Abstract:
:In order to further understand the developmental aspects of B-1 cells, we characterized the ontogeny of this B cell population in the spleen and peritoneal cavity of BALB/c mice. Although there are B-1 cells in the spleen within the first 1-3 weeks after birth, they do not at any stage represent the majority of splenic B cells. Splenic B-1 cells reach peak levels at approximately 9 days after birth. The mesenteric lining that covers the small intestine of 7-day-old mice contains a population of IgM+ B cells, while at the same age, there are few lymphoid cells in the peritoneal cavity. Between 7 and 8 days after birth there is an influx of B cells into the peritoneal cavity. At 8 days, the first detectable peritoneal B cells appear to be of the B-1 type based on expression of IL-5 receptor and CD5. However, these peritoneal B-1 cells do not express Mac-1. This antigen is not expressed by the majority of peritoneal B-1 cells until 3 weeks. This study indicates that the majority of early splenic B cells are not B-1 cells and it suggests that the mesenteric tissues surrounding the gut contain B lymphocytes which traffic into the peritoneal cavity where they then reside.
journal_name
Int Immunoljournal_title
International immunologyauthors
Hamilton AM,Lehuen A,Kearney JFdoi
10.1093/intimm/6.3.355subject
Has Abstractpub_date
1994-03-01 00:00:00pages
355-61issue
3eissn
0953-8178issn
1460-2377journal_volume
6pub_type
杂志文章abstract::Linomide (LS-2616, quinoline-3-carboxamide) has strong immunomodulating effects in animal models, inhibiting toxic shock, progressive autoimmune disease and cancer. In humans, linomide strongly reduced the appearance of new lesions in multiple sclerosis yet enhanced immune responses after bone marrow transplantation. ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/8.10.1603
更新日期:1996-10-01 00:00:00
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journal_title:International immunology
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更新日期:2001-04-01 00:00:00
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journal_title:International immunology
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更新日期:1996-03-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxq462
更新日期:2011-02-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/5.2.231
更新日期:1993-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/12.8.1157
更新日期:2000-08-01 00:00:00
abstract::The previously defined binding motif of MHC class I H-2Kd-restricted antigenic peptides consists of a Y residue in position P2 and a hydrophobic residue with a large aliphatic side chain (L, I, or V) in position P9/P10 of optimal 9- or 10-mer peptides. We show now that the presence of a charged or a F residue in posit...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/5.11.1489
更新日期:1993-11-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxaa070
更新日期:2020-10-10 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxn080
更新日期:2008-09-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/4.1.67
更新日期:1992-01-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxt012
更新日期:2013-08-01 00:00:00
abstract::In this paper we describe a monoclonal antibody, JR9-318, which was obtained from a wild-derived mouse immunized with the M14T cell line (CD3+CD4-CD8-) in order to describe antigenic molecules expressed during T cell differentiation. This mAb precipitated a protein from the M14T cell line or subclones that migrates li...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/4.6.699
更新日期:1992-06-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxm021
更新日期:2007-04-01 00:00:00
abstract::We have previously cloned the murine homolog of cDNA for the human myelomonocytic differentiation antigen, CD14. We synthesized three hydrophilic peptides derived from the predicted amino acid sequence of murine CD14 (mCD14), designated MS7.1, MS7.2, and MS7.3, respectively, and raised antisera against them. Each anti...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/3.2.205
更新日期:1991-02-01 00:00:00
abstract::In an attempt to identify autoantigens of synovium in rheumatoid arthritis (RA), we constructed lambda phage expression cDNA libraries from synovium and screened them by IgG purified from synovial fluids, both of which were derived from RA patients. As a result of this unique combination of the libraries and probes, w...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/10.9.1305
更新日期:1998-09-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxn081
更新日期:2008-10-01 00:00:00
abstract::LPS-binding protein (LBP) can facilitate the transfer of cell wall components of both Gram-negative bacteria (LPS) and Gram-positive bacteria (lipoteichoic acid) to inflammatory cells. Although LBP is predominantly produced in the liver, recent studies have indicated that this protein is also synthesized locally in th...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh161
更新日期:2004-11-01 00:00:00
abstract::Mouse CD4+ T cells were subdivided into two subpopulations, naive (CD44low CD45RBhigh) and memory (CD44high CD45RBlow) T cells, by flow cytometric analysis. Examination of spleen and peripheral blood of C57BL/6 mice of various ages revealed that there was a reciprocal age-associated change in these two subpopulations,...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/7.1.97
更新日期:1995-01-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxn009
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1093/intimm/dxx059
更新日期:2017-12-30 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/2.10.921
更新日期:1990-01-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/13.2.167
更新日期:2001-02-01 00:00:00
abstract::NOD mice spontaneously develop type I diabetes resulting from autoimmune destruction of their insulin-producing beta cells. Among the self-antigens targeted by NOD autoimmune T cells is a peptide, p277, from the sequence of the 60 kDa heat shock protein (hsp60). Common to the anti-p277 T cell populations of NOD mice i...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.6.957
更新日期:1999-06-01 00:00:00
abstract::Fas (CD95) is a cell surface death receptor belonging to the tumor necrosis factor receptor superfamily, which mediates apoptosis-inducing signaling when activated by Fas ligand or its agonistic antibody. lpr mice with a loss of apoptosis-inducing function mutation in the Fas gene develop systemic autoimmune disease a...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxs109
更新日期:2013-05-01 00:00:00
abstract::The class II trans-activator (CIITA) is a bi- or multi-functional domain protein which plays a critical role in the expression of MHC class II genes. We report that removal of the N-terminal 151 amino acids, encompassing all of the acidic domain but leaving intact the proline/serine/threonine-rich domain, results in a...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/9.10.1545
更新日期:1997-10-01 00:00:00
abstract::Soluble recombinant (r) P-selectin and rP-selectin immobilized on plastic surfaces were tested for their capacity to activate neutrophils to produce superoxide anion. Soluble rP-selectin was incapable of activating leukocytes, whereas immobilized rP-selectin was able to induce leukocyte activation. When neutrophils we...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.4.487
更新日期:2000-04-01 00:00:00
abstract::We report here that different organ grafts are not equally competent to induce tolerance of the host even if they are performed early in development, i.e. before the host's immune system has started to develop. We have grafted the epithelio-mesenchymal rudiment of the bursa of Fabricius between histoincompatible chick...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/6.6.795
更新日期:1994-06-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh115
更新日期:2004-08-01 00:00:00
abstract::Toll-like receptors (TLRs) traffic to distinct membranes for signaling. TLR7 and TLR9 recognize viral nucleic acids in the endosomes and induce robust anti-viral program. Signaling from these TLRs bifurcate at the level of distinct endosomal compartments, namely VAMP3(+) and LAMP(+) endosomes, to mediate the induction...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxv021
更新日期:2015-09-01 00:00:00
abstract::Naturally arising CD25(+)CD4(+) regulatory T (T(R)) cells can be exploited to establish immunologic tolerance to non-self antigens. In vivo exposure of CD25(+)CD4(+) T cells from normal naive mice to alloantigen in a T cell-deficient environment elicited spontaneous expansion of alloantigen-specific CD25(+)CD4(+) T(R)...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh122
更新日期:2004-08-01 00:00:00