Conserved regions of protein disulfide isomerase are targeted by natural IgA antibodies in humans.

abstract：:Lymphocyte migration from the blood into specific tissues is directed by their expression of adhesion molecules referred to as homing receptors. The homing receptor L-selectin, for example, directs the migration of lymphocytes into peripheral lymph nodes (PLN). Since bovine gamma delta T cells, a major lymphocyte subs...

journal_title：International immunology

authors： Walcheck B,Jutila MA

更新日期：1994-01-01 00:00:00

abstract：:Human monocytes isolated from peripheral blood of healthy donors show a time-dependent differentiation into macrophages upon in vitro cultivation, closely mimicking their in vivo migration and maturation into extravascular tissues. The mediator(s) of this maturation process has not been yet defined. We investigated th...

journal_title：International immunology

authors： Coccia EM,Del Russo N,Stellacci E,Testa U,Marziali G,Battistini A

更新日期：1999-07-01 00:00:00

abstract：:Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. Because of the wide range of ligand distribution in the body, its b...

journal_title：International immunology

authors： Okazaki T,Honjo T

更新日期：2007-07-01 00:00:00

abstract：:Monoclonal non-specific suppressor factor (MNSF), a lymphokine produced by a murine hybridoma, was originally found to inhibit the generation of lipopolysaccharide (LPS)-induced Ig-secreting cells. Most recently, we demonstrated the recombinant form of the ubiquitin-like segment (rUbi-L) or MNSF beta, an isoform of MN...

journal_title：International immunology

authors： Nakamura M,Nagata T,Xavier M,Tanigawa Y

更新日期：1996-11-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) T cell-mediated, inflammatory disease with similarities to multiple sclerosis in humans. Intranasal (i.n.) administration of a myelin basic protein (MBP)-derived peptide can protect susceptible mice from EAE. The mechanisms underlying this phenomenon, however...

journal_title：International immunology

authors： Burkhart C,Liu GY,Anderton SM,Metzler B,Wraith DC

更新日期：1999-10-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells expressing the retinoic acid receptor-related orphan receptor γt (RORγt) and producing IL-17 represent a minor subset of CD1d-restricted iNKT cells (iNKT17) in C57BL/6J (B6) mice. We aimed in this study to define the reasons for their low distribution and the sequence of events ...

journal_title：International immunology

authors： Klibi J,Li S,Amable L,Joseph C,Brunet S,Delord M,Parietti V,Jaubert J,Marie J,Karray S,Eberl G,Lucas B,Toubert A,Benlagha K

更新日期：2020-02-07 00:00:00

abstract：:In order to further understand the developmental aspects of B-1 cells, we characterized the ontogeny of this B cell population in the spleen and peritoneal cavity of BALB/c mice. Although there are B-1 cells in the spleen within the first 1-3 weeks after birth, they do not at any stage represent the majority of spleni...

journal_title：International immunology

authors： Hamilton AM,Lehuen A,Kearney JF

更新日期：1994-03-01 00:00:00

abstract：:A small proportion of the sIg+ B lymphocytes in peripheral lymphoid organs [22% in spleen and 6% in lymph node (LN)] in rat carries the Thy-1 antigen. These Thy-1+ B cells represent newly formed bone marrow (BM) derived (or immature) B cells. In this study we investigated the kinetic behavior of Thy-1+ and Thy-1- B ce...

journal_title：International immunology

authors： Deenen GJ,Kroese FG

更新日期：1993-07-01 00:00:00

abstract：:The lectin complement pathway is initiated by binding of mannose-binding lectin (MBL) and MBL-associated serine protease (MASP) to carbohydrates. In the human lectin pathway, MASP-1 and MASP-2 are involved in the proteolysis of C4, C2 and C3. Here we report that the human MBL-MASP complex contains a new 22 kDa protein...

journal_title：International immunology

authors： Takahashi M,Endo Y,Fujita T,Matsushita M

更新日期：1999-05-01 00:00:00

abstract：:It is now generally recognized that bone marrow is the survival niche for antigen-specific plasma cells with long-term immunological memory. These cells release antibodies into the circulation, needed to prime effector cells in the secondary immune response. These antibodies participate in the surveillance for antigen...

journal_title：International immunology

authors： Gould HJ,Wu YB

更新日期：2018-08-30 00:00:00

abstract：:Acute graft-versus-host disease (GvHD) is a serious complication after allogeneic bone marrow transplantation. Donor-derived T cells infiltrate recipient target organs and cause severe tissue damage, often leading to death of the affected patient. Tissue destruction is a direct result of donor CD8+ T cell activation a...

journal_title：International immunology

authors： Arnold D,Wasem C,Juillard P,Graber P,Cima I,Frutschi C,Herren S,Jakob S,Alouani S,Mueller C,Chvatchko Y,Brunner T

更新日期：2002-05-01 00:00:00

abstract：:The profile of cytokines produced by CD4 T cells is profoundly influenced by the presence of IL-12. Here we demonstrate that during re-stimulation of antigen-specific immune responses in vitro, antigen-primed lymph node cells from DBA/2 mice produced 3- to 30-fold more IL-12 than did cells from BALB/c mice, which are ...

journal_title：International immunology

authors： Gieni RS,Fang Y,Trinchieri G,Umetsu DT,DeKruyff RH

更新日期：1996-10-01 00:00:00

abstract：:The ileal Peyer's patch (PP) plays a central role in B cell development in young sheep and it is hypothesized that this B cell development occurs independent of extrinsic antigen and T cells. Therefore, it was of interest to examine ileal PP follicular (iPf) B cell responses to CD40 ligand, a molecule integral to T ce...

journal_title：International immunology

authors： Griebel P,Ferrari G

更新日期：1995-03-01 00:00:00

abstract：:Germline CH transcripts initiate from a non-coding I exon and terminate downstream of the associated CH exons. Ig heavy chain class switch recombination from the VDJ-C mu gene to particular downstream CH genes appears to be regulated by a process that involves mitogen and/or cytokine induction of germline CH transcrip...

journal_title：International immunology

authors： Li SC,Rothman PB,Zhang J,Chan C,Hirsh D,Alt FW

更新日期：1994-04-01 00:00:00

abstract：:Epitope spreading has been best characterized as an exacerbating factor in CD4(+) T cell-dependent autoimmune disease models and is believed to occur via presentation of antigens liberated by tissue destruction initiated by CD4(+) T cells specific for a primary epitope. The growing evidence that exogenous antigens can...

journal_title：International immunology

authors： Markiewicz MA,Fallarino F,Ashikari A,Gajewski TF

更新日期：2001-05-01 00:00:00

abstract：:CD40 has been shown to play an important role in the regulation of B cell survival, proliferation and Ig class switching. The natural partner for CD40 is CD40 ligand, gp 39, which is transiently expressed on activated T cells. In vitro, CD40 ligation leads to polyclonal B cell proliferation and, in the presence of app...

journal_title：International immunology

authors： Wohlleben G,Gray D,Schimpl A

更新日期：1996-03-01 00:00:00

abstract：:We have isolated two cDNA clones encoding the guinea pig receptor for the Fc portion of IgG2 (Fc gamma 2R) from a guinea pig peritoneal macrophage cDNA library. Analysis of the predicted amino acid sequence of the one cDNA clone indicated that the guinea pig Fc gamma 2R is a type I transmembrane protein and has approx...

journal_title：International immunology

authors： Isashi Y,Yamashita T,Nagasawa S,Murakami M,Uede T

更新日期：1996-09-01 00:00:00

abstract：:Naturally arising CD25(+)CD4(+) regulatory T (T(R)) cells can be exploited to establish immunologic tolerance to non-self antigens. In vivo exposure of CD25(+)CD4(+) T cells from normal naive mice to alloantigen in a T cell-deficient environment elicited spontaneous expansion of alloantigen-specific CD25(+)CD4(+) T(R)...

journal_title：International immunology

authors： Nishimura E,Sakihama T,Setoguchi R,Tanaka K,Sakaguchi S

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Intranasal administration of high amount of allergen was shown to induce tolerance and to reverse the allergic phenotype. However, mechanisms of tolerance induction via the mucosal route are still unclear. OBJECTIVES:To characterize the therapeutic effects of intranasal application of ovalbumin (OVA) in a m...

journal_title：International immunology

authors： Pellaton-Longaretti C,Boudousquié C,Barbier N,Barbey C,Argiroffo CB,Donati Y,Sauty A,Spertini F

更新日期：2011-01-01 00:00:00

abstract：:The role of B7 co-stimulatory signaling in in vivo tumor rejection remains incompletely characterized. In particular, the relative competence of B7-1 (CD80) and B7-2 (CD86) to provide effective co-stimulus is not well defined, and the identification of the T cell co-stimulatory receptor that mediates B7 co-stimulation...

journal_title：International immunology

authors： Yu X,Abe R,Hodes RJ

更新日期：1998-06-01 00:00:00

abstract：:Earlier studies have suggested that in adults the n-positive allele of the human IgG2 gene is more productive than the n-negative allele. This superiority was seen to be manifested in IgG2 antibody responses to polysaccharides, in the higher serum concentration of total IgG2 in the n/n than in -/- individuals, and in ...

journal_title：International immunology

authors： Sarvas H,Rautonen N,Käyhty H,Kallio M,Mäkelä O

更新日期：1990-01-01 00:00:00

abstract：:The endocytic and phagocytic activities of a population of MHC IIhi CD11c+ dendritic cell (DC)-like cells in synovium-rich tissues (SRTs) of normal rat paws were compared with CD163+ cells (putative macrophages) from the same tissues and pseudo-afferent lymph DCs, peritoneal macrophages and blood monocytes. Fifty perc...

journal_title：International immunology

authors： Moghaddami M,Mayrhofer G,Cleland LG

更新日期：2005-08-01 00:00:00

abstract：:NKT cells are characterized by their expression of an NKT-cell-specific invariant antigen-receptor α chain encoded by Vα14Jα18 gene segments. These NKT cells bridge the innate and acquired immune systems to mediate effective and augmented responses; however, the limited number of NKT cells in vivo hampers their analys...

journal_title：International immunology

authors： Ren Y,Dashtsoodol N,Watarai H,Koseki H,Quan C,Taniguchi M

更新日期：2014-10-01 00:00:00

abstract：:In contrast to most organs, the anatomy of the liver may allow naive CD8(+) T cells to make direct contact with liver parenchymal cells. We have previously shown, using a combination of TCR transgenic T cells specific for H-2 K(b) and hepatocytes expressing a transgenic H-2 K(b) molecule, that hepatocytes can induce a...

journal_title：International immunology

authors： Bertolino P,Trescol-Biémont MC,Thomas J,Fazekas de St Groth B,Pihlgren M,Marvel J,Rabourdin-Combe C

更新日期：1999-08-01 00:00:00

abstract：:EBV-encoded latent membrane protein 1 (LMP1) is critical for EBV-driven B-cell transformation and most EBV-associated malignancies and is also implicated in exacerbation of autoimmunity. LMP1 functionally mimics the TNFR superfamily member CD40, but LMP1-induced signals and downstream B-cell functions are amplified an...

journal_title：International immunology

authors： Arcipowski KM,Stunz LL,Bishop GA

更新日期：2014-03-01 00:00:00

abstract：:To investigate the role of the Toll-like receptor (TLR) family in host defense against Toxoplasma gondii, we infected TLR2-, TLR4- and MyD88-deficient mice with the avirulent cyst-forming Fukaya strain of T. gondii. All TLR2- and MyD88-deficient mice died within 8 days, whereas all TLR4-deficient and wild-type mice su...

journal_title：International immunology

authors： Mun HS,Aosai F,Norose K,Chen M,Piao LX,Takeuchi O,Akira S,Ishikura H,Yano A

更新日期：2003-09-01 00:00:00

abstract：:We have determined the origin and cell surface phenotype of B cells producing antibody in response to immunization with the non-self TI-2 antigen polyvinyl pyrrolidinone (PVP). We report that the responding cells are derived from precursors in adult bone marrow and display the phenotype characteristic of B-1 cells. By...

journal_title：International immunology

authors： Whitmore AC,Haughton G,Arnold LW

更新日期：1996-04-01 00:00:00

abstract：:Semaphorin 3A (Sema3A), originally identified as a potent growth cone collapsing factor in developing sensory neurons, is now recognized as a key player in immune, cardiovascular, bone metabolism and neurological systems. Here we established an anti-Sema3A monoclonal antibody that neutralizes the effects of Sema3A bot...

journal_title：International immunology

authors： Yamashita N,Jitsuki-Takahashi A,Ogawara M,Ohkubo W,Araki T,Hotta C,Tamura T,Hashimoto S,Yabuki T,Tsuji T,Sasakura Y,Okumura H,Takaiwa A,Koyama C,Murakami K,Goshima Y

更新日期：2015-09-01 00:00:00

abstract：:Heat shock protein (Hsp) 60 is thought to function as endogenous danger signal by activating professional antigen-presenting cells (APC) through toll-like receptor (TLR) 4 and CD14, a mechanism that is also used by bacterial LPS. We recently showed that Hsp60 binds LPS and enhances LPS-induced immune stimulation. On t...

journal_title：International immunology

authors： Osterloh A,Veit A,Gessner A,Fleischer B,Breloer M

更新日期：2008-03-01 00:00:00

abstract：:Cyclosporin A (CsA) prevents most immature thymocytes from progressing to a mature phenotype and blocks the deletion of T cells that express self-specific TCR in the small population of cells that achieve maturity. The latter effect may explain the paradoxical observation that this immunosuppressive drug can induce au...

journal_title：International immunology

authors： Urdahl KB,Pardoll DM,Jenkins MK

更新日期：1992-12-01 00:00:00