Abstract:
BACKGROUND:In a pig liver transplantation model, we compared the effects of Celsior solution (CS), an extracellular preservation solution, with Viaspan (University of Wisconsin solution, UW) on graft function and animal survival. METHODS:Pig livers were flushed with either CS or UW solution and cold-stored for 12 hr (group 1) or for 8 to 10 hr (group 2). Grafts were transplanted orthotopically. Intrahepatic reduced and oxidized glutathione and adenine nucleotides were evaluated 1 hr after reperfusion. Liver function of transplanted animals was monitored for up to 6 days by serum transaminases, total bilirubin, purine nucleoside phosphorylase, and prothrombin levels. RESULTS:In group 1, all animals died within 24 hr after reperfusion regardless of the preservation solution used. In group 2, no significant difference was seen in survival between the CS (72%) and the UW (67%) groups 6 days after transplantation, and there were no statistically significant differences in the biochemical data. There were no differences in histological evaluation of the livers at the time of death or killing of the animals between the CS and UW groups. CONCLUSION:Within the limits of this pilot study, CS is equivalent to UW in terms of graft function and animal survival.
journal_name
Transplantationjournal_title
Transplantationauthors
Audet M,Alexandre E,Mustun A,David P,Chenard-Neu MP,Tiollier J,Jaeck D,Cinqualbre J,Wolf P,Boudjema Kdoi
10.1097/00007890-200106270-00005subject
Has Abstractpub_date
2001-06-27 00:00:00pages
1731-5issue
12eissn
0041-1337issn
1534-6080journal_volume
71pub_type
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