CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection.

abstract：:It is now generally recognized that bone marrow is the survival niche for antigen-specific plasma cells with long-term immunological memory. These cells release antibodies into the circulation, needed to prime effector cells in the secondary immune response. These antibodies participate in the surveillance for antigen...

journal_title：International immunology

authors： Gould HJ,Wu YB

更新日期：2018-08-30 00:00:00

abstract：:NK cells limit the emergence of cancers and viral infections by surveillance of 'missing-self' and 'induced-self' ligands, and by direct recognition of pathogen-associated molecules. We examined individual roles for Toll-like receptors (TLRs)-7 and -8 in human NK-cell activation using synthetic, small molecule agonist...

journal_title：International immunology

authors： Gorski KS,Waller EL,Bjornton-Severson J,Hanten JA,Riter CL,Kieper WC,Gorden KB,Miller JS,Vasilakos JP,Tomai MA,Alkan SS

更新日期：2006-07-01 00:00:00

abstract：:Leukocyte diapedesis is a chemotactic multistep process that requires optimal chemoattractant presentation by the endothelial barrier. Recent studies have described a critical role for heparan sulfate glycosaminoglycans (HSGAGs) in the presentation and functions of chemokines essential for lymphocyte interactions with...

journal_title：International immunology

authors： Stoler-Barak L,Barzilai S,Zauberman A,Alon R

更新日期：2014-06-01 00:00:00

abstract：:The CD2 co-receptor expressed on the surface of T lymphocytes is able to stimulate T cell activation, proliferation and cytokine production in the absence of direct engagement of the antigen-specific TCR. Engagement of human CD2 by mitogenic pairs of anti-CD2 mAb induces tyrosine phosphorylation of a number of intrace...

journal_title：International immunology

authors： Lin H,Martelli MP,Bierer BE

更新日期：2001-01-01 00:00:00

abstract：:A small proportion of the sIg+ B lymphocytes in peripheral lymphoid organs [22% in spleen and 6% in lymph node (LN)] in rat carries the Thy-1 antigen. These Thy-1+ B cells represent newly formed bone marrow (BM) derived (or immature) B cells. In this study we investigated the kinetic behavior of Thy-1+ and Thy-1- B ce...

journal_title：International immunology

authors： Deenen GJ,Kroese FG

更新日期：1993-07-01 00:00:00

abstract：:T(h)17 cells, an inflammatory T helper cell subset, are involved in the pathogenesis of various inflammatory, autoimmune and allergic diseases. Recent evidence supports the idea that immune cell functions and the inflammatory response are finely regulated by various physiological substances. Calcitonin gene-related pe...

journal_title：International immunology

authors： Mikami N,Watanabe K,Hashimoto N,Miyagi Y,Sueda K,Fukada S,Yamamoto H,Tsujikawa K

更新日期：2012-11-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) and S1P receptor 1 (S1P1) play an important role in the egress of mature CD4 or CD8 single-positive (SP) thymocytes from the thymus. Fingolimod hydrochloride (FTY720), an S1P1 functional antagonist, induced significant accumulation of CD62L(high)CD69(low) mature SP thymocytes in the thymi...

journal_title：International immunology

authors： Maeda Y,Yagi H,Takemoto K,Utsumi H,Fukunari A,Sugahara K,Masuko T,Chiba K

更新日期：2014-05-01 00:00:00

abstract：:A central tenet of vaccine development is to identify immune correlates of protection. Both plasmid-encoded gD as well as recombinant protein gD can protect mice from lethal herpes simplex virus (HSV) challenge. It is known that different vaccine modalities should induce different immune phenotypes. Yet, paradoxically...

journal_title：International immunology

authors： Sin JI,Ayyavoo V,Boyer J,Kim J,Ciccarelli RB,Weiner DB

更新日期：1999-11-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are among the major causes of death worldwide due to acute inflammation in the lung. AT-rich interactive domain-containing 5a (Arid5a) is an RNA-binding protein involved in inflammatory autoimmune disease through post-transcriptional control of Il6...

journal_title：International immunology

authors： Dubey PK,Masuda K,Nyati KK,-Uz Zaman MM,Chalise JP,Millrine D,Kai W,Ripley B,Kishimoto T

更新日期：2017-02-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) T cell-mediated, inflammatory disease with similarities to multiple sclerosis in humans. Intranasal (i.n.) administration of a myelin basic protein (MBP)-derived peptide can protect susceptible mice from EAE. The mechanisms underlying this phenomenon, however...

journal_title：International immunology

authors： Burkhart C,Liu GY,Anderton SM,Metzler B,Wraith DC

更新日期：1999-10-01 00:00:00

abstract：:Chronic viral infections are often characterized by CD8 T-cell responses with poor cytokine secretion potential and limited expansion of the CD8 T-cell pool, collectively referred to as CD8 T-cell exhaustion. Exhaustion of lymphocytic choriomeningitis virus (LCMV)-specific CD8 T cells was shown to be partially regulat...

journal_title：International immunology

authors： Richter K,Agnellini P,Oxenius A

更新日期：2010-01-01 00:00:00

abstract：:bcl-2 transgenic mice develop anti-double-stranded (ds) DNA antibodies similar to those present in systemic lupus erythematosus. To begin to understand where a breakdown in the regulation of autoreactive lymphocytes is occurring, we have used a bcl-2 transgene (Tg) in conjunction with an Ig Tg that allows us to identi...

journal_title：International immunology

authors： Mandik-Nayak L,Nayak S,Sokol C,Eaton-Bassiri A,Madaio MP,Caton AJ,Erikson J

更新日期：2000-03-01 00:00:00

abstract：:The two-signal model states that activation of naive T cells requires a signal 1 stimulus through the TCR and a co-stimulatory signal 2. By contrast, signal 1 alone is sufficient for pre-activated T cells. Recently, however, it has been shown that under certain conditions T cells can bypass the requirement for co-stim...

journal_title：International immunology

authors： Pardigon N,Bercovici N,Calbo S,Santos-Lima EC,Liblau R,Kourilsky P,Abastado JP

更新日期：1998-05-01 00:00:00

abstract：:Specific antibodies increase antigen uptake and presentation by antigen-presenting cells via the B cell receptor in B cells or FcgammaR in dendritic cells. To determine whether the interaction between antibody and antigen could influence the set of peptides presented by MHC II molecules, we analyzed the presentation o...

journal_title：International immunology

authors： Guermonprez P,Lo-Man R,Sedlik C,Rojas MJ,Poljak RJ,Leclerc C

更新日期：1999-11-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells expressing the retinoic acid receptor-related orphan receptor γt (RORγt) and producing IL-17 represent a minor subset of CD1d-restricted iNKT cells (iNKT17) in C57BL/6J (B6) mice. We aimed in this study to define the reasons for their low distribution and the sequence of events ...

journal_title：International immunology

authors： Klibi J,Li S,Amable L,Joseph C,Brunet S,Delord M,Parietti V,Jaubert J,Marie J,Karray S,Eberl G,Lucas B,Toubert A,Benlagha K

更新日期：2020-02-07 00:00:00

abstract：:Fc receptors play important roles for a wide array of immune responses. In contrast to the well-defined Fcγ and Fcε receptors, the molecular and functional characteristics of Fc receptors for IgA and IgM have remained incompletely understood for years. Recent progress has unveiled the characteristics of Fc receptors f...

journal_title：International immunology

authors： Shibuya A,Honda SI,Shibuya K

更新日期：2017-12-30 00:00:00

abstract：:Sequestration of neutrophils and release of histotoxic mediators are considered important for the development of pathologic alterations of the lung defined as adult respiratory distress syndrome. Mechanisms of inflammatory lung injury caused by abdominal sepsis were investigated using the colon ascendens stent periton...

journal_title：International immunology

authors： Neumann B,Zantl N,Veihelmann A,Emmanuilidis K,Pfeffer K,Heidecke CD,Holzmann B

更新日期：1999-02-01 00:00:00

abstract：:Factors responsible for the predictable generation of Th1 or Th2 immune responses to microorganisms in vivo are not well characterized, although the ability of antigen presenting cells (APC) to provide co-stimulation, the kinetics of MHC-peptide ligand generation as well as the cytokine environment are all considered ...

journal_title：International immunology

authors： Pashine A,John B,Rath S,George A,Bal V

更新日期：1999-04-01 00:00:00

abstract：:The human chymase (HC) is a major granule constituent of mast cells (MCs) residing in the connective tissue and the sub-mucosa. Although many potential substrates have been described for this important MC enzyme, its full range of in vivo substrates has most likely not yet been identified. A major step toward a better...

journal_title：International immunology

authors： Andersson MK,Enoksson M,Gallwitz M,Hellman L

更新日期：2009-01-01 00:00:00

abstract：:Mice lacking the IL-2 receptor beta chain (IL-2R beta) exhibit an autoimmune reaction characterized by generalized T cell activation, production of autoantibodies, myeloproliferation and severe anemia. T cells of IL-2R beta-/- mice were examined to elucidate the mechanism responsible for their abnormal activation and ...

journal_title：International immunology

authors： Suzuki H,Hayakawa A,Bouchard D,Nakashima I,Mak TW

更新日期：1997-09-01 00:00:00

abstract：:Induction of alphaEbeta7 expression on T cells by transforming growth factor (TGF)-beta is thought to be important for intestinal intraepithelial T lymphocyte (IEL) entry into the epithelial compartment. However, there has been no in vivo evidence that up-regulation of alphaEbeta7 expression on T cells by TGF-beta is ...

journal_title：International immunology

authors： Suzuki R,Nakao A,Kanamaru Y,Okumura K,Ogawa H,Ra C

更新日期：2002-04-01 00:00:00

abstract：:Constitutive expression of p35 and p40 IL-12 mRNA was detected in splenic macrophages isolated from aged mice. Macrophages were also implicated as the cell type responsible for the dysregulated IL-6 and tumor necrosis factor (TNF)-alpha commonly observed to be constitutively produced by lymphoid cells from aged donors...

journal_title：International immunology

authors： Spencer NF,Daynes RA

更新日期：1997-05-01 00:00:00

abstract：:NK cells were first identified in 1975 and represent the prototypical group 1 innate lymphoid cell (ILC). More recently, the discovery of new members of the ILC family has highlighted the complexity of this innate lymphoid lineage. Importantly, it has been recognized that different subsets exist within the group 1 ILC...

journal_title：International immunology

authors： Seillet C,Belz GT

更新日期：2016-01-01 00:00:00

abstract：:At least three B cell subsets, B-1a, B-1b and B-2, or conventional B cells are present in the mouse periphery. Here we demonstrate that B-1 cells spontaneously proliferate in stationary cultures of normal adherent mouse peritoneal cells. B-1 cells were characterized by morphology, immunohistochemistry and flow cytomet...

journal_title：International immunology

authors： Almeida SR,Aroeira LS,Frymuller E,Dias MA,Bogsan CS,Lopes JD,Mariano M

更新日期：2001-09-01 00:00:00

abstract：:IL-12 has been shown to play a central role in cell-mediated inflammatory reactions through direct activation of T cells and NK cells. IL-12 also strongly influences humoral immunity but these effects have been thought to be indirect and caused by intermediary cytokines. Using flow cytometry, we now show that IL-12 di...

journal_title：International immunology

authors： Vogel LA,Showe LC,Lester TL,McNutt RM,Van Cleave VH,Metzger DW

更新日期：1996-12-01 00:00:00

abstract：:Cells bearing the gamma delta form of the TCR make up only 1-3% of T cells in the adult murine thymus and peripheral lymphoid organs. Evidence from studies of nude mice suggests that the development of at least some gamma delta T cells is thymus dependent; however, until now it has not been directly demonstrated that ...

journal_title：International immunology

authors： Kelly KA,Pearse M,Lefrancois L,Scollay R

更新日期：1993-04-01 00:00:00

abstract：:Antigen-driven interaction of dendritic cells (DC) with CD4(+) T(h) cells results in the exchange of bidirectional activating signals. Cross-linking of TCR by MHC class II-bound antigen activates T(h) cells, resulting in their up-regulation of CD40 ligand. Here we show that MHC class II molecules, in addition to their...

journal_title：International immunology

authors： Lokshin AE,Kalinski P,Sassi RR,Mailliard RB,Müller-Berghaus J,Storkus WJ,Peng X,Marrangoni AM,Edwards RP,Gorelik E

更新日期：2002-09-01 00:00:00

abstract：:Despite intense recent interest, the suppressive mechanisms of regulatory CD25+CD4 T cells remain poorly understood. One deficiency in the field is the lack of in vivo models where the effects of regulatory CD25+CD4 T cells on antigen-specific responder T cells can be measured quantitatively. We describe one such mode...

journal_title：International immunology

authors： Thorstenson KM,Herzovi L,Khoruts A

更新日期：2005-04-01 00:00:00

abstract：:Type II collagen (CII) is of immunological interest because of its repetitive structure and properties as an autoantigen. The mouse gene has recently been cloned, thus enabling T cell-defined epitopes to be identified. Multiple novel epitopes on mouse CII are here detected in the autoreactive T cell response. The majo...

journal_title：International immunology

authors： Bayrak S,Holmdahl R,Travers P,Lauster R,Hesse M,Dölling R,Mitchison NA

更新日期：1997-11-01 00:00:00

abstract：:After a 3 week course (approximately), during which there is marked lymphoid hyperplasia, Trypanosoma musculi infections in young-adult mice are cured by an immune mechanism involving antibodies of the IgG2a isotype. Both the lymphoid hyperplasia and IgG2a antibody response are T-cell-dependent events and both process...

journal_title：International immunology

authors： Utsuyama M,Albright JW,Holmes KL,Hirokawa K,Albright JF

更新日期：1994-08-01 00:00:00