Abstract:
:NK cells were first identified in 1975 and represent the prototypical group 1 innate lymphoid cell (ILC). More recently, the discovery of new members of the ILC family has highlighted the complexity of this innate lymphoid lineage. Importantly, it has been recognized that different subsets exist within the group 1 ILC, which have potential roles in mediating immune protection and immunosurveillance, and in regulating tissue homeostasis and inflammation. Here, we review the developmental relationships between the different group 1 ILC, which have been identified to date and discuss how heterogeneity within this expanding family may have arisen.
journal_name
Int Immunoljournal_title
International immunologyauthors
Seillet C,Belz GTdoi
10.1093/intimm/dxv051subject
Has Abstractpub_date
2016-01-01 00:00:00pages
3-11issue
1eissn
0953-8178issn
1460-2377pii
dxv051journal_volume
28pub_type
杂志文章,评审abstract::The Lewis rat, an inbred rat strain susceptible to several well-characterized experimental autoimmune diseases, provides a good model to study peptide-mediated immunotherapy. Peptide immunotherapy focussing on the modulation of T cell responses by interfering with TCR-peptide-MHC complex formation requires the elucida...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/9.2.281
更新日期:1997-02-01 00:00:00
abstract::In vascularized organ transplantation, vascular endothelial cells (EC) confronting recipient T cells are potentially significant APC initiating cellular immune responses that lead to rejection. In the present study, we studied the ability of human EC to stimulate allogeneic T cells and the co-stimulatory molecules inv...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/7.8.1331
更新日期:1995-08-01 00:00:00
abstract::Regulatory T cells (Tregs), which could be down-regulated by IL-28B, were reported to suppress T-cell-mediated immunity. The aim of this study was to investigate the role of IL-28B on the immune responses and protective efficacy of a tuberculosis (TB) subunit vaccine. First, a recombinant adenoviral vector expressing ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxv061
更新日期:2016-02-01 00:00:00
abstract::T lymphocytes (pivotal in many inflammatory pathologies) are targets for glucocorticoid hormone (GC). How TCR-mediated activation and GC signaling via glucocorticoid receptor (GR) impact on T-cell fates is not fully defined. We delineated here the expression of a recently identified glucocorticoid-induced TNF receptor...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh134
更新日期:2004-09-01 00:00:00
abstract::Acute graft-versus-host disease (GvHD) is a serious complication after allogeneic bone marrow transplantation. Donor-derived T cells infiltrate recipient target organs and cause severe tissue damage, often leading to death of the affected patient. Tissue destruction is a direct result of donor CD8+ T cell activation a...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/14.5.503
更新日期:2002-05-01 00:00:00
abstract::Synovial tissues are frequent sites of inflammatory disorders in which dendritic cells (DCs) may play an important role. This study examines potential antigen-presenting cells obtained from synovium-rich tissues (SRTs) by vascular perfusion of rat hind limbs with collagenase and further enzymatic digestion of the disa...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh290
更新日期:2005-08-01 00:00:00
abstract::It was recently shown that paf-acether (paf) synthesized in different cell types remains partly cell-associated. In the present work, we tested the hypothesis that cell-associated paf might in fact remain exposed on the external plasma membrane and be able to exert its biological functions. Human polymorphonuclear neu...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/3.11.1157
更新日期:1991-11-01 00:00:00
abstract::T-cell immune responses are critical for protection of the host and for disease pathogenesis during infection with Plasmodium species. We examined the regulation of CD4(+) T-cell cytokine responses during infection with Plasmodium berghei ANKA (PbA). CD4(+) T cells from PbA-infected mice produced IFN-γ, IL-4 and IL-10...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxq448
更新日期:2010-12-01 00:00:00
abstract::IgE plus antigen-stimulated mast cells degranulate, synthesize leukotrienes and secrete cytokines. According to the coalescence model this process is initiated in specific membrane compartments termed rafts. There, enhanced levels of glycosphingolipids and cholesterol stabilize the interaction of FcepsilonRI and Lyn, ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxg120
更新日期:2003-10-01 00:00:00
abstract::Absence of transforming growth factor-beta (TGF-beta) signaling to T cells in mice results in an increase in T cell numbers, an activated CD44 high, CD69-, CD25- T cell phenotype and a T cell-mediated injury to many organs. It is not known if such T cell activation in the absence of TGF-beta signaling is spontaneous o...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh233
更新日期:2005-05-01 00:00:00
abstract::We have evaluated the capacity of a novel, nanoparticle-based tumor vaccine to eradicate established tumors in mice. C57BL/6 mice were intradermally (i.d.) inoculated with ovalbumin (OVA)-expressing EG-7 tumor cells. When the tumor size reached 7-8 mm, the tumor-bearing mice were i.d. injected near the tumor-draining ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh381
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:The pathogenesis of inflammatory skin disease involves the release of cytokines from keratinocytes, and one of these, IL-1β, has been previously implicated in inflammatory skin disease. T(h)17 cells, a subset of T(h) cells involved in autoimmunity and inflammation, possess IL-1β receptors and secrete cytokin...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxr110
更新日期:2012-03-01 00:00:00
abstract::We report the characterization of the Fc epsilon RI gamma chain which associates with the transmembrane form of CD16 to form the low affinity receptor for IgG (Fc gamma RIII) expressed on human natural killer (NK) cells. cDNA cloning and sequence analysis of Fc epsilon RI gamma from a polyclonal CD3-CD16+ NK line esta...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/4.8.955
更新日期:1992-08-01 00:00:00
abstract::Two major B cell subpopulations were identified in the IgD- compartment of tonsils and subsequently isolated. They displayed the following phenotypes: CD10+CD38+CD44- (CD38+ B cells) and CD10-CD38-CD44+ (CD38- B cells). Of the CD38- B cells, 70% also expressed CD24 and CD39, whereas CD77 was specifically distributed o...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/5.10.1259
更新日期:1993-10-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/4.4.519
更新日期:1992-04-01 00:00:00
abstract::Virus-like particles are a highly effective type of subunit vaccine that mimics the overall structure of virus particles without containing infectious genetic material. In this work, a particulate form of the recombinant capsid protein from dengue-2 was evaluated in mice to determine the level of protection against vi...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxp082
更新日期:2009-10-01 00:00:00
abstract::In this review, we propose that certain modifications in cellular metabolism might function as danger signals triggering inflammasome-mediated immune responses. We propose to call them danger-associated metabolic modifications (DAMMs). As intracellular bacteria can actively modulate macrophage metabolism for their ben...
journal_title:International immunology
pub_type: 杂志文章,评审
doi:10.1093/intimm/dxaa035
更新日期:2020-06-26 00:00:00
abstract::To investigate potential roles of the RAG-1 and RAG-2 gene products in Ig heavy chain class recombination (CSR), we have generated RAG-1(-/-) and RAG-2(-/-) mice which contain both a rearranged Ig HC V(D)J gene (referred to as B1-8) inserted into the endogenous Ig heavy chain (HC) locus in place of the JH segments, an...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/10.3.325
更新日期:1998-03-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.7.1085
更新日期:2000-07-01 00:00:00
abstract::Despite intense recent interest, the suppressive mechanisms of regulatory CD25+CD4 T cells remain poorly understood. One deficiency in the field is the lack of in vivo models where the effects of regulatory CD25+CD4 T cells on antigen-specific responder T cells can be measured quantitatively. We describe one such mode...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh213
更新日期:2005-04-01 00:00:00
abstract::Effective vaccination using in vitro peptide-loaded heat-shock proteins (HSP), tumor-derived HSP and HSP fusion proteins has been shown in viral, parasite and tumor model systems. We demonstrate protective DNA vaccination using gp96-peptide fusion proteins against the intracellular bacterial pathogen Listeria monocyto...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh064
更新日期:2004-04-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/8.7.1045
更新日期:1996-07-01 00:00:00
abstract::To investigate the role of the Toll-like receptor (TLR) family in host defense against Toxoplasma gondii, we infected TLR2-, TLR4- and MyD88-deficient mice with the avirulent cyst-forming Fukaya strain of T. gondii. All TLR2- and MyD88-deficient mice died within 8 days, whereas all TLR4-deficient and wild-type mice su...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxg108
更新日期:2003-09-01 00:00:00
abstract::The two-signal model states that activation of naive T cells requires a signal 1 stimulus through the TCR and a co-stimulatory signal 2. By contrast, signal 1 alone is sufficient for pre-activated T cells. Recently, however, it has been shown that under certain conditions T cells can bypass the requirement for co-stim...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/10.5.619
更新日期:1998-05-01 00:00:00
abstract::Using a complete series of overlapping peptides, we have identified the T cell epitopes of a malaria vaccine candidate, the circumsporozoite (CS) protein, that are recognized by sporozoite-exposed residents of a non-endemic country. This protein and subunits from it are being considered as malaria sporozoite vaccine c...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/2.10.945
更新日期:1990-01-01 00:00:00
abstract::Treatment of melanoma cell lines with IFN-gamma induces the switch from proteasome (PS) to immunoproteasome (iPS). This finding has profound implications for the immunobiology of melanoma cells since certain peptides (such as Melan-A(mart1)(27-35)) are cleaved differently by iPS, thus implying a different ability to b...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxg140
更新日期:2003-12-01 00:00:00
abstract::HIV infected T and monocytic cell lines could activate and fix C3 fragments when incubated in human serum under conditions allowing for activation of the alternative complement pathway. Normal T lymphocytes incubated with HIV could also activate and fix C3. This activity was, at least in part, the property of the viru...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/3.4.395
更新日期:1991-04-01 00:00:00
abstract::The B cell-activating factor from the tumor necrosis factor family (BAFF) is an important regulator of B cell immunity. Recently, we demonstrated that recombinant BAFF also provides a co-stimulatory signal to T cells. Here, we studied expression of BAFF in peripheral blood leukocytes and correlated this expression wit...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh043
更新日期:2004-03-01 00:00:00
abstract::Induction of alphaEbeta7 expression on T cells by transforming growth factor (TGF)-beta is thought to be important for intestinal intraepithelial T lymphocyte (IEL) entry into the epithelial compartment. However, there has been no in vivo evidence that up-regulation of alphaEbeta7 expression on T cells by TGF-beta is ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/14.4.339
更新日期:2002-04-01 00:00:00
abstract::The integrins have been grouped into three subfamilies based on the utilization of three distinct beta chain subunits, beta 1, beta 2, and beta 3. The recent discovery of beta 4 and beta 5 subunits, and the sharing of alpha subunits between beta subfamilies reflects a greater structural and functional diversity of the...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/2.11.1097
更新日期:1990-01-01 00:00:00