Nondepleting anti-CD4 antibodies in transplantation. Evidence that modulation is far less effective than prolonged CD4 blockade.

abstract：:Based upon encouraging experimental results, we began employing a synthetic perfusate for cadaver kidney preservation. The new perfusate contains hydroxyethyl starch (HES) as the sole colloid for oncotic support; 107 cadaver kidneys were preserved and transplanted (93 primary, 14 nonprimary) using the HES solution and...

journal_title：Transplantation

authors： Hoffmann RM,Stratta RJ,D'Alessandro AM,Sollinger HW,Kalayoglu M,Pirsch JD,Southard JH,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Remote ischemic preconditioning (RIPC) protects against liver ischemia reperfusion (IR) injury. An essential circulating mediator of this protection is nitric oxide (NO) induced by lower limb RIPC. One of the mechanisms through which NO generally acts is the soluble guanylyl cyclase-cyclic GMP (sGC-cGMP) pat...

journal_title：Transplantation

authors： Abu-Amara M,Yang SY,Quaglia A,Rowley P,Tapuria N,Fuller B,Davidson B,Seifalian A

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:Circulating transthyretin (TTR) is derived from the liver, and orthotopic liver transplantation (OLT) is widely performed for variant TTR-associated familial amyloid polyneuropathy (FAP). The effect of OLT on FAP-related cardiac amyloid is of particular interest because wild-type TTR can itself be deposited ...

journal_title：Transplantation

authors： Stangou AJ,Hawkins PN,Heaton ND,Rela M,Monaghan M,Nihoyannopoulos P,O'Grady J,Pepys MB,Williams R

更新日期：1998-07-27 00:00:00

abstract：:LEW rats with long-surviving (> 100 days) (DA x LEW)F1 kidney allografts were generated by treating the recipients with cyclosporine for 14 days after grafting. All rats were monitored after transplantation for the development of antibodies to intact donor class I MHC molecules. Cyclosporine completely suppressed the ...

journal_title：Transplantation

authors： Benham Am,Sawyer GJ,Fabre JW

更新日期：1996-05-27 00:00:00

abstract：:Eradicating transplant tourism depends on complex solutions that include efforts to progress towards self-sufficiency in transplantation. Meanwhile, professionals and authorities are faced with medical, legal, and ethical problems raised by patients who return home after receiving an organ transplant abroad, particula...

journal_title：Transplantation

authors： Domínguez-Gil B,Danovitch G,Martin DE,López-Fraga M,Van Assche K,Morris ML,Lavee J,Erlich G,Fadhil R,Busic M,Rankin G,Al-Rukhaimi M,OʼConnell P,Chin J,Norman T,Massari P,Kamel R,Delmonico FL,Declaration of Istanbul Cu

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Decapeptides derived from human HLA class I sequences have been shown to prolong allograft survival. The mechanism of action of these peptides has been uncertain, because they act in an MHC unrestricted manner. Recently, it was found that these peptides bind heme oxygenase 1 (HO-1). In the present study, we ...

journal_title：Transplantation

authors： DeBruyne LA,Magee JC,Buelow R,Bromberg JS

更新日期：2000-01-15 00:00:00

abstract：BACKGROUND:The role of CD20+ B cells in renal allograft rejection has been reappreciated. Importantly, recent studies suggest a relation between CD20+ B cell aggregates and poorer clinical outcome. In the present study, we attempted to confirm these early reports in a tightly controlled patient population and to differ...

journal_title：Transplantation

authors： Scheepstra C,Bemelman FJ,van der Loos C,Rowshani AT,van Donselaar-Van der Pant KA,Idu MM,ten Berge IJ,Florquin S

更新日期：2008-09-27 00:00:00

abstract：BACKGROUND:AGI-1096 is a novel phenolic intracellular antioxidant with anti-inflammatory and antiproliferative properties. In vitro, AGI-1096 inhibited the inducible expression of vascular cell adhesion molecule (VCAM)-1, E-selectin, and monocyte chemoattractant protein (MCP)-1 in endothelial cells and tumor necrosis f...

journal_title：Transplantation

authors： Murata S,Sundell CL,Lijkwan MA,Balsam LB,Hammainen P,Coleman C,York C,Luchoomun J,Suen KL,Howard R,Somers PK,Morris RE,Robbins RC

更新日期：2004-05-27 00:00:00

abstract：:ABO-incompatible (ABOi) kidney transplantation has gained a renewed interest during the past years. In 2001, a protocol for ABOi kidney transplantation based on antigen-specific immunoadsorption and rituximab was introduced at our center. In this study long-term graft function using this protocol was assessed. All ABO...

journal_title：Transplantation

authors： Genberg H,Kumlien G,Wennberg L,Tydén G

更新日期：2007-12-27 00:00:00

abstract：BACKGROUND:Post-lung transplant infection is one of the leading causes of morbidity and mortality. The cause and incidence are similar in many series; however, infections such as Mycobacterium tuberculosis are influenced by the epidemiologic situation. The authors present a prospective and observational study to define...

journal_title：Transplantation

authors： Bravo C,Roldán J,Roman A,Degracia J,Majo J,Guerra J,Monforte V,Vidal R,Morell F

更新日期：2005-01-15 00:00:00

abstract：:The fate of cell surface I-Ak and H-2Kk antigens shed by murine spleen cells in culture was studied by incubation of nonlabeled spleen cells or splenic T or B cells with culture fluids containing shed radiolabeled alloantigens. Approximately 30 to 40% of the shed alloantigens could be absorbed by syngeneic or allogene...

journal_title：Transplantation

authors： Emerson SG,Cone RE

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:To identify factors related with successful pregnancy in renal transplant recipients and the effect of pregnancy on long-term graft outcome. METHODS:The study group consisted of 48 women who conceived after undergoing renal transplantation (total pregnancies 74). The control group consisted of 187 nonpregna...

journal_title：Transplantation

authors： Kim HW,Seok HJ,Kim TH,Han DJ,Yang WS,Park SK

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:Generation of non-human primate regulatory T cells (Treg) with alloantigen (alloAg) specificity would allow their testing in preclinical transplant models. Low recovery of Treg from peripheral blood limits their potential utility. In small animals and humans, conventional myeloid dendritic cells (DC) have be...

journal_title：Transplantation

authors： Zahorchak AF,Raimondi G,Thomson AW

更新日期：2009-11-15 00:00:00

abstract：:Invasive aspergillosis and mucormycosis are life-threatening infections in solid organ and hematopoietic cell transplant recipients. Despite medical advancements in the care of these patients and the availability of new mold-active drugs, the outcomes remain suboptimal. Therefore, there has been increased interest in ...

journal_title：Transplantation

authors： Haidar G,Singh N

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Hepatic artery thrombosis (HAT) is a significant cause of morbidity after liver transplantation. The aims of this study are to identify and compare risk factors that might contribute to HAT. METHODS:A total of 424 liver transplants performed at the University of Virginia were reviewed. HAT was defined as co...

journal_title：Transplantation

authors： Oh CK,Pelletier SJ,Sawyer RG,Dacus AR,McCullough CS,Pruett TL,Sanfey HA

更新日期：2001-03-27 00:00:00

abstract：BACKGROUND:Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant and nonmalignant hematologic diseases. However, acute graft-versus-host disease (aGVHD) is a lethal complication of hematopoietic stem cell transplantation, which limits its application. Cytokines such as ...

journal_title：Transplantation

authors： Qian L,Mei K,Shen J,Cai J

更新日期：2013-03-15 00:00:00

abstract：:A major impediment to the wider application of clinical liver transplantation is the paucity of acceptable organs. Most centers refuse organs that come from donors who are hepatitis B core antibody positive because of a fear of transmission of hepatitis B virus (HBV) infection to the recipient. The risk related to the...

journal_title：Transplantation

authors： Van Thiel DH,De Maria N,Colantoni A,Friedlander L

更新日期：1999-08-27 00:00:00

abstract：:T cell receptor (TCR) beta-chain usage by HLA-DR1 alloreactive T cell lines was examined to determine whether common TCR gene segments were used preferentially. We have demonstrated previously that a DR1-specific, human renal allograft-derived T cell line and replicate, anti-DR1 mixed lymphocyte reactions (MLR), estab...

journal_title：Transplantation

authors： Hand SL,Alter MD,Finn OJ

更新日期：1996-04-15 00:00:00

abstract：BACKGROUND:We have previously shown that CD8 depletion or CD34 selection of peripheral blood stem cells (PBSC) reduced the incidence of acute graft-versus-host disease (GvHD) after nonmyeloablative stem-cell transplantation (NMSCT). In this study, we analyze the effect of CD8 depletion or CD34 selection of the graft on...

journal_title：Transplantation

authors： Baron F,Schaaf-Lafontaine N,Humblet-Baron S,Meuris N,Castermans E,Baudoux E,Frère P,Bours V,Fillet G,Beguin Y

更新日期：2003-12-27 00:00:00

abstract：:The development of erythrocytosis following renal transplantation has been reported to be caused by a number of factors. These include acute and chronic rejection, hydronephrosis and renal artery stenosis. In this study, seven patients were noted to have erythrocytosis with hematocrits ranging between 53.5 and 66%. Se...

journal_title：Transplantation

authors： Dagher FJ,Ramos E,Erslev AJ,Alongi SV,Karmi SA,Caro J

更新日期：1979-12-01 00:00:00

abstract：:Monocytes play a crucial role in the response of lymphocytes to phytomitogens. This role is evident during the very early events after exposure to the mitogen. Thus, significant lymphocyte transformation does occur when monocytes are removed from the culture within a few hours after exposure to mitogen, and the presen...

journal_title：Transplantation

authors： Mookerjee BK,Ballard J

更新日期：1979-01-01 00:00:00

abstract：:Phenotype, donor-specific cytolytic activity, and helper activity to release cytokines of cells infiltrating within renal allografts of hosts rendered unresponsive by perioperative administration of donor lymphocytes via the portal vein (p.v.) were investigated in order to analyze the mechanism of prolongation of allo...

journal_title：Transplantation

authors： Hamashima T,Yoshimura N,Matsui S,Lee CJ,Ohsaka Y,Oka T

更新日期：1990-01-01 00:00:00

abstract：:Zero-time kidney biopsies, obtained at time of transplantation, are performed in many transplant centers worldwide. Decisions on kidney discard, kidney allocation, and choice of peritransplant and posttransplant treatment are sometimes based on the histological information obtained from these biopsies. This comprehens...

journal_title：Transplantation

authors： Naesens M

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Recipients of simultaneous kidney-pancreas transplantation receive a combination of polyclonal antithymocyte globulin (ATG), cyclosporin or tacrolimus, mycophenolate mofetil (MMF) and corticosteroids (Cs). To avoid the side effects and adverse events associated with Cs, we investigated a new immunosuppressiv...

journal_title：Transplantation

authors： Cantarovich D,Giral-Classe M,Hourmant M,Dantal J,Blancho G,Karam G,Soulillou JP

更新日期：2000-04-15 00:00:00

abstract：:Sixty-two adults who underwent orthotopic liver transplantations between February 1981 and June 1983 were followed for a mean of 170 days after the operation. Twenty-six patients developed 30 episodes of significant fungal infection. Candida species and Torulopsis glabrata were responsible for 22 episodes and Aspergil...

journal_title：Transplantation

authors： Wajszczuk CP,Dummer JS,Ho M,Van Thiel DH,Starzl TE,Iwatsuki S,Shaw B Jr

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:The genetic modification of pigs is a powerful strategy that may ultimately enable successful xenotransplantation of porcine organs into humans. METHODS:Transgenic pigs were produced by microinjection of gene constructs for human complement regulatory proteins CD55 and CD59 and the enzyme alpha1,2-fucosyltr...

journal_title：Transplantation

authors： Cowan PJ,Aminian A,Barlow H,Brown AA,Chen CG,Fisicaro N,Francis DM,Goodman DJ,Han W,Kurek M,Nottle MB,Pearse MJ,Salvaris E,Shinkel TA,Stainsby GV,Stewart AB,d'Apice AJ

更新日期：2000-06-27 00:00:00

abstract：BACKGROUND:We studied whether T-cell clones, which appear in the periphery as a result of the failure of thymic negative selection during graft-versus-host disease (GVHD), have any in vivo anti-host reactivity and can cause GVHD in an adoptive transfer model. METHODS:We performed our studies in a murine model (B10.BR ...

journal_title：Transplantation

authors： van den Brink MR,Moore E,Ferrara JL,Burakoff SJ

更新日期：2000-02-15 00:00:00

abstract：BACKGROUND:Better preservation strategies for the storage of donation after circulatory death grafts are essential to improve graft function and to increase the kidney donor pool. We compared continuous normothermic ex vivo kidney perfusion (NEVKP) with hypothermic anoxic machine perfusion (HAMP) and static cold storag...

journal_title：Transplantation

authors： Urbanellis P,Hamar M,Kaths JM,Kollmann D,Linares I,Mazilescu L,Ganesh S,Wiebe A,Yip PM,John R,Konvalinka A,Mucsi I,Ghanekar A,Bagli DJ,Robinson LA,Selzner M

更新日期：2020-05-01 00:00:00

abstract：:Following liver transplantation bile formation may be influenced by hepatic denervation and cyclosporine therapy. To better establish any effect of liver transplantation on bile secretion, 6 mongrel dogs were studied: 3 underwent liver denervation by a modified autotransplantation procedure and insertion of a Thomas c...

journal_title：Transplantation

authors： Sutherland FR,Preshaw RM,Shaffer EA

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Tacrolimus has been shown to have a less adverse effect on the lipid profiles of transplant patients when the drug is started as induction therapy. In order to determine the effect tacrolimus has on lipid profiles in stable cyclosporine-treated renal transplant patients with established hyperlipidemia, a ran...

journal_title：Transplantation

authors： McCune TR,Thacker LR II,Peters TG,Mulloy L,Rohr MS,Adams PA,Yium J,Light JA,Pruett T,Gaber AO,Selman SH,Jonsson J,Hayes JM,Wright FH Jr,Armata T,Blanton J,Burdick JF

更新日期：1998-01-15 00:00:00