Abstract:
:Cyclosporin A (CsA) prevents most immature thymocytes from progressing to a mature phenotype and blocks the deletion of T cells that express self-specific TCR in the small population of cells that achieve maturity. The latter effect may explain the paradoxical observation that this immunosuppressive drug can induce autoimmunity in irradiated rodents and humans if administered while new T cells are developing in the thymus. This study shows that the repopulation of the periphery with mature T cells is delayed in irradiated CsA-treated mice, presumably because CsA blocks T cell development in the thymus. The peripheral repertoire of these mice contained self-reactive IL-2 producing T cells that could be detected in a sensitive limiting dilution assay. In addition, self-reactive T cell hybridomas were isolated from the IL-2 receptor+ population present in CsA-treated mice. One of these hybridomas expressed a TCR V beta chain that is normally expressed on thymocytes that are deleted via recognition of self-antigens. Despite the presence of self-reactive T cells that had escaped clonal deletion, CsA-treated mice rarely developed lethal autoimmune disease, implying that a peripheral mechanism of tolerance can prevent the onset of autoimmune disease.
journal_name
Int Immunoljournal_title
International immunologyauthors
Urdahl KB,Pardoll DM,Jenkins MKdoi
10.1093/intimm/4.12.1341subject
Has Abstractpub_date
1992-12-01 00:00:00pages
1341-9issue
12eissn
0953-8178issn
1460-2377journal_volume
4pub_type
杂志文章abstract::Naive and primed alpha beta T cells can be distinguished on the basis of their differential expression of CD45RA and CD45RO, respectively. The present study indicates that these CD45-isoforms also identify naive and primed maturational stages of gamma delta T cells and natural killer (NK) cells. In peripheral blood, a...
journal_title:International immunology
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
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更新日期:2001-10-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/4.6.673
更新日期:1992-06-01 00:00:00
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更新日期:2006-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/5.6.591
更新日期:1993-06-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/dxs048
更新日期:2012-08-01 00:00:00
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更新日期:2009-08-01 00:00:00
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更新日期:1990-01-01 00:00:00
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更新日期:1997-03-01 00:00:00
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更新日期:1999-03-01 00:00:00
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更新日期:2016-07-01 00:00:00
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更新日期:2002-07-01 00:00:00
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更新日期:2002-07-01 00:00:00