Rearrangement and expression of kappa light chain genes can occur without mu heavy chain expression during differentiation of pre-B cells.

abstract：:CD161(++)IL-18Rα(+)CD8(+) human T cells have recently been identified as a new subset of memory cells but their exact role remains unclear. CD161(++)IL-18Rα(+)CD8(+), mucosal-associated invariant T cells express a semi-invariant TCR Vα7.2-Jα33, which recognizes the MHC-related protein 1. On the basis of properties inc...

journal_title：International immunology

authors： Havenith SH,Yong SL,Henson SM,Piet B,Idu MM,Koch SD,Jonkers RE,Kragten NA,Akbar AN,van Lier RA,ten Berge IJ

更新日期：2012-10-01 00:00:00

abstract：:EBV-encoded latent membrane protein 1 (LMP1) is critical for EBV-driven B-cell transformation and most EBV-associated malignancies and is also implicated in exacerbation of autoimmunity. LMP1 functionally mimics the TNFR superfamily member CD40, but LMP1-induced signals and downstream B-cell functions are amplified an...

journal_title：International immunology

authors： Arcipowski KM,Stunz LL,Bishop GA

更新日期：2014-03-01 00:00:00

abstract：:The non-obese diabetic (NOD) mouse spontaneously develops T-cell-mediated autoimmune insulitis. We analyzed the clonotypes of T cell infiltrates of the NOD mouse islets using a new method we have developed recently, which consists of RT-PCR amplification of the CDR3 region of the TCR beta chain mRNA and subsequent sin...

journal_title：International immunology

authors： Komagata Y,Masuko K,Tashiro F,Kato T,Ikuta K,Nishioka K,Ito K,Miyazaki J,Yamamoto K

更新日期：1996-06-01 00:00:00

abstract：:Lymphocyte homing to lymph nodes is regulated by transient but specific interactions between lymphocytes and high endothelial venules (HEVs), the initial phase of which is mainly governed by the leukocyte adhesion molecule L-selectin, which recognizes sulfated and sialylated O-linked oligosaccharides displayed on sial...

journal_title：International immunology

authors： Kanda H,Tanaka T,Matsumoto M,Umemoto E,Ebisuno Y,Kinoshita M,Noda M,Kannagi R,Hirata T,Murai T,Fukuda M,Miyasaka M

更新日期：2004-09-01 00:00:00

abstract：:Auto-antibodies against heat shock proteins (HSPs) are frequently found in the sera of patients with rheumatic and other autoimmune diseases. However, it is unclear whether these auto-antibodies play a role in the pathophysiology and etiology of these diseases. We found that a murine anti-HSP60 mAb enhanced the produc...

journal_title：International immunology

authors： Yokota S,Minota S,Fujii N

更新日期：2006-04-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS). MD-2 is associated with TLR4 and imparts LPS responsiveness to it. Little is known, however, as to whether MD-2 directly regulates LPS recognition by TLR4. To address the issue, we took advantage of a species-specific pharmacology of lipid IVa, an analog...

journal_title：International immunology

authors： Akashi S,Nagai Y,Ogata H,Oikawa M,Fukase K,Kusumoto S,Kawasaki K,Nishijima M,Hayashi S,Kimoto M,Miyake K

更新日期：2001-12-01 00:00:00

abstract：:In this study we investigated the role of the invariant chain (li) in the presentation of hen egg lysozyme (HEL) and measles virus hemagglutinin (HA) antigens to MHC class II-restricted T hybridoma cells. Fibroblastic cells transfected with Ed or Ak genes, and supertransfected or not with the li gene, were used as ant...

journal_title：International immunology

authors： Bertolino P,Forquet F,Pont S,Koch N,Gerlier D,Rabourdin-Combe C

更新日期：1991-05-01 00:00:00

abstract：:The recent emergence of severe acute respiratory syndrome (SARS) was caused by a novel coronavirus, SARS-CoV. It spread rapidly to many countries and developing a SARS vaccine is now urgently required. In order to study the immunogenicity of UV-inactivated purified SARS-CoV virion as a vaccine candidate, we subcutaneo...

journal_title：International immunology

authors： Takasuka N,Fujii H,Takahashi Y,Kasai M,Morikawa S,Itamura S,Ishii K,Sakaguchi M,Ohnishi K,Ohshima M,Hashimoto S,Odagiri T,Tashiro M,Yoshikura H,Takemori T,Tsunetsugu-Yokota Y

更新日期：2004-10-01 00:00:00

abstract：:In vascularized organ transplantation, vascular endothelial cells (EC) confronting recipient T cells are potentially significant APC initiating cellular immune responses that lead to rejection. In the present study, we studied the ability of human EC to stimulate allogeneic T cells and the co-stimulatory molecules inv...

journal_title：International immunology

authors： Seino K,Azuma M,Bashuda H,Fukao K,Yagita H,Okumura K

更新日期：1995-08-01 00:00:00

abstract：:To investigate the involvement of retinoic acid receptor (RAR)-alpha in allograft rejection, we investigated the effect of a novel selective agonist to the receptor, ER-38925, in a mouse cardiac allograft model. Prophylactic treatment with ER-38925 inhibited the acute rejection of the mouse cardiac allograft (BALB/c -...

journal_title：International immunology

authors： Seino K,Yamauchi T,Shikata K,Kobayashi S,Nagai M,Taniguchi M,Fukao K

更新日期：2004-05-01 00:00:00

abstract：:NOD mice spontaneously develop type I diabetes resulting from autoimmune destruction of their insulin-producing beta cells. Among the self-antigens targeted by NOD autoimmune T cells is a peptide, p277, from the sequence of the 60 kDa heat shock protein (hsp60). Common to the anti-p277 T cell populations of NOD mice i...

journal_title：International immunology

authors： Elias D,Tikochinski Y,Frankel G,Cohen IR

更新日期：1999-06-01 00:00:00

abstract：:The M54 transgenic mouse line, which carries the 17.2.25 Ig mu heavy chain gene, rearranges Ig heavy chains and expresses both transgenic and endogenous mu. B cell lineage development is selectively impaired in these mice and cells that simultaneously express transgenic and endogenous mu ('double-producers') are commo...

journal_title：International immunology

authors： Lam KP,Herzenberg LA,Stall AM

更新日期：1993-09-01 00:00:00

abstract：:The adaptive immune response is involved in the development and progression of atherosclerosis and IL-17A(+) cells play a role in this disease. Although elevated number of CD4(+) IL-17A(+) (Th17) and IL-17A(+)TCRγδ(+) T cells are found within murine atherosclerotic aortas and human plaques, the mechanisms governing IL...

journal_title：International immunology

authors： Butcher MJ,Wu CI,Waseem T,Galkina EV

更新日期：2016-05-01 00:00:00

abstract：:Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. Because of the wide range of ligand distribution in the body, its b...

journal_title：International immunology

authors： Okazaki T,Honjo T

更新日期：2007-07-01 00:00:00

abstract：:Activation of T cells leads to the induction of many cytokine genes that are required for appropriate immune responses, including IL-2, a key cytokine for T cell proliferation and homeostasis. The activating transcription factors such as nuclear factor of activated T cells, nuclear factor kappaB/Rel and activated prot...

journal_title：International immunology

authors： Wang J,Lee S,Teh CE,Bunting K,Ma L,Shannon MF

更新日期：2009-03-01 00:00:00

abstract：:Dendritic cells (DC) are potent antigen-presenting cells and understanding their mechanisms of antigen uptake is important for loading DC with antigen for immunotherapy. The multilectin receptors, DEC-205 and macrophage mannose receptor (MMR), are potential antigen-uptake receptors; therefore, we examined their expres...

journal_title：International immunology

authors： Kato M,Neil TK,Fearnley DB,McLellan AD,Vuckovic S,Hart DN

更新日期：2000-11-01 00:00:00

abstract：:Tyrosine kinase 2 (Tyk2), a member of the Jak kinase family, mediates signals triggered by various cytokines, which are related to the pathogenesis of psoriasis. In this study, we investigated the role of Tyk2 in IL-23-induced psoriasis-like skin inflammation. Tyk2(-/-) mice when injected with IL-23 showed significant...

journal_title：International immunology

authors： Ishizaki M,Muromoto R,Akimoto T,Sekine Y,Kon S,Diwan M,Maeda H,Togi S,Shimoda K,Oritani K,Matsuda T

更新日期：2014-05-01 00:00:00

abstract：:The role of adjuvant on the T(h)1 and T(h)2 immune responses to Abeta-immunotherapy (Abeta(42 )peptide) was examined in wild-type mice. Fine epitope analysis with overlapping oligomers of the Abeta(42) sequence identified the 1-15 region as a dominant B cell epitope. The 6-20 peptide was recognized only weakly by anti...

journal_title：International immunology

authors： Cribbs DH,Ghochikyan A,Vasilevko V,Tran M,Petrushina I,Sadzikava N,Babikyan D,Kesslak P,Kieber-Emmons T,Cotman CW,Agadjanyan MG

更新日期：2003-04-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired type hemolytic disorder. Hematopoietic cells of patients with PNH are deficient in glycosylphosphatidylinositol (GPI) anchored membrane proteins. Since some membrane-bound complement inhibitors, such as CD59 and decay accelerating factor (DAF), are GPI anchored ...

journal_title：International immunology

authors： Ueda E,Nishimura J,Kitani T,Nasu K,Kageyama T,Kim YU,Takeda J,Kinoshita T

更新日期：1992-11-01 00:00:00

abstract：:Mercury-induced autoimmunity is characterized by a T cell-dependent B cell activation (mainly of IgG1 and IgE isotypes), production of anti-nucleolar autoantibodies (ANolA) and the formation of renal IgG deposits. The autoimmunity is to a large extent controlled by genetic factors. We studied 15 different inbred mouse...

journal_title：International immunology

authors： Abedi-Valugerdi M,Möller G

更新日期：2000-10-01 00:00:00

abstract：:Intracellular signaling triggered by the antigen receptor of primary B-1 (CD5+ B) lymphocytes is insufficient to bring about cell cycle progression to S phase; this appears to result from a block in signal propagation prior to the activation of protein kinase C. The present studies were undertaken to evaluate specific...

journal_title：International immunology

authors： Morris DL,Rothstein TL

更新日期：1994-07-01 00:00:00

abstract：:Evidence from several different experimental systems suggests that regulatory cells specific for self-antigens exist in the normal immune repertoire, and that these cells are necessary for maintenance of self-tolerance and prevention of autoimmune disease. We attempted to demonstrate the existence of regulatory cells ...

journal_title：International immunology

authors： Lindsey JW,Jin R

更新日期：2000-11-01 00:00:00

abstract：:Liver and activation-regulated chemokine (LARC)/CCL20 is expressed by surface-lining epithelial and epidermal cells, and is likely to link innate and acquired immunity by attracting immature dendritic cells, effector memory T cells and B cells via CCR6. Here we examined the mechanism of LARC expression in epithelial-t...

journal_title：International immunology

authors： Fujiie S,Hieshima K,Izawa D,Nakayama T,Fujisawa R,Ohyanagi H,Yoshie O

更新日期：2001-10-01 00:00:00

abstract：:Soluble recombinant (r) P-selectin and rP-selectin immobilized on plastic surfaces were tested for their capacity to activate neutrophils to produce superoxide anion. Soluble rP-selectin was incapable of activating leukocytes, whereas immobilized rP-selectin was able to induce leukocyte activation. When neutrophils we...

journal_title：International immunology

authors： Nagata K,Tsuji T,Matsushima K,Hanai N,Irimura T

更新日期：2000-04-01 00:00:00

abstract：:Previous evidence from several laboratories suggests that CD8+ T suppressor cells may be important regulatory elements governing specific unresponsiveness of lepromatous lepromatous leprosy patients to M.leprae. To analyse the mechanism of suppression, CD8+ Ts clones were established from lesions and peripheral blood ...

journal_title：International immunology

authors： Salgame P,Modlin R,Bloom BR

更新日期：1989-01-01 00:00:00

abstract：:The dynamic behaviour of isolated populations of peritoneal LPS-reactive (LPSr) B lymphocytes was studied upon transfer of peritoneal cells (PerC) from C57BL/6 LPS responder into C57BL/10ScCr LPS non-responder mice. We have followed the persistence and life-span of the transferred LPSr donor B cells in the spleen and ...

journal_title：International immunology

authors： Thomas-Vaslin V,Feitas AA

更新日期：1990-01-01 00:00:00

abstract：:Ig are multifunctional molecules with distinct properties assigned to individual domains. To assess the importance of IgM domain assembly in B cell development we generated two transgenic mouse lines with truncated muH chains by homologous integration of the neomycin resistance gene (neo(r)) into exons C(mu)1 and C(mu...

journal_title：International immunology

authors： Zou X,Ayling C,Xian J,Piper TA,Barker PJ,Brüggemann M

更新日期：2001-12-01 00:00:00

abstract：:We have used a set of single-chain variable fragment antibodies (sc) genetically fused with an influenza hemagglutinin-derived peptide as a means to investigate the role of CR1 and CR2 in antigen presentation by B cells. When incubated with the B cell lymphoma 2PK3, peptide-containing sc specific for either CR1 or CR1...

journal_title：International immunology

authors： Prechl J,Baiu DC,Horváth A,Erdei A

更新日期：2002-03-01 00:00:00

abstract：:The transcription factor interferon regulatory factor-5 (IRF5) plays an important role in innate immune responses via the TLR-MyD88 (Toll-like receptor - myeloid differentiation primary response 88) pathway. IRF5 is also involved in the pathogenesis of the autoimmune disease systemic lupus erythematosus (SLE). Recent ...

journal_title：International immunology

authors： Ban T,Sato GR,Tamura T

更新日期：2018-10-29 00:00:00

abstract：:Experiments in transgenic mice have demonstrated that thymocyte differentiation into the mature CD4+ helper or CD8+ cytotoxic T cell lineage is ultimately dependent upon the specificity of the TCR for class II or class I MHC molecules respectively. However, the initial mechanistic events involved in this process remai...

journal_title：International immunology

authors： DeKoning J,Carbone FR,Kaye J

更新日期：1995-04-01 00:00:00