Allorecognition of human neural stem cells by peripheral blood lymphocytes despite low expression of MHC molecules: role of TGF-beta in modulating proliferation.

abstract：:Spectroscopic methods have been applied to elucidate conformational differences responsible for the immunological diversity of two synthetic multichain copolymers, Tyr1Tyr2Glu3Glu4-poly-DL-Ala--poly-Lys and Tyr1Glu2Tyr3Glu4-poly-DL-Ala--poly-Lys. Despite their far-reaching structural similarity in the epitope peptide ...

journal_title：International immunology

authors： Muszkat KA,Schechter B,Sela M

更新日期：1993-06-01 00:00:00

abstract：:Transforming growth factor (TGF)-beta has been shown to stimulate isotype switching to IgA in cultures of lipopolysaccharide (LPS)-stimulated B cells. The induction of isotype switching is associated with the appearance of novel germline alpha transcripts that cannot be found in cultures stimulated with LPS alone. TGF...

journal_title：International immunology

authors： Lebman DA,Park MJ,Hansen-Bundy S,Pandya A

更新日期：1994-01-01 00:00:00

abstract：:CD4 T cells are not thought to play a significant role in generating an effective primary CD8 T cell response to most viral infections. We have challenged this view by demonstrating that antigen-specific CD4 T cells can indeed suppress the proliferation of antigen-specific naive CD8 T cells in response to low doses of...

journal_title：International immunology

authors： Cose S,Brammer C,Zammit DJ,Blair DA,Lefrançois L

更新日期：2006-08-01 00:00:00

abstract：:Three MHC class II-derived synthetic peptides (I-A beta (g7)1-16, I-A beta (g7)52-77 and I-A alpha (g7)63-82YC) were analyzed for their ability to bind to syngeneic and allogeneic MHC class II molecules using a whole cell, competitive peptide binding assay. These studies demonstrated that the A beta (g7)1-16 peptide w...

journal_title：International immunology

authors： Feili-Hariri M,Kao H,Mietzner TA,Morel PA

更新日期：1996-12-01 00:00:00

abstract：:Sequestration of neutrophils and release of histotoxic mediators are considered important for the development of pathologic alterations of the lung defined as adult respiratory distress syndrome. Mechanisms of inflammatory lung injury caused by abdominal sepsis were investigated using the colon ascendens stent periton...

journal_title：International immunology

authors： Neumann B,Zantl N,Veihelmann A,Emmanuilidis K,Pfeffer K,Heidecke CD,Holzmann B

更新日期：1999-02-01 00:00:00

abstract：:A subclone (160b) of the human B cell (Karpas 160) was shown to produce a novel cytotoxic lymphokine [Factor 2 (F2)] in addition to tumour necrosis factor alpha (TNF-alpha) and beta (TNF-beta). F2 was found to have selective toxicity to numerous human tumour cell lines, particularly the erythroleukaemic cell line K562...

journal_title：International immunology

authors： Ni J,Meager A,Karpas A

更新日期：1992-04-01 00:00:00

abstract：:The alternative complement pathway (ACP) in vertebrates is known to be important in inflammatory reactions, and to be activated by foreign substances such as bacterial lipopolysaccharide (LPS) and zymosan, although to date no intrinsic activators have been identified except complement receptor type 2. From the point o...

journal_title：International immunology

authors： Oshima H,Soma G,Mizuno D

更新日期：1993-10-01 00:00:00

abstract：:Mice lacking the IL-2 receptor beta chain (IL-2R beta) exhibit an autoimmune reaction characterized by generalized T cell activation, production of autoantibodies, myeloproliferation and severe anemia. T cells of IL-2R beta-/- mice were examined to elucidate the mechanism responsible for their abnormal activation and ...

journal_title：International immunology

authors： Suzuki H,Hayakawa A,Bouchard D,Nakashima I,Mak TW

更新日期：1997-09-01 00:00:00

abstract：:The kinetics of kappa light (kappa L) chain gene rearrangement and expression on mRNA and protein level has been studied with four stromal cell/IL-7 reactive, long-term in vitro proliferating pre-B cell lines and clones, two from fetal liver of normal mice and two from fetal liver of E microH-bcl-2 transgenic (bcl-2-t...

journal_title：International immunology

authors： Grawunder U,Haasner D,Melchers F,Rolink A

更新日期：1993-12-01 00:00:00

abstract：:Schnurri (Shn)-2 is a large zinc finger-containing protein, which plays a critical role in cell growth, signal transduction and lymphocyte development. In Shn-2-deficient (Shn-2(-/-)) CD4 T cells, the activation of nuclear factor-kappaB is up-regulated and their ability to differentiate into Th2 is enhanced. Here, we ...

journal_title：International immunology

authors： Iwamura C,Kimura MY,Shinoda K,Endo Y,Hasegawa A,Yamashita M,Nakayama T

更新日期：2007-06-01 00:00:00

abstract：:The peptide motifs of two HLA molecules, B8 and DR3(17), which are associated with autoimmune diseases including myasthenia gravis, were determined from natural peptide pools using Edman degradation. The majority of HLA-B8 ligands are nonamers preferentially terminated by leucine. As a characteristic feature of the HL...

journal_title：International immunology

authors： Malcherek G,Falk K,Rötzschke O,Rammensee HG,Stevanović S,Gnau V,Jung G,Melms A

更新日期：1993-10-01 00:00:00

abstract：:After a 3 week course (approximately), during which there is marked lymphoid hyperplasia, Trypanosoma musculi infections in young-adult mice are cured by an immune mechanism involving antibodies of the IgG2a isotype. Both the lymphoid hyperplasia and IgG2a antibody response are T-cell-dependent events and both process...

journal_title：International immunology

authors： Utsuyama M,Albright JW,Holmes KL,Hirokawa K,Albright JF

更新日期：1994-08-01 00:00:00

abstract：:The invertebrate pattern-recognition protein named coelomic cytolytic factor (CCF) and the mammalian cytokine tumor necrosis factor (TNF) share functional analogies that are based on a similar saccharide recognition specificity. In particular, CCF and TNF have been shown to interact with ion channels on the surface of...

journal_title：International immunology

authors： Bilej M,Josková R,Van den Bergh R,Procházková P,Silerová M,Ameloot P,De Baetselier P,Beschin A

更新日期：2006-12-01 00:00:00

abstract：:NK cells limit the emergence of cancers and viral infections by surveillance of 'missing-self' and 'induced-self' ligands, and by direct recognition of pathogen-associated molecules. We examined individual roles for Toll-like receptors (TLRs)-7 and -8 in human NK-cell activation using synthetic, small molecule agonist...

journal_title：International immunology

authors： Gorski KS,Waller EL,Bjornton-Severson J,Hanten JA,Riter CL,Kieper WC,Gorden KB,Miller JS,Vasilakos JP,Tomai MA,Alkan SS

更新日期：2006-07-01 00:00:00

abstract：:Inadequate co-stimulation of tumor reactive T cells may contribute to the fact that antigenic tumors are not normally rejected by the immune system. We recently reported that the induction of profound unresponsiveness in a T cell clone by melanoma cells expressing MHC class II antigens may provide a mechanism for thes...

journal_title：International immunology

authors： Becker JC,Czerny C,Bröcker EB

更新日期：1994-10-01 00:00:00

abstract：:In order to develop predictive markers for a beneficial humoral immune response, we evaluated the in vivo and in vitro response to the pandemic (p)H1N1 vaccine in young and elderly individuals. We measured serum antibody response and associated this with the in vitro B-cell response to the vaccine, measured by activat...

journal_title：International immunology

authors： Frasca D,Diaz A,Romero M,Phillips M,Mendez NV,Landin AM,Blomberg BB

更新日期：2012-03-01 00:00:00

abstract：:Sera of patients suffering from systemic lupus erythematosus (SLE) frequently contain oligoclonal IgG autoantibodies with high affinity for the ribosomal protein L7 (rpL7). The humoral autoimmune response to rpL7 apparently is driven by antigen and T cell dependent. In order to analyze the T cell response to rpL7 we c...

journal_title：International immunology

authors： Donauer J,Wochner M,Witte E,Peter HH,Schlesier M,Krawinkel U

更新日期：1999-02-01 00:00:00

abstract：:Fc receptors play important roles for a wide array of immune responses. In contrast to the well-defined Fcγ and Fcε receptors, the molecular and functional characteristics of Fc receptors for IgA and IgM have remained incompletely understood for years. Recent progress has unveiled the characteristics of Fc receptors f...

journal_title：International immunology

authors： Shibuya A,Honda SI,Shibuya K

更新日期：2017-12-30 00:00:00

abstract：:To investigate the involvement of retinoic acid receptor (RAR)-alpha in allograft rejection, we investigated the effect of a novel selective agonist to the receptor, ER-38925, in a mouse cardiac allograft model. Prophylactic treatment with ER-38925 inhibited the acute rejection of the mouse cardiac allograft (BALB/c -...

journal_title：International immunology

authors： Seino K,Yamauchi T,Shikata K,Kobayashi S,Nagai M,Taniguchi M,Fukao K

更新日期：2004-05-01 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells that play a central role in the control of immunity. Mature DC are characterized by high expression levels of MHC and co-stimulatory molecules, and by the secretion of IL-12, a key cytokine for the priming of cytotoxic T lymphocytes. Here, we have compared...

journal_title：International immunology

authors： Rouas R,Lewalle P,El Ouriaghli F,Nowak B,Duvillier H,Martiat P

更新日期：2004-05-01 00:00:00

abstract：:Linomide (LS-2616, quinoline-3-carboxamide) has strong immunomodulating effects in animal models, inhibiting toxic shock, progressive autoimmune disease and cancer. In humans, linomide strongly reduced the appearance of new lesions in multiple sclerosis yet enhanced immune responses after bone marrow transplantation. ...

journal_title：International immunology

authors： Arad G,Katzenellenbogen M,Levy R,Slavin S,Kaempfer R

更新日期：1996-10-01 00:00:00

abstract：:The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. In the past decade, significant progress has been made in the development of culture technologies to maintain intestinal epithelial cells (...

journal_title：International immunology

authors： Nakamura T

更新日期：2019-02-06 00:00:00

abstract：:The human IL-3 gene, located on chromosome 5, contains several cis-acting DNA sequences, i.e. CLE (conserved lymphokine element) and a GC-rich region, similar to the GM-CSF gene. To investigate the role of these elements, the 5' flanking region of the IL-3 gene was attached to a bacterial chloramphenicol acetyltransfe...

journal_title：International immunology

authors： Nishida J,Yoshida M,Arai K,Yokota T

更新日期：1991-03-01 00:00:00

abstract：:Fas (CD95) is a cell surface death receptor belonging to the tumor necrosis factor receptor superfamily, which mediates apoptosis-inducing signaling when activated by Fas ligand or its agonistic antibody. lpr mice with a loss of apoptosis-inducing function mutation in the Fas gene develop systemic autoimmune disease a...

journal_title：International immunology

authors： Takahashi S,Futatsugi-Yumikura S,Fukuoka A,Yoshimoto T,Nakanishi K,Yonehara S

更新日期：2013-05-01 00:00:00

abstract：:Organs of transgenic pigs that express human complement regulatory proteins are under assessment as an alternative to transplantation. A major barrier to the transplantation of pig organs is the hyperacute rejection caused by pre-existing antibodies and complement. Pig cells are very susceptible to human complement, p...

journal_title：International immunology

authors： Toyomura K,Fujimura T,Murakami H,Natsume T,Shigehisa T,Inoue N,Takeda J,Kinoshita T

更新日期：1997-06-01 00:00:00

abstract：:Cells bearing the gamma delta form of the TCR make up only 1-3% of T cells in the adult murine thymus and peripheral lymphoid organs. Evidence from studies of nude mice suggests that the development of at least some gamma delta T cells is thymus dependent; however, until now it has not been directly demonstrated that ...

journal_title：International immunology

authors： Kelly KA,Pearse M,Lefrancois L,Scollay R

更新日期：1993-04-01 00:00:00

abstract：:The A6H mAb raised primarily against human renal cell carcinoma (RCC) has previously been shown to bind strongly to RCC, to some degree to colon carcinoma but only marginally to a variety of normal tissues. Immunohistochemical analysis or RCC tissues containing tumor-infiltrating lymphocytes revealed that A6H stained ...

journal_title：International immunology

authors： Labuda T,Lando P,Björkdahl O,Kalland T,Vessella R,Hedlund G,Eriksson H,Sjögren HO,Dohlsten M

更新日期：1995-09-01 00:00:00

abstract：:Tissue selective traffic of lymphocytes into different lymphoid organs is mediated by adherence of blood borne lymphocytes to specialized endothelial cells lining the high endothelial venules (HEV) in lymphoid organs. Lymphocytes discriminate between HEV in peripheral lymph nodes and in mucosal lymphoid tissues by mea...

journal_title：International immunology

authors： Mebius RE,Brevé J,Kraal G,Streeter PR

更新日期：1993-05-01 00:00:00

abstract：:Acute graft-versus-host disease (GvHD) is a serious complication after allogeneic bone marrow transplantation. Donor-derived T cells infiltrate recipient target organs and cause severe tissue damage, often leading to death of the affected patient. Tissue destruction is a direct result of donor CD8+ T cell activation a...

journal_title：International immunology

authors： Arnold D,Wasem C,Juillard P,Graber P,Cima I,Frutschi C,Herren S,Jakob S,Alouani S,Mueller C,Chvatchko Y,Brunner T

更新日期：2002-05-01 00:00:00

abstract：:The immunomodulator FTY720 inhibits lymph node (LN) and thymic egress, thereby constraining T cell circulation and reducing peripheral T cell numbers. Here, we analyzed in mouse models the as yet scarcely characterized impact of long-term (up to 6 months) FTY720 exposure on T cell homeostasis and possible consequences...

journal_title：International immunology

authors： Metzler B,Gfeller P,Wieczorek G,Li J,Nuesslein-Hildesheim B,Katopodis A,Mueller M,Brinkmann V

更新日期：2008-05-01 00:00:00