Abstract:
:Stroke is one of the major causes of lethality and disability, yet few effective therapies have been established for ischemic stroke. Inflammation in the ischemic brain is induced by the infiltration and subsequent activation of immune cells. Loss of cerebral blood flow and ischemic brain-cell death trigger the activation of infiltrating immune cells and drastic changes in the lipid content of the ischemic brain. In particular, polyunsaturated fatty acids and their metabolites regulate cerebral post-ischemic inflammation and ischemic stroke pathologies. In this review, we discuss the relationships between the lipid mediators and cerebral post-ischemic inflammation and their relevance to possible future therapeutic strategies targeting lipid mediators for ischemic stroke.
journal_name
Int Immunoljournal_title
International immunologyauthors
Nakamura A,Otani K,Shichita Tdoi
10.1093/intimm/dxaa027subject
Has Abstractpub_date
2020-10-20 00:00:00pages
719-725issue
11eissn
0953-8178issn
1460-2377pii
5821148journal_volume
32pub_type
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