Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury.

abstract：:The dynamic behaviour of isolated populations of peritoneal LPS-reactive (LPSr) B lymphocytes was studied upon transfer of peritoneal cells (PerC) from C57BL/6 LPS responder into C57BL/10ScCr LPS non-responder mice. We have followed the persistence and life-span of the transferred LPSr donor B cells in the spleen and ...

journal_title：International immunology

authors： Thomas-Vaslin V,Feitas AA

更新日期：1990-01-01 00:00:00

abstract：:Lymphokine activity in seven myelin basic protein (MBP)-specific T cell clones was examined. All of the clones recognize MBP peptide 1-9 in the context of I-Au. A strong positive correlation was found between levels of lymphotoxin (LT) and tumor necrosis factor alpha (TNF-alpha) mRNA and biological activity on L929 ce...

journal_title：International immunology

authors： Powell MB,Mitchell D,Lederman J,Buckmeier J,Zamvil SS,Graham M,Ruddle NH,Steinman L

更新日期：1990-01-01 00:00:00

abstract：:Linomide (LS-2616, quinoline-3-carboxamide) has strong immunomodulating effects in animal models, inhibiting toxic shock, progressive autoimmune disease and cancer. In humans, linomide strongly reduced the appearance of new lesions in multiple sclerosis yet enhanced immune responses after bone marrow transplantation. ...

journal_title：International immunology

authors： Arad G,Katzenellenbogen M,Levy R,Slavin S,Kaempfer R

更新日期：1996-10-01 00:00:00

abstract：:In the final analysis, the self (S)-non-self (NS) discrimination is regulated by the sufficiency or insufficiency of effector T(h) (eT(h)) specific for the given antigen. We have described a model (Th genesis) for the origin of eT(h) based on an antigen-independent pathway from initial state T(h) (iT(h)) to eT(h), and...

journal_title：International immunology

authors： Langman RE,Mata JJ,Cohn M

更新日期：2003-05-01 00:00:00

abstract：:Dendritic cells (DCs) are specialized antigen-presenting cells that play pivotal roles in initiating immune responses. However, DC maturation is usually strongly restricted by the stromal microenvironment, especially in non-lymphoid tissues, such as skin and mucosa. Although suppression of DC maturation by stromal cel...

journal_title：International immunology

authors： Shiraishi H,Yoshida H,Saeki K,Miura Y,Watanabe S,Ishizaki T,Hashimoto M,Takaesu G,Kobayashi T,Yoshimura A

更新日期：2008-09-01 00:00:00

abstract：:Fas (CD95) is a cell surface death receptor belonging to the tumor necrosis factor receptor superfamily, which mediates apoptosis-inducing signaling when activated by Fas ligand or its agonistic antibody. lpr mice with a loss of apoptosis-inducing function mutation in the Fas gene develop systemic autoimmune disease a...

journal_title：International immunology

authors： Takahashi S,Futatsugi-Yumikura S,Fukuoka A,Yoshimoto T,Nakanishi K,Yonehara S

更新日期：2013-05-01 00:00:00

abstract：:IFN-regulatory factor (IRF)-4 is a member of the IRF family of transcription factors expressed in lymphocytes and macrophages. The previous studies using mice deficient in the IRF-4 gene showed profound defects in function of both B and T cells. To further investigate the role of IRF-4 in CD4(+) T cell function, IRF-4...

journal_title：International immunology

authors： Tominaga N,Ohkusu-Tsukada K,Udono H,Abe R,Matsuyama T,Yui K

更新日期：2003-01-01 00:00:00

abstract：:Intestinal intraepithelial lymphocytes (i-IEL) of aged rats comprise CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ T cells expressing TCR alphabeta. In the present study, we compared characteristics between CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ i-IEL, which were purified by a cell sorter from the i-IEL of 6-month-old ...

journal_title：International immunology

authors： Yamada K,Kimura Y,Nishimura H,Namii Y,Murase M,Yoshikai Y

更新日期：1999-01-01 00:00:00

abstract：:We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marke...

journal_title：International immunology

authors： Shiozawa S,Hayashi S,Tsukamoto Y,Goko H,Kawasaki H,Wada T,Shimizu K,Yasuda N,Kamatani N,Takasugi K,Tanaka Y,Shiozawa K,Imura S

更新日期：1998-12-01 00:00:00

abstract：:Adhesion molecules of the integrin family are implicated not only in leukocyte migration but also in leukocyte activation. Here we characterize the expression and function of fibronectin receptor integrins on rat mast cells. A rat basophilic leukemia cell line (RBL-2H3) and phorbol ester-stimulated rat peritoneal mast...

journal_title：International immunology

authors： Yasuda M,Hasunuma Y,Adachi H,Sekine C,Sakanishi T,Hashimoto H,Ra C,Yagita H,Okumura K

更新日期：1995-02-01 00:00:00

abstract：:Signal transducer and activator of transcription-1 (STAT1) signaling mediate most biological functions of IFNalpha, IFNbeta and IFNgamma although recent studies indicate that IFNgamma can alter expression of several genes via a STAT1-independent pathway. STAT1 is critical for immunity against a variety of intracellula...

journal_title：International immunology

authors： Roth KM,Gunn JS,Lafuse W,Satoskar AR

更新日期：2009-01-01 00:00:00

abstract：:Natural killer (NK) cells are a major FcγRIIIA-expressing lymphocyte population that mediate antibody-dependent cellular cytotoxicity. Although NK cells are critical for immunity against viruses and tumors, they are also activated in the joints of patients with rheumatoid arthritis (RA) and may be involved in disease ...

journal_title：International immunology

authors： Shimizu Y,Kohyama M,Yorifuji H,Jin H,Arase N,Suenaga T,Arase H

更新日期：2019-04-26 00:00:00

abstract：:Quantitative expression of class I genes varies widely in different tissues, during development and in some neoplastic cells. Regulatory DNA sequences controlling levels of transcription of class I genes have been characterized in the murine and swine promoters. Although some regulatory features appear to be retained ...

journal_title：International immunology

authors： Blanchet O,Gazin C,L'Haridon M,Tatari Z,Degos L,Sigaux F,Paul P

更新日期：1994-10-01 00:00:00

abstract：:The utilization of individual VH7183 genes in the autoimmune non-obese diabetic (NOD) mouse and the normal C57BL/6 mouse, both carrying the IgHb haplotype, was investigated. Nucleotide sequence analyses of a large number of VHDJH rearrangements utilizing VH7183 gene segments allowed us to identify 10 individual member...

journal_title：International immunology

authors： Andersson A,Ekstrand-Hammarström B,Eriksson B,Overmo C,Holmberg D

更新日期：1994-04-01 00:00:00

abstract：:Earlier studies have suggested that in adults the n-positive allele of the human IgG2 gene is more productive than the n-negative allele. This superiority was seen to be manifested in IgG2 antibody responses to polysaccharides, in the higher serum concentration of total IgG2 in the n/n than in -/- individuals, and in ...

journal_title：International immunology

authors： Sarvas H,Rautonen N,Käyhty H,Kallio M,Mäkelä O

更新日期：1990-01-01 00:00:00

abstract：:In vaccine development, a major objective is to induce strong, specific T cell responses. This might be obtained by targeting antigen to cell surface molecules that efficiently channel the antigen into endocytic compartments for loading of MHC molecules. Antibodies have been used to deliver antigen; however, it is imp...

journal_title：International immunology

authors： Schjetne KW,Thompson KM,Aarvak T,Fleckenstein B,Sollid LM,Bogen B

更新日期：2002-12-01 00:00:00

abstract：:It has previously been described that V gamma 3 cells can proliferate extensively in vitro in the presence of different cytokines. Here, the role of cytokines in the maintenance of V gamma 3 cells in the thymus has been determined. Culture of fetal thymocytes in cell suspension for 24 h showed that, whereas immature T...

journal_title：International immunology

authors： Leclercq G,De Smedt M,Plum J

更新日期：1995-05-01 00:00:00

abstract：:The contribution of the HLA-DRB1, -B3, and -B5 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T cells isolated from an atopic individual (HLA-DRw12, DR7; DRw52b) with perennial rhinitis was investigated. Using a panel of histocompatible and histoincompatible accessory cells, the ...

journal_title：International immunology

authors： O'Hehir RE,Mach B,Berte C,Greenlaw R,Tiercy JM,Bal V,Lechler RI,Trowsdale J,Lamb JR

更新日期：1990-01-01 00:00:00

abstract：:Cells bearing the gamma delta form of the TCR make up only 1-3% of T cells in the adult murine thymus and peripheral lymphoid organs. Evidence from studies of nude mice suggests that the development of at least some gamma delta T cells is thymus dependent; however, until now it has not been directly demonstrated that ...

journal_title：International immunology

authors： Kelly KA,Pearse M,Lefrancois L,Scollay R

更新日期：1993-04-01 00:00:00

abstract：:HLA class II molecules present superantigens more efficiently than their murine counterpart. Therefore, transgenic mice expressing HLA-DQ8 with and without CD28 were used to address the role of CD28 in staphylococcal enterotoxin B (SEB)-driven immune responses. SEB-induced in vitro proliferation of naive DQ8.CD28(-/-)...

journal_title：International immunology

authors： Rajagopalan G,Smart MK,Marietta EV,David CS

更新日期：2002-07-01 00:00:00

abstract：:Structural and functional aspects of the accessory molecule lymphocyte function associated antigen (LFA)-3 (CD58) have been examined following the transfection of DAP.3 and P815 cells with a cDNA clone encoding the glycosyl phosphatidylinositol (GPI)-linked form of human LFA-3. Despite earlier observations that DAP.3 ...

journal_title：International immunology

authors： Greenlaw R,Robinson P,Heaton T,Lombardi G,Lechler R

更新日期：1992-06-01 00:00:00

abstract：:The origin of cell activation in post-radiation fibrosis and its chronic extension are still poorly understood. Since local IL-2 cancer treatment sometimes triggers intraperitoneal fibrosis we have analyzed three myofibroblastic cell strains from post-radiation skin fibrosis (FPR7, FPR10 and FPR15) for their interacti...

journal_title：International immunology

authors： Alileche A,Han D,Plaisance S,Assier E,Sahraoui Y,Clemanceau C,Metivier D,Brouty-Boyer D,Jasmin C,Azzarone B

更新日期：1994-10-01 00:00:00

abstract：:In an attempt to identify autoantigens of synovium in rheumatoid arthritis (RA), we constructed lambda phage expression cDNA libraries from synovium and screened them by IgG purified from synovial fluids, both of which were derived from RA patients. As a result of this unique combination of the libraries and probes, w...

journal_title：International immunology

authors： Tanaka M,Ozaki S,Osakada F,Mori K,Okubo M,Nakao K

更新日期：1998-09-01 00:00:00

abstract：:Induction of alphaEbeta7 expression on T cells by transforming growth factor (TGF)-beta is thought to be important for intestinal intraepithelial T lymphocyte (IEL) entry into the epithelial compartment. However, there has been no in vivo evidence that up-regulation of alphaEbeta7 expression on T cells by TGF-beta is ...

journal_title：International immunology

authors： Suzuki R,Nakao A,Kanamaru Y,Okumura K,Ogawa H,Ra C

更新日期：2002-04-01 00:00:00

abstract：:Using anti-Tac (anti-alpha chain) and 2R-B (anti-beta chain) antibodies, we studied the roles of IL-2 receptor subunits (alpha and beta chains) in the formation of IL-2 and high-affinity IL-2 receptor complex, which is the initial event of IL-2 induced T cell growth. High-affinity IL-2 binding which was undetectable i...

journal_title：International immunology

authors： Kamio M,Uchiyama T,Arima N,Itoh K,Ishikawa T,Hori T,Uchino H

更新日期：1990-01-01 00:00:00

abstract：:Naturally arising CD25(+)CD4(+) regulatory T (T(R)) cells can be exploited to establish immunologic tolerance to non-self antigens. In vivo exposure of CD25(+)CD4(+) T cells from normal naive mice to alloantigen in a T cell-deficient environment elicited spontaneous expansion of alloantigen-specific CD25(+)CD4(+) T(R)...

journal_title：International immunology

authors： Nishimura E,Sakihama T,Setoguchi R,Tanaka K,Sakaguchi S

更新日期：2004-08-01 00:00:00

abstract：:Sequestration of neutrophils and release of histotoxic mediators are considered important for the development of pathologic alterations of the lung defined as adult respiratory distress syndrome. Mechanisms of inflammatory lung injury caused by abdominal sepsis were investigated using the colon ascendens stent periton...

journal_title：International immunology

authors： Neumann B,Zantl N,Veihelmann A,Emmanuilidis K,Pfeffer K,Heidecke CD,Holzmann B

更新日期：1999-02-01 00:00:00

abstract：:Several cis-acting elements regulate the expression of germline transcripts of heavy chain constant region genes and their subsequent switch recombination. To study such elements in the murine gamma1 gene, we have utilized a transgenic approach. In this study we focused on a DNase I hypersensitive site (termed 'Site I...

journal_title：International immunology

authors： Adams K,Ackerly H,Cunningham K,Dunnick W

更新日期：2000-12-01 00:00:00

abstract：:Streptococcus suis capsular type 2 is an important swine pathogen and an agent of zoonosis. Although meningitis is the most common form of disease, septicemia and septic shock are also frequently reported. Despite reports that CD14 is involved in the recognition of encapsulated S. suis by host cells, the mechanisms un...

journal_title：International immunology

authors： Graveline R,Segura M,Radzioch D,Gottschalk M

更新日期：2007-04-01 00:00:00

abstract：:Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and T(h) cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage ...

journal_title：International immunology

authors： Romani L,Montagnoli C,Bozza S,Perruccio K,Spreca A,Allavena P,Verbeek S,Calderone RA,Bistoni F,Puccetti P

更新日期：2004-01-01 00:00:00