Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells.

abstract：:Plasmid DNA vectors have been constructed with minigenes encoding a single cytotoxic T lymphocyte (CTL) epitope from either the M2 protein of respiratory syncytial virus (RSV) or from the nucleoprotein of measles virus (MV) with or without a signal sequence (also called secretory or leader sequence). Following intrade...

journal_title：International immunology

authors： Hsu SC,Obeid OE,Collins M,Iqbal M,Chargelegue D,Steward MW

更新日期：1998-10-01 00:00:00

abstract：:IFN-regulatory factor (IRF)-4 is a member of the IRF family of transcription factors expressed in lymphocytes and macrophages. The previous studies using mice deficient in the IRF-4 gene showed profound defects in function of both B and T cells. To further investigate the role of IRF-4 in CD4(+) T cell function, IRF-4...

journal_title：International immunology

authors： Tominaga N,Ohkusu-Tsukada K,Udono H,Abe R,Matsuyama T,Yui K

更新日期：2003-01-01 00:00:00

abstract：:T cell apoptosis has been proposed as an important contributor to the functional defects and depletion of T cells in HIV-infected individuals. However, the mechanisms involved in this apoptosis have not been elucidated. We recently showed that peripheral blood T cells from HIV-infected individuals are especially susce...

journal_title：International immunology

authors： Katsikis PD,García-Ojeda ME,Wunderlich ES,Smith CA,Yagita H,Okumura K,Kayagaki N,Alderson M,Herzenberg LA,Herzenberg LA

更新日期：1996-08-01 00:00:00

abstract：:We established an experimental system in vitro to examine the developmental capacity of individual hematopoietic progenitors to generate T, B and myeloid (M) cells. By using this system we analyzed the process of lineage commitment of hematopoietic progenitors in murine fetal liver (FL). It is known that small numbers...

journal_title：International immunology

authors： Kawamoto H,Ohmura K,Katsura Y

更新日期：1997-07-01 00:00:00

abstract：:Antigen-coupled antigen-presenting cells (APC) serve as potent tolerogens for inhibiting immune responses in vivo and in vitro, apparently by providing an antigen-specific signal through the TCR in the absence of co-stimulation. Although this approach has been well studied in rodents, little is known about its effects...

journal_title：International immunology

authors： Vandenbark AA,Barnes D,Finn T,Bourdette DN,Whitham R,Robey I,Kaleeba J,Bebo BF Jr,Miller SD,Offner H,Chou YK

更新日期：2000-01-01 00:00:00

abstract：:To develop a comprehensive catalogue of phenotypic and functional parameters of human CD4(+) T cell differentiation stages, we have performed microarray gene expression profiling on subpopulations of human thymocytes and circulating naive CD4(+) T cells, including CD3(-)CD4(+)CD8(-) intrathymic T progenitor cells, CD3...

journal_title：International immunology

authors： Lee MS,Hanspers K,Barker CS,Korn AP,McCune JM

更新日期：2004-08-01 00:00:00

abstract：:Transforming growth factor (TGF)-beta has been shown to stimulate isotype switching to IgA in cultures of lipopolysaccharide (LPS)-stimulated B cells. The induction of isotype switching is associated with the appearance of novel germline alpha transcripts that cannot be found in cultures stimulated with LPS alone. TGF...

journal_title：International immunology

authors： Lebman DA,Park MJ,Hansen-Bundy S,Pandya A

更新日期：1994-01-01 00:00:00

abstract：:The ability of Bcl-2 to inhibit apoptotic cell death is well established. Several homologues of the bcl-2 gene, such as bax, bcl-x or mcl-1, have recently been identified. Like Bcl-2, both Bcl-XL and Mcl-1 appear to function as repressors of apoptotic cell death, whereas Bax facilitates it, indicating possible interac...

journal_title：International immunology

authors： Ohta K,Iwai K,Kasahara Y,Taniguchi N,Krajewski S,Reed JC,Miyawaki T

更新日期：1995-11-01 00:00:00

abstract：:The anti-CD20 chimeric monoclonal antibody rituximab mediates cytotoxicity in malignant B cells via multiple mechanisms, including complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC) and direct induction of apoptosis. To optimize treatment of non-Hodgkin's lymphoma, a fuller unders...

journal_title：International immunology

authors： Mishima Y,Terui Y,Mishima Y,Kuniyoshi R,Matsusaka S,Mikuniya M,Kojima K,Hatake K

更新日期：2012-08-01 00:00:00

abstract：:Lymphokine activity in seven myelin basic protein (MBP)-specific T cell clones was examined. All of the clones recognize MBP peptide 1-9 in the context of I-Au. A strong positive correlation was found between levels of lymphotoxin (LT) and tumor necrosis factor alpha (TNF-alpha) mRNA and biological activity on L929 ce...

journal_title：International immunology

authors： Powell MB,Mitchell D,Lederman J,Buckmeier J,Zamvil SS,Graham M,Ruddle NH,Steinman L

更新日期：1990-01-01 00:00:00

abstract：:AbstractImmune homeostasis is critically regulated by the balance between activating and inhibitory receptors expressed on various immune cells such as T and B lymphocytes, and myeloid cells. The inhibitory receptors play a fundamental role in the immune checkpoint pathway, thus maintaining peripheral tolerance. We re...

journal_title：International immunology

authors： Wong YL,Su MT,Sugahara-Tobinai A,Itoi S,Kezuka D,Endo S,Inui M,Takai T

更新日期：2019-05-21 00:00:00

abstract：:Cyclosporin A (CsA) prevents most immature thymocytes from progressing to a mature phenotype and blocks the deletion of T cells that express self-specific TCR in the small population of cells that achieve maturity. The latter effect may explain the paradoxical observation that this immunosuppressive drug can induce au...

journal_title：International immunology

authors： Urdahl KB,Pardoll DM,Jenkins MK

更新日期：1992-12-01 00:00:00

abstract：:Taking advantage of the recently demonstrated presence of N-aminopeptidases and the serine protease dipeptidyl aminopeptidase IV (DPP IV) at the surface of human myeloblastic HL-60 cells, the regulation of these protease activities in HL-60 cell differentiation has been assessed using combined spectrophotometric and f...

journal_title：International immunology

authors： Laouar A,Wietzerbin J,Bauvois B

更新日期：1993-08-01 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune disease, caused by autoantibodies against the muscle acetylcholine receptor (AChR), an oligomeric transmembrane glycoprotein composed of alpha(2)beta gamma delta subunits. The alpha subunit carries in its N-terminal extracellular domain the main immunogenic region (MIR), a group...

journal_title：International immunology

authors： Tsouloufis T,Mamalaki A,Remoundos M,Tzartos SJ

更新日期：2000-09-01 00:00:00

abstract：:Deletion of alpha i2 subunit of heterotrimeric G proteins induces a 2-4-fold increase in the proportions of CD4 and CD8 single-positive (SP) thymocytes as compared with wild-type littermates, but how G alpha i2 is involved in thymocyte development is unknown. To determine a role for G alpha i2 in a specific developmen...

journal_title：International immunology

authors： Zhang Y,Finegold MJ,Jin Y,Wu MX

更新日期：2005-03-01 00:00:00

abstract：:Lactic acid bacteria (LAB) are abundant in the gastrointestinal tract where they continuously regulate the immune system. NK cells are potently activated by dendritic cells (DCs) matured by inflammatory stimuli, and NK cells are present in the gut epithelium and in mesenteric lymph nodes, but it is not known how NK-DC...

journal_title：International immunology

authors： Fink LN,Zeuthen LH,Christensen HR,Morandi B,Frøkiaer H,Ferlazzo G

更新日期：2007-12-01 00:00:00

abstract：:Ig are multifunctional molecules with distinct properties assigned to individual domains. To assess the importance of IgM domain assembly in B cell development we generated two transgenic mouse lines with truncated muH chains by homologous integration of the neomycin resistance gene (neo(r)) into exons C(mu)1 and C(mu...

journal_title：International immunology

authors： Zou X,Ayling C,Xian J,Piper TA,Barker PJ,Brüggemann M

更新日期：2001-12-01 00:00:00

abstract：:Behçet's syndrome (BS) is a systemic inflammatory disorder with unknown etiology. Features of both innate and adaptive immunity have been claimed in the pathogenesis of BS. To test the possible dysregulation of the NLRP3/cryopyrin (Nod-like receptor with a pyrin domain 3) inflammasome, as a result of mutation(s), we p...

journal_title：International immunology

authors： Yüksel Ş,Eren E,Hatemi G,Sahillioğlu AC,Gültekin Y,Demiröz D,Akdiş C,Fresko İ,Özören N

更新日期：2014-02-01 00:00:00

abstract：:It was recently shown that paf-acether (paf) synthesized in different cell types remains partly cell-associated. In the present work, we tested the hypothesis that cell-associated paf might in fact remain exposed on the external plasma membrane and be able to exert its biological functions. Human polymorphonuclear neu...

journal_title：International immunology

authors： Ninio E,Leyravaud S,Bidault J,Jurgens P,Benveniste J

更新日期：1991-11-01 00:00:00

abstract：:Secretory IgA (sIgA) antibodies in human tears and milk were found to recognize protein disulfide isomerase (PDI) on a Toxoplasma gondii lysate immunoblot (IB). These antibodies were already detectable in tears of infants. To determine the epitope containing-regions on PDI, we generated truncated versions of recombina...

journal_title：International immunology

authors： Meek B,Back JW,Klaren VN,Speijer D,Peek R

更新日期：2002-11-01 00:00:00

abstract：:Using anti-Tac (anti-alpha chain) and 2R-B (anti-beta chain) antibodies, we studied the roles of IL-2 receptor subunits (alpha and beta chains) in the formation of IL-2 and high-affinity IL-2 receptor complex, which is the initial event of IL-2 induced T cell growth. High-affinity IL-2 binding which was undetectable i...

journal_title：International immunology

authors： Kamio M,Uchiyama T,Arima N,Itoh K,Ishikawa T,Hori T,Uchino H

更新日期：1990-01-01 00:00:00

abstract：:Leukocyte diapedesis is a chemotactic multistep process that requires optimal chemoattractant presentation by the endothelial barrier. Recent studies have described a critical role for heparan sulfate glycosaminoglycans (HSGAGs) in the presentation and functions of chemokines essential for lymphocyte interactions with...

journal_title：International immunology

authors： Stoler-Barak L,Barzilai S,Zauberman A,Alon R

更新日期：2014-06-01 00:00:00

abstract：:The granulocyte macrophage colony stimulating factor (GM-CSF) promoter contains a 10 bp element known as CK-1 or CD28RE that specifically responds to the co-stimulatory signal delivered to T cells via the CD28 surface receptor. This element is a variant NFkappaB site that does not function alone but requires an adjace...

journal_title：International immunology

authors： Shang C,Attema J,Cakouros D,Cockerill PN,Shannon MF

更新日期：1999-12-01 00:00:00

abstract：:The mature dendritic cell (DC) is considered to be the most potent antigen-presenting cell. Regulation of the DC, particularly its survival, is therefore critical. Mature DC are markedly more sensitive to HLA-DR-mediated apoptosis than immature DC. To further characterize this key survival difference, we compared the ...

journal_title：International immunology

authors： Bertho N,Blancheteau VM,Setterblad N,Laupeze B,Lord JM,Drénou B,Amiot L,Charron DJ,Fauchet R,Mooney N

更新日期：2002-08-01 00:00:00

abstract：:J11d is expressed on a variety of hemopoietic cells, including B cells. In previous studies, we have shown that B cells are heterogeneous with respect to their levels of J11d expression and that memory B cells are contained within the J11dlo B cell population. In this report, we have further examined the relationship ...

journal_title：International immunology

authors： Yin XM,Vitetta ES

更新日期：1992-06-01 00:00:00

abstract：:Organs of transgenic pigs that express human complement regulatory proteins are under assessment as an alternative to transplantation. A major barrier to the transplantation of pig organs is the hyperacute rejection caused by pre-existing antibodies and complement. Pig cells are very susceptible to human complement, p...

journal_title：International immunology

authors： Toyomura K,Fujimura T,Murakami H,Natsume T,Shigehisa T,Inoue N,Takeda J,Kinoshita T

更新日期：1997-06-01 00:00:00

abstract：:Normal human sera contained 10-60 ng/ml of soluble membrane cofactor protein (MCP, CD46) whereas sera of > 50% of the cancer patients contained > 60 ng/ml. MCP purified by immunoaffinity chromatography from both normal and cancer patients' sera consisted of three bands of 56, 47 and 29 kDa on SDS-PAGE/immunoblotting. ...

journal_title：International immunology

authors： Seya T,Hara T,Iwata K,Kuriyama S,Hasegawa T,Nagase Y,Miyagawa S,Matsumoto M,Hatanaka M,Atkinson JP

更新日期：1995-05-01 00:00:00

abstract：:Apoptosis is a major mechanism whereby HIV-1 depletes uninfected CD4+ and CD8+ T cells. We previously showed that resting peripheral blood T cells derived from healthy donors were killed by an apoptotic mechanism after adsorption to gp120-containing, protease-defective HIV-1 (L-2) particles, more effectively than pare...

journal_title：International immunology

authors： Kameoka M,Suzuki S,Kimura T,Fujinaga K,Auwanit W,Luftig RB,Ikuta K

更新日期：1997-10-01 00:00:00

abstract：:HLA-G, a human MHC class I molecule expressed on the trophoblast during pregnancy, was expressed in transgenic mice by recombining the HLA-G gene with a transcriptional promoter from a murine H-2 MHC class I gene. Skin grafts from HLA-G transgenic mice were rejected by non-transgenic mice showing that HLA-G behaves as...

journal_title：International immunology

authors： Horuzsko A,Antoniou J,Tomlinson P,Portik-Dobos V,Mellor AL

更新日期：1997-05-01 00:00:00

abstract：:Type II collagen (CII) is of immunological interest because of its repetitive structure and properties as an autoantigen. The mouse gene has recently been cloned, thus enabling T cell-defined epitopes to be identified. Multiple novel epitopes on mouse CII are here detected in the autoreactive T cell response. The majo...

journal_title：International immunology

authors： Bayrak S,Holmdahl R,Travers P,Lauster R,Hesse M,Dölling R,Mitchison NA

更新日期：1997-11-01 00:00:00