Efficient gene transfer to pancreatic islets mediated by adenoviral vectors.

abstract：BACKGROUND:We investigated a novel immunosuppressive protocol including thymoglobulin induction in combination with sirolimus and corticosteroids, followed by introduction of markedly reduced exposures to cyclosporine to prevent pancreas-transplant rejection. METHODS:A 7-day course of thymoglobulin (1.5 mg/kg per day)...

journal_title：Transplantation

authors： Knight RJ,Kerman RH,Zela S,Podder H,Van Buren CT,Katz S,Kahan BD

更新日期：2003-04-27 00:00:00

abstract：:Murine lymphoid cells sensitized against allografts express two types of cytotoxicity measured in vitro in short-term assays of 2 to 3 hr by 51Cr release. One type of cytotoxicity is specific against target cells carrying the sensitizing alloantigens, and the other type is nonspecific against both syngeneic and unrela...

journal_title：Transplantation

authors： Bonavida B,Bradley TP

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:At the time of transplantation, a recipient's serum is tested against the prospective donor's lymphocytes to identify specific reactivity and to look for a donor-specific crossmatch (CXM). Here, we investigated the relationship between the pretransplantation lymphocytotoxic CXM results and the long-term outc...

journal_title：Transplantation

authors： Shin M,Moon HH,Kim JM,Park JB,Kwon CH,Kim SJ,Lee SK,Joh JW

更新日期：2013-06-15 00:00:00

abstract：:Preexisting diabetes mellitus (DM) has been regarded as a contraindication to heart transplantation (HT). This prejudice has been based upon concern over increased infection rates and worsening DM with the initiation of prednisone immunosuppression. To better evaluate these suppositions, we reviewed our experience wit...

journal_title：Transplantation

authors： Ladowski JS,Kormos RL,Uretsky BF,Griffith BP,Armitage JM,Hardesty RL

更新日期：1990-02-01 00:00:00

abstract：:The case studies of four patients with post-transplantation calcinosis are presented. Three of the four patients died of inanition and sepsis secondary to infection of extensive soft tissue ulcers and diffuse cutaneous vascular calcification with gangrene. The fourth patient survived following removal of all four para...

journal_title：Transplantation

authors： Perloff LJ,Spence RK,Grossman RA,Barker CF

更新日期：1979-01-01 00:00:00

abstract：:Living organ donation is of increasing importance to satisfy the demand of good quality organs for patients remaining for extended periods on the waiting list. While the benefit for the recipient is undeniable, the organ procurement represents an important burden to live donors in terms of invasiveness and long-term c...

journal_title：Transplantation

authors： Horgan S,Galvani C,Gorodner V,Bareato U,Panaro F,Oberholzer J,Benedetti E

更新日期：2007-10-15 00:00:00

abstract：:The use of immunosuppressive agents (primarily azathioprine and prednisone) to promote human allograft survival is known to be associated with an enhanced rate of skin cancer development by ultraviolet radiation (UVR). These observations raise the question of whether the immunosuppressive agents are functioning as coc...

journal_title：Transplantation

authors： Servilla KS,Burnham DK,Daynes RA

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Oral administration of alloantigens induces down-regulation of Th1 immune responses and reduces the incidence of corneal graft rejection. This study examined the role of Th1 and Th2 cytokines, accessory cells, and lymphoid organs that are known to be instrumental in other forms of antigen-specific tolerance....

journal_title：Transplantation

authors： Niederkorn JY,Mayhew E

更新日期：2002-05-15 00:00:00

abstract：BACKGROUND:In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points. ME...

journal_title：Transplantation

authors： Malinoski D,Patel MS,Axelrod DA,Broglio K,Lewis RJ,Groat T,Niemann CU

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Kidney transplant graft survival is almost uniformly superior for initial transplants compared to repeat transplants. We investigate the association between first second kidney transplant graft survival in patients who underwent initial transplant during their pediatric years whether age at se...

journal_title：Transplantation

authors： Gupta M,Wood A,Mitra N,Furth SL,Abt PL,Levine MH

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Current immunosuppression regimens are toxic to transplant recipients and, in many cases, acute rejection episodes occur because of escape of donor-reactive lymphocytes from the immunosuppression. T cells are the mediators of acute, cell-mediated graft damage and are hypothesized to use the CXCR3 chemokine a...

journal_title：Transplantation

authors： Rosenblum JM,Zhang QW,Siu G,Collins TL,Sullivan T,Dairaghi DJ,Medina JC,Fairchild RL

更新日期：2009-02-15 00:00:00

abstract：:A monoclonal anti-Lyt-1.1 serum has been characterized in terms of its effect on various cell populations involved in cell-mediated immune responses. The monoclonal serum was compared to a conventionally prepared anti-Lyt-1.1 serum. Cytotoxic T cell precursors and effectors were found to be Lyt-1.1+. Helper T cells wh...

journal_title：Transplantation

authors： Shaw J,Pilarski LM,Al Adra AR,Leigh JB,Wilkins J,Hogarth PM,McKenzie IF,Paetkau V

更新日期：1981-01-01 00:00:00

abstract：:Frozen sections of lymph nodes from normal mice were examined by immunofluorescence with anti-T lymphocyte and anti-Ig reagents and by autoradiography following [3H]TdR administration. The scattered T lymphocytes present among B lymphocytes of primary follicles were found to be mostly nonproliferating; the few prolife...

journal_title：Transplantation

authors： Berman MA,Rafiei S,Gutman GA

更新日期：1981-11-01 00:00:00

abstract：:Graft-versus-host disease is a potential problem following small bowel transplantation. We have previously shown that a two-day intraperitoneal course of polyclonal antilymphocyte serum completely prevents GVHD without impairing allograft function in a unidirectional rat small bowel transplant model. In the present st...

journal_title：Transplantation

authors： Shaffer D,Ubhi CS,Simpson MA,Gottschalk R,Milford EL,Maki T,Monaco AP

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:The shortage of organs for liver transplantation has forced transplant centers to expand the donor pool by using donors traditionally labeled as marginal. One such example is liver transplantation using a donor with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), a disorder of late pre...

journal_title：Transplantation

authors： Briceno PJ,Ortiz JA,Manzarbeitia C,Jeon H,Munoz SJ,Rothstein KD,Araya V,Gala I,Reich DJ

更新日期：2004-01-15 00:00:00

abstract：BACKGROUND:Cold ischemia-reperfusion injury is unavoidable during organ transplantation, and prolonged preservation is associated with poorer function recovery. Cardiotrophin-1 (CT-1) is an IL-6 family cytokine with cytoprotective properties. This preclinical study in rats tested whether CT-1 mitigates cold renal ische...

journal_title：Transplantation

authors： García-Cenador B,Blanco-Gozalo V,López-Montañés D,Sanz Giménez-Rico JR,López-Novoa JM,López-Hernández FJ

更新日期：2018-10-01 00:00:00

abstract：:In liver allograft rejection, interlobular bile ducts are thought to be the main target of rejection. In contrast, in other organ allografts the capillary bed of the graft appears to be the primary target. To determine whether portal tract microvasculature is destroyed in liver allografts during rejection, we have ide...

journal_title：Transplantation

authors： Matsumoto Y,McCaughan GW,Painter DM,Bishop GA

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:We previously reported that posttransplant lymphoproliferative disorders (PTLD) occurred more frequently in non-African American (AF) kidney transplant recipients. An in-depth analysis of racial differences in the development of PTLD has not been reported. METHODS:We assessed Medicare claims for PTLD in a r...

journal_title：Transplantation

authors： Nee R,Hurst FP,Dharnidharka VR,Jindal RM,Agodoa LY,Abbott KC

更新日期：2011-07-27 00:00:00

abstract：BACKGROUND:The impact of the age of the donor on the outcome of living related liver transplantation is yet to be clarified. METHODS:During October 14, 1996 and December 20, 1999, 34 living related liver transplantations were performed. Of these, 26 cases were performed using the extended left lobe graft, which were c...

journal_title：Transplantation

authors： Ikegami T,Nishizaki T,Yanaga K,Shimada M,Kishikawa K,Nomoto K,Uchiyama H,Sugimachi K

更新日期：2000-12-27 00:00:00

abstract：BACKGROUND:The use of anti-B-cell and T-cell immunosuppressive agents leads to only a few weeks' survival of mouse-to-rat cardiac xenografts. METHODS:BALB/c cardiac xenografts were transplanted to Lewis rats treated with cyclosporine (CsA) and/or cobra venom factor (CVF). RESULTS:CsA alone did not prolong xenograft s...

journal_title：Transplantation

authors： Koyamada N,Miyatake T,Candinas D,Mark W,Hechenleitner P,Hancock WW,Soares MP,Bach FH

更新日期：1998-05-15 00:00:00

abstract：:Israel's rates of organ donation have been one of the lowest among developed countries. An attempt to change this has led to the introduction of a pioneering new law, the Organ Transplant Act 2008, which came into effect in January 2010 and sets out principles underlying a new policy in relation to the allocation of o...

journal_title：Transplantation

authors： Quigley M,Wright L,Ravitsky V

更新日期：2012-05-27 00:00:00

abstract：BACKGROUND:Cyclosporine (CsA) therapy must often be continued during pregnancy to maintain maternal health in such conditions as organ transplantation and autoimmune disease. This meta-analysis was performed to determine whether CsA exposure during pregnancy is associated with an increased risk of congenital malformati...

journal_title：Transplantation

authors： Bar Oz B,Hackman R,Einarson T,Koren G

更新日期：2001-04-27 00:00:00

abstract：BACKGROUND:Humanized Fc receptor (FcR)-nonbinding antibodies against CD3 are promising immunosuppressive agents that may overcome both the neutralizing response to and the cytokine release syndrome seen with conventional monoclonal antibodies against CD3. In addition, evidence from several murine models suggests that t...

journal_title：Transplantation

authors： Chau LA,Tso JY,Melrose J,Madrenas J

更新日期：2001-04-15 00:00:00

abstract：BACKGROUND:Cell-based insulin therapies can potentially improve glycemic regulation in insulin-dependent diabetic patients. Enteroendocrine cells engineered to secrete recombinant insulin have exhibited glycemic efficacy, but have been primarily studied as uncontrollable growth systems in immune incompetent mice. Furth...

journal_title：Transplantation

authors： Tiernan AR,Thulé PM,Sambanis A

更新日期：2014-09-15 00:00:00

abstract：BACKGROUND:This study addresses the question of the mechanism for maintaining tolerance to donor alloantigen in the absence of antigen and the role of secondary lymphoid tissues. METHODS:Depleting anti-CD4 antibody administration in conjunction with allogeneic heart transplantation generates donor-specific operational...

journal_title：Transplantation

authors： Chosa E,Hara M,Watanabe A,Matsuzaki Y,Nakamura K,Hamano K,Wood KJ,Onitsuka T

更新日期：2007-05-15 00:00:00

abstract：:A group of 170 patients having functional renal allografts were evaluated at least six months after renal transplantation. They were assessed for symptoms and signs of tendinitis in the Achilles and Supraspinatus tendons. Of the 170 patients, 34 had tendinitis. Four patients (11.8%) had spontaneous rupture of the Achi...

journal_title：Transplantation

authors： Murison MS,Eardley I,Slapak M

更新日期：1989-10-01 00:00:00

abstract：:Rat recipients of renal allografts and unilaterally nephrectomized control rats were studied to evaluate the response in blood pressure to prednisolone in diverse doses, and to determine the dosage required to achieve adequate immunosuppression without undue complication of hypertension. While a continuous infusion of...

journal_title：Transplantation

authors： de Keijzer MH,Provoost AP,Van Aken M,Wolff ED,Molenaar JC

更新日期：1987-03-01 00:00:00

abstract：:CD2 is a 50-kDa transmembrane glycoprotein that plays an important role in T and natural killer (NT) lymphocyte functions. CD2 serves as both an adhesion molecule and as a costimulatory molecule through interactions with its ligand, CD58, on antigen presenting or target cells. Consistent with earlier studies using a r...

journal_title：Transplantation

authors： Branco L,Barren P,Mao SY,Pfarr D,Kaplan R,Postema C,Langermann S,Koenig S,Johnson S

更新日期：1999-11-27 00:00:00

abstract：BACKGROUND:Tacrolimus is a potent immunosuppressive agent that provides higher freedom from acute and chronic rejection than cyclosporine after liver transplantation (LTx). Initially, a steroid-free state was observed in about 70% of patients at 1 year; this did not change over the next 5 years. The present study ident...

journal_title：Transplantation

authors： Jain A,Kashyap R,Marsh W,Rohal S,Khanna A,Fung JJ

更新日期：2001-04-27 00:00:00

abstract：BACKGROUND:Renal allografts were performed in rhesus monkeys using FN18-CRM9, a potent immunotoxin capable of depleting T cells to less than 1% of baseline levels in blood and lymph nodes, as a preparative agent. We have recently reported that animals pretreated with FN18-CRM9 1 week before transplantation without furt...

journal_title：Transplantation

authors： Fechner JH Jr,Vargo DJ,Geissler EK,Graeb C,Wang J,Hanaway MJ,Watkins DI,Piekarczyk M,Neville DM Jr,Knechtle SJ

更新日期：1997-05-15 00:00:00