardiovascular risk-modifying drugs on CRP in renal transplant recipients. METHODS:We retrospectively identified stable patients...

journal_title：Transplantation

authors： Wong BM,Huang M,Zaltzman JS,Prasad GV

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:The aim was to compare efficacy of multiple daily injections (MDI), continuous subcutaneous insulin infusion (CSII) and islet transplantation to reduce hypoglycemia and glycemic variability in type 1 diabetes subjects with severe hypoglycemia. METHODS:This was a within-subject, paired comparison of MDI and ...

journal_title：Transplantation

authors： Holmes-Walker DJ,Gunton JE,Hawthorne W,Payk M,Anderson P,Donath S,Loudovaris T,Ward GM,Kay TW,OʼConnell PJ

更新日期：2017-06-01 00:00:00

abstract：:The overall incidence of malignancy in renal transplant recipients is 100-fold higher compared with age matched controls. Routine clinical evaluation therefore often includes the determination of serum tumor markers AFP, CA19-9, CEA, CA125, CA15-3, PSA, and calcitonin. We evaluated the specificity and the sensitivity ...

journal_title：Transplantation

authors： Oberbauer R,Banyai S,Schmidt A,Kornek G,Scheithauer W,Mayer G

更新日期：1996-11-27 00:00:00

abstract：BACKGROUND:The number of living donor kidney transplantations increases steeply in Europeans, whereas the non-Europeans are dependent on deceased donor transplantations. We wondered whether a low attendance or a high decline of potential non-European donors could explain this difference. METHODS:This retrospective stu...

journal_title：Transplantation

authors： Roodnat JI,van de Wetering J,Zuidema W,van Noord MA,Kal-van Gestel JA,Ijzermans JN,Weimar W

更新日期：2010-05-27 00:00:00

abstract：BACKGROUND:This study evaluates whether surgical strategies such as the portosystemic shunt and ischemic preconditioning can protect against hepatic and pulmonary injury associated with liver transplantation. METHODS:The effect of the portosystemic shunt, ischemic preconditioning, and both surgical procedures together...

journal_title：Transplantation

authors： Fernández L,Heredia N,Peralta C,Xaus C,Roselló-Catafau J,Rimola A,Marco A,Serafín A,Deulofeu R,Gelpí E,Grande L

更新日期：2003-07-27 00:00:00