Prevention of graft-versus-host disease following small bowel transplantation with polyclonal and monoclonal antilymphocyte serum. The effect of timing and route of administration.

abstract：BACKGROUND:Warm ischemia/reperfusion injury during liver transplantation is the most important cause of primary nonfunction of liver allografts. Tumor-necrosis factor (TNF)-alpha apparently mediates tissue damage by inducing apoptosis and/or necrosis in liver transplants. The aim of the study was to determine, using an...

journal_title：Transplantation

authors： Ben-Ari Z,Hochhauser E,Burstein I,Papo O,Kaganovsky E,Krasnov T,Vamichkim A,Vidne BA

更新日期：2002-06-27 00:00:00

abstract：:There is considerable current interest in the possibility that long-term graft acceptance in clinical solid-organ transplantation might be dependent upon the development of a microchimeric state between the donor and recipient. This possibility has been prompted by the observation that in some transplant patients cell...

journal_title：Transplantation

authors： Bushell A,Pearson TC,Morris PJ,Wood KJ

更新日期：1995-05-27 00:00:00

abstract：BACKGROUND:Liver transplant (LT) for nonalcoholic steatohepatitis (NASH) related hepatocellular carcinoma (HCC) is not well characterized in the literature. The aim of the study was to examine characteristics and outcomes of patients who had LT for NASH-HCC (NASH) versus HCC from other liver diseases (non-NASH). METHO...

journal_title：Transplantation

authors： Sadler EM,Mehta N,Bhat M,Ghanekar A,Greig PD,Grant DR,Yao F,Sapisochin G

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:There are anti-idiotypes in the sera of highly sensitized (HS) patients that stimulate B cells to produce antibody to HLA class I antigens. The purpose of this study is to determine if there is an abnormality in B cell responses to these anti-idiotypes. METHODS:Supernatants from normal and HS B cells expose...

journal_title：Transplantation

authors： Hack N,Angra S,McKnight TL,den Hollander N,Cardella CJ

更新日期：2005-11-15 00:00:00

abstract：BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...

journal_title：Transplantation

authors： Arnault I,Bao YM,Sebagh M,Anjo A,Dimicoli JL,Lemoine A,Delvart V,Adam R

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Recently the United Network for Organ Sharing (UNOS) began a pilot study to evaluate prospectively the merits of an allocation of cadaveric kidneys based on broader classes of HLA antigens, called cross-reactive groups (CREG). The objectives of the pilot study consider patient outcomes, but not the potential...

journal_title：Transplantation

authors： Hollenbeak CS,Woodward RS,Cohen DS,Lowell JA,Singer GG,Tesi RJ,Howard TK,Mohanakumar T,Brennan DC,Schnitzler MA

更新日期：2000-08-15 00:00:00

abstract：BACKGROUND:Graft thrombosis immediately after surgery remains a problem for successful pancreas transplantation. The present study evaluated the efficacy of computed tomography (CT) angiography for monitoring of graft patency in the immediate postoperative period. METHODS:The study involved 119 patients who underwent ...

journal_title：Transplantation

authors： Kim YH,Park JB,Lee SS,Byun JH,Kim SC,Han DJ

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:The expression of xenogeneic epitopes and the activation of human complement by adult pig islets after prolonged culture have hitherto not been described. MATERIALS AND METHODS:Freshly isolated and cultured islets were analyzed by fluorescence-activated cell sorter analysis, fluorescence microscopy, and imm...

journal_title：Transplantation

authors： Mirenda V,Le Mauff B,Cassard A,Huvelin JM,Boeffard F,Faivre A,Soulillou JP,Anegon I

更新日期：1997-05-27 00:00:00

abstract：BACKGROUND:We sought to determine the risk factors, molecular epidemiology, antibiotic therapy, and outcomes of bacteremia because of extensively drug-resistant (XDR) Pseudomonas aeruginosa in solid organ transplant (SOT) recipients. METHODS:All episodes of bacteremia occurring in SOT recipients were prospectively doc...

journal_title：Transplantation

authors： Bodro M,Sabé N,Tubau F,Lladó L,Baliellas C,González-Costello J,Cruzado JM,Carratalà J

更新日期：2015-03-01 00:00:00

abstract：:Antibody-mediated rejection (AMR) is an important cause of graft loss and continues to present a formidable obstacle to successful transplantation. Unresolved problems continue to be the absence of effective strategies to ablate the donor-specific antibody (DSA) response as well as to attenuate the antibody-mediated g...

journal_title：Transplantation

authors： Miyairi S,Baldwin WM 3rd,Valujskikh A,Fairchild RL

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Cytotoxic IgG against class I antigens can contribute to renal dysfunction or failure after transplantation. However, the clinical relevance of IgG measured by flow cytometric cross-matching is controversial. This study correlated pre- and postoperative flow reactivity with clinical outcome among renal trans...

journal_title：Transplantation

authors： Kimball P,Rhodes C,King A,Fisher R,Ham J,Posner M

更新日期：1998-02-15 00:00:00

abstract：:Two patients at our institution underwent single lung transplantation. The procedure and the patient's postoperative course were uncomplicated in each case. Pathological examination of each pneumonectomy specimen revealed a well-differentiated adenocarcinoma; both were less than 1 cm in size. The remainder of each lun...

journal_title：Transplantation

authors： Svendsen CA,Bengtson RB,Park SJ,Shumway SJ

更新日期：1998-10-27 00:00:00

abstract：:This study focuses upon two discrete components of posttransplant hepatic reticuloendothelial system (RES) function-phagocytosis and killing of bacteria-under various conditions of ischemic preservation. We had previously reported that, following intravenous injection of rats with 51Cr and 125I double-labeled Escheric...

journal_title：Transplantation

authors： Klein AS,Zhadkevich M,Wang D,Margolick JB,Winkelstein JA,Bulkley GB

更新日期：1996-04-27 00:00:00

abstract：BACKGROUND:It is unclear to what extent cancer history affects posttransplantation mortality in solid organ transplant recipients. METHODS:We identified a Swedish population-based cohort of solid organ transplant recipients in the National Patient Register 1970 to 2008 and linked it to the Cancer and Cause-of-Death Re...

journal_title：Transplantation

authors： Brattström C,Granath F,Edgren G,Smedby KE,Wilczek HE

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion injury (IRI) plays key roles in graft viability and posttransplantation function. Caspase-3 associated with apoptosis and inflammation is up-regulated by IRI. We propose that naked small interfering RNA (siRNA) targeting caspase-3 may prevent IRI and improve kidney preservation. METHODS...

journal_title：Transplantation

authors： Yang B,Hosgood SA,Nicholson ML

更新日期：2011-03-15 00:00:00

abstract：:The mixed lymphocyte culture tests between one patient with acute lymphocytic leukemia and her mother and between another patient with aplastic anemia and his mother were found nonreactive, despite a one-haplotype difference for HL-A. Two crossovers in each family at the MLC locus or a specific defect in lymphocyte r...

journal_title：Transplantation

authors： Opelz G

更新日期：1975-01-01 00:00:00

abstract：:Feline bone marrow cells treated with the soybean agglutinin (SBA) lectin are separated into two populations, the agglutinated SBA(+) fraction containing predominantly cells of myeloid origin and the nonagglutinated SBA(-) fraction consisting of cells primarily of the erythroid lineage. FACScan analyses revealed a cle...

journal_title：Transplantation

authors： Gengozian N,Reyes L,Pu R,Homer BL,Bova FJ,Yamamoto JK

更新日期：1997-08-15 00:00:00

abstract：:Graft-versus-host disease (GVHD)* is a frequent complication of allogeneic bone marrow transplantation. The potentially beneficial effect of phototherapy for treatment of cutaneous manifestations of GVHD led us to investigate retrospectively the effect of this therapy in a larger series of patients. Eleven patients wi...

journal_title：Transplantation

authors： Aubin F,Brion A,Deconinck E,Plouvier E,Hervé P,Humbert P,Cahn JY

更新日期：1995-01-15 00:00:00

abstract：:Subsets of T cells have been identified by the expression of different isoforms of CD45. Some T cells expressing CD45RA (gp220) have been characterized as "naive" in their response to antigens including alloantigens, whereas T cells expressing CD45RO (gp180) have been characterized as "memory" T cells. To examine the ...

journal_title：Transplantation

authors： Ibrahim S,Dawson DV,Sanfilippo F

更新日期：1995-03-15 00:00:00

abstract：BACKGROUND:We developed a nonviral gene transfer method using rapid injection of naked DNA targeting the liver and applied it in a rat model of liver transplantation. METHODS:Inbred Dark Agouti and Lewis rats were used. To test the efficacy and adverse effects of systemic or local (catheter-based) injection, different...

journal_title：Transplantation

authors： Inoue S,Hakamata Y,Kaneko M,Kobayashi E

更新日期：2004-04-15 00:00:00

abstract：BACKGROUND:In organ transplantation, several immunosuppressants are currently used to control graft rejection. Clinically, no single immunosuppressive agent can completely prevent posttransplantation immunoreaction; thus, combination therapy is usually performed. Novel agents with more powerful immunosuppressive activi...

journal_title：Transplantation

authors： Yamamoto S,Okuda T,Yamasaki K,Tanaka H,Kubo S,Takemura S,Ikeda K,Minamiyama Y,Hirohashi K,Suehiro S

更新日期：2004-12-15 00:00:00

abstract：BACKGROUND:Frequencies of alloreactive T cells determined by limiting dilution assays (LDA) may not adequately reflect the donor-reactive immune status in transplant recipients. To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared the...

journal_title：Transplantation

authors： De Haan A,Van Der Gun I,Van Der Bij W,De Leij LF,Prop J

更新日期：2002-08-27 00:00:00

abstract：OBJECTIVES:To determine whether humoral autoimmune responses associated with dilated cardiomyopathy (DCM) influence the postoperative clinical course following cardiac transplantation. METHODS:ELISA levels of preformed cardiac myosin (CM) autoantibodies (Abs) in patients with a pretransplant diagnosis of dilated cardi...

journal_title：Transplantation

authors： Warraich RS,Pomerance A,Stanley A,Banner NR,Dunn MJ,Yacoub MH

更新日期：2000-04-27 00:00:00

abstract：:Rabbit antisera to rat thoracic duct lymphocytes were examined by absorption analysis with quantitative radioimmunoassays to determine the tissue distribution of the antigens recognised and the amount of antibody against different specificities. Seven of eight sera were remarkably specific for leucocytes and one serum...

journal_title：Transplantation

authors： Fabre JW,Williams AF

更新日期：1977-04-01 00:00:00

abstract：:The ability of the popliteal lymph node assay (PLNA) To detect host-versus-graft activity in response to H-Y antigens was investigated in the rat by using presensitized recipients. It was shown that significant popliteal lymph node (PLN) enlargement in response to H-Y-incompatible lymphocytes from syngeneic donors cou...

journal_title：Transplantation

authors： Markwick JR,Pegrum GD

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:The shortage of cadaveric livers has sparked an interest in adult-to-adult living donor transplantation. Right lobe donor hepatectomy is frequently required to obtain a graft of adequate size for adult recipients. Careful donor selection is necessary to minimize complications and assure a functional graft. ...

journal_title：Transplantation

authors： Marcos A,Fisher RA,Ham JM,Olzinski AT,Shiffman ML,Sanyal AJ,Luketic VA,Sterling RK,Olbrisch ME,Posner MP

更新日期：2000-06-15 00:00:00

abstract：:Significant extended survival of C3H/He skin grafts in antilymphocyte serum (ALS)-treated B6AF1 mice can be brought about by the injection of donor-strain bone marrow on day 6 or 7 after grafting. In the present study, survival of the active graft-prolonging bone marrow cells under several storage conditions was inves...

journal_title：Transplantation

authors： De Fazio SR,Hartner WC,Monaco AP,Gozzo JJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:We began a clinical trial in African Americans comparing sirolimus-tacrolimus to standard immunosuppression. We report two African American male living donor kidney recipients who developed acute renal failure after exposure to sirolimus-tacrolimus. METHODS:Both patients received similar doses of sirolimus ...

journal_title：Transplantation

authors： Lawsin L,Light JA

更新日期：2003-01-15 00:00:00

abstract：BACKGROUND:Brain death (BD) affects the viability of lungs for transplantation. A correlation exists between high lung inflammation after BD and the decrease in female sex hormones, especially estradiol. Therefore, we investigated the effects of 17β-estradiol (E2) treatment on the lungs of female brain dead rats. METH...

journal_title：Transplantation

authors： Ricardo-da-Silva FY,Armstrong R Jr,Vidal-Dos-Santos M,Correia CJ,Coutinho E Silva RDS,da Anunciação LF,Moreira LFP,Leuvenink HGD,Breithaupt-Faloppa AC

更新日期：2020-10-07 00:00:00

abstract：:Since chemotaxis is an important mechanism by which leukocytes are recruited to allografts during rejection, the effect of immunosuppressant agents on in vitro chemotactic responses of neutrophils, monocytes, and lymphocytes was studied. Cyclosporine caused profound inhibition of lymphocyte chemotaxis to three differe...

journal_title：Transplantation

authors： Adams DH,Wang LF,Neuberger JM,Elias E

更新日期：1990-11-01 00:00:00