Dog leukocyte antigen-haploidentical stem cell allografts after anti-CD44 therapy and nonmyeloablative conditioning in a preclinical canine model.

abstract：:After the progressive improvement in the results of organ transplantation we now face the challenge of shortage in organ supply. The decreasing number of organ retrievals performed in 1990 at our hospital has raised questions concerning loss of potential organ donors and opposition to donation by the next of kin. We i...

journal_title：Transplantation

authors： Faltin DL,Jeannet M,Suter PM

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Heart transplantation (HTx) remains the most effective long-term treatment for advanced heart failure. Primary graft dysfunction (PGD) continues to be a potentially life-threatening early complication. In 2014, a consensus statement released by International Society for Heart and Lung Transplantation (ISHLT)...

journal_title：Transplantation

authors： Avtaar Singh SS,Banner NR,Rushton S,Simon AR,Berry C,Al-Attar N

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Bone marrow stromal cells (BMSC) transplantation offers promise in the treatment of chronic paraplegia in rodents. Here, we report the effect of this cell therapy in adult pigs suffering chronic paraplegia. METHODS:Three months after spinal cord injury, autologous BMSC in autologous plasma was injected into...

journal_title：Transplantation

authors： Zurita M,Vaquero J,Bonilla C,Santos M,De Haro J,Oya S,Aguayo C

更新日期：2008-09-27 00:00:00

abstract：BACKGROUND:Thrombotic microangiopathy (TMA) is a fatal complication characterized by microvascular occlusive disorder resulting in systemic or intrarenal platelet aggregation, severe thrombocytopenia, and microangiopathic hemolytic anemia. Only sporadic case reports of TMA after cadaveric or living-donor liver transpla...

journal_title：Transplantation

authors： Tamura S,Sugawara Y,Matsui Y,Kishi Y,Akamatsu N,Kaneko J,Makuuchi M

更新日期：2005-07-27 00:00:00

abstract：:We performed a multicenter study to investigate the problem of cadaver kidney transplants that never achieve function, or that recover after a period of delayed function, and we used multivariate techniques to model the results. Sixty-nine patients who received cadaver kidney transplants that never functioned (NF) wer...

journal_title：Transplantation

authors： Halloran P,Aprile M

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Although the outcome of islet transplantation has improved, there remains a major obstacle in isolating viable islets from prolonged preserved pancreas. We previously reported that the two-layer cold storage method (TLM) improved the yield and in vitro function. In this study, we performed in vivo accurate f...

journal_title：Transplantation

authors： Kakinoki K,Fujino Y,Suzuki Y,Li S,Tanioka Y,Sakai T,Kuroda Y

更新日期：2005-06-15 00:00:00

abstract：BACKGROUND:The delayed allograft rejection in C6-deficient PVG C6- rats compared with normal PVG rats has been attributed to the lack of alloantibody activation of the membrane attack complex of complement. As T cells alone have been shown to effect graft rejection, we examined T-cell responses in PVG C6- rats. METHOD...

journal_title：Transplantation

authors： Merten S,Chen JC,Ha H,Plain K,Boyd RA,Penny MJ,Leenaerts P,Hall BM

更新日期：1998-05-15 00:00:00

abstract：:We have previously observed that transplant recipient sera with endothelial antibodies are bound to epidermal cells, as shown by immunofluorescence on sections of skin. It was also reported that early kidney failures that occurred despite negative T cell crossmatches were associated with, and could have been predicted...

journal_title：Transplantation

authors： Moraes JR,Moraes ME,Luo YM,Stastny P

更新日期：1991-02-01 00:00:00

abstract：:The influence of race on the outcome of cadaver renal transplantation (CRT) continues to be controversial even in the cyclosporine era. The present study examines the effect of race in 343 adult CRT performed from 1/1/82 through 10/1/88 with regard to the incidence of delayed function (DF), graft survival (GS), and pa...

journal_title：Transplantation

authors： Dawidson IJ,Coorpender L,Fisher D,Helderman H,Hull A,Palmer B,Peters P,Sagalowsky A,Sandor ZF,Toto R

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:This is a follow-up of a withdrawal study that we previously performed on 104 liver transplant patients in which immunosuppression was gradually withdrawn over a period of 3 years. Eighty-one patients were not able to be withdrawn (rejectors), and 23 patients were successfully weaned off immunosuppression ...

journal_title：Transplantation

authors： Tryphonopoulos P,Ruiz P,Weppler D,Nishida S,Levi DM,Moon J,Tekin A,Velez M,Neuman DR,Island E,Selvaggi G,Tzakis AG

更新日期：2010-12-27 00:00:00

abstract：BACKGROUND:Induction therapy is associated with excellent short-term kidney graft outcome. The aim of this study was to evaluate differences in the intragraft transcriptome after successful induction therapy using two rabbit antithymocyte globulins. METHODS:The expression of 376 target genes involved in tolerance, inf...

journal_title：Transplantation

authors： Urbanova M,Brabcova I,Girmanova E,Zelezny F,Viklicky O

更新日期：2012-03-27 00:00:00

abstract：BACKGROUND:Several single nucleotide polymorphisms (SNPs) in the multidrug resistance (MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) absorption in renal transplant patients. METHODS:An analysis of CsA absorption measured by the dose- and weight-adjusted 4 hr area under the time-co...

journal_title：Transplantation

authors： Foote CJ,Greer W,Kiberd B,Fraser A,Lawen J,Nashan B,Belitsky P

更新日期：2007-05-27 00:00:00

abstract：:Islet transplantation is currently being explored as a treatment for patients with type 1 diabetes. At present, the number of patients becoming insulin-independent is rapidly increasing world-wide applying the transplantation protocol originally described by the group in Edmonton. A hallmark in this procedure is repea...

journal_title：Transplantation

authors： Korsgren O,Nilsson B,Berne C,Felldin M,Foss A,Kallen R,Lundgren T,Salmela K,Tibell A,Tufveson G

更新日期：2005-05-27 00:00:00

abstract：:Endothelial cells, one of several in vivo host cells for cytomegalovirus (CMV), participate in solid organ allograft rejection in part through the expression of leukocyte adhesion molecules. The hypothesis that CMV infection alters the constitutive and induced expression of ELAM-1, ICAM-1, and VCAM-1 on infected human...

journal_title：Transplantation

authors： Sedmak DD,Knight DA,Vook NC,Waldman JW

更新日期：1994-12-27 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) after solid organ transplantation is rare, with only six AML cases after liver transplantation (LT) being reported. METHODS:Characteristics of three AML cases observed among 799 recipients of LT in the authors' institution and estimation of the standardized incidence ratio (SIR)...

journal_title：Transplantation

authors： Camós M,Esteve J,Rimola A,Grande L,Rozman M,Colomer D,Villamor N,Costa D,Montserrat E

更新日期：2004-01-27 00:00:00

abstract：:A series of rat monoclonal antibodies against the human leukocyte-common antigen were isolated and, by means of competitive binding assays with purified antigen, two distinct groups were defined that recognize different epitopes of the molecule. None of these antibodies were lytic with human complement, but when antib...

journal_title：Transplantation

authors： Bindon CI,Hale G,Clark M,Waldmann H

更新日期：1985-11-01 00:00:00

abstract：:Rapid and precise cyclosporine measurements are necessary to maximize immunosuppression and minimize toxicity. The new cyclosporine and metabolites TDx fluorescent polarization immunoassay was studied to determine its precision, sensitivity, and stability. Further, it was compared with the existing radioimmunoassay an...

journal_title：Transplantation

authors： Schroeder TJ,Brunson ME,Pesce AJ,Hindenlang LL,Mauser PA,Ruckrigl DI,Weibel ML,Wadih G,First MR

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Delayed xenograft rejection (DXR) remains a roadblock to successful xenotransplantation. A feature of DXR is early recruitment of monocytes to the xenograft. Naïve human monocytes can recognize and adhere to unstimulated porcine aortic endothelial cells (PAEC) more than human aortic endothelial cells, partly...

journal_title：Transplantation

authors： Greenwald AG,Jin R,Waddell TK

更新日期：2009-01-15 00:00:00

abstract：BACKGROUND:Hemorrhagic cystitis (HC) is an important cause of morbidity in patients undergoing allogeneic stem-cell transplantation (SCT). Various causes have been identified, such as the use of high-dose cyclophosphamide or busulfan and the occurrence of acute graft-versus-host disease or viral infections (cytomegalov...

journal_title：Transplantation

authors： Demesmay K,Tissot E,Bulabois CE,Bertrand MA,Racadot E,Woronoff-Lemsi MC,Cahn JY,Deconinck E

更新日期：2002-10-27 00:00:00

abstract：:Blocking activity of mouse pregnancy serum was investigated using a well defined one-way mixed lymphocyte culture and a cell-mediated microcytotoxicity test. Allogeneic (C57BL (H-2b) X CBA/Ca (H-2k)) and syngeneic (C57BL (H-2b) X C57BL (H-2b)) pregnancy and postpartum sera were found to stimulate rather than inhibit t...

journal_title：Transplantation

authors： Smith G

更新日期：1978-11-01 00:00:00

abstract：:OKT3, an anti-CD3 MAB, depletes T cells in vivo and is among the most potent inhibitors of acute allograft rejection. The mechanism of this inhibition is unknown. The present studies investigate whether anti-CD3 antibodies have the ability to crosslink CD3 on two different cells and induce TCR-dependent antibody-bridg...

journal_title：Transplantation

authors： Wong JT,Eylath AA,Ghobrial I,Colvin RB

更新日期：1990-10-01 00:00:00

abstract：:The effect of the tritiated thymidine (3H-TdR) suicide technique on the ability of donor cells to induce fatal graft-versus-host disease (GVHD) was studied. C57BL/6 (H-2b) spleen cells were stimulated in vitro with irradiated BALB/c (H-2d) Moloney lymphoma cells in mixed culture and 3H-TdR of high-specific activity ad...

journal_title：Transplantation

authors： Cheever MA,Einstein AB Jr,Kempf RA,Fefer A

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:In transplantation, novel methods are required to augment the supply of donor organs. We report the first domino liver transplant in which a patient with familial amyloid polyneuropathy (FAP) received an orthotopic split liver graft, and her explanted liver was donated to another patient. Three successful li...

journal_title：Transplantation

authors： Stangou AJ,Heaton ND,Rela M,Pepys MB,Hawkins PN,Williams R

更新日期：1998-06-15 00:00:00

abstract：BACKGROUND:Recipients with multiple (more than one) acute rejection (AR) episodes have significantly lower graft survival rates than those with no AR or only one treated episode. However, fewer than 50% of recipients treated for one AR episode will have another episode. METHODS:We studied recipients with at least one ...

journal_title：Transplantation

authors： Humar A,Payne WD,Sutherland DE,Matas AJ

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:Genetic variants of the renin-angiotensin system (RAS) have been implicated in the progression of native kidney diseases. A decreased long-term renal allograft function has also been associated with increased activity of RAS, which may be genetically determined. METHODS:The effect of the angiotensinogen (AG...

journal_title：Transplantation

authors： Nicod J,Richard A,Frey FJ,Ferrari P

更新日期：2002-03-27 00:00:00

abstract：BACKGROUND:The efficiency of islet graft survival after intraportal implantation is compromised by host innate immune responses and the production of proinflammatory cytokines that cause acute cellular injury. This reaction activates intraislet nuclear factor-κB (NF-κB), causing production of gene products that have de...

journal_title：Transplantation

authors： Rink JS,McMahon KM,Zhang X,Chen X,Mirkin CA,Thaxton CS,Kaufman DB

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:Renal dysfunction early after kidney transplantation has multiple causes including ischemia-reperfusion (I/R) injury and drug-induced nephrotoxicity. This study assesses the acute nephrotoxicity of tacrolimus (Tac) and sirolimus (Sir) in a rat renal isograft model. METHODS:Lewis renal isografts and uninephr...

journal_title：Transplantation

authors： Ninova D,Covarrubias M,Rea DJ,Park WD,Grande JP,Stegall MD

更新日期：2004-08-15 00:00:00

abstract：BACKGROUND:Thymoglobulin given before allo-hematopoietic stem-cell transplantation (HSCT) from unrelated donors reduces acute graft-versus-host disease (GvHD), but the optimal dose is unknown. METHOD:Four different doses of Thymoglobulin were given to 162 patients with hematologic malignancies undergoing unrelated don...

journal_title：Transplantation

authors： Remberger M,Svahn BM,Mattsson J,Ringdén O

更新日期：2004-07-15 00:00:00

abstract：:The development of allospecific cellular immunity during acute rat renal allograft rejection parallels alterations occurring in arachidonic acid metabolism, including increased production of the vasoconstrictor eicosanoid thromboxane A2 (TxA2). We have previously demonstrated that chronic inhibition of thromboxane syn...

journal_title：Transplantation

authors： Ruiz P,Coffman TM,Klotman PE,Sanfilippo F

更新日期：1989-10-01 00:00:00

abstract：:The immune response to cytomegalovirus (CMV) infection is highly complex, including humoral, cellular, innate, and adaptive immune responses. Detection of CMV by the innate immune system triggers production of type I IFNs and inflammatory cytokines which initiate cellular and humoral responses that are critical during...

journal_title：Transplantation

authors： Carbone J

更新日期：2016-03-01 00:00:00