Abnormal B-cell regulation in highly sensitized patients with sustained serum levels of antibody to HLA class I antigens.

abstract：:The number of patients awaiting hepatic transplantation continues to exceed organ donation. As a result, many liver transplant candidates will develop life-threatening complications of their liver disease and not survive the pretransplant waiting period. Recent studies have demonstrated that hepatic lidocaine metaboli...

journal_title：Transplantation

authors： Shiffman ML,Fisher RA,Sanyal AJ,Edinboro LE,Luketic VA,Purdum PP 3rd,Raymond P,Posner MP

更新日期：1993-04-01 00:00:00

abstract：:A comparative study of 24 hr preservation at 4 degrees C of excised rat livers with Euro-Collins and hydroxyethyl starch-free University of Wisconsin (UWm) solutions has been conducted based on the assessment of (1) the cellular energy status determined by 31P NMR spectroscopy and (2) cellular injury estimated from th...

journal_title：Transplantation

authors： Gulian JM,Dalmasso C,Desmoulin F,Scheiner C,Cozzone PJ

更新日期：1992-10-01 00:00:00

abstract：:The reactions of a number of LEW anti-ACI allospecific rat monoclonal antibodies were examined in a series of breeding studies. Analysis of (LEW X ACI) F2 progeny demonstrated concordance of the monoclonal class I and class II specificities with results of conventional alloantisera typing. In addition, a "gene dosage"...

journal_title：Transplantation

authors： Fuks A,Guttmann RD

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Finding the best combination of immunosuppression is an important challenge in kidney transplantation. Current short-term (1- and 3-year) allograft survival is quite good, making it difficult to determine differences in therapeutic regimens without large sample sizes. Using data from the United Network for O...

journal_title：Transplantation

authors： Cherikh WS,Myron Kauffman H,Maghirang J,Bleyer AJ,Johnson CP

更新日期：2003-08-15 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) replication has been associated with more risk for solid organ graft rejection. We wondered whether this association still holds when patients at risk receive prophylactic treatment for CMV. METHODS:We correlated CMV infection, biopsy-proven graft rejection, and graft loss in 1,414 pat...

journal_title：Transplantation

authors： Stern M,Hirsch H,Cusini A,van Delden C,Manuel O,Meylan P,Boggian K,Mueller NJ,Dickenmann M,Members of Swiss Transplant Cohort Study.

更新日期：2014-11-15 00:00:00

abstract：:Using antisera to human beta2-microglobulin and an immunofluorescent technique, beta2-microglobulin was found to be localized along tubular and glomerular basement membranes of renal bipsies studied. Since beta2-microglobulin is a subunit of HLA preparations, it may also serve as an indirect marker for the presence of...

journal_title：Transplantation

authors： Ooi BS,Rubin SC,Pesce AJ,Pollak VE

更新日期：1977-07-01 00:00:00

abstract：:Renal function was observed retrospectively in a population of 228 adults who underwent a cardiac allograft at the University of Pittsburgh from June 1980 through June 1987, survived a minimum of one year, and received cyclosporine. Renal function was determined by serial measurement of serum creatinine concentration....

journal_title：Transplantation

authors： Greenberg A,Thompson ME,Griffith BJ,Hardesty RL,Kormos RL,el-Shahawy MA,Janosky JE,Puschett JB

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Avascular osteonecrosis (AVN) is a serious complication of allogeneic stem cell transplantation (SCT). Graft-versus-host disease and its treatment with steroids are the main risk factors; underlying diagnosis, age and gender are further risk factors. It has been speculated that low baseline bone mineral dens...

journal_title：Transplantation

authors： Schulte CM,Beelen DW

更新日期：2005-06-27 00:00:00

abstract：BACKGROUND:Plasma level of plasminogen activator inhibitor (PAI)-1 is genetically determined by a polymorphism in the promoter region, involving two alleles, 4G and 5G. Plasma PAI-1 concentrations are higher in subjects homozygous for the 4G allele than other genotypes (5G/5G and 4G/5G). Such genetic variation in fibri...

journal_title：Transplantation

authors： Chow KM,Szeto CC,Szeto CY,Poon P,Lai FM,Li PK

更新日期：2002-12-27 00:00:00

abstract：BACKGROUND:The depletion of differential B cell and xenoreactive natural antibodies (XNA) by anti-delta and anti-mu injections was analyzed in adult mice. Sequential treatment with anti-delta and then anti-mu induces a complete depletion of B cells and XNA and represents a potential approach to induce xenograft toleran...

journal_title：Transplantation

authors： Chentoufi AA,Nizet Y,Havaux X,De La Parra B,Cormont F,Hermans D,Bazin H,Latinne D

更新日期：1999-12-15 00:00:00

abstract：BACKGROUND:T-cell receptor transgenic (TCR-tg) mouse models with direct CD4 alloreactivity will help elucidate mechanisms of transplant rejection and tolerance in vivo. Although such models exist, they are limited by unusual strain combinations or are based on model antigens. METHODS:A TCR-tg mouse with direct CD4 spe...

journal_title：Transplantation

authors： Brennan TV,Hoang V,Garrod KR,Liu FC,Hayden T,Kim J,Kang SM

更新日期：2008-01-27 00:00:00

abstract：:Enhancement of skin grafts in mice by passively administered alloantiserum was examined in conjunction with the simultaneous use of other immunosuppressive regimens. It could be clearly shown that when a "weak" antilymphocyte serum (ALS) was used, a significant further prolongation of graft survival occurred over that...

journal_title：Transplantation

authors： Koene RA,Gerlag PG,McKenzie IF,Hagemann JF,Wijdeveld PG

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND:Little is known about associations between low physical activity (PA) and its correlates and outcomes in solid organ transplant recipients. This systematic review with meta-analysis examined correlates and outcomes associated with low PA (ie, not meeting individual study's definition of being physically acti...

journal_title：Transplantation

authors： Berben L,Engberg SJ,Rossmeissl A,Gordon EJ,Kugler C,Schmidt-Trucksäss A,Klem ML,Sereika SM,De Simone P,Dobbels F,De Geest SM,B-SERIOUS consortium.

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Metabolic syndrome (MS) is a known cardiovascular risk factor in the general population. We explored the influence of MS on the occurrence of atherosclerotic events (AEs) after renal transplantation. METHODS:Three hundred thirty-seven renal transplant recipients were included in the study. Various parameter...

journal_title：Transplantation

authors： Courivaud C,Kazory A,Simula-Faivre D,Chalopin JM,Ducloux D

更新日期：2007-06-27 00:00:00

abstract：BACKGROUND:Vascular complications remain an important cause of postoperative morbidity in liver transplant patients. Herein, we present an unusual case of nonanastomotic inferior vena cava (IVC) stenosis in a patient with a "piggyback" caval anastomosis. METHODS:A 59-year-old woman underwent liver transplantation usin...

journal_title：Transplantation

authors： Orons PD,Hari AK,Zajko AB,Marsh JW

更新日期：1997-11-15 00:00:00

abstract：BACKGROUND:In December 2018, United Network for Organ Sharing approved an allocation scheme based on recipients' geographic distance from a deceased donor (acuity circles [ACs]). Previous analyses suggested that ACs would reduce waitlist mortality overall, but their impact on pediatric subgroups was not considered. ME...

journal_title：Transplantation

authors： Mogul DB,Perito ER,Wood N,Mazariegos GV,VanDerwerken D,Ibrahim SH,Mohammad S,Valentino PL,Gentry S,Hsu E

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:We hypothesized that tissue-engineered contractile cardiomyocyte sheets without a scaffold would show histological and electrical integration with impaired myocardium, leading to the regeneration of infarcted myocardium. METHODS:Neonatal rat cardiomyocytes were cultured on Poly(N-isopropylacrylamide)-grafte...

journal_title：Transplantation

authors： Miyagawa S,Sawa Y,Sakakida S,Taketani S,Kondoh H,Memon IA,Imanishi Y,Shimizu T,Okano T,Matsuda H

更新日期：2005-12-15 00:00:00

abstract：:Two anti-H-2Ld sera were analyzed, BALB/c-H-2dm2 anti-BALB/cBy and (C3H X BALB/c-H-2dm2)F1 anti-BALB/cHe, the latter also containing anti-Qa antibodies. Their reaction patterns were compared with an anti-Qa serum (C3H X BALB/cBy)F1 anti-BALB/cHe. Four H-2 specificities could be detected by the anti-H-2Ld sera, two alr...

journal_title：Transplantation

authors： Oudshoorn-Snoek M,Iványi D,Démant P

更新日期：1981-08-01 00:00:00

abstract：:Modified limiting dilution analysis (LDA) techniques were used to evaluate the mobilization of antigen-stimulated helper T lymphocytes (HTL) and cytotoxic T lymphocytes (CTL) following allogeneic heterotopic cardiac transplantation. These modified LDA techniques allow a quantitative comparison of T cells that have bee...

journal_title：Transplantation

authors： Bishop DK,Shelby J,Eichwald EJ

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Although the outcome of islet transplantation has improved, there remains a major obstacle in isolating viable islets from prolonged preserved pancreas. We previously reported that the two-layer cold storage method (TLM) improved the yield and in vitro function. In this study, we performed in vivo accurate f...

journal_title：Transplantation

authors： Kakinoki K,Fujino Y,Suzuki Y,Li S,Tanioka Y,Sakai T,Kuroda Y

更新日期：2005-06-15 00:00:00

abstract：BACKGROUND:Chronic allograft nephropathy (CAN) is the most common cause of long-term renal-allograft dysfunction and the second most common cause of transplant loss. There are concerns that prolonged patient exposure to calcineurin inhibitors (CNIs) exacerbates or promotes the process of CAN. METHODS:In our unit, we c...

journal_title：Transplantation

authors： Afzali B,Shah S,Chowdhury P,O'sullivan H,Taylor J,Goldsmith D

更新日期：2005-02-15 00:00:00

abstract：:The intestinal phase of the graft-versus-host reaction (GVHR) has been investigated in adult F1 mice bearing grafts of fetal gut using an H-2-incompatible and an H-2-compatible, Mls-incompatible combination. The results indicate that the mitotic activity of the intestinal crypts and the number of intraepithelial lymph...

journal_title：Transplantation

authors： Mowat AM,Ferguson A

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:Early calcineurin inhibitor (CNI) withdrawal with mycophenolate mofetil (MMF) has not become routine practice, due to concerns about excess acute rejection. Therapeutic drug monitoring may be advantageous when the CNI or MMF is withdrawn. METHODS:This prospective, randomized, concentration-controlled withdr...

journal_title：Transplantation

authors： Mourer JS,Hartigh Jd,van Zwet EW,Mallat MJ,Dubbeld J,de Fijter JW

更新日期：2012-05-15 00:00:00

abstract：:A cluster of five cases of Legionnaires' disease in renal transplant patients is described. They were treated with erythromycin and rifampicin, and all five survived. Two of them had rejected their grafts prior to their Legionella pneumonia; two rejected their transplants after reduction of immunosuppressive therapy t...

journal_title：Transplantation

authors： Wilczek H,Kallings I,Nyström B,Hoffner S

更新日期：1987-06-01 00:00:00

abstract：:The purpose of this study was to determine the changes of hepatic sinusoidal endothelial cell (SEC) function in acute liver rejection with respect to receptor-mediated endocytosis. Orthotopic rat liver transplantation was performed in Lewis rats grafted with DA livers and in Lewis rats grafted with Lewis livers as rej...

journal_title：Transplantation

authors： Yokoi Y,Nakamura S,Muro H,Baba S

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil (MMF) based immunosuppression after renal transplantation has proven to be safe and beneficial for children and adolescents. However, long-term analysis, in particular of pediatric patients, is scarce. PATIENTS:Data of 140 patients receiving MMF versus azathioprine (AZA) in combination...

journal_title：Transplantation

authors： Jungraithmayr TC,Wiesmayr S,Staskewitz A,Kirste G,Bulla M,Fehrenbach H,Dippell J,Greiner C,Griebel M,Helmchen U,Klaus G,Leichter HE,Mihatsch MJ,Michalk DV,Misselwitz J,Plank C,Tönshoff B,Weber LT,Zimmerhackl LB,Germ

更新日期：2007-04-15 00:00:00

abstract：:Glutathione is important in cellular defense against oxidative stress. We postulated that administration of N-acetylcysteine (NAC), a glutathione precursor, might help maintain or replenish hepatic glutathione stores, thereby reducing reperfusion injury in liver grafts after warm ischemia. Eighteen pigs were subjected...

journal_title：Transplantation

authors： Fukuzawa K,Emre S,Senyuz O,Acarli K,Schwartz ME,Miller CM

更新日期：1995-01-15 00:00:00

abstract：:Orthotopic liver transplantation is frequently associated with a complex coagulation disorder, influencing the outcome of the procedure. In this respect, disseminated intravascular coagulation (DIC) had been suggested to be of causative importance for bleeding complications after reperfusion of the liver graft. In 10 ...

journal_title：Transplantation

authors： Riess H,Jochum M,Machleidt W,Himmelreich G,Blumhardt G,Roissaint R,Neuhaus P

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Liver transplantation using ABO-incompatible grafts is rarely performed because the reported outcome is poorer than with compatible grafts. We report our positive experience with adult-to-adult living-donor liver transplant (LDLT) using ABO-incompatible grafts. METHODS:The immunosuppressive protocol consist...

journal_title：Transplantation

authors： Testa G,Vidanovic V,Chejfec G,Gangemi A,Iqpal R,Porubsky M,Pham T,Benedetti E

更新日期：2008-03-15 00:00:00

abstract：BACKGROUND:Small bowel transplantation in children weighing less than 10 kg is hindered by the lack of size-matched donors. The ability to create reduced size small bowel grafts from adult cadaveric donors suitable for use in young children has been studied. METHODS:Volumetric assessment of computed tomography scans w...

journal_title：Transplantation

authors： Delrivière L,Muiesan P,Marshall M,Davenport M,Dhawan A,Kane P,Karani J,Rela M,Heaton N

更新日期：2000-04-15 00:00:00