Liver disease after bone marrow transplantation--the Taiwan experience.

abstract：:We have analyzed PBL from 7 children exposed to CsA in utero and 4 children exposed to AZA in utero. Expression of CD3, CD4, CD8, and CD20 were normal for both groups of children; however, significant differences were detected in the expression of CD45RA, CD45R0, and CD29. While CsA-exposed children had higher density...

journal_title：Transplantation

authors： Pilarski LM,Yacyshyn BR,Lazarovits AI

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Prophylactic ganciclovir (GCV) is used in high-risk renal transplant patients to prevent acute cytomegalovirus (CMV) disease, but its impact on inflammation within the allograft itself remains undefined. METHODS:To study the effect of GCV prophylaxis on allograft inflammation, murine CMV (MCMV)-infected all...

journal_title：Transplantation

authors： Shimamura M,Saunders U,Rha B,Guo L,Cassady KA,George JF,Britt WJ

更新日期：2011-10-15 00:00:00

abstract：BACKGROUND:Most transplant centers in the United States, including our own, use creatinine clearance (Ccr) to estimate glomerular filtration rate (GFR) in potential living kidney donors. The purpose of this study was to evaluate our experience with estimation of donor GFR by Ccr and to explore other potential strategie...

journal_title：Transplantation

authors： Bertolatus JA,Goddard L

更新日期：2001-01-27 00:00:00

abstract：:BACKGROUND.: Rabbit antithymocyte globulins (rATGs) are known to convert CD4CD25FoxP3 T cells from healthy individuals to CD4CD25FoxP3 T cells. In this study, we investigated the effect of rATG on the induction of regulatory T cells (Tregs) from blood cells of patients with end-stage renal disease who are candidates f...

journal_title：Transplantation

authors： Sewgobind VD,van der Laan LJ,Kho MM,Kraaijeveld R,Korevaar SS,van Dam T,Ijzermans JN,Weimar W,Baan CC

更新日期：2010-03-27 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the influence of IL-10 and TGFbeta1 gene polymorphisms on the development of acute rejection and coronary disease in pediatric heart transplant recipients. METHODS:Patients were classified as either Rejectors or Nonrejectors. Coronary artery disease (CAD) was diagnosed by...

journal_title：Transplantation

authors： Di Filippo S,Zeevi A,McDade KK,Bastien O,Webber SA

更新日期：2006-03-27 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (CMV) uses different strategies to escape from human host defense reactions. Previously we have observed that infection of endothelial cells with CMV in vitro leads to enhanced activity of endothelial ectonucleotidases. These ectoenzymes are responsible for hydrolysis of extracellular a...

journal_title：Transplantation

authors： Zandberg M,van Son WJ,Harmsen MC,Bakker WW

更新日期：2007-11-27 00:00:00

abstract：:In this study we examined the functional capacity of unseparated, IL-2R positive and IL-2R negative leukocytes infiltrating BN rat hearts or kidneys grafted into allogeneic LEW rats. Upon adoptive transfer into syngeneic LEW recipients, splenocytes or day-3 graft infiltrate cells of either cardiac or renal transplants...

journal_title：Transplantation

authors： Heidecke CD,Brauer R,Schneider-Eicke J,Schilling T,Wolff S,Diamantstein T

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Although proportionally more veterans live in rural areas compared to nonveterans, the impact of rurality status on kidney transplantation (KTP) access among veterans is unknown. Our objective was to study KTP rates among veterans listed for KTP and to compare the impact of rurality status on KTP rates among...

journal_title：Transplantation

authors： O'Shea AMJ,Franciscus CL,Kaboli PJ,Kalil RS

更新日期：2019-09-01 00:00:00

abstract：:Ninety-eight renal transplant recipients who had been followed for 1-6.5 years (median 3.2 years) were reviewed to determine the effect of donor and recipient hepatitis B surface antigen status on the incidence of hepatitis and on patient survival. The cumulative risk of developing hepatitis posttransplant was signifi...

journal_title：Transplantation

authors： Chan PC,Lok AS,Cheng IK,Chan MK

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Liver endothelial cells (LECs) perform an essential role in important pathophysiologic functions in the liver. Establishment of a human LEC line facilitates advances in LEC research. Here, we present immortalization of human LECs using retroviral gene transfer of simian virus 40 large T antigen (SV4...

journal_title：Transplantation

authors： Matsumura T,Takesue M,Westerman KA,Okitsu T,Sakaguchi M,Fukazawa T,Totsugawa T,Noguchi H,Yamamoto S,Stolz DB,Tanaka N,Leboulch P,Kobayashi N

更新日期：2004-05-15 00:00:00

abstract：BACKGROUND:The clinical impact of chronic transplant glomerulopathy (CTG) on the outcome of kidney allograft receiving calcineurin inhibitors (CNIs) remains uncertain. A retrospective study of renal transplant recipients at Ospedale Maggiore of Milan was undertaken to evaluate the clinical outcome of patients with CTG....

journal_title：Transplantation

authors： Banfi G,Villa M,Cresseri D,Ponticelli C

更新日期：2005-11-27 00:00:00

abstract：BACKGROUND:Patients with high tacrolimus clearance eliminate more drug within a dose interval compared with those with low clearance. Delays in dosing time will result in transient periods of lower concentrations in high versus low clearance patients. Transient subtherapeutic tacrolimus concentrations may induce acute ...

journal_title：Transplantation

authors： Egeland EJ,Robertsen I,Hermann M,Midtvedt K,Størset E,Gustavsen MT,Reisæter AV,Klaasen R,Bergan S,Holdaas H,Hartmann A,Åsberg A

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high interpatient and intrapatient variability (IPV) leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC IPV (I...

journal_title：Transplantation

authors： Rayar M,Tron C,Jézéquel C,Beaurepaire JM,Petitcollin A,Houssel-Debry P,Camus C,Verdier MC,Dehlawi A,Lakéhal M,Desfourneaux V,Meunier B,Sulpice L,Bellissant E,Boudjema K,Lemaitre F

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Renal transplant patients have an increased incidence of skin cancers, predominantly on sun-exposed surfaces. Clinical observation identified some patients with an increased number of viral warts, keratoses, and skin malignancies on the side of the arteriovenous fistula. METHODS:In a population of 980 patie...

journal_title：Transplantation

authors： Bordea C,Cortina-Borja M,Wojnarowska F,Morris PJ

更新日期：2001-01-15 00:00:00

abstract：BACKGROUND:Increasing use of kidney grafts for simultaneous liver and kidney (SLK) transplants is causing concern about the most effective utilization of scarce kidney graft resources. This study evaluated the impact of implementing the proposed United Network for Organ Sharing SLK transplant policy on outcomes for end...

journal_title：Transplantation

authors： Chang Y,Gallon L,Shetty K,Chang Y,Jay C,Levitsky J,Ho B,Baker T,Ladner D,Friedewald J,Abecassis M,Hazen G,Skaro AI

更新日期：2015-02-01 00:00:00

abstract：:With advances in microsurgery and molecular biology, the mouse model for organ transplantation has become increasingly popular. However, knowledge about these models is limited, as only a small number of centers have experience with murine models. In this study, we compared the rejection pattern after liver, kidney, h...

journal_title：Transplantation

authors： Zhang Z,Zhu L,Quan D,Garcia B,Ozcay N,Duff J,Stiller C,Lazarovits A,Grant D,Zhong R

更新日期：1996-11-15 00:00:00

abstract：INTRODUCTION:Some Indoasian (IA) patients with established renal failure travel abroad for commercial kidney transplantation. We compared the 1-year outcomes of IA patients from one UK region who received overseas transplants with IA patients receiving local living donor (LD) kidney transplantation, deceased donor (DD)...

journal_title：Transplantation

authors： Krishnan N,Cockwell P,Devulapally P,Gerber B,Hanvesakul R,Higgins R,Ready A,Carmichael P,Tomlinson K,Kumar S,Baharani J,Dasgupta I

更新日期：2010-06-27 00:00:00

abstract：:To investigate whether graft-versus-host reactivity (GVHR) and the graft-versus-leukemia (GVL) effect can be differentiated, C3H-->AKR mixed bone marrow (BM) chimeras were prepared using two different conditioning regimens. Total body irradiation (TBI) chimeras were induced by infusing 5 x 1O(6) T cell depleted syngen...

journal_title：Transplantation

authors： Salam A,Waer M

更新日期：1996-03-15 00:00:00

abstract：BACKGROUND:Primary hyperoxaluria type-1 (PH1) is an autosomal recessive disease characterized by excessive oxalate production by hepatocytes caused by the deficiency of peroxisomal alanine-glyoxylate aminotransferase (AGT) activity. Persistent hyperoxaluria causes nephrocalcinosis and urolithiasis, leading to renal fai...

journal_title：Transplantation

authors： Jiang J,Salido EC,Guha C,Wang X,Moitra R,Liu L,Roy-Chowdhury J,Roy-Chowdhury N

更新日期：2008-05-15 00:00:00

abstract：BACKGROUND:Human herpesvirus-6 (HHV-6) is known to reactivate after renal transplantation and has been associated with several clinical manifestations. Risk factors for sustained viral replication, however, remain unclear. METHODS:Thirty consecutive kidney transplant patients were prospectively followed for HHV-6 repl...

journal_title：Transplantation

authors： Luiz CR,Machado CM,Canto CL,Christ SC,Pestana JO,Kotton CN,Camargo LF

更新日期：2013-03-27 00:00:00

abstract：BACKGROUND:Immunosuppression in renal transplantation, although manageable in the short-term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4CD25 regulatory T cells (Tregs) have been described as an additional mechanism that induces alloimmune tolerance. METHODS:We assessed 64 re...

journal_title：Transplantation

authors： Segundo DS,Ruiz JC,Izquierdo M,Fernández-Fresnedo G,Gómez-Alamillo C,Merino R,Benito MJ,Cacho E,Rodrigo E,Palomar R,López-Hoyos M,Arias M

更新日期：2006-08-27 00:00:00

abstract：BACKGROUND:Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks per day) are scanty. METHODS:Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with non-HD (ND) donors. RESULTS:Of 56 182 firs...

journal_title：Transplantation

authors： Arora SS,Chahal KS,Axley P,Eckhoff DE,Kuo YF,Satapathy SK,Wiesner R,Singal AK

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Combined lung and liver transplantation (Lu-LTx) is a therapeutic option for selected patients with coexisting lung and liver disease. For several reasons, Lu-LTx is performed in few centers and information about the technical issues, posttransplant management and long-term outcomes associated with this proc...

journal_title：Transplantation

authors： Grannas G,Neipp M,Hoeper MM,Gottlieb J,Lück R,Becker T,Simon A,Strassburg CP,Manns MP,Welte T,Haverich A,Klempnauer J,Nashan B,Strueber M

更新日期：2008-02-27 00:00:00

abstract：:The mode of action of glucocorticosteroids as immunosuppressive and antiinflammatory agents is not fully understood. Glucocorticosteroids block synthesis of interleukin 1 by interfering with the transcription of the IL-1 beta gene. Glucocorticosteroids may also induce rapid degradation of IL-1 mRNA. In the presence of...

journal_title：Transplantation

authors： Zanker B,Walz G,Wieder KJ,Strom TB

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Clinical trial data suggest that continuous hypothermic machine perfusion (HMP) during the entire preservation period reduces the incidence of delayed graft function and improves graft survival. This study evaluates whether short-term MP after cold storage (CS) is also effective. METHODS:Kidney function aft...

journal_title：Transplantation

authors： Gallinat A,Paul A,Efferz P,Lüer B,Kaiser G,Wohlschlaeger J,Treckmann J,Minor T

更新日期：2012-04-27 00:00:00

abstract：:Hepatic artery thrombosis is a continuing source of morbidity and mortality following orthotopic liver transplantation. The cornerstone of therapy has been urgent retransplantation that is limited by organ availability. For this reason we developed a policy of urgent revascularization for allograft rescue. Hepatic art...

journal_title：Transplantation

authors： Langnas AN,Marujo W,Stratta RJ,Wood RP,Li SJ,Shaw BW

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Treatment of fetal pancreas (FP) isografts with insulin-like growth factor-I greatly improves the rate of conversion to euglycemia in diabetic rats. Complete knowledge of other factors that may facilitate the engraftment and function of FP in vivo is still embryonic. Augmenter of liver regeneration (ALR) is ...

journal_title：Transplantation

authors： Adams GA,Maestri M,Squiers EC,Alfrey EJ,Starzl TE,Dafoe DC

更新日期：1998-01-15 00:00:00

abstract：BACKGROUND:Hyperparathyroidism is reported in 10% to 66% of renal transplant recipients (RTR). The influence of persisting hyperparathyroidism on long-term clinical outcomes in RTR has not been examined in a large prospective study. METHODS:We investigated the association between baseline parathyroid hormone (PTH) lev...

journal_title：Transplantation

authors： Pihlstrøm H,Dahle DO,Mjøen G,Pilz S,März W,Abedini S,Holme I,Fellström B,Jardine AG,Holdaas H

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:The low efficiency of islet transplantation necessitating sequential transplantations with the use of 2 to 3 donors for a recipient has been a major obstacle facing clinical islet transplantation. We determined whether adenosine has any beneficial effects on preventing early loss of transplanted islets in th...

journal_title：Transplantation

authors： Nitta T,Itoh T,Matsuoka N,Mera T,Kojima D,Nakano M,Yamashita Y,Yasunami Y

更新日期：2009-07-15 00:00:00

abstract：BACKGROUND:ABO-incompatible organ transplantation typically induces hyperacute rejection. A2-to-O liver transplantations have been successful. This study compared overall and graft survival in O recipients of A2 and O grafts based on Organ Procurement and Transplantation Network data. METHODS:Scientific Registry of Tr...

journal_title：Transplantation

authors： Kluger MD,Guarrera JV,Olsen SK,Brown RS Jr,Emond JC,Cherqui D

更新日期：2012-09-15 00:00:00