LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia.


:LPS-binding protein (LBP) can facilitate the transfer of cell wall components of both Gram-negative bacteria (LPS) and Gram-positive bacteria (lipoteichoic acid) to inflammatory cells. Although LBP is predominantly produced in the liver, recent studies have indicated that this protein is also synthesized locally in the lung by epithelial cells. To determine the role of LBP in the immune response to pneumonia, LBP gene-deficient (-/-) and normal wild-type (WT) mice were intra-nasally infected with either Streptococcus pneumoniae or Klebsiella pneumoniae, common Gram-positive and Gram-negative pathogens, respectively. Pneumococcal pneumonia was associated with a 7-fold rise in LBP concentrations in bronchoalveolar lavage fluid of WT mice; LBP-/- mice infected with S. pneumoniae showed a similar survival and a similar bacterial burden in their lungs 48 h post-infection. In Klebsiella pneumonia, however, LBP-/- mice demonstrated a diminished survival together with an enhanced bacterial outgrowth in their lungs. These data suggest that LBP is important for a protective immune response in Klebsiella pneumonia, but does not contribute to an effective host response in pneumococcal pneumonia.


Int Immunol


International immunology


Branger J,Florquin S,Knapp S,Leemans JC,Pater JM,Speelman P,Golenbock DT,van der Poll T




Has Abstract


2004-11-01 00:00:00














  • Loss of MHC II ubiquitination inhibits the activation and differentiation of CD4 T cells.

    abstract::Peptide-MHC class II complexes (pMHC II) are degraded by MARCH-I-mediated ubiquitination, and the stabilization of pMHC II by loss of its ubiquitination is one phenotype defining the activation of conventional dendritic cells (cDCs). However, the role of such stabilization of pMHC II in the context of T-cell activatio...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Ishikawa R,Kajikawa M,Ishido S

    更新日期:2014-05-01 00:00:00

  • Sulfates are main targets of immune responses to cruzipain and are involved in heart damage in BALB/c immunized mice.

    abstract::Trypanosoma cruzi, the agent of Chagas disease contains a major cysteine proteinase, cruzipain (Cz), with an unusual carboxyl-terminal extension (C-T). We have previously reported the presence of sulfate groups in the N-linked oligosaccharide chains of this domain. In order to evaluate the immune responses to sulfated...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Acosta DM,Arnaiz MR,Esteva MI,Barboza M,Stivale D,Orlando UD,Torres S,Laucella SA,Couto AS,Duschak VG

    更新日期:2008-04-01 00:00:00

  • Unique and conserved functions of B cell-activating factor of the TNF family (BAFF) in the chicken.

    abstract::The chicken represents the best-characterized animal model for B cell development in the so-called gut-associated lymphoid tissue (GALT) and the molecular processes leading to B cell receptor diversification in this species are well investigated. However, the mechanisms regulating B cell development and homeostasis in...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Kothlow S,Morgenroth I,Graef Y,Schneider K,Riehl I,Staeheli P,Schneider P,Kaspers B

    更新日期:2007-02-01 00:00:00

  • Protective cytotoxic T lymphocyte responses against paramyxoviruses induced by epitope-based DNA vaccines: involvement of IFN-gamma.

    abstract::Plasmid DNA vectors have been constructed with minigenes encoding a single cytotoxic T lymphocyte (CTL) epitope from either the M2 protein of respiratory syncytial virus (RSV) or from the nucleoprotein of measles virus (MV) with or without a signal sequence (also called secretory or leader sequence). Following intrade...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Hsu SC,Obeid OE,Collins M,Iqbal M,Chargelegue D,Steward MW

    更新日期:1998-10-01 00:00:00

  • Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl-1, in human peripheral blood and lymphoid tissues.

    abstract::The ability of Bcl-2 to inhibit apoptotic cell death is well established. Several homologues of the bcl-2 gene, such as bax, bcl-x or mcl-1, have recently been identified. Like Bcl-2, both Bcl-XL and Mcl-1 appear to function as repressors of apoptotic cell death, whereas Bax facilitates it, indicating possible interac...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Ohta K,Iwai K,Kasahara Y,Taniguchi N,Krajewski S,Reed JC,Miyawaki T

    更新日期:1995-11-01 00:00:00

  • Glycosyltransferase regulation mediated by pre-TCR signaling in early thymocyte development.

    abstract::CT1 is a carbohydrate moiety of CD45 that is expressed on fetal thymocytes in vivo. Examination of CT1 expression on thymocyte subsets revealed that primarily pro-T cells (CD44+ CD25+) and pre-T cells (CD44- CD25+) expressed CT1. Interestingly, non-T-lineage committed lymphoid progenitors (CD44+ CD25-) lacked CT1 indi...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Reed DS,Olson S,Lefrançois L

    更新日期:1998-04-01 00:00:00

  • Differential effect of insulin and elevated glucose level on adenosine transport in rat B lymphocytes.

    abstract::Impaired lymphocyte function is a common feature of human diabetes. Nucleoside transport across the plasma membrane is an essential step during lymphocyte growth and activation. In our study, we evaluated the impact of diabetic conditions on nucleoside transport system in B lymphocytes. Examination of the nucleoside t...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Sakowicz M,Szutowicz A,Pawelczyk T

    更新日期:2005-02-01 00:00:00

  • A novel approach to induce human DCs from monocytes by triggering 4-1BBL reverse signaling.

    abstract::Dendritic cells (DCs) are responsible for the initiation of immune responses. Our study demonstrates a new pathway for generating a large quantity of stimulatory monocyte-derived DCs (Mo-DCs) from human monocytes using anti-4-1BB ligand (4-1BBL) mAb to trigger reverse signaling. The anti-4-1BBL-driven Mo-DCs (DCs(alph...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Ju S,Ju S,Ge Y,Qiu H,Lu B,Qiu Y,Fu J,Liu G,Wang Q,Hu Y,Shu Y,Zhang X

    更新日期:2009-10-01 00:00:00

  • Selective IgG2 deficiency due to a point mutation causing abnormal splicing of the Cgamma2 gene.

    abstract::The mechanism underlying selective IgG subclass deficiency is largely unknown in humans. We have previously reported the acquisition of a complete IgG2 deficiency in a leukemia patient after bone marrow transplantation. Southern blot analysis showed a deletion including the Cgamma2 and Cgamma4 genes on one chromosome ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Zhao Y,Pan-Hammarström Q,Zhao Z,Wen S,Hammarström L

    更新日期:2005-01-01 00:00:00

  • Involvement of CD70 and CD80 intracytoplasmic domains in the co-stimulatory signal required to provide an antitumor immune response.

    abstract::CD70 and CD80 are co-stimulatory molecules which belong to the tumor necrosis factor family and the B7 family respectively. When they are co-expressed by gene-modified TS/A tumor cells, they provide an efficient protective and long-lasting T-dependent antitumor response. We first showed that when CD70 and CD80 were de...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Douin-Echinard V,Péron JM,Lauwers-Cancès V,Favre G,Couderc B

    更新日期:2003-03-01 00:00:00

  • Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching.

    abstract::Germline CH transcripts initiate from a non-coding I exon and terminate downstream of the associated CH exons. Ig heavy chain class switch recombination from the VDJ-C mu gene to particular downstream CH genes appears to be regulated by a process that involves mitogen and/or cytokine induction of germline CH transcrip...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Li SC,Rothman PB,Zhang J,Chan C,Hirsh D,Alt FW

    更新日期:1994-04-01 00:00:00

  • Antibody-secreting cells in respiratory tract tissues in the absence of eosinophils as supportive partners.

    abstract::Antibody-secreting cells (ASCs) in respiratory tract tissues provide a first line of defense against invading pathogens. These cells often secrete IgA that is efficiently transcytosed across epithelial barriers into the airway lumen where pathogens can be blocked at their point of entry. Previous literature has report...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Sealy RE,Surman SL,Vogel P,Hurwitz JL

    更新日期:2016-11-01 00:00:00

  • MHC class II and invariant chain biosynthesis and transport during maturation of human precursor dendritic cells.

    abstract::Dendritic cells (DC) are highly potent activators of the immune response. The precise mechanisms that give rise to the DC phenotype are not known. To investigate the mechanisms that contribute to the generation of the DC phenotype, precursor DC were freshly isolated from human blood and allowed to mature in vitro. The...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Engering AJ,Richters CD,Fluitsma DM,van Pelt AM,Kamperdijk EW,Hoefsmit EC,Pieters J

    更新日期:1998-11-01 00:00:00

  • HLA-G functions as a restriction element and a transplantation antigen in mice.

    abstract::HLA-G, a human MHC class I molecule expressed on the trophoblast during pregnancy, was expressed in transgenic mice by recombining the HLA-G gene with a transcriptional promoter from a murine H-2 MHC class I gene. Skin grafts from HLA-G transgenic mice were rejected by non-transgenic mice showing that HLA-G behaves as...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Horuzsko A,Antoniou J,Tomlinson P,Portik-Dobos V,Mellor AL

    更新日期:1997-05-01 00:00:00

  • Skewed V beta TCR repertoire of CD8+ T cells in murine Trypanosoma cruzi infection.

    abstract::We have followed CD4 and CD8 TCR V beta repertoires during the acute phase of Trypanosoma cruzi infection in a resistant mouse strain (C57BL/6). No major changes were found in the V beta TCR distributions analyzed (covering roughly 40% of the TCR repertoire) in peripheral CD4 T lymphocytes, confirming the polyclonal n...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Leite-de-Moraes MC,Coutinho A,Hontebeyrie-Joskowicz M,Minoprio P,Eisen H,Bandeira A

    更新日期:1994-03-01 00:00:00

  • A mouse C kappa-specific T cell clone indicates that DC-SIGN is an efficient target for antibody-mediated delivery of T cell epitopes for MHC class II presentation.

    abstract::In vaccine development, a major objective is to induce strong, specific T cell responses. This might be obtained by targeting antigen to cell surface molecules that efficiently channel the antigen into endocytic compartments for loading of MHC molecules. Antibodies have been used to deliver antigen; however, it is imp...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Schjetne KW,Thompson KM,Aarvak T,Fleckenstein B,Sollid LM,Bogen B

    更新日期:2002-12-01 00:00:00

  • Expression of CD45 isoforms by fresh and activated human gamma delta T lymphocytes and natural killer cells.

    abstract::Naive and primed alpha beta T cells can be distinguished on the basis of their differential expression of CD45RA and CD45RO, respectively. The present study indicates that these CD45-isoforms also identify naive and primed maturational stages of gamma delta T cells and natural killer (NK) cells. In peripheral blood, a...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Braakman E,Sturm E,Vijverberg K,van Krimpen BA,Gratama JW,Bolhuis RL

    更新日期:1991-07-01 00:00:00

  • Two intermediate-avidity cytotoxic T lymphocyte clones with a disparity between functional avidity and MHC tetramer staining.

    abstract::The efficacy of cytotoxic T lymphocytes (CTL) has been shown to be highly dependent upon their functional avidity (the sensitivity of their cellular response to MHC-peptide complexes). To examine this relationship, we employed target cell lysis as a quantitative measure and established a set of four CTL clones that ex...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Derby MA,Wang J,Margulies DH,Berzofsky JA

    更新日期:2001-06-01 00:00:00

  • Antigen localization within the splenic marginal zone restores humoral immune response and IgG class switch in complement C4-deficient mice.

    abstract::Defects of early complement components (C1, C4 and C2) are associated with the development of systemic lupus erythematosus (SLE). The availability of complement knockout mice has increased our knowledge on the role of complement in the regulation of adaptive immunity. An impaired removal of apoptotic bodies, a disturb...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Zachrau B,Finke D,Kropf K,Gosink HJ,Kirchner H,Goerg S

    更新日期:2004-12-01 00:00:00

  • Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure.

    abstract::The immunomodulator FTY720 inhibits lymph node (LN) and thymic egress, thereby constraining T cell circulation and reducing peripheral T cell numbers. Here, we analyzed in mouse models the as yet scarcely characterized impact of long-term (up to 6 months) FTY720 exposure on T cell homeostasis and possible consequences...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Metzler B,Gfeller P,Wieczorek G,Li J,Nuesslein-Hildesheim B,Katopodis A,Mueller M,Brinkmann V

    更新日期:2008-05-01 00:00:00

  • Characterization of dendritic-like cells derived from t(9;22) acute lymphoblastic leukemia blasts.

    abstract::We asked herein whether functional dendritic-like cells could be generated from t(9;22) acute lymphoblastic leukemia (ALL) blasts. We first determined that the combination of interleukin (IL)-1beta, IL-3, IL-7, tumor necrosis factor-alpha, stem cell factor and CD40 ligand was optimal for generating dendritic-like cell...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Lee J,Sait SN,Wetzler M

    更新日期:2004-10-01 00:00:00

  • Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain.

    abstract::Human intestinal intraepithelial lymphocytes (iIEL) are a unique population of predominantly CD8 alpha beta+, TCR alpha beta+ lymphocytes and, to a lesser extent, TCP gamma delta+ lymphocytes that proliferate poorly to anti-CD3 mitogenic signals but display significant cytolytic activity. Studies in mouse model system...

    journal_title:International immunology

    pub_type: 杂志文章,评审


    authors: Balk SP,Polischuk JE,Probert C,Stevens C,Ebert E,She J,Terhorst C,Blumberg RS

    更新日期:1995-08-01 00:00:00

  • Recent progress in organoid culture to model intestinal epithelial barrier functions.

    abstract::The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. In the past decade, significant progress has been made in the development of culture technologies to maintain intestinal epithelial cells (...

    journal_title:International immunology

    pub_type: 杂志文章,评审


    authors: Nakamura T

    更新日期:2019-02-06 00:00:00

  • Thrombospondin orchestrates the tolerance-promoting properties of TGFbeta-treated antigen-presenting cells.

    abstract::Eye-derived antigen-presenting cells (APCs) are known to contribute to the immune privilege status of the eye by inducing a form of peripheral tolerance that deviates T(h)1 type of pro-inflammatory immune responses. Similar systemic tolerance can also be induced by non-ocular APCs exposed to transforming growth factor...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Masli S,Turpie B,Streilein JW

    更新日期:2006-05-01 00:00:00

  • Peripheral human CD8(+)CD28(+)T lymphocytes give rise to CD28(-)progeny, but IL-4 prevents loss of CD28 expression.

    abstract::At birth, virtually all peripheral CD8(+) T cells express the CD28 co-stimulatory molecule, but healthy human adults accumulate CD28(-)CD8(+) T cells that often express the CD57 marker. While these CD28(-) subpopulations are known to exert effector-type functions, the generation, maintenance and regulation of CD28(-) ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Labalette M,Leteurtre E,Thumerelle C,Grutzmacher C,Tourvieille B,Dessaint JP

    更新日期:1999-08-01 00:00:00

  • Isolation of human minor histocompatibility peptides.

    abstract::Incompatibility of human minor histocompatibility (hmH) antigens induces rejection of grafts in organ transplantation and graft versus host disease in bone marrow transplantation if donor and recipient are matched for human leukocyte antigen (HLA) genes. These antigens are recognized only by T cells. We describe here ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Sekimata M,Griem P,Egawa K,Rammensee HG,Takiguchi M

    更新日期:1992-02-01 00:00:00

  • Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse.

    abstract::Mounting evidence has demonstrated that NOD-Shi/scid/γc(null) (NOG) mice are one of the most suitable mouse strains for humanized mouse technologies, in which various human cells or tissues can be engrafted without rejection and autonomously maintained. We have characterized and analyzed various features of the human ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Suzuki M,Takahashi T,Katano I,Ito R,Ito M,Harigae H,Ishii N,Sugamura K

    更新日期:2012-04-01 00:00:00

  • Activation-induced peripheral blood T cell apoptosis is Fas independent in HIV-infected individuals.

    abstract::T cell apoptosis has been proposed as an important contributor to the functional defects and depletion of T cells in HIV-infected individuals. However, the mechanisms involved in this apoptosis have not been elucidated. We recently showed that peripheral blood T cells from HIV-infected individuals are especially susce...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Katsikis PD,García-Ojeda ME,Wunderlich ES,Smith CA,Yagita H,Okumura K,Kayagaki N,Alderson M,Herzenberg LA,Herzenberg LA

    更新日期:1996-08-01 00:00:00

  • Differential antibody binding to the surface alphabetaTCR.CD3 complex of CD4+ and CD8+ T lymphocytes is conserved in mammals and associated with differential glycosylation.

    abstract::We have previously shown that the surface alphabeta T cell antigen receptor (TCR).CD3 complex borne by human CD4(+) and CD8(+) T lymphocytes can be distinguished using mAbs. Using two unrelated sets of antibodies, we have now extended this finding to the surface alphabetaTCR.CD3 of seven additional mammalian species (...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Rossi NE,Reiné J,Pineda-Lezamit M,Pulgar M,Meza NW,Swamy M,Risueno R,Schamel WW,Bonay P,Fernández-Malavé E,Regueiro JR

    更新日期:2008-10-01 00:00:00

  • Immunofluorescence analysis of B-1 cell ontogeny in the mouse.

    abstract::In order to further understand the developmental aspects of B-1 cells, we characterized the ontogeny of this B cell population in the spleen and peritoneal cavity of BALB/c mice. Although there are B-1 cells in the spleen within the first 1-3 weeks after birth, they do not at any stage represent the majority of spleni...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Hamilton AM,Lehuen A,Kearney JF

    更新日期:1994-03-01 00:00:00