Abstract:
:HIV infected T and monocytic cell lines could activate and fix C3 fragments when incubated in human serum under conditions allowing for activation of the alternative complement pathway. Normal T lymphocytes incubated with HIV could also activate and fix C3. This activity was, at least in part, the property of the virus itself since cell-free HIV could efficiently activate C3. The C3 activating HIV infected cells were resistant to complement-mediated lysis, even after prolonged incubation periods. However, their sensitivity to cell-mediated natural killing increased, presumably due to their interaction with complement receptor bearing NK lymphocytes. The results suggest that the alternative complement pathway may contribute to the depletion of CD4+ T lymphocytes during HIV infection in vivo.
journal_name
Int Immunoljournal_title
International immunologyauthors
Yefenof E,Asjö B,Klein Edoi
10.1093/intimm/3.4.395subject
Has Abstractpub_date
1991-04-01 00:00:00pages
395-401issue
4eissn
0953-8178issn
1460-2377journal_volume
3pub_type
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