Abstract:
:We report a case of adenovirus infection of the renal allograft in a combined kidney/pancreas transplant recipient. The clinical presentation was renal allograft failure, which eventually reversed. The pancreatic graft function remained stable. A renal biopsy showed massive tubular necrosis associated with a prominent granulomatous reaction. The process had a striking regional distribution within the kidney with the injury and inflammation limited to the outer medulla. Adenovirus type 11 was isolated from renal tissue by culture, and adenovirus was demonstrated by immunofluorescence and electron microscopy in the kidney biopsy. Immunosuppression may result in unusual patterns of response to infectious agents. This case demonstrated tropism of the adenovirus to only selected tubules within the kidney, with sparing of other organ function including, specifically, the pancreas allograft. The differential diagnosis of a granulomatous reaction in the transplant kidney must be expanded to include viral infection, in particular, adenovirus.
journal_name
Transplantationjournal_title
Transplantationauthors
Mathur SC,Squiers EC,Tatum AH,Szmalc FS,Daucher JW,Welker DM,Shanley PFdoi
10.1097/00007890-199801150-00027subject
Has Abstractpub_date
1998-01-15 00:00:00pages
138-41issue
1eissn
0041-1337issn
1534-6080journal_volume
65pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Isolator-maintained CBH/Ola (Rtlc) rats were lethally irradiated and reconstituted with spleen and bone marrow cells from fully allogeneic WAG or Wistar (Rtlu) donors. Hematopoietically reconstituted rats were treated with cyclosporine (CsA)4 as prophylaxis for graft-versus-host disease (GVHD) for periods ranging from...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198511000-00002
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:It is imperative for healthcare providers to examine Western Muslim attitudes on organ donation, because they are reluctant donors. We explored such opinion with the aid of a quantitative survey. METHODS:Voluntary completion of an anonymous survey was promoted (online and paper sampling). For a population t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318231ea17
更新日期:2011-11-27 00:00:00
abstract::The improvement of graft survival over the past decade has mainly been due to the development of more highly specific immunosuppressive agents, such as cyclosporine (CsA) and FK506. CsA and FK506 inhibit T cell activation by interfering with the calcium-mediated pathway, one of two pathways needed for T cell activatio...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199606150-00015
更新日期:1996-06-15 00:00:00
abstract:BACKGROUND:The significance of late urinary tract infections (UTIs) after renal transplantation and their association with scarring and graft dysfunction remains controversial. We sought to define the prevalence of renal scarring in allograft recipients with a history of late recurrent UTIs, to determine whether the pr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000275377.09660.fa
更新日期:2007-08-15 00:00:00
abstract::The prevalence of angiographically proven coronary artery disease (CAD) in adults with end-stage liver disease who undergo evaluation for liver transplantation is unknown; also it is unclear if cholestatic liver disease represents an independent risk factor. Patients with end-stage liver disease over age 50 having liv...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-03-27 00:00:00
abstract:BACKGROUND:There is an increasing appreciation of the deleterious effects of antibody and B cells on acute and chronic transplant outcomes. Many effector functions of antibody are mediated by a family of receptors (FcγRs) that are expressed on most immune cells, including neutrophils, natural killer cells, and B cells....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000287
更新日期:2014-08-15 00:00:00
abstract::This study extends the finding that intrathymic (IT) injection of 3M KC1 extracts of T cells induces transplant tolerance to the use of well defined polymorphic MHC class I allopeptides derived from the hypervariable domain of RT1.Au (WF MHC class I). While three of the six synthetic RT1.Au peptides were immunogenic, ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612270-00034
更新日期:1996-12-27 00:00:00
abstract::T cells play an important role in protective immunity against tuberculosis. As patients are not reimmunized with BCG after BMT, the question arises as to whether PPD-specific memory T cells are transferred from the marrow donor to the recipient and persist in the long-term. We studied long-term survivors of non-T cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199301000-00014
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Centrilobular necrosis is not an uncommon finding after isolated liver transplantation. In this study, we sought to describe hepatic centrilobular necrosis in children after combined liver and small bowel transplantation (LSBT), and to assess the predictive factors, possible causes, and prognosis. METHODS:S...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200201270-00018
更新日期:2002-01-27 00:00:00
abstract:BACKGROUND:Long-term follow-up and management of donors was undertaken in a specialist kidney transplant unit in Pakistan to identify risk and prevent adverse outcomes in living related kidney donors. METHODS:In an observation cohort study between 1985 and 2012, 3748 donors were offered free medical follow-up and trea...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001075
更新日期:2016-06-01 00:00:00
abstract::In a randomized trial conducted in 9 Ontario transplant centers, 107 cadaver kidney donors were randomized so that both kidneys were preserved either by simple cold storage (CS) or by pulsatile perfusion (PP). After exclusions and losses to follow-up, there were 90 patients in the CS group and 91 in the PP group. Tota...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-06-01 00:00:00
abstract:OBJECTIVES:Recent studies demonstrated that prolactin (PRL) has beneficial effects on beta cells for islet transplantation. We examined the effect of human recombinant PRL (rhPRL) supplementation to the culture media to determine its potential use in the context of clinical islet transplantation. MATERIALS AND METHODS...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181d98af1
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:Renal allograft rejection is associated with the expression of adhesion molecules on vascular endothelial and tubular epithelial cells. METHODS:To assess whether the number of cell adhesion molecules expressed in donor kidneys can predict early rejection or delayed graft function, kidney biopsies from 20 li...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200106150-00028
更新日期:2001-06-15 00:00:00
abstract::Three strains of miniature swine, each homozygous for a different allele of the major histocompatibility locus (MHC), have been developed by a selective breeding scheme based on tissue typing of the offspring of each generation. Prior to breeding, the original parents were reciprocally immunized by skin grafts and lym...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197612000-00004
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:Heart transplantation (HTx) remains the most effective long-term treatment for advanced heart failure. Primary graft dysfunction (PGD) continues to be a potentially life-threatening early complication. In 2014, a consensus statement released by International Society for Heart and Lung Transplantation (ISHLT)...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002220
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Preoperative mapping of the hepatic venous system of the partial liver graft is indispensable to the success of living-related liver transplantation. We assessed the accuracy of magnetic resonance (MR) venography with angular reconstruction in depicting the tributaries of the middle hepatic vein and left hep...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199907270-00019
更新日期:1999-07-27 00:00:00
abstract:BACKGROUND:Nephrotoxicity is a major side effect of calcineurin inhibitors (CNI). Earlier we reported 8% of our heart transplant recipients reaching end-stage renal failure (ESRF). Now, with an extended follow up of 20 years, we re-evaluated the development of ESRF and studied its influence on survival and the impact o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000250360.78553.5e
更新日期:2006-12-27 00:00:00
abstract:BACKGROUND:New insights into mechanisms of injury in orthotopic liver transplantation (OLT) often come from experiments in small animal models. Mice are particularly suitable because of the growing availability of gene-altered animals and specific antibodies. A validated model of OLT in mice is not available and, in pa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200211150-00008
更新日期:2002-11-15 00:00:00
abstract::The immunosuppressive potentials of mAbs to lymphocyte function-associated antigen-1 (LFA-1) and CD2 molecules were examined in murine islet transplantation. Crude digested islets from BALB/c (H-2d) mice were transplanted into the renal subcapsular space of streptozotocin-induced diabetic C57BL/6 (H-2b) mice. The rat ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:We hypothesized that solitary pancreas transplants could be performed successfully even in the presence of poor HLA matching if an aggressive approach were taken with regard to immunosuppressive protocol and the performance of allograft biopsy. METHODS:Seven pancreas-after-kidney transplants and seven pancr...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/00007890-200007270-00028
更新日期:2000-07-27 00:00:00
abstract::Rapid and precise cyclosporine measurements are necessary to maximize immunosuppression and minimize toxicity. The new cyclosporine and metabolites TDx fluorescent polarization immunoassay was studied to determine its precision, sensitivity, and stability. Further, it was compared with the existing radioimmunoassay an...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198902000-00013
更新日期:1989-02-01 00:00:00
abstract::Total lymphoid irradiation (TLI) induces a unique state of immunosuppression. Although permanent bone marrow chimerism has been obtained in rodents prepared by TLI, uniform marrow engraftment has been more difficult to obtain in larger mammals. Accordingly, studies were performed to assess the immunologic perturbation...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198307000-00004
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant and nonmalignant hematologic diseases. However, acute graft-versus-host disease (aGVHD) is a lethal complication of hematopoietic stem cell transplantation, which limits its application. Cytokines such as ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31827e6b23
更新日期:2013-03-15 00:00:00
abstract::The immunosuppressive effects of leflunomide and cyclosporine were evaluated in a rat neurovascularized myocutaneous allograft model. Inbred Brown-Norway and Lewis rats were served as donors and recipients, respectively. All recipients were observed for 60 days or until allograft rejection occurred. All isograft contr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199609270-00027
更新日期:1996-09-27 00:00:00
abstract:BACKGROUND:Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species and the subsequent production of antibodies to environmental mi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200107150-00028
更新日期:2001-07-15 00:00:00
abstract::Immunosuppressive therapy increases the risk of recurrence of initial cancers in organ transplant patients, and compelling therapeutic protocols are needed to suppress the malignancy and protect the allograft. We examined the potential use of 15-deoxyspergualin (DSG) in relation to organ transplantation and cancer. Th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000271496.75233.f6
更新日期:2007-08-15 00:00:00
abstract:BACKGROUND:Immunological unresponsiveness of T cells to alloantigen can be induced by intrathymic injection of donor-specific antigen in small-animal models. Intrathymic tolerance to vascularized grafts in large animals has not previously been reported. METHODS:Thirty-two dogs were allocated into dog leukocyte antigen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181910e67
更新日期:2008-12-27 00:00:00
abstract:BACKGROUND:The UK Kidney Fast-Track Scheme (KFTS) was introduced in 2012 to identify kidneys at high risk of discard and to rapidly facilitate transplantation. A retrospective analysis of kidneys transplanted through the KFTS was undertaken. METHODS:UK Transplant Registry data were collected on deceased donor kidneys ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001860
更新日期:2017-12-01 00:00:00
abstract::A non-complement-binding monoclonal antibody, TA-1, recognizing determinants on human T lymphocytes, was linked to the plant seed toxin ricin, either the intact molecule or purified ricin A chain. Peripheral blood lymphocytes were pretreated with conjugate for 2 hr, washed, and then measured in vitro for T cell prolif...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198404000-00015
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:Treatment of chronic hepatitis C virus (HCV) infection after renal allograft transplantation has been an obstacle because of contraindications associated with IFN-based therapies. Direct-acting antiviral agents are highly efficient treatment options that do not require IFN and may not require ribavirin. Ther...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001414
更新日期:2017-05-01 00:00:00